Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Gene Expression in FRTL-5 Cells

Molecular cloning: A laboratory manual

1990 • 85,659 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Regulation of the mevalonate pathway

1990 • 5,282 citations

ras GENES

1987 • 3,818 citations

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

A general method ofin vitropreparation and specific mutagenesis of DNA fragments: study of protein and DNA interactions

1988 • 2,410 citations

All ras proteins are polyisoprenylated but only some are palmitoylated

1989 • 1,806 citations

Identification of a cyclic-AMP-responsive element within the rat somatostatin gene.

1986 • 1,424 citations

Culture of hormone-dependent functional epithelial cells from rat thyroids.

1980 • 959 citations

Inhibition by cAMP of Ras-Dependent Activation of Raf

1993 • 955 citations

Inhibition of the EGF-Activated MAP Kinase Signaling Pathway by Adenosine 3′,5′-Monophosphate

1993 • 939 citations

p21ras is modified by a farnesyl isoprenoid.

1989 • 847 citations

HMG CoA reductase: A negatively regulated gene with unusual promoter and 5′ untranslated regions

1984 • 523 citations

Posttranslational modification of proteins by isoprenoids in mammalian cells

1990 • 515 citations

MINIREVIEW: Cyclic AMP Response Element Binding Proteins: A Cornucopia of Transcription Factors

1990 • 394 citations

Discovery, biochemistry and biology of lovastatin

1988 • 348 citations

Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation.

1990 • 333 citations

Sterol-dependent repression of low density lipoprotein receptor promoter mediated by 16-base pair sequence adjacent to binding site for transcription factor Sp1.

1988 • 271 citations

Nucleotide sequence of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, a glycoprotein of endoplasmic reticulum

1984 • 263 citations

Evidence for post-translational incorporation of a product of mevalonic acid into Swiss 3T3 cell proteins.

1984 • 236 citations

42 bp element from LDL receptor gene confers end-product repression by sterols when inserted into viral TK promoter

1987 • 220 citations

Thyrotropin- Stimulated Iodide Transport Mediated by Adenosine 3′ 5′-Monophosphate and Dependent on Protein Synthesis

1984 • 204 citations

[73] Interaction of protein with DNA in vitro

1987 • 203 citations

Thyroglobulin gene expression is regulated by insulin and insulin-like growth factor I, as well as thyrotropin, in FRTL-5 thyroid cells.

1987 • 194 citations

Operator constitutive mutation of 3-hydroxy-3-methylglutaryl coenzyme A reductase promoter abolishes protein binding to sterol regulatory element.

1988 • 194 citations

5′ end of hmg CoA reductase gene contains sequences responsible for cholesterol-mediated inhibition of transcription

1985 • 187 citations

Antibodies That Promote Thyroid Growth

1983 • 181 citations

Cis- and trans-acting elements responsible for the cell-specific expression of the human alpha 1-antitrypsin gene.

1987 • 178 citations

Detection of activated ras oncogenes in human thyroid carcinomas.

1988 • 104 citations

ras-induced c-fos expression and proliferation in living rat fibroblasts involves C-kinase activation and the serum response element pathway.

1990 • 88 citations

Identification of promoter elements required for in vitro transcription of hamster 3-hydroxy-3-methylglutaryl coenzyme A reductase gene.

1987 • 78 citations

Block in the expression of differentiation markers of rat thyroid epithelial cells by transformation with Kirsten murine sarcoma virus.

1982 • 74 citations

Single nucleotide resolution of sterol regulatory region in promoter for 3-hydroxy-3-methylglutaryl coenzyme A reductase

1991 • 72 citations

Structure of an exophthalmos-producing factor derived from thyrotropin by partial pepsin digestion

1975 • 70 citations

Reversible inhibition of a thyroid-specific trans-acting factor by Ras.

1991 • 68 citations

v-ras and protein kinase C dedifferentiate thyroid cells by down-regulating nuclear cAMP-dependent protein kinase A.

1992 • 66 citations

Dissociation between transformed and differentiated phenotype in rat thyroid epithelial cells after transformation with a temperature-sensitive mutant of the Kirsten murine sarcoma virus.

1983 • 57 citations

Hormonal regulation of major histocompatibility complex class I genes in rat thyroid FRTL-5 cells: thyroid-stimulating hormone induces a cAMP-mediated decrease in class I expression.

1992 • 47 citations

Red 25, a protein that binds specifically to the sterol regulatory region in the promoter for 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

1992 • 46 citations

Transformation of rat thyroid epithelial cells by kirsten murine sarcoma virus

1981 • 43 citations

A rapid procedure for isolating hemopoietic cell nuclei

1988 • 42 citations

Thyrotropin receptor gene expression in oncogene-transfected rat thyroid cells: Correlation between transformation, loss of thyrotropin-dependent growth, and loss of thyrotropin receptor gene expression

1990 • 42 citations

Cell cycle progression and 3-hydroxy-3-methylglutaryl coenzyme A reductase are regulated by thyrotropin in FRTL-5 rat thyroid cells.

1990 • 34 citations

The cAMP response element in the rat thyrotropin receptor promoter. Regulation by each decanucleotide of a flanking tandem repeat uses different, additive, and novel mechanisms.

1993 • 29 citations

Molecular sieve chromatography of proteoglycans: A comparative analysis

1976 • 27 citations

Adenylate cyclase activity of ν‐ras‐k transformed rat epithelial thyroid cells

1988 • 22 citations

Thyrotropin Regulation of Malic Enzyme in FRTL-5 Rat Thyroid Cells

1990 • 21 citations

Protein kinase C activities are increased in rat thyroid epithelial cells expressing V-ras genes

1988 • 14 citations

Thyrotropin modulates low density lipoprotein binding activity in FRTL-5 thyroid cells.

1990 • 13 citations