Thyrotropin-dependent proliferation of in vitro rat thyroid cell systems

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

CDK inhibitors: positive and negative regulators of G1-phase progression

1999 • 6,003 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone

1973 • 3,509 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

The MAPK signaling cascade

1995 • 3,300 citations

Inhibitors of mammalian G1 cyclin-dependent kinases.

1995 • 3,258 citations

Oncogenes and signal transduction

1991 • 2,816 citations

G1 phase progression: Cycling on cue

1994 • 2,706 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization

1998 • 2,096 citations

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

1994 • 2,071 citations

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.

1994 • 1,970 citations

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

1998 • 1,931 citations

Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27

1995 • 1,848 citations

E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

1992 • 1,552 citations

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

1994 • 1,475 citations

Cloning of Senescent Cell-Derived Inhibitors of DNA Synthesis Using an Expression Screen

1994 • 1,368 citations

A Family of cAMP-Binding Proteins That Directly Activate Rap1

1998 • 1,351 citations

The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

1995 • 1,280 citations

Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

1993 • 1,258 citations

Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle

1991 • 1,190 citations

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G ₁

1995 • 1,142 citations

Transforming growth factor-beta in disease: the dark side of tissue repair.

1992 • 1,126 citations

cAMP-DEPENDENT PROTEIN KINASE: FRAMEWORK FOR A DIVERSE FAMILY OF REGULATORY ENZYMES

1990 • 1,121 citations

D-type cyclin-dependent kinase activity in mammalian cells.

1994 • 1,073 citations

Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras

1997 • 1,064 citations

Functional Inactivation of the Retinoblastoma Protein Requires Sequential Modification by at Least Two Distinct Cyclin-cdk Complexes

1998 • 1,058 citations

Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts.

1993 • 1,057 citations

Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

1993 • 1,047 citations

Formation and Activation of a Cyclin E-cdk2 Complex During the G ₁ Phase of the Human Cell Cycle

1992 • 1,046 citations

The Ras-Related Protein Cdc42Hs and Bradykinin Promote Formation of Peripheral Actin Microspikes and Filopodia in Swiss 3T3 Fibroblasts

1995 • 1,033 citations

Regulation of retinoblastoma protein functions by ectopic expression of human cyclins

1992 • 1,031 citations

Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation.

1992 • 1,030 citations

The Role of Phosphoinositide 3-Kinase Lipid Products in Cell Function

1999 • 1,007 citations

Acceleration of the G₁/S Phase Transition by Expression of Cyclins Dl and E with an Inducible System

1994 • 986 citations

Culture of hormone-dependent functional epithelial cells from rat thyroids.

1980 • 959 citations

Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta.

1995 • 959 citations

p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.

1995 • 956 citations

Inhibition by cAMP of Ras-Dependent Activation of Raf

1993 • 955 citations

Inhibition of the EGF-Activated MAP Kinase Signaling Pathway by Adenosine 3′,5′-Monophosphate

1993 • 939 citations

Regulation of protein kinase C

1997 • 919 citations

Cyclin E-CDK2 is a regulator of p27Kip1.

1997 • 915 citations

Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution.

1995 • 910 citations

Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas

1993 • 907 citations

Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins

1992 • 906 citations

lnterleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin

1994 • 903 citations

Association of human cyclin E with a periodic G1-S phase protein kinase

1992 • 900 citations

A Retroviral Oncogene, akt , Encoding a Serine-Threonine Kinase Containing an SH2-Like Region

1991 • 900 citations

An essential role for Rac in Ras transformation

1995 • 895 citations

Crystal structure of the p27Kip1 cyclin-dependent-kinase inibitor bound to the cyclin A–Cdk2 complex

1996 • 889 citations

Identification of G1 kinase activity for cdk6, a novel cyclin D partner.

1994 • 798 citations

Physical interaction of the retinoblastoma protein with human D cyclins

1993 • 780 citations

Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit

1993 • 778 citations

Cyclin-Dependent Regulation of G ₁ in Mammalian Fibroblasts

1993 • 767 citations

Mechanism of activation and function of protein kinase B

1998 • 753 citations

Cell Biology of the Amyloid beta-Protein Precursor and the Mechanism of Alzheimer's Disease

1994 • 749 citations

Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation

1994 • 742 citations

Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.

