Signaling through protein kinase C

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

Mechanism of activation of protein kinase B by insulin and IGF-1.

1996 • 2,965 citations

Protein kinase C and lipid signaling for sustained cellular responses

1995 • 2,527 citations

Protein Kinase C: Structure, Function, and Regulation

1995 • 1,640 citations

The extended protein kinase C superfamily

1998 • 1,544 citations

Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.

1980 • 1,317 citations

Mechanisms and consequences of activation of protein kinase B/Akt

1998 • 1,305 citations

Protein Kinase C Isotypes Controlled by Phosphoinositide 3-Kinase Through the Protein Kinase PDK1

1998 • 1,118 citations

Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.

1993 • 966 citations

Regulation of protein kinase C

1997 • 919 citations

Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. II. Proenzyme and its activation by calcium-dependent protease from rat brain.

1977 • 865 citations

Activation of the Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Pathway by Conventional, Novel, and Atypical Protein Kinase C Isotypes

1998 • 765 citations

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

1997 • 740 citations

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

1993 • 730 citations

MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium–calmodulin

1992 • 728 citations

Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding fold

1995 • 680 citations

Regulation of protein kinase C ζ by PI 3-kinase and PDK-1

1998 • 612 citations

Anchoring proteins for protein kinase C: a means for isozyme selectivity

1998 • 584 citations

Protein Kinase C δ Activates the MEK-ERK Pathway in a Manner Independent of Ras and Dependent on Raf

1996 • 570 citations

Determination of the Specific Substrate Sequence Motifs of Protein Kinase C Isozymes

1997 • 557 citations

Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3.

1994 • 553 citations

Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity.

1993 • 546 citations

PKCu is a novel, atypical member of the protein kinase C family.

1994 • 519 citations

PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid.

1995 • 506 citations

Identification of intracellular receptor proteins for activated protein kinase C.

1991 • 505 citations

Protein kinase C is regulated in vivo by three functionally distinct phosphorylations

1995 • 472 citations

Protein Kinase C-ζ as a Downstream Effector of Phosphatidylinositol 3-Kinase during Insulin Stimulation in Rat Adipocytes

1997 • 434 citations

Molecular cloning and characterization of protein kinase D: a target for diacylglycerol and phorbol esters with a distinctive catalytic domain.

1994 • 406 citations

Protein kinase C ζ isoform is critical for mitogenic signal transduction

1993 • 383 citations

The Product of par-4, a Gene Induced during Apoptosis, Interacts Selectively with the Atypical Isoforms of Protein Kinase C

1996 • 367 citations

Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

1998 • 365 citations

Taxonomy and function of C1 protein kinase C homology domains

1997 • 350 citations

Activation of Protein Kinase C (α, β, and ζ) by Insulin in 3T3/L1 Cells

1997 • 290 citations

Activation of the c-Raf protein kinase by protein kinase C phosphorylation.

1992 • 288 citations

Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta.

1995 • 271 citations

EGF or PDGF receptors activate atypical PKClambda through phosphatidylinositol 3-kinase.

1996 • 270 citations

Identification and localization of an actin-binding motif that is unique to the epsilon isoform of protein kinase C and participates in the regulation of synaptic function.

1996 • 252 citations

Protein kinase D (PKD) activation in intact cells through a protein kinase C-dependent signal transduction pathway.

1996 • 244 citations

Mechanism of Interaction of Protein Kinase C with Phorbol Esters

1995 • 243 citations

zeta PKC induces phosphorylation and inactivation of I kappa B-alpha in vitro.

1994 • 231 citations

A Dominant Negative Protein Kinase C ζ Subspecies Blocks NF-κ B Activation

1993 • 223 citations

The epsilon isoform of protein kinase C is an oncogene when overexpressed in rat fibroblasts.

1993 • 222 citations

Evidence for the in vitro and in vivo interaction of Ras with protein kinase C zeta.

