Induction of Cell Proliferation in Quiescent NIH 3T3 Cells by Oncogenic c-Raf-1

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

G1 phase progression: Cycling on cue

1994 • 2,706 citations

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

1994 • 2,154 citations

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

1994 • 2,071 citations

Mammalian G1 cyclins

1993 • 1,990 citations

Mice Lacking p27 Display Increased Body Size, Multiple Organ Hyperplasia, Retinal Dysplasia, and Pituitary Tumors

1996 • 1,583 citations

A Syndrome of Multiorgan Hyperplasia with Features of Gigantism, Tumorigenesis, and Female Sterility in p27 -Deficient Mice

1996 • 1,488 citations

Enhanced Growth of Mice Lacking the Cyclin-Dependent Kinase Inhibitor Function of p27

1996 • 1,283 citations

Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle

1991 • 1,190 citations

A Heparin-Binding Growth Factor Secreted by Macrophage-Like Cells That Is Related to EGF

1991 • 1,135 citations

p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage.

1995 • 1,114 citations

Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

1994 • 1,092 citations

Parallel signal processing among mammalian MAPKs

1995 • 1,015 citations

Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta.

1995 • 959 citations

Transforming p21 Mutants and c-Ets-2 Activate the Cyclin D1 Promoter through Distinguishable Regions

1995 • 803 citations

A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins

1995 • 798 citations

Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit

1993 • 778 citations

Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation

1994 • 742 citations

Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B

1990 • 730 citations

p21-containing cyclin kinases exist in both active and inactive states.

1994 • 646 citations

The ins and outs of Raf kinases

1994 • 537 citations

Raf-1 protein kinase is required for growth of induced NIH/3T3 cells

1991 • 489 citations

Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase.

1992 • 453 citations

Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase.

1993 • 348 citations

Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase.

1996 • 308 citations

Induction of cyclin D1 overexpression by activated ras.

1994 • 295 citations

Inactivation of a Cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes.

1994 • 289 citations

Rho family GTPases: the cytoskeleton and beyond

1996 • 262 citations

Role of Raf-1 serine/threonine protein kinase in growth factor signal transduction.

1991 • 248 citations

Definition of the human raf amino-terminal regulatory region by deletion mutagenesis.

1989 • 240 citations

Cyclin D and oncogenesis

1993 • 233 citations

Mutational Activation of c-raf-1 and Definition of the Minimal Transforming Sequence

1990 • 232 citations

Role of Diffusion Boundary Layer in Contact Inhibition of Growth

1973 • 230 citations

The complete coding sequence of the human raf oncogene and the corresponding structure of the c-raf-1 gene

1986 • 225 citations

Conditionally Oncogenic Forms of the A-Raf and B-Raf Protein Kinases Display Different Biological and Biochemical Properties in NIH 3T3 Cells

1995 • 222 citations

Regulation of the cell cycle machinery by oncogenic ras.

1996 • 202 citations

Rapid induction of heparin-binding epidermal growth factor/diphtheria toxin receptor expression by Raf and Ras oncogenes.

1995 • 195 citations

Expression of raf family proto-oncogenes in normal mouse tissues.

1990 • 194 citations

B-raf, a new member of the raf family, is activated by DNA rearrangement.

1988 • 149 citations

The complete coding sequence of the human A-raf-1 oncogene and transforming activity of a human A-rafcarrying retrovirus

1987 • 145 citations

Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies.

1990 • 112 citations

Deregulated expression of cyclin D1 and other cell cycle-related genes in carcinogen-induced rat mammary tumors

1995 • 62 citations

Inhibition of platelet-derived growth factor- and epidermal growth factor-mediated mitogenesis and signaling in 3T3 cells expressing delta Raf-1:ER, an estradiol-regulated form of Raf-1.

1994 • 58 citations

New evidence that growth in 3T3 cell cultures is a diffusion-limited process

1984 • 55 citations

v-raf confers CSF-1 independent growth to a macrophage cell line and leads to immediate early gene expression without MAP-kinase activation.

1993 • 48 citations

Altered responsiveness of rat liver epithelial cells to transforming growth factor beta 1 following their transformation with v-raf.

1990 • 37 citations

Induction of transformation and DNA synthesis after microinjection of raf proteins.

1990 • 37 citations

Developmental and cell lineage specificity of raf family gene expression in mouse testis.

1993 • 35 citations