1994 • 731 citations

The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling.

1993 • 705 citations

Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1

1997 • 698 citations

Requirement of p27 ^Kip1 for Restriction Point Control of the Fibroblast Cell Cycle

1996 • 683 citations

Activation of Rac1, RhoA, and Mitogen-Activated Protein Kinases Is Required for Ras Transformation

1995 • 683 citations

Multiple ras functions can contribute to mammalian cell transformation

1995 • 658 citations

Novel INK4 Proteins, p19 and p18, Are Specific Inhibitors of the Cyclin D-Dependent Kinases CDK4 and CDK6

1995 • 657 citations

p21-containing cyclin kinases exist in both active and inactive states.

1994 • 646 citations

A novel cyclin associates with M015/CDK7 to form the CDK-activating kinase

1994 • 636 citations

The Thyrotropin Receptor and the Regulation of Thyrocyte Function and Growth*

1992 • 592 citations

Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides.

1987 • 589 citations

Comparison of adenosine 3':5'-monophosphate-dependent protein kinases from rabbit skeletal and bovine heart muscle.

1975 • 569 citations

Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA

1995 • 561 citations

Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes.

1996 • 560 citations

The modular phosphorylation and activation of p70^s6k

1997 • 539 citations

A role for Rho in Ras transformation.

1995 • 538 citations

Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily.

1991 • 537 citations

Physiological and pathological regulation of thyroid cell proliferation and differentiation by thyrotropin and other factors

1992 • 535 citations

Cell Cycle Control of DNA Replication

1996 • 512 citations

Assembly of cyclin D-dependent kinase and titration of p27 ^Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)

1998 • 497 citations

Evidence that the G1-S and G2-M transitions are controlled by different cdc2 proteins in higher eukaryotes

1991 • 493 citations

Molecular cloning and characterisation of a novel putative protein‐serine kinase related to the cAMP‐dependent and protein kinase C families

1991 • 485 citations

Structure and Function of Cyclic Nucleotide-Dependent Protein Kinases

1994 • 442 citations

Coupling of Hormonal Stimulation and Transcription via the Cyclic AMP-Responsive Factor CREB Is Rate Limited by Nuclear Entry of Protein Kinase A

1993 • 426 citations

Replacement of serum by hormones permits growth of cells in a defined medium

1976 • 412 citations

Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase

1997 • 402 citations

Increasing cAMP attenuates activation of mitogen-activated protein kinase.

1993 • 383 citations

Germline mutations in the thyrotropin receptor gene cause non–autoimmune autosomal dominant hyperthyroidism

1994 • 376 citations

Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein

1997 • 359 citations

RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts.

1993 • 356 citations

Iodide Transport in a Continuous Line of Cultured Cells from Rat Thyroid

1984 • 342 citations

Identification of Human and Mouse p19, a Novel CDK4 and CDK6 Inhibitor with Homology to p16^ink4

1995 • 336 citations

Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation.

1996 • 335 citations

Bridging Ral GTPase to Rho Pathways

1995 • 330 citations

Signaling through protein kinase C

1998 • 326 citations

Insulin Signal Transduction and the IRS Proteins

1996 • 323 citations

Clonal stability and phenotypic expression of chick cartilage cells in vitro.

1966 • 322 citations

Rapid and reversible translocation of the catalytic subunit of cAMP-dependent protein kinase type II from the Golgi complex to the nucleus.

1985 • 317 citations

Cyclin-Binding Motifs Are Essential for the Function of p21^CIP1

1996 • 313 citations

Cdc42 Regulates Anchorage-Independent Growth and Is Necessary for Ras Transformation

1997 • 312 citations

Mechanism of inhibition of Raf-1 by protein kinase A.

1994 • 311 citations

Cyclin/Cdk-Dependent Initiation of DNA Replication in a Human Cell-Free System

1997 • 311 citations

Signal transduction from multiple Ras effectors

1997 • 308 citations

Regions of the alpha 1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function.

1990 • 302 citations

The 70 kDa S6 Kinase Complexes with and Is Activated by the Rho Family G Proteins Cdc42 and Rac1

1996 • 293 citations

Inactivation of a Cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes.

