TGFβ: Roles in DNA Damage Responses

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

1994 • 5,994 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Cell-cycle checkpoints and cancer

2004 • 2,699 citations

DNA double-strand breaks: signaling, repair and the cancer connection

2001 • 2,372 citations

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

1993 • 1,941 citations

Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling

1997 • 1,774 citations

Making sense of latent TGFβ activation

2002 • 1,579 citations

TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes

1997 • 1,404 citations

Apoptosis in cancer therapy: Crossing the threshold

1994 • 1,351 citations

The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling

1997 • 1,328 citations

A Chemical Inhibitor of p53 That Protects Mice from the Side Effects of Cancer Therapy

1999 • 1,248 citations

Post‐translational modifications and activation of p53 by genotoxic stresses

2001 • 1,076 citations

Abnormal lung development and cleft palate in mice lacking TGF–β3 indicates defects of epithelial–mesenchymal interaction

1995 • 1,027 citations

Interaction of the p53-Regulated Protein Gadd45 with Proliferating Cell Nuclear Antigen

1994 • 941 citations

Protein phosphatase 1 – targeted in many directions

2002 • 911 citations

Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1

1997 • 625 citations

The Breast Cancer Susceptibility Gene BRCA1 Is Required for Subnuclear Assembly of Rad51 and Survival following Treatment with the DNA Cross-linking Agent Cisplatin

2000 • 565 citations

Activation of latent TGF-β by thrombospondin-1: mechanisms and physiology

2000 • 563 citations

Redox modifications of protein–thiols: Emerging roles in cell signaling

2005 • 562 citations

The role of p53 in determining sensitivity to radiotherapy

2003 • 549 citations

Redox-mediated activation of latent transforming growth factor-beta 1.

1996 • 532 citations

p53: traffic cop at the crossroads of DNA repair and recombination

2005 • 529 citations

Structure, Function, and Inhibition of O6-Alkylguanine-DNA Alkyltransferase

1995 • 502 citations

Radiation and the microenvironment – tumorigenesis and therapy

2005 • 495 citations

Maternal Rescue of Transforming Growth Factor-β 1 Null Mice

1994 • 494 citations

Transforming growth factor beta: the good, the bad, and the ugly.

1994 • 491 citations

The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth.

1994 • 484 citations

Stress and Radiation-Induced Activation of Multiple Intracellular Signaling Pathways¹

2003 • 460 citations

Cell adhesion system and human cancer morphogenesis

2003 • 440 citations

Transforming growth factor-beta activation in irradiated murine mammary gland.

1994 • 414 citations

Latent Transforming Growth Factor-β (TGF-β) Binding Proteins: Orchestrators of TGF-β Availability

2004 • 414 citations

Homology-directed dna repair, mitomycin-c resistance, and chromosome stability is restored with correction of a Brca1 mutation.

2001 • 379 citations

Links between Tumor Suppressors

2003 • 372 citations

Conversion of a high molecular weight latent β-TGF from chicken embryo fibroblasts into a low molecular weight active β-TGF under acidic conditions

1985 • 366 citations

Radiotherapy As Primary Treatment for Stage IE and IIE Nasal Natural Killer/T-Cell Lymphoma

2005 • 346 citations

Physicochemical Activation of Recombinant Latent Transforming Growth Factor-beta's 1, 2, and 3

1990 • 343 citations

CHOP (GADD153) and its oncogenic variant, TLS-CHOP, have opposing effects on the induction of G1/S arrest.

1994 • 331 citations

Transforming growth factor-β1 is a new form of tumor suppressor with true haploid insufficiency

1998 • 319 citations

Combinatorial control of protein phosphatase-1

2001 • 293 citations

Important advances in oncology 1994

1994 • 282 citations

Coordinated regulation of apoptosis and cell proliferation by transforming growth factor beta 1 in cultured uterine epithelial cells.

1991 • 279 citations

Apoptosis Induced by Transforming Growth Factor-β in Fetal Hepatocyte Primary Cultures

1996 • 262 citations

Isoform-Specific Activation of Latent Transforming Growth Factor β (LTGF-β) by Reactive Oxygen Species

2006 • 256 citations

GADD34–PP1c recruited by Smad7 dephosphorylates TGFβ type I receptor

2004 • 252 citations

TGFβ-related pathways

2000 • 251 citations

Redox-mediated activation of latent transforming growth factor-beta 1

1996 • 245 citations

Repeated exposure of human skin fibroblasts to UVB at subcytotoxic level triggers premature senescence through the TGF-β1 signaling pathway

2005 • 238 citations

Site-directed Mutagenesis of Cysteine Residues in the Pro Region of the Transforming Growth Factor β1 Precursor

1989 • 220 citations

Alterations of Smad signaling in human breast carcinoma are associated with poor outcome: a tissue microarray study.

