Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR)

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA

1989 • 7,327 citations

Ultrasensitive Stain for Proteins in Polyacrylamide Gels Shows Regional Variation in Cerebrospinal Fluid Proteins

1981 • 2,972 citations

Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis

1990 • 1,756 citations

Demonstration That CFTR Is a Chloride Channel by Alteration of Its Anion Selectivity

1991 • 1,108 citations

Trends in the Development of Baculovirus Expression Vectors

1988 • 1,022 citations

Expression of cystic fibrosis transmembrane conductance regulator corrects defective chloride channel regulation in cystic fibrosis airway epithelial cells

1990 • 706 citations

Altered chloride ion channel kinetics associated with the ΔF508 cystic fibrosis mutation

1991 • 689 citations

Selective solubilization of proteins from red blood cell membranes by protein perturbants

1973 • 611 citations

Correction of the cystic fibrosis defect in vitro by retrovirus-mediated gene transfer

1990 • 576 citations

Phosphorylation-regulated CI− channel in CHO cells stably expressing the cystic fibrosis gene

1991 • 564 citations

Generation of cAMP-Activated Chloride Currents by Expression of CFTR

1991 • 550 citations

Nucleoside triphosphates are required to open the CFTR chloride channel

1991 • 520 citations

Expression of the cystic fibrosis gene in non-epithelial invertebrate cells produces a regulated anion conductance

1991 • 508 citations

Chloride Conductance Expressed by ΔF508 and Other Mutant CFTRs In Xenopus Oocytes

1991 • 498 citations

Purified ryanodine receptor from rabbit skeletal muscle is the calcium-release channel of sarcoplasmic reticulum.

1988 • 475 citations

A human colonic tumor cell line that maintains vectorial electrolyte transport

1984 • 398 citations

Purification of P-glycoprotein from plasma membrane vesicles of Chinese hamster ovary cell mutants with reduced colchicine permeability.

1979 • 368 citations

Effect of Deleting the R Domain on CFTR-Generated Chloride Channels

1991 • 271 citations

Identification and regulation of the cystic fibrosis transmembrane conductance regulator-generated chloride channel.

1991 • 251 citations

Synthesis of the membrane fusion and hemagglutinin proteins of measles virus, using a novel baculovirus vector containing the beta-galactosidase gene

1990 • 245 citations

Maturation and function of cystic fibrosis transmembrane conductance regulator variants bearing mutations in putative nucleotide-binding domains 1 and 2.

1991 • 245 citations

Denaturation and renaturation of bacteriorhodopsin in detergents and lipid-detergent mixtures.

1982 • 243 citations

Two types of chloride channel on duct cells cultured from human fetal pancreas

1989 • 224 citations

Cl- channel activity in Xenopus oocytes expressing the cystic fibrosis gene.

1991 • 196 citations

Low‐conductance chloride channel activated by cAMP in the epithelial cell line T₈₄

1990 • 178 citations

Porin channel triplets merge into single outlets in Escherichia coli outer membranes

1985 • 163 citations

Functional reconstitution of the purified brain sodium channel in planar lipid bilayers.

1985 • 158 citations

Structure-function studies on bacteriorhodopsin. IV. Purification and renaturation of bacterio-opsin polypeptide expressed in Escherichia coli.

1987 • 123 citations

Nystatin-induced liposome fusion. A versatile approach to ion channel reconstitution into planar bilayers

1990 • 122 citations

Reconstitution of membrane receptor systems

1985 • 96 citations

Amiloride-sensitive epithelial Na+ channels reconstituted into planar lipid bilayer membranes

1984 • 94 citations

Different channel properties of Torpedo acetylcholine receptor monomers and dimers reconstituted in planar membranes.

1984 • 65 citations

Properties of an anion-selective channel from rat colonic enterocyte plasma membranes reconstituted into planar phospholipid bilayers

1987 • 62 citations

Channel properties of the purified acetylcholine receptor from Torpedo californica reconstituted in planar lipid bilayer membranes

1984 • 46 citations

Reconstitution and Phosphorylation of Chloride Channels from Airway Epithelium Membranes

1988 • 40 citations

Voltage-dependent activation in purified reconstituted sodium channels from rabbit T-tubular membranes.

1986 • 33 citations

Regulation of epithelial chloride channels by protein phosphatase

1991 • 22 citations

The CF Gene Product as a Member of a Membrane Transporter (TM6-NBF) Super Family

1991 • 21 citations

[38] Localization of enzymes in denaturing polyacrylamide gels

1979 • 13 citations