1994 • 289 citations

INSULIN-LIKE GROWTH FACTOR-I STIMULATES THE GROWTH OF RAT THYROID CELLS IN CULTURE AND SYNERGIZES THE STIMULATION OF DNA SYNTHESIS INDUCED BY TSH AND GRAVES′-IgG

1986 • 286 citations

Cell Cycle Control of DNA Replication by a Homologue from Human Cells of the p34 ^cdc2 Protein Kinase

1990 • 285 citations

A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen

1995 • 276 citations

The phosphatidylinositol 3-kinase alpha is required for DNA synthesis induced by some, but not all, growth factors.

1994 • 270 citations

cAMP-induced Morphological Changes Are Counteracted by the Activated RhoA Small GTPase and the Rho Kinase ROKα

1998 • 267 citations

Nucleotide sequence of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, a glycoprotein of endoplasmic reticulum

1984 • 263 citations

Collaboration of G1 cyclins in the functional inactivation of the retinoblastoma protein.

1994 • 253 citations

RAS pathways to cell cycle control and cell transformation

1998 • 247 citations

PDK1, one of the missing links in insulin signal transduction?¹

1997 • 246 citations

A Role for the Ral Guanine Nucleotide Dissociation Stimulator in Mediating Ras-induced Transformation

1996 • 245 citations

One- and Two-Step Transformations of Rat Thyroid Epithelial Cells by Retroviral Oncogenes

1987 • 244 citations

The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signalling

1995 • 243 citations

Geranylgeranylated Rho Small GTPase(s) Are Essential for the Degradation of p27 and Facilitate the Progression from G1 to S Phase in Growth-stimulated Rat FRTL-5 Cells

1997 • 238 citations

Transforming growth factor-beta 1 knockout mice. A mutation in one cytokine gene causes a dramatic inflammatory disease.

1993 • 235 citations

Somatic mutations causing constitutive activity of the thyrotropin receptor are the major cause of hyperfunctioning thyroid adenomas: identification of additional mutations activating both the cyclic adenosine 3',5'-monophosphate and inositol phosphate-Ca2+ cascades.

1995 • 234 citations

Using structure to define the function of phosphoinositide 3‐kinase family members

1997 • 230 citations

Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry

1998 • 227 citations

The oncogenic forms of N-ras or H-ras prevent skeletal myoblast differentiation.

1987 • 221 citations

Hormone-dependent terminal differentiation in vitro of chicken erythroleukemia cells transformed by ts mutants of avian erythroblastosis virus

1982 • 220 citations

Thyroid-specific gene expression

1994 • 218 citations

A novel Cdc42Hs mutant induces cellular transformation

1997 • 213 citations

A Drosophila gene encoding a protein resembling the human beta-amyloid protein precursor.

1989 • 212 citations

A cdc2-like protein is involved in the initiation of DNA replication in Xenopus egg extracts

1990 • 209 citations

The Relationship of Growth and Adenylate Cyclase Activity in Cultured Thyroid Cells: Separate Bioeffects of Thyrotropin

1983 • 204 citations

Abrogation of p27 by cDNA Antisense Suppresses Quiescence (G0 State) in Fibroblasts

1996 • 203 citations

Thyroglobulin gene expression is regulated by insulin and insulin-like growth factor I, as well as thyrotropin, in FRTL-5 thyroid cells.

1987 • 194 citations

Identification of the active region of the DNA synthesis inhibitory gene p21Sdi1/CIP1/WAF1.

1995 • 186 citations

Protein Kinase A-Dependent and -Independent Signaling Pathways Contribute to Cyclic AMP-Stimulated Proliferation

1999 • 186 citations

High affinity binding protein for the regulatory subunit of cAMP-dependent protein kinase II-B

1989 • 184 citations

Temperature-sensitive expression of differentiation in transformed myoblasts

1975 • 172 citations

Induction of Cell Proliferation in Quiescent NIH 3T3 Cells by Oncogenic c-Raf-1

1997 • 168 citations

Localization of A-kinase through anchoring proteins.

