Cell Cycle Control of DNA Replication

Cell Cycle Checkpoints: Preventing an Identity Crisis

1996 • 2,056 citations

ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex

1992 • 1,279 citations

How Proteolysis Drives the Cell Cycle

1996 • 1,277 citations

The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae

1994 • 902 citations

Mammalian Cell Fusion : Studies on the Regulation of DNA Synthesis and Mitosis

1970 • 759 citations

Systemic Lupus Erythematosus

1996 • 677 citations

A Yeast Chromosomal Origin of DNA Replication Defined by Multiple Functional Elements

1992 • 634 citations

A role for the nuclear envelope in controlling DNA replication within the cell cycle

1988 • 605 citations

Two steps in the assembly of complexes at yeast replication origins in vivo

1994 • 566 citations

Genes involved in sister chromatid separation are needed for b-type cyclin proteolysis in budding yeast

1995 • 561 citations

CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiae.

1993 • 521 citations

Cut2 proteolysis required for sister-chromatid separation in fission yeast

1996 • 451 citations

The fission yeast cdc18+ gene product couples S phase to START and mitosis

1993 • 446 citations

Yeast Origin Recognition Complex Functions in Transcription Silencing and DNA Replication

1993 • 435 citations

MUTANTS OF S. CEREVISIAE DEFECTIVE IN THE MAINTENANCE OF MINICHROMOSOMES

1984 • 419 citations

Isolation of ORC6 , a Component of the Yeast Origin Recognition Complex by a One-Hybrid System

1993 • 416 citations

Cdc6 is an unstable protein whose de novo synthesis in G1 is important for the onset of S phase and for preventing a ‘reductional’ anaphase in the budding yeast Saccharomyces cerevisiae.

1995 • 402 citations

Sequential gene function in the initiation of Saccharomyces cerevisiae DNA synthesis

1974 • 394 citations

Temporal order of S phase and mitosis in fission yeast is determined by the state of the p34cdc2-mitotic B cyclin complex

1994 • 393 citations

The Xenopus Cdc6 Protein Is Essential for the Initiation of a Single Round of DNA Replication in Cell-Free Extracts

1996 • 387 citations

Protein-DNA interactions at a yeast replication origin

1992 • 380 citations

S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state

1995 • 366 citations

An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast

1996 • 362 citations

Purification of an MCM-containing complex as a component of the DNA replication licensing system

1995 • 361 citations

ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome

1995 • 357 citations

Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s).

1996 • 357 citations

Regulation of progression through the Gl phase of the cell cycle by the rum1+ gene

1994 • 356 citations

DNA replication in eukaryotic cells

1997 • 346 citations

Involvement of p34cdc2 in establishing the dependency of S phase on mitosis

1991 • 340 citations

Roles and regulation of Cln-Cdc28 kinases at the start of the cell cycle of Saccharomyces cerevisiae.

1995 • 337 citations

Transition in Specification of Embryonic Metazoan DNA Replication Origins

1995 • 321 citations

Origin Recognition Complex (ORC) in Transcriptional Silencing and DNA Replication in S. cerevisiae

1993 • 314 citations

Cdc53 Targets Phosphorylated G1 Cyclins for Degradation by the Ubiquitin Proteolytic Pathway

1996 • 306 citations

Sequential function of gene products relative to DNA synthesis in the yeast cell cycle

1976 • 302 citations

Activation of S-phase-promoting CDKs in late G1 defines a "point of no return" after which Cdc6 synthesis cannot promote DNA replication in yeast.

1996 • 293 citations

Identification of the yeast MCM3-related protein as a component of xenopus DNA replication licensing factor

1995 • 280 citations

Replication structure of the human & beta;-globin gene domain

1993 • 277 citations

A multicopy suppressor gene of the Saccharomyces cerevisiae G1 cell cycle mutant gene dbf4 encodes a protein kinase and is identified as CDC5.

