Thyrotropin-Induced Mitogenesis Is Ras Dependent but Appears To Bypass the Raf-Dependent Cytoplasmic Kinase Cascade

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

The regulation of transcription by phosphorylation

1992 • 1,316 citations

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

1993 • 1,313 citations

Raf-1 activates MAP kinase-kinase

1992 • 1,308 citations

In yeast, RAS proteins are controlling elements of adenylate cyclase

1985 • 1,142 citations

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

1994 • 1,012 citations

Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation.

1993 • 992 citations

Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter

1992 • 980 citations

Activation of Raf as a Result of Recruitment to the Plasma Membrane

1994 • 979 citations

Culture of hormone-dependent functional epithelial cells from rat thyroids.

1980 • 959 citations

Inhibition by cAMP of Ras-Dependent Activation of Raf

1993 • 955 citations

Inhibition of the EGF-Activated MAP Kinase Signaling Pathway by Adenosine 3′,5′-Monophosphate

1993 • 939 citations

Activation of the MAP kinase pathway by the protein kinase raf

1992 • 816 citations

Activation of Mitogen-Activated Protein Kinase Kinase by v-Raf in NIH 3T3 Cells and in Vitro

1992 • 691 citations

Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts

1993 • 668 citations

The Thyrotropin Receptor and the Regulation of Thyrocyte Function and Growth*

1992 • 592 citations

Physiological and pathological regulation of thyroid cell proliferation and differentiation by thyrotropin and other factors

1992 • 535 citations

Raf-1 protein kinase is required for growth of induced NIH/3T3 cells

1991 • 489 citations

Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells.

1993 • 465 citations

c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases.

1994 • 463 citations

Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase.

1992 • 453 citations

A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis.

1987 • 403 citations

Protein kinase C ζ isoform is critical for mitogenic signal transduction

1993 • 383 citations

Increasing cAMP attenuates activation of mitogen-activated protein kinase.

1993 • 383 citations

cAMP antagonizes p21ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor.

1993 • 362 citations

Serum-induced translocation of mitogen-activated protein kinase to the cell surface ruffling membrane and the nucleus

1993 • 328 citations

Cyclic AMP activates the mitogen-activated protein kinase cascade in PC12 cells.

1994 • 326 citations

Signal transduction within the nucleus by mitogen-activated protein kinase.

1992 • 323 citations

The activation of phosphatidylinositol 3-kinase by Ras

1994 • 322 citations

Mechanism of inhibition of Raf-1 by protein kinase A.

1994 • 311 citations

The mitogen-activated protein kinase activator

1992 • 285 citations

Purification and characterization of the zeta isoform of protein kinase C from bovine kidney.

1992 • 283 citations

ralGDS family members interact with the effector loop of ras p21.

1994 • 260 citations

Presence of mutations in all three ras genes in human thyroid tumors.

1990 • 250 citations

A requirement for extracellular signal-regulated kinase (ERK) function in the activation of AP-1 by Ha-Ras, phorbol 12-myristate 13-acetate, and serum.

1994 • 214 citations

Raf-1 kinase is essential for early Xenopus development and mediates the induction of mesoderm by FGF

1993 • 199 citations

gsp mutations in human thyroid tumours.

1991 • 198 citations

Association of p21ras with phosphatidylinositol 3-kinase.

1991 • 174 citations

Phosphoinositide 3-kinase: A new effector in signal transduction?

1991 • 166 citations

Evidence for a Role of Protein Kinase C ζ Subspecies in Maturation of Xenopus laevis Oocytes

1992 • 162 citations

B-Raf-dependent regulation of the MEK-1/mitogen-activated protein kinase pathway in PC12 cells and regulation by cyclic AMP.

1994 • 157 citations

The Role of Raf-1 Phosphorylation in Signal Transduction

1992 • 136 citations

Hydrolysis of phosphatidylcholine couples Ras to activation of Raf protein kinase during mitogenic signal transduction.

1993 • 135 citations

Differentiation of PC12 cells in response to a cAMP analogue is accompanied by sustained activation of mitogen‐activated protein kinase

1994 • 125 citations

Phosphorylation of mitogen-activated protein kinases is involved in the epidermal growth factor and phorbol ester, but not in the thyrotropin/cAMP, thyroid mitogenic pathway.

1993 • 119 citations

c-Jun N-Terminal Phosphorylation Correlates with Activation of the JNK Subgroup but Not the ERK Subgroup of Mitogen-Activated Protein Kinases

1994 • 105 citations

An epidermal growth factor receptor/ret chimera generates mitogenic and transforming signals: evidence for a ret-specific signaling pathway

1994 • 102 citations

Purification and Characterization of Human H-ras Proteins Expressed in Escherichia coli

1985 • 101 citations

Raf-1 and p21v-ras cooperate in the activation of mitogen-activated protein kinase.

1993 • 101 citations

Mitogen-Activated Protein (MAP) Kinase Phosphorylation of MAP Kinase Kinase: Determination of Phosphorylation Sites by Mass Spectrometry and Site-Directed Mutagenesis1

1994 • 100 citations

Inhibition of Thyrotropin-Stimulated DNA Synthesis by Microinjection of Inhibitors of Cellular Ras and Cyclic AMP-Dependent Protein Kinase

1993 • 67 citations

Networking with protein kinases

1993 • 62 citations

Epidermal growth factor potentiates cyclic AMP accumulation in A-431 cells.

1990 • 55 citations

ralGDS Family Members Interact with the Effector Loop of ras p21

1994 • 47 citations

Overexpression of c-src enhances beta-adrenergic-induced cAMP accumulation.

1990 • 42 citations

Inhibition of thyrotropin-induced DNA synthesis in thyroid follicular cells by microinjection of an antibody to the stimulatory G protein of adenylate cyclase, Gs.

1992 • 38 citations

Probing structure and function of the raf protein kinase domain with monoclonal antibodies.

1990 • 35 citations

Divergent patterns of immediate early gene expression in response to thyroid-stimulating hormone and insulin-like growth factor I in Wistar rat thyrocytes.

1994 • 27 citations

Interactions between p21ras proteins and their GTPase activating proteins.

1992 • 26 citations

B-Raf-Dependent Regulation of the MEK-1/Mitogen-Activated Protein Kinase Pathway in PC12 Cells and Regulation by Cyclic AMP

1994 • 24 citations

Mechanism of Inhibition of Raf-1 by Protein Kinase A

1994 • 23 citations