1994 • 164 citations

Characterization of the Optimal Stimulatory Effects of Graves’ Monoclonal and Serum Immunoglobulin G on Adenosine 3′,5′-Monophosphate Production in FRTL-5 Thyroid Cells: A Potential Clinical Assay

1983 • 160 citations

The genetic subtypes of cAMP-dependent protein kinase — Functionally different or redundant?

1993 • 160 citations

A neomutation of the thyroid-stimulating hormone receptor in a severe neonatal hyperthyroidism.

1996 • 150 citations

A G-protein beta gamma-subunit-responsive phosphoinositide 3-kinase activity in human platelet cytosol

1994 • 148 citations

Distinct sub-populations of the retinoblastoma protein show a distinct pattern of phosphorylation.

1994 • 148 citations

Phorbol Esters Stimulate Growth and Inhibit Differentiation in Cultured Thyroid Cells*

1985 • 142 citations

Single cellular origin of somatostatin and calcitonin in the rat thyroid gland

1977 • 142 citations

Thyrotropin and dibutyryl cyclic AMP increase levels of c-myc and c-fos mRNAs in cultured rat thyroid cells.

1986 • 140 citations

Cyclic AMP-dependent Activation of Rap1b

1995 • 131 citations

Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression.

1994 • 130 citations

Thyrotropin effects on thyroid cells in culture. Effects of trypsin on the thyrotropin receptor and on thyrotropin-mediated cyclic 3':5'-AMP changes

1975 • 125 citations

cAMP signaling in neurons: patterns of neuronal expression and intracellular localization for a novel protein, AKAP 150, that anchors the regulatory subunit of cAMP-dependent protein kinase II beta.

1992 • 121 citations

Phosphorylation of mitogen-activated protein kinases is involved in the epidermal growth factor and phorbol ester, but not in the thyrotropin/cAMP, thyroid mitogenic pathway.

1993 • 119 citations

A regulatory role for cAMP in phosphatidylinositol 3-kinase/p70 ribosomal S6 kinase-mediated DNA synthesis in platelet-derived-growth-factor-stimulated bovine airway smooth-muscle cells

1996 • 118 citations

Regulation of a collagen gene promoter by the product of viral mos oncogene

1985 • 115 citations

A Tyrosine Kinase Signaling Pathway Accounts for the Majority of Phosphatidylinositol 3,4,5-Trisphosphate Formation in Chemoattractant-stimulated Human Neutrophils

1996 • 115 citations

Polyclonal and monoclonal thyroid nodules coexist within human multinodular goiters.

1994 • 112 citations

Genetic alterations in thyroid hyperfunctioning adenomas.

1995 • 110 citations

Analysis of Wild-Type and Mutant p21^WAF-1 Gene Activities

1996 • 108 citations

Microinjection of smg/rap1/Krev-1 p21 into Swiss 3T3 cells induces DNA synthesis and morphological changes.

1992 • 107 citations

Cloning and expression of an intron-less gene for AKAP 75, an anchor protein for the regulatory subunit of cAMP-dependent protein kinase II beta.

1992 • 102 citations

Inhibition by Islet-Activating Protein, Pertussis Toxin, of P₂-Purinergic Receptor-Mediated Iodide Efflux and Phosphoinositide Turnover in FRTL-5 Cells*

1988 • 101 citations

Multiple Mechanisms of Interference between Transformation and Differentiation in Thyroid Cells

1992 • 100 citations

Protein kinase C involvement in apoptosis

1995 • 99 citations

Stimulation of cell proliferation and inhibition of differentiation expression by tumor-promoting phorbol esters in dog thyroid cells in primary culture.

1986 • 96 citations

Evidence that Adenosine 3′,5′-Monophosphate Mediates Stimulation of Thyroid Growth in FRTL₅Cells*

1986 • 90 citations

Demonstration of the production and physiological role of insulin-like growth factor II in rat thyroid follicular cells in culture.