1994 • 221 citations

Evidence for Involvement of Protein Kinase C (PKC)-ζ and Noninvolvement of Diacylglycerol-Sensitive PKCs in Insulin-Stimulated Glucose Transport in L6 Myotubes*

1997 • 218 citations

Interaction of protein kinase C ζ with ZIP, a novel protein kinase C-binding protein

1997 • 214 citations

Intracellular receptors for activated protein kinase C. Identification of a binding site for the enzyme

1991 • 212 citations

Conditional Inhibition of the Mitogen-activated Protein Kinase Cascade by Wortmannin

1997 • 196 citations

Anchoring proteins for protein kinase C: a means for isozyme selectivity

1998 • 194 citations

Protein phosphatase 2A is a critical regulator of protein kinase C zeta signaling targeted by SV40 smallt to promote cell growth and NF-kappa B activation

1997 • 194 citations

Protein Kinase C and the Cytoskeleton

1998 • 194 citations

Analysis of the Role of Protein Kinase C-α, -ε, and -ζ in T Cell Activation

1995 • 184 citations

Atypical Protein Kinase C ι Protects Human Leukemia Cells against Drug-induced Apoptosis

1997 • 175 citations

Platelet-derived growth factor activates protein kinase C epsilon through redundant and independent signaling pathways involving phospholipase C gamma or phosphatidylinositol 3-kinase.

1996 • 168 citations

Bombesin, Vasopressin, Endothelin, Bradykinin, and Platelet-derived Growth Factor Rapidly Activate Protein Kinase D through a Protein Kinase C-dependent Signal Transduction Pathway

1997 • 166 citations

MARCKS regulates membrane ruffling and cell spreading

1997 • 161 citations

Biosynthesis and Posttranslational Modifications of Protein Kinase C in Human Breast Cancer Cells

1989 • 160 citations

Requirement for negative charge on “activation loop” of protein kinase C.

1994 • 153 citations

PKC epsilon functions as an oncogene by enhancing activation of the Raf kinase.

1996 • 153 citations

Cloning and Expression Patterns of two Members of A Novel Protein‐kinase‐C‐related Kinase Family

1995 • 146 citations

Overexpression of ∊-Protein Kinase C Enhances Nerve Growth Factor-induced Phosphorylation of Mitogen-activated Protein Kinases and Neurite Outgrowth

1995 • 143 citations

Protein Kinase D Activation by Mutations within Its Pleckstrin Homology Domain

1998 • 142 citations

Intrapeptide regulation of protein kinase C.

1994 • 139 citations

Phosphatidylinositol 3-Kinase-dependent Activation of Protein Kinase C-ζ in Bacterial Lipopolysaccharide-treated Human Monocytes

1997 • 139 citations

Non-equivalent Roles for the First and Second Zinc Fingers of Protein Kinase Cδ

1996 • 133 citations

Protein Kinase C βII Specifically Binds to and Is Activated by F-actin

1996 • 133 citations

Inhibition of Protein Kinase C ζ Subspecies Blocks the Activation of an NF-Kappa B-Like Activity in Xenopus laevis Oocytes

1993 • 131 citations

Protein Kinase C μ (PKCμ) Associates with the B Cell Antigen Receptor Complex and Regulates Lymphocyte Signaling

1996 • 130 citations

Threonine-497 is a critical site for permissive activation of protein kinase Cα

1994 • 129 citations

A dominant negative protein kinase C zeta subspecies blocks NF-kappa B activation.

