Inhibition of Thyrotropin-Stimulated DNA Synthesis by Microinjection of Inhibitors of Cellular Ras and Cyclic AMP-Dependent Protein Kinase

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

Transcription factor AP-2 mediates induction by two different signal-transduction pathways: Protein kinase C and cAMP

1987 • 1,391 citations

A Cytoplasmic Protein Stimulates Normal N- ras p21 GTPase, But Does Not Affect Oncogenic Mutants

1987 • 1,197 citations

Two G Protein Oncogenes in Human Endocrine Tumors

1990 • 1,038 citations

The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21

1990 • 984 citations

Culture of hormone-dependent functional epithelial cells from rat thyroids.

1980 • 959 citations

Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

1985 • 913 citations

Inhibition of NIH 3T3 Cell Proliferation by a Mutant ras Protein with Preferential Affinity for GDP

1988 • 757 citations

Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation

1985 • 738 citations

The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae

1990 • 684 citations

Insulin-like growth factor I mediates selective anabolic effects of parathyroid hormone in bone cultures.

1989 • 541 citations

Physiological and pathological regulation of thyroid cell proliferation and differentiation by thyrotropin and other factors

1992 • 535 citations

Microinjection of the oncogene form of the human H-ras (t-24) protein results in rapid proliferation of quiescent cells

1984 • 401 citations

Transformation of NIH 3T3 cells by microinjection of Ha-ras p21 protein

1984 • 379 citations

Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts.

1993 • 377 citations

The G protein coupled to the thromboxane A2 receptor in human platelets is a member of the novel Gq family

1991 • 373 citations

Point Mutations of Ras Oncogenes are an Early Event in Thyroid Tumorigenesis

1990 • 361 citations

Parathyroid Hormone Enhances the Transcript and Polypeptide Levels of Insulin-Like Growth Factor I in Osteoblast-Enriched Cultures from Fetal Rat Bone*

1989 • 337 citations

Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells.

1990 • 327 citations

INSULIN-LIKE GROWTH FACTOR-I STIMULATES THE GROWTH OF RAT THYROID CELLS IN CULTURE AND SYNERGIZES THE STIMULATION OF DNA SYNTHESIS INDUCED BY TSH AND GRAVES′-IgG

1986 • 286 citations

Insulin stimulation of gene expression mediated by p21ras activation.

1991 • 284 citations

Thyroid follicular cell carcinogenesis*1

1989 • 260 citations

Two growth factor signalling pathways in fibroblasts distinguished by pertussis toxin

1987 • 254 citations

Presence of mutations in all three ras genes in human thyroid tumors.

1990 • 250 citations

Effect of a dominant inhibitory Ha-ras mutation on mitogenic signal transduction in NIH 3T3 cells.

1990 • 242 citations

A Cytosolic Protein Catalyzes the Release of GDP from p21 ^ras

1990 • 231 citations

HRas-dependent pathways can activate morphological and genetic markers of cardiac muscle cell hypertrophy.

1993 • 228 citations

Dominant inhibitory mutations in the Mg(2+)-binding site of RasH prevent its activation by GTP.

1991 • 211 citations

gsp mutations in human thyroid tumours.

1991 • 198 citations

Association between B-lymphocyte membrane immunoglobulin and multiple members of the Src family of protein tyrosine kinases.

1992 • 181 citations

Pertussis Toxin-Sensitive Pathway in the Stimulation of c- myc Expression and DNA Synthesis by Bombesin

1986 • 171 citations

Dominant inhibitory Ras mutants selectively inhibit the activity of either cellular or oncogenic Ras.

1991 • 164 citations

Tyrosine phosphorylation of G protein alpha subunits by pp60c-src.

1992 • 110 citations

Purification and Characterization of Human H-ras Proteins Expressed in Escherichia coli

1985 • 101 citations

Serum, bradykinin and vasopressin stimulate release of inositol phosphates from human fibroblasts

1984 • 88 citations

Evidence for autocrine production of IGF-1 in human thyroid adenomas

1989 • 77 citations

Mitogenic pathways regulated by G protein oncogenes.

1992 • 63 citations

Inhibition of DNA synthesis in living cells by microinjection of Gi2 antibodies.

1992 • 60 citations

Novel Cyclic Adenosine 3′,5′- Monophosphate Response Element in the Human Chorionic Gonadotropin β-Subunit Gene

1991 • 57 citations

Expression in Escherichia coli and characterization of the heat-stable inhibitor of the cAMP-dependent protein kinase

1991 • 55 citations

Activation of transforming G protein-coupled receptors induces rapid tyrosine phosphorylation of cellular proteins, including p125FAK and the p130 v-src Substrate

1992 • 51 citations

Thyrotropin and insulin-like growth factor I regulation of tyrosine phosphorylation in FRTL-5 cells. Interaction between cAMP-dependent and growth factor-dependent signal transduction.

1991 • 48 citations

Partial transformation of human thyroid epithelial cells by mutant Ha-ras oncogene.

1990 • 41 citations

Mediation of Follicle-Stimulating Hormone Action on Follicular Deoxyribonucleic Acid Synthesis by Epidermal Growth Factor*

1991 • 40 citations

Inhibition of thyrotropin-induced DNA synthesis in thyroid follicular cells by microinjection of an antibody to the stimulatory G protein of adenylate cyclase, Gs.

1992 • 38 citations

Gonadotropin regulation of Leydig cell DNA synthesis

1986 • 28 citations

Cloning and sequence analysis of TFE, a helix-loop-helix transcription factor able to recognize the thyroglobulin gene promoterin vitro

1991 • 24 citations

TSH, IGF-1 and activated ras protein induce DNA synthesis in cultured thyroid cells.

1991 • 10 citations