1993 • 270 citations

A quantitative model for the cdc2 control of S phase and mitosis in fission yeast

1996 • 267 citations

p65cdc18 Plays a major role controlling the initiation of DNA replication in fission yeast

1995 • 259 citations

The multidomain structure of Orc1 p reveals similarity to regulators of DNA replication and transcriptional silencing

1995 • 259 citations

Interaction between the Origin Recognition Complex and the Replication Licensing Systemin Xenopus

1996 • 255 citations

Cell Cycle Regulation of the Yeast Cdc7 Protein Kinase by Association With the Dbf4 Protein†

1993 • 250 citations

Conserved Initiator Proteins in Eukaryotes

1995 • 246 citations

An Inhibitor of p34 ^CDC28 Protein Kinase Activity from Saccharomyces cerevisiae

1993 • 236 citations

Purification of a yeast protein that binds to origins of DNA replication and a transcriptional silencer.

1988 • 234 citations

Yeast origin recognition complex is involved in DNA replication and transcriptional silencing

1993 • 231 citations

Linkage of Replication to Start by the Cdk Inhibitor Sic1

1996 • 230 citations

MCM3 complex required for cell cycle regulation of DNA replication in vertebrate cells

1995 • 220 citations

Pds1p is required for faithful execution of anaphase in the yeast, Saccharomyces cerevisiae

1996 • 219 citations

Participation of the Human β-Globin Locus Control Region in Initiation of DNA Replication

1995 • 217 citations

Interaction of Dbf4, the Cdc7 Protein Kinase Regulatory Subunit, with Yeast Replication Origins in Vivo

1994 • 213 citations

Role for a Xenopus Orc2-related protein in controlling DNA replication

1996 • 207 citations

The origin recognition complex in silencing, cell cycle progression, and DNA replication.

1995 • 204 citations

The origin recognition complex interacts with a bipartite DNA binding site within yeast replicators.

1995 • 204 citations

Nuclease digestion of circular TRP1ARS1 chromatin reveals positioned nucleosomes separated by nuclease-sensitive regions

1984 • 196 citations

Simple and Complex Cell Cycles

1989 • 192 citations

p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase

1995 • 190 citations

Regulation of prolactin release by endogenous opiates

1977 • 186 citations

Initiation complex assembly at budding yeast replication origins begins with the recognition of a bipartite sequence by limiting amounts of the initiator, ORC.

1995 • 179 citations

Physical Interactions among Mcm Proteins and Effects of Mcm Dosage on DNA Replication in Saccharomyces cerevisiae

1996 • 179 citations

The role of MCM/P1 proteins in the licensing of DNA replication.

1996 • 176 citations

DNA polymerase alpha associated protein P1, a murine homolog of yeast MCM3, changes its intranuclear distribution during the DNA synthetic period.

1994 • 173 citations

REGULATION OF EUKARYOTIC DNA REPLICATION

1994 • 170 citations

Establishing Genetic Interactions by a Synthetic Dosage Lethality Phenotype

1996 • 164 citations

Record of last interglacial–glacial cycle from northeastern Queensland

1978 • 157 citations

hsk1+, a Schizosaccharomyces pombe gene related to Saccharomyces cerevisiae CDC7, is required for chromosomal replication.

1995 • 152 citations

A Drosophila Homolog of the Yeast Origin Recognition Complex

1995 • 152 citations

The cyclin-dependent kinase inhibitor p40SIC1 imposes the requirement for Cln G1 cyclin function at Start.

1996 • 151 citations

Functional conservation of multiple elements in yeast chromosomal replicators.

1994 • 145 citations

Dual functions of CDC6: a yeast protein required for DNA replication also inhibits nuclear division.

1992 • 143 citations

The nuclear membrane prevents replication of human G2 nuclei but not G1 nuclei in Xenopus egg extract

1992 • 140 citations

The role of MCM proteins in the cell cycle control of genome duplication

1996 • 139 citations

Genetic analysis of an ARS element from the fission yeast Schizosaccharomyces pombe.

1995 • 137 citations

Interaction of Cdc2 and CdclS with a fission yeast ORC2-like protein

1996 • 131 citations

The role of MCM/P1 proteins in the licensing of DNA replication

1996 • 131 citations

cdc18+ regulates initiation of DNA replication in Schizosaccharomyces pombe.