1993 • 128 citations

Activation of PRK1 by Phosphatidylinositol 4,5-Bisphosphate and Phosphatidylinositol 3,4,5-Trisphosphate

1995 • 127 citations

Requirement of Protein Kinase Cζ for Stimulation of Protein Synthesis by Insulin

1997 • 127 citations

Lambda-Interacting Protein, A Novel Protein That Specifically Interacts with the Zinc Finger Domain of the Atypical Protein Kinase C Isotype λ/ι and Stimulates Its Kinase Activity In Vitro and In Vivo

1996 • 121 citations

Nucleolin Is a Protein Kinase C-ζ Substrate

1997 • 120 citations

The protein kinase C and protein kinase C related gene families

1995 • 119 citations

Regulation of the AKAP79-Protein Kinase C Interaction by Ca2+/Calmodulin

1997 • 116 citations

Regulation of Raf-1 kinase by TNF via its second messenger ceramide and cross-talk with mitogenic signalling

1998 • 112 citations

Conventional PKC-α, Novel PKC-ε and PKC-θ, but Not Atypical PKC-λ Are MARCKS Kinases in Intact NIH 3T3 Fibroblasts

1997 • 111 citations

C2 domain conformational changes in phospholipase C-δ1

1996 • 104 citations

An Inhibitory Fragment Derived from Protein Kinase Cε Prevents Enhancement of Nerve Growth Factor Responses by Ethanol and Phorbol Esters

1997 • 102 citations

Epsilon-isoenzyme of protein kinase C induces a Ca(2+)-independent contraction in vascular smooth muscle

1996 • 102 citations

Overexpression of protein kinase C epsilon is oncogenic in rat colonic epithelial cells.

1996 • 99 citations

Protein kinase C-epsilon is implicated in neurite outgrowth in differentiating human neuroblastoma cells.

1996 • 93 citations

Activation of protein kinase C-zeta and phosphatidylinositol 3'-kinase and promotion of macrophage differentiation by insulin-like growth factor-I.

1998 • 92 citations

Integrin-Induced Protein Kinase Cα and Cε Translocation to Focal Adhesions Mediates Vascular Smooth Muscle Cell Spreading

1998 • 88 citations

Differential Translocation of Protein Kinase C ε during HeLa Cell Adhesion to a Gelatin Substratum

1996 • 87 citations

Identification of Heterogeneous Ribonucleoprotein A1 as a Novel Substrate for Protein Kinase C ζ

1995 • 85 citations

Activation of novel protein kinases C delta and C epsilon upon mitogenic stimulation of quiescent rat 3Y1 fibroblasts

1994 • 80 citations

Protein kinases C-beta and C-epsilon link the mast cell high-affinity receptor for IgE to the expression of c-fos and c-jun.

1994 • 79 citations

Insulin stimulates the activity of a novel protein kinase C, PKC-epsilon, in cultured fetal chick neurons.

1990 • 79 citations

Protein kinase Cε is oncogenic in colon epithelial cells by interaction with the ras signal transduction pathway

1998 • 77 citations

Activation of Protein Kinase C by Phosphatidylinositol 3,4,5-Trisphosphate

1993 • 76 citations

Protein Kinase Cσ-specific Phosphorylation of the Elongation Factor eEF-1α and an eEF-1α Peptide at Threonine 431

1995 • 76 citations

Platelet-derived Growth Factor Stimulates Protein Kinase D through the Activation of Phospholipase Cγ and Protein Kinase C

1998 • 75 citations

Diacylglycerol generated by exogenous phospholipase C activates the mitogen-activated protein kinase pathway independent of Ras- and phorbol ester-sensitive protein kinase C: dependence on protein kinase C-ζ

1997 • 75 citations

Bryostatin 1 Induces Biphasic Activation of Protein Kinase D in Intact Cells

1997 • 74 citations

Protein kinase C-ε associates with the Raf-1 kinase and induces the production of growth factors that stimulate Raf-1 activity

1997 • 71 citations

The broad specificity of dominant inhibitory protein kinase C mutants infers a common step in phosphorylation

1998 • 71 citations

Transcriptional activation of c-fos by oncogenic Ha-Ras in mouse mammary epithelial cells requires the combined activities of PKC-λ, ε and ζ

1998 • 69 citations

Angiotensin II Stimulates MAP Kinase Kinase Kinase Activity in Vascular Smooth Muscle Cells

1996 • 67 citations

Protein kinase C: Ports of anchor in the cell

1996 • 67 citations

Association of the Insulin Receptor with Phospholipase C-γ (PLCγ) in 3T3-L1 Adipocytes Suggests a Role for PLCγ in Metabolic Signaling by Insulin

1998 • 66 citations

Inhibition of protein kinase C zeta subspecies blocks the activation of an NF-kappa B-like activity in Xenopus laevis oocytes.

