RalGDS Functions in Ras- and cAMP-mediated Growth Stimulation

Antibodies, a laboratory manual

1989 • 12,929 citations

Mammalian Ras interacts directly with the serine/threonine kinase raf

1993 • 1,983 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

Inhibition of NIH 3T3 Cell Proliferation by a Mutant ras Protein with Preferential Affinity for GDP

1988 • 757 citations

Multiple ras functions can contribute to mammalian cell transformation

1995 • 658 citations

Complex formation between RAS and RAF and other protein kinases.

1993 • 633 citations

Molecular Cloning of Two Types of GAP Complementary DNA from Human Placenta

1988 • 492 citations

Raf-1 protein kinase is required for growth of induced NIH/3T3 cells

1991 • 489 citations

Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation.

1996 • 335 citations

Bridging Ral GTPase to Rho Pathways

1995 • 330 citations

Identification and Characterization of Ral-Binding Protein 1, a Potential Downstream Target of Ral GTPases

1995 • 304 citations

Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator.

1994 • 281 citations

Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap.

1994 • 270 citations

Involvement of Ral GTPase in v-Src-induced phospholipase D activation

1995 • 261 citations

ralGDS family members interact with the effector loop of ras p21.

1994 • 260 citations

Schwann cell growth factors

1978 • 254 citations

A Role for the Ral Guanine Nucleotide Dissociation Stimulator in Mediating Ras-induced Transformation

1996 • 245 citations

Construction of an improved host strain for two hybrid screening

1994 • 242 citations

Interaction of Ras and Raf in intact mammalian cells upon extracellular stimulation.

1994 • 221 citations

Evidence for the in vitro and in vivo interaction of Ras with protein kinase C zeta.

1994 • 221 citations

Identification of AF-6 and Canoe as Putative Targets for Ras

1996 • 207 citations

Direct Interaction between Ras and the Kinase Domain of Mitogen-activated Protein Kinase Kinase Kinase (MEKK1)

1995 • 177 citations

Cyclic AMP as a mitogenic signal for cultured rat Schwann cells

1978 • 177 citations

A putative effector of Ral has homology to Rho/Rac GTPase activating proteins.

1995 • 176 citations

Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase.

1993 • 174 citations

A Human Protein Selected for Interference with Ras Function Interacts Directly with Ras and Competes with Raf1

1995 • 170 citations

A dominant-negative mutant of raf blocks mitogen-activated protein kinase activation by growth factors and oncogenic p21ras.

1993 • 161 citations

Purification and expansion of human Schwann cells in vitro

1995 • 158 citations

B-Raf-dependent regulation of the MEK-1/mitogen-activated protein kinase pathway in PC12 cells and regulation by cyclic AMP.

1994 • 157 citations

Phosphorylation of mitogen-activated protein kinases is involved in the epidermal growth factor and phorbol ester, but not in the thyrotropin/cAMP, thyroid mitogenic pathway.

1993 • 119 citations

p42 mitogen-activated protein kinase and p90 ribosomal S6 kinase are selectively phosphorylated and activated during thrombin-induced platelet activation and aggregation

1994 • 107 citations

Association of the Viral Oncoprotein STP-C488 with Cellular ras

1995 • 101 citations

Differential effects on cAMP on the MAP kinase cascade: evidence for a cAMP-insensitive step that can bypass Raf-1.

1995 • 68 citations

Inhibition of Thyrotropin-Stimulated DNA Synthesis by Microinjection of Inhibitors of Cellular Ras and Cyclic AMP-Dependent Protein Kinase

1993 • 67 citations

Regulation of Interaction of ras p21 with RalGDS and Raf-1 by Cyclic AMP-dependent Protein Kinase

1996 • 67 citations

The Ras-related protein R-ras interacts directly with Raf-1 in a GTP-dependent manner

1994 • 62 citations

Thyrotropin-Induced Mitogenesis Is Ras Dependent but Appears To Bypass the Raf-Dependent Cytoplasmic Kinase Cascade

1995 • 60 citations

Association of pRas and pRaf-1 in a complex correlates with activation of a signal transduction pathway

1993 • 54 citations

Inhibition of thyrotropin-induced DNA synthesis in thyroid follicular cells by microinjection of an antibody to the stimulatory G protein of adenylate cyclase, Gs.

1992 • 38 citations

Post-translational Modifications of Ras and Ral Are Important for the Action of Ral GDP Dissociation Stimulator

1996 • 38 citations

The TC21 oncoprotein interacts with the Ral guanosine nucleotide dissociation factor.

1996 • 30 citations

Ras-interacting domain of Ral GDP dissociation stimulator like (RGL) reverses v-Ras-induced transformation and Raf-1 activation in NIH3T3 cells.

1996 • 23 citations

Ras-interacting domain of RGL blocks Ras-dependent signal transduction inXenopusoocytes

1996 • 15 citations