1996 • 129 citations

Domain B of ARS307 contains two functional elements and contributes to chromosomal replication origin function.

1994 • 123 citations

A Distinct G ₁ Step Required to Specify the Chinese Hamster DHFR Replication Origin

1996 • 123 citations

Large, complex modular structure of a fission yeast DNA replication origin

1996 • 115 citations

Chromatin binding, nuclear localization and phosphorylation of Xenopus cdc21 are cell-cycle dependent and associated with the control of initiation of DNA replication.

1996 • 112 citations

Initiation at Closely Spaced Replication Origins in a Yeast Chromosome

1993 • 104 citations

Temperature-sensitive cdc7 mutations of Saccharomyces cerevisiae are suppressed by the DBF4 gene, which is required for the G1/S cell cycle transition.

1992 • 103 citations

The yeast gene, DBF4, essential for entry into S phase is cell cycle regulated

1989 • 101 citations

A DNA replication enhancer in Saccharomyces cerevisiae.

1990 • 100 citations

Orp1, a member of the Cdc18/Cdc6 family of S-phase regulators, is homologous to a component of the origin recognition complex.

1995 • 98 citations

Rum1 and Cdc18 link inhibition of cyclin-dependent kinase to the initiation of DNA replication in Schizosaccharomyces pombe.

1996 • 96 citations

A new pair of B-type cyclins from Saccharomyces cerevisiae that function early in the cell cycle.

1993 • 95 citations

Purification and characterization of proteins that bind to yeast ARSs.

1988 • 94 citations

Replicator dominance in a eukaryotic chromosome.

1994 • 94 citations

Multiple DNA Elements in ARS305 Determine Replication Origin Activity in a Yeast Chromosome

1996 • 87 citations

The Yeast CDC16 and CDC27 Genes Restrict DNA Replication to Once per Cell Cycle

1996 • 85 citations

XMCM7, a novel member of the Xenopus MCM family, interacts with XMCM3 and colocalizes with it throughout replication.

1996 • 84 citations

A Multicopy Suppressor Gene of the Saccharomyces cerevisiae G₁ Cell Cycle Mutant Gene dbf4 Encodes a Protein Kinase and Is Identified as CDC5

1993 • 84 citations

DNA metabolism gene CDC7 from yeast encodes a serine (threonine) protein kinase.

1990 • 78 citations

Characterization of an Essential Orc2p-Associated Factor That Plays a Role in DNA Replication

1996 • 69 citations

2 Origins of DNA Replication

1996 • 58 citations

The CDC7 protein of Saccharomyces cerevisiae is a phosphoprotein that contains protein kinase activity.

1991 • 54 citations

In vivo protein-DNA interactions at human DNA replication origin.

1996 • 50 citations

The ras and myc oncogenes cooperate in tumor induction in many tissues when introduced into midgestation mouse embryos by retroviral vectors.

1989 • 42 citations

Defining origins of replication in mammalian cells

1994 • 41 citations

Biochimica et Biophysica Acta

1980 • 39 citations

Physical mapping of origins of replication in the fission yeast Schizosaccharomyces pombe.

1994 • 39 citations

Coordinating DNA Replication To Produce One Copy of the Genome Requires Genes That Act in Ubiquitin Metabolism

1996 • 36 citations

The chromatin structure of Saccharomyces cerevisiae autonomously replicating sequences changes during the cell division cycle.

1991 • 34 citations

Coordinating DNA replication with cell division: current status of the licensing concept.

1996 • 31 citations

Characterization of a novel CDC gene (ORC1) partly homologous to CDC6 of Saccharomyces cerevisiae.

1996 • 26 citations

Multiple cycles of global unfolding of GroEL-bound cyclophilin A evidenced by NMR

1997 • 26 citations

Sister chromatid separation in vivo and in vitro

1995 • 20 citations

Eukaryotic DNA Replication

1996 • 8 citations

The Nebraska Ornithologists' Union

1901 • 3 citations

A multicopy suppressor gene of the Saccharomyces cerevisiae G1 cell cycle mutant gene dbf4 encodes protein kinase and is periodically expressed in the cell cycle

1993 • 2 citations