1993 • 65 citations

Calcium-Independent Binding to Interfacial Phorbol Esters Causes Protein Kinase C To Associate with Membranes in the Absence of Acidic Lipids

1996 • 56 citations

Nerve growth factor-induced differentiation of PC12 cells employs the PMA-insensitive protein kinase C-ζ isoform

1994 • 56 citations

Protein kinase C isoforms play differential roles in the regulation of adipocyte differentiation

1998 • 54 citations

Rapid activation of the novel serine/threonine protein kinase, protein kinase D by phorbol esters, angiotensin II and PDGF‐BB in vascular smooth muscle cells

1998 • 53 citations

Transport of protein kinase C isoforms to the nucleus of PC12 cells by nerve growth factor: Association of atypical ?-PKC with the nuclear matrix

1997 • 50 citations

Protein Kinase C-ε Is Necessary for Erythropoietin's Up-regulation of c-myc and for Factor-dependent DNA Synthesis

1996 • 48 citations

Nerve growth factor activates calcium-insensitive protein kinase C-ɛ in PC-12 rat pheochromocytoma cells

1993 • 46 citations

Insulin stimulates phospholipase D-dependent phosphatidylcholine hydrolysis, Rho translocation, de novo phospholipid synthesis, and diacylglycerol/protein kinase C signaling in L6 myotubes.

1996 • 44 citations

Protein kinase C-zeta reverts v-raf transformation of NIH-3T3 cells.

1996 • 43 citations

Phosphorylation of GAP-43 (growth-associated protein of 43 kDa) by conventional, novel and atypical isotypes of the protein kinase C gene family: differences between oligopeptide and polypeptide phosphorylation

1996 • 36 citations

Protein kinase C‐α and ‐ε are enriched in growth cones of differentiating SH‐SY5Y human neuroblastoma cells

1995 • 35 citations

Structural aspects of the functional modules in human protein kinase-Cα deduced from comparative analyses

1996 • 34 citations

A Putative Phosphatidylserine Binding Motif Is Not Involved in the Lipid Regulation of Protein Kinase C

1997 • 30 citations

Overexpression of PKCɛ in R6 fibroblasts causes increased production of active TGFβ

1998 • 28 citations

Phosphorylation and subcellular redistribution of pleckstrin in human neutrophils.

1997 • 27 citations

Protein kinase C isozyme distribution and down-regulation in relation to insulin-stimulated c-fos induction.

1994 • 22 citations

Overexpression of PKC zeta in NIH3T3 cells does not induce cell transformation nor tumorigenicity and does not alter NF kappa B activity.

1995 • 21 citations

Association of phosphatidylinositol 3 kinase to protein kinase C ζ during interleukin‐2 stimulation

1996 • 21 citations

Evidence for different signalling pathways of PKC zeta and ras-p21 in Xenopus oocytes.

1995 • 21 citations

Effects of insulin on protein kinase-C (PKC) in HIRC-B cells: specific activation of PKC epsilon and its resistance to phorbol ester-induced down-regulation.

1994 • 18 citations

Insulin stimulates phospholipase D-dependent phosphatidylcholine hydrolysis, Rho translocation, de novo phospholipid synthesis, and diacylglycerol/protein kinase C signaling in L6 myotubes

1996 • 13 citations

Effects of insulin on protein kinase-C (PKC) in HIRC-B cells: specific activation of PKC epsilon and its resistance to phorbol ester-induced down-regulation

1994 • 5 citations