Inhibitors of protein kinases and phosphatases

A mammalian protein targeted by G1-arresting rapamycin–receptor complex

1994 • 1,954 citations

Okadaic acid: a new probe for the study of cellular regulation

1990 • 1,396 citations

The Toxins of Cyanobacteria

1994 • 1,101 citations

Liver tumor promotion by the cyanobacterial cyclic peptide toxin microcystin-LR

1992 • 817 citations

A Specific Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase

1994 • 800 citations

Rapamycin-Induced Inhibition of the 70-Kilodalton S6 Protein Kinase

1992 • 666 citations

Inhibition of Cyclin‐Dependent Kinases by Purine Analogues

1994 • 625 citations

MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase.

1992 • 486 citations

PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity.

1994 • 450 citations

[30] Use and specificity of genistein as inhibitor of protein-tyrosine kinases

1991 • 421 citations

Braking the cycle

1993 • 378 citations

Prevention of Lipopolysaccharide-Induced Lethal Toxicity by Tyrosine Kinase Inhibitors

1994 • 339 citations

Protein Phosphorylation; A Practical Approach

1994 • 273 citations

Coupling of mitosis to the completion of S phase in Xenopus occurs via modulation of the tyrosine kinase that phosphorylates p34cdc2

1992 • 231 citations

X-ray structure of a decameric cyclophilin-cyclosporin crystal complex

1993 • 217 citations

Ser/Thr-specific protein phosphatases are required for both catalytic steps of pre-mRNA splicing

1992 • 209 citations

Calcineurin mediates inhibition by FK506 and cyclosporin of recovery from α-factor arrest in yeast

1992 • 195 citations

Tautomycin from the bacterium Streptomyces verticillatus

1990 • 191 citations

Phosphorylation of PHAS-I by mitogen-activated protein (MAP) kinase. Identification of a site phosphorylated by MAP kinase in vitro and in response to insulin in rat adipocytes.

1994 • 165 citations

Protein kinase C: is its pivotal role in cellular activation over-stated?

1994 • 161 citations

Inhibitors of protein kinase C. 3. Potent and highly selective bisindolylmaleimides by conformational restriction

1993 • 157 citations

FKBP-rapamycin inhibits a cyclin-dependent kinase activity and a cyclin D1-Cdk association in early G1 of an osteosarcoma cell line.

1993 • 149 citations

Therapeutic potential of protein kinase C inhibitors

1993 • 144 citations

Protein phosphatase 2A and its [3H]cantharidin/[3H]endothall thioanhydride binding site

1993 • 129 citations

[24] Pseudosubstrate-based peptide inhibitors

1991 • 103 citations

Treatment of myeloid leukemic cells with the phosphatase inhibitor okadaic acid induces cell cycle arrest at either G1/S or G2/M depending on dose

1992 • 93 citations

FK506 and ciclosporin: molecular probes for studying intracellular signal transduction

1993 • 89 citations

[29] Inhibition of protein-tyrosine kinases by tyrphostins

1991 • 76 citations

[25] Utilization of the inhibitor protein of adenosine cyclic monophosphate-dependent protein kinase, and peptides derived from it, as tools to study adenosine cyclic monophosphate-mediated cellular processes

1991 • 69 citations

Inhibitors of protein phosphatase-1 and -2A; two of the major serine/threonine protein phosphatases involved in cellular regulation

1993 • 64 citations

Protein phosphorylation; a practical approach

1994 • 50 citations

Mutation induction by okadaic acid, a protein phosphatase inhibitor, in CHL cells, but not in S. typhimurium

1991 • 47 citations

The discovery of protein phosphatases: From chaos and confusion to an understanding of their role in cell regulation and human disease

1994 • 41 citations