1988 • 90 citations

Ras‐effector interactions, the problem of specificity

1995 • 89 citations

Plasma membrane recruitment of RalGDS is critical for Ras-dependent Ral activation

1999 • 89 citations

Activation of Cyclic AMP-Dependent Kinase Is Required but May Not Be Sufficient To Mimic Cyclic AMP-Dependent DNA Synthesis and Thyroglobulin Expression in Dog Thyroid Cells

1997 • 88 citations

Identification of a substrate-targeting domain in cyclin E necessary for phosphorylation of the retinoblastoma protein

1998 • 86 citations

Somatostatin Regulates Somatostatin Receptor Subtype mRNA Expression in GH3 Cells

1994 • 83 citations

Overexpression of the Type II Regulatory Subunit of the cAMP-Dependent Protein Kinase Eliminates the Type I Holoenzyme in Mouse Cells

1989 • 80 citations

Growth factors and goitrogenesis

1999 • 80 citations

The Effects of Transforming Growth Factor-β on Growth and Differentiation of the Continuous Rat Thyroid Follicular Cell Line, FRTL-5

1988 • 79 citations

Regulation of Ion Channels By Inositol Trisphosphate and Diacylglycerol

1986 • 78 citations

General inhibition by transforming growth factor β1 of thyrotropin and cAMP responses in human thyroid cells in primary culture

1993 • 77 citations

A mutant insulin receptor induces formation of a Shc-growth factor receptor bound protein 2 (Grb2) complex and p21ras-GTP without detectable interaction of insulin receptor substrate 1 (IRS1) with Grb2. Evidence for IRS1-independent p21ras-GTP formation

1994 • 76 citations

Acute effect of thyrotropin on phosphatidylinositol degradation and transient accumulation of diacylglycerol in isolated thyroid follicles

1980 • 74 citations

Differential Effects of Protein Kinase A on Ras Effector Pathways

1998 • 73 citations

RalGDS Functions in Ras- and cAMP-mediated Growth Stimulation

1997 • 72 citations

Somatostatin Inhibits PC Cl3 Thyroid Cell Proliferation through the Modulation of Phosphotyrosine Phosphatase Activity

1996 • 71 citations

Specific Activation of p85-p110 Phosphatidylinositol 3′-Kinase Stimulates DNA Synthesis by ras- and p70 S6 Kinase-Dependent Pathways

1997 • 71 citations

Differential Modulation of G1 Cyclins and the Cdk Inhibitor p27 by Platelet-derived Growth Factor and Plasma Factors in Density-arrested Fibroblasts

1996 • 71 citations

Growth Factor Control of Rat Thyroid Follicular Cell Proliferation

1986 • 71 citations

Molecular events involved in differentiation of thyroid follicular cells

1998 • 70 citations

A Refractory Phase in Cyclic AMP-Responsive Transcription Requires Down Regulation of Protein Kinase A

1995 • 70 citations

The level of thyroglobulin mRNA is regulated by TSH both in vitro and in vivo

1984 • 70 citations

ATP, bradykinin, TRH and TSH activate the Ca2+-phosphatidylinositol cascade of human thyrocytes in primary culture

1991 • 69 citations

Presence of nonfunctional thyrotropin receptor variant transcripts in retroocular and other tissues.

1994 • 68 citations

Reversible inhibition of a thyroid-specific trans-acting factor by Ras.

1991 • 68 citations

Inhibition of Thyrotropin-Stimulated DNA Synthesis by Microinjection of Inhibitors of Cellular Ras and Cyclic AMP-Dependent Protein Kinase

1993 • 67 citations

v-ras and protein kinase C dedifferentiate thyroid cells by down-regulating nuclear cAMP-dependent protein kinase A.

1992 • 66 citations

Novel Mammalian Cyclins (CYL Genes) Expressed during G1

1991 • 66 citations

TGF-β1 actions on FRTL-5 cells provide a model for the physiological regulation of thyroid growth

1998 • 63 citations

Identification of a high affinity binding protein for the regulatory subunit RII beta of cAMP-dependent protein kinase in Golgi enriched membranes of human lymphoblasts.

1992 • 62 citations

Relationship between proliferation and cell cycle-dependent Ca2+ influx induced by a combination of thyrotropin and insulin-like growth factor-I in rat thyroid cells.

