Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

Inhibitors of mammalian G1 cyclin-dependent kinases.

1995 • 3,258 citations

G1 phase progression: Cycling on cue

1994 • 2,706 citations

Cepharanthine potently enhances the sensitivity of anticancer agents in K562 cells

2005 • 2,216 citations

Cyclin D1 is a nuclear protein required for cell cycle progression in G1.

1993 • 1,605 citations

Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

1993 • 1,258 citations

Cyclin D1 Expression Is Regulated Positively by the p42/p44 and Negatively by the p38/HOG Pathway

1996 • 1,203 citations

Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle

1991 • 1,190 citations

Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs).

1995 • 1,117 citations

D-type cyclin-dependent kinase activity in mammalian cells.

1994 • 1,073 citations

Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts.

1993 • 1,057 citations

Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

1993 • 1,047 citations

D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA

1992 • 1,023 citations

Acceleration of the G₁/S Phase Transition by Expression of Cyclins Dl and E with an Inducible System

1994 • 986 citations

D-type cyclins

1995 • 978 citations

Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins

1992 • 906 citations

Transforming p21 Mutants and c-Ets-2 Activate the Cyclin D1 Promoter through Distinguishable Regions

1995 • 803 citations

Physical interaction of the retinoblastoma protein with human D cyclins

1993 • 780 citations

Different Roles for Cyclins D1 and E in Regulation of the G₁-to-S Transition

1995 • 469 citations

Overexpression of cyclin D1 in rat fibroblasts causes abnormalities in growth control, cell cycle progression and gene expression.

1993 • 393 citations

D-Type Cyclin-Dependent Kinase Activity in Mammalian Cells

1994 • 322 citations

Ras Transformation Results in an Elevated Level of Cyclin D1 and Acceleration of G₁ Progression in NIH 3T3 cells

1995 • 276 citations

CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1.

1994 • 260 citations

Collaboration of G1 cyclins in the functional inactivation of the retinoblastoma protein.

1994 • 253 citations

Regulation of the cell cycle machinery by oncogenic ras.

1996 • 202 citations

Differential activation of p44mapk (ERK1) by α-thrombin and thrombin-receptor peptide agonist

1993 • 163 citations

Cyclin D2 is a moderately oscillating nucleoprotein required for G1 phase progression in specific cell types.

1995 • 121 citations

Biochemical Analysis of MEK Activation in NIH3T3 Fibroblasts

1995 • 111 citations

Cells regulate their mitogenic response to thrombin through release of protease nexin

1982 • 82 citations

G1 cyclins control the retinoblastoma gene product growth regulation activity via upstream mechanisms.

1995 • 42 citations