1990 • 61 citations

Thyrotropin-Induced Mitogenesis Is Ras Dependent but Appears To Bypass the Raf-Dependent Cytoplasmic Kinase Cascade

1995 • 60 citations

Somatostatin Inhibits Deoxyribonucleic Acid Synthesis Induced by Both Thyrotropin and Insulin-Like Growth Factor-I in FRTL5 Cells*

1990 • 59 citations

Expression of a kinase anchor protein 75 depletes type II cAMP-dependent protein kinases from the cytoplasm and sequesters the kinases in a particulate pool.

1993 • 59 citations

Activation of the Small G Protein Rap1 in Dog Thyroid Cells by Both cAMP-Dependent and -Independent Pathways

2000 • 58 citations

Purinergic agonist ATP is a comitogen in thyroid FRTL-5 cells

1996 • 56 citations

Insulin and TSH promote growth in size of PC Cl3 rat thyroid cells, possibly via a pathway different from DNA synthesis: comparison with FRTL-5 cells

1999 • 54 citations

3',5'-cyclic adenosine monophosphate-regulated enhancer binding (CREB) activity is required for normal growth and differentiated phenotype in the FRTL5 thyroid follicular cell line.

1992 • 53 citations

Induction of a negative autocrine loop by expression of sst2 somatostatin receptor in NIH 3T3 cells.

1996 • 53 citations

Control of c-fos and c-myc Proto-Oncogene Induction in Rat Thyroid Cells in Culture

1987 • 53 citations

Newly Synthesized Rho A, Not Ras, Is Isoprenylated and Translocated to Membranes Coincident with Progression of the G1 to S Phase of Growth-stimulated Rat FRTL-5 Cells

1998 • 52 citations

Independent and Interactive Effects of Tetradecanoyl Phorbol Acetate on Growth and Differentiated Functions of FRTL5 Cells*

1988 • 52 citations

The v-Ki-Ras Oncogene Alters cAMP Nuclear Signaling by Regulating the Location and the Expression of cAMP-dependent Protein Kinase IIβ

1996 • 52 citations

Thyrotropin induces changes in the morphology and the organization of microfilament structures in cultured thyroid cells

1982 • 52 citations

A Role for RalGDS and a Novel Ras Effector in the Ras-mediated Inhibition of Skeletal Myogenesis

1998 • 50 citations

Transforming growth factor-beta blocks protein kinase-A-mediated iodide transport and protein kinase-C-mediated DNA synthesis in FRTL-5 rat thyroid cells.

1992 • 49 citations

Enhanced expression of transforming growth factor-β1 during thyroid hyperplasia in rats

1994 • 49 citations

cAMP-dependent protein kinases I and II: divergent turnover of subunits

1986 • 48 citations

Intracellular Ca²⁺Mobilization by Thyrotropin, Carbachol, and Adenosine Triphosphate in Dog Thyroid Cells*

1989 • 46 citations

Phosphorylation of the regulatory subunit of type II beta cAMP-dependent protein kinase by cyclin B/p34cdc2 kinase impairs its binding to microtubule-associated protein 2.

1993 • 45 citations

Iodine Inhibits the Proliferation of Rat Thyroid Cells in Culture*

1989 • 44 citations

P₂‐purinergic agonists activate phospholipase C in a guanine nucleotide‐ and Ca²⁺‐dependent manner in FRTL‐5 thyroid cell membranes

1989 • 44 citations

Insulin stimulates cell growth of a new strain of differentiated rat thyroid cells

1987 • 44 citations

Thyrotropin and norepinephrine stimulate the metabolism of phosphoinositides in FRTL‐5 thyroid cells

1986 • 44 citations

Thyrotropin induces G1 cyclin expression and accelerates G1 phase after insulin-like growth factor I stimulation in FRTL-5 cells.

1996 • 42 citations

Pairs of cyclic AMP analogs, that are specifically synergistic for type I and type II cAMP‐dependent protein kinases, mimic thyrotropin effects on the function, differentiation expression and mitogenesis of dog thyroid cells

1989 • 41 citations

Somatostatin Is Expressed in FRTL-5 Thyroid Cells and Prevents Thyrotropin-Mediated Down-Regulation of the Cyclin-Dependent Kinase Inhibitor p27^kip11

1999 • 40 citations

Inhibition of thyrotropin-induced DNA synthesis in thyroid follicular cells by microinjection of an antibody to the stimulatory G protein of adenylate cyclase, Gs.

1992 • 38 citations

Ras inhibits thyroglobulin expression but not cyclic adenosine monophosphate-mediated signaling in Wistar rat thyrocytes.

1996 • 35 citations

Basic fibroblast growth factor: an autocrine mitogen of rat thyroid follicular cells?

1992 • 35 citations

Sphingosine 1-Phosphate Mobilizes Sequestered Calcium, Activates Calcium Entry, and Stimulates Deoxyribonucleic Acid Synthesis in Thyroid FRTL-5 Cells*

1997 • 34 citations

G‐Protein Coupled Receptor‐Mediated Activation of PI 3‐Kinase in Neutrophils^a

1997 • 34 citations

Cell cycle progression and 3-hydroxy-3-methylglutaryl coenzyme A reductase are regulated by thyrotropin in FRTL-5 rat thyroid cells.

1990 • 34 citations

Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Gene Expression in FRTL-5 Cells

1995 • 33 citations

Evidence that the inhibitory effects of iodide on thyroid cell proliferation are due to arrest of the cell cycle at G0G1 and G2M phases.

1993 • 30 citations

Opposite regulation of deoxyribonucleic acid synthesis and iodide uptake in rat thyroid cells by basic fibroblast growth factor: correlation with opposite regulation of c-fos and thyrotropin receptor gene expression.

1992 • 26 citations

Oncogenic potential of a mutant human thyrotropin receptor expressed in FRTL-5 cells

1998 • 26 citations

Thyroid-stimulating hormone-regulated growth and cell cycle distribution of thyroid cells involve type I isozyme of cyclic AMP-dependent protein kinase.

1993 • 26 citations

Activation of Phospholipase D in FRTL-5 Thyroid Cells by Forskolin and Dibutyryl-Cyclic Adenosine Monophosphate*

1997 • 25 citations

Identification of Protein Kinase C and Its Multiple Isoforms in FRTL-5 Thyroid Cells

1995 • 24 citations

Protein kinase-C activation during thyrotropin-stimulated proliferation of rat FRTL-5 thyroid cells.

1992 • 22 citations

Mutations of thyrotropin receptor gene

1997 • 21 citations

Growth regulation of rat thyrocytes (FRTL-5 cells) by the secreted ectodomain of beta-amyloid precursor-like proteins.

1996 • 21 citations

Ha-ras Interference with Thyroid Cell Differentiation Is Associated with a Down-Regulation of Thyroid Transcription Factor-1 Phosphorylation*

1998 • 20 citations

Ablation of Goα Overrides G1Restriction Point Control through Ras/ERK/Cyclin D1-CDK Activities

1997 • 19 citations

Ki-ras oncogene interferes with the expression of cyclic AMP-dependent promoters.

1995 • 19 citations

Thyroid-stimulating hormone activates phospholipase D in FRTL-5 thyroid cells via stimulation of protein kinase C.

1995 • 19 citations

Thyrotropin Dependent and Independent Thyroid Cell Lines Selected from FRTL-5 Derived Tumors Grown in Nude Mice*

1990 • 19 citations

Comparison of FRTL-5 Cell Growthin Vitrowith That of Xenotransplanted Cells and the Thyroid of the Recipient Mouse*

1991 • 18 citations

Suppression of insulin‐stimulated phosphatidylinositol 3‐kinase activity by the β₃‐adrenoceptor agonist CL316243 in rat adipocytes

1997 • 14 citations

Thyrotropin-dependent transforming growth factor beta expression in thyroid gland

1996 • 14 citations

Effects of ceramide and protein kinase C on the regulation of type I 5'-deiodinase in FRTL-5 rat thyroid cells.

1996 • 13 citations

[75] The isolation and culture of thyroid cells

1974 • 13 citations

Regulation of Protein Kinase C Isoforms in FRTL-5 Thyroid Cells by TSH and Phorbol Ester

1996 • 11 citations

Thyrotropin-Induced Elevation of 1,2-Diacylglycerol and Stimulation of Growth of FRTL-5 Cells Are Not Dependent on Inositol Lipid Hydrolysis*

1990 • 10 citations

Species Differences of the Thyroid Protein Kinase C Heterogeneity

1994 • 4 citations