2002 • 219 citations

Transforming growth factor-β-related proteins: an ancestral and widespread superfamily of cytokines in metazoans

2003 • 216 citations

Radiation-induced transforming growth factor beta and subsequent extracellular matrix reorganization in murine mammary gland.

1993 • 208 citations

The p53 response to ionising radiation in adult and developing murine tissues.

1996 • 206 citations

A mammary-specific model demonstrates the role of the p53 tumor suppressor gene in tumor development

2000 • 198 citations

Regulation of protein phosphatase-1

2000 • 191 citations

How Do Tissues Respond to Damage at the Cellular Level? The Role of Cytokines in Irradiated Tissues

1998 • 191 citations

Important advances in oncology 1996

1997 • 184 citations

Mammalian GADD34, an Apoptosis- and DNA Damage-inducible Gene

1997 • 166 citations

Phosphorylation of murine p53 at Ser-18 regulates the p53 responses to DNA damage

2000 • 164 citations

Ultraviolet Irradiation Blocks Cellular Responses to Transforming Growth Factor-β by Down-regulating Its Type-II Receptor and Inducing Smad7

2001 • 162 citations

Chronic liver injury, TGF-β, and cancer

2001 • 156 citations

Inhibition of Transforming Growth Factor-β1 Signaling Attenuates Ataxia Telangiectasia Mutated Activity in Response to Genotoxic Stress

2006 • 156 citations

Targeted deletion of the TGF-beta 1 gene causes rapid progression to squamous cell carcinoma.

1994 • 155 citations

Regulation of transforming growth factor beta1 by nitric oxide.

1999 • 142 citations

Transforming growth factor-beta1 mediates cellular response to DNA damage in situ.

2002 • 141 citations

Asbestos-derived reactive oxygen species activate TGF-β1

2004 • 137 citations

Methylnitrosourea-induced tumorigenesis in MGMT gene knockout mice.

1997 • 130 citations

Functional proteomics of transforming growth factor-beta1-stimulated Mv1Lu epithelial cells: Rad51 as a target of TGFbeta1-dependent regulation of DNA repair

2002 • 130 citations

Characterization of human Gadd45, a p53-regulated protein.

1994 • 126 citations

Mutant p53 can induce tumorigenic conversion of human bronchial epithelial cells and reduce their responsiveness to a negative growth factor, transforming growth factor beta 1.

1992 • 126 citations

Latency and activation in the control of TGF-β

1996 • 121 citations

Transforming growth factor beta 1 suppresses genomic instability independent of a G1 arrest, p53, and Rb.

1996 • 115 citations

Fusions near telomeres occur very early in the amplification of CAD genes in Syrian hamster cells.

1992 • 108 citations

Ultraviolet Irradiation Induces Smad7 via Induction of Transcription Factor AP-1 in Human Skin Fibroblasts

2004 • 90 citations

Targeted expression of human O(6)-methylguanine-DNA methyltransferase (MGMT) in transgenic mice protects against tumor initiation in two-stage skin carcinogenesis.

1996 • 86 citations

Blockade of Tumor Cell Transforming Growth Factor-βs Enhances Cell Cycle Progression and Sensitizes Human Breast Carcinoma Cells to Cytotoxic Chemotherapy

1998 • 84 citations

Enhanced rate of H2O2 release from bovine pulmonary artery endothelial cells induced by TGF-beta 1

1993 • 75 citations

Ionizing radiation induces heritable disruption of epithelial cell interactions

2003 • 72 citations

Mutant p53 tumor suppressor gene causes resistance to transforming growth factor beta 1 in murine keratinocytes.

1993 • 68 citations

Radiation-induced changes in the breast

1984 • 64 citations

Reactive Oxygen Species Act at both TGF-β-Dependent and -Independent Steps during Induction of Apoptosis of Transformed Cells by Normal Cells

1996 • 63 citations

Cytoplasmic sequestration and functional repression of p53 in the mammary epithelium is reversed by hormonal treatment.

2000 • 63 citations

TGFβ1/Smad3 counteracts BRCA1-dependent repair of DNA damage

2005 • 63 citations

Correlated abnormalities of transforming growth factor-β1 response and p53 expression in thyroid epithelial cell transformation

1991 • 63 citations

Defects in transforming growth factor-β signaling cooperate with a Ras oncogene to cause rapid aneuploidy and malignant transformation of mouse keratinocytes

1999 • 62 citations

Restoration of Transforming Growth Factor-β Signaling Enhances Radiosensitivity by Altering the Bcl-2/Bax Ratio in the p53 Mutant Pancreatic Cancer Cell Line MIA PaCa-2

2002 • 61 citations

The role of cytokines in radiation oncology.

1993 • 59 citations

The relevance of transforming growth factor β1 in pulmonary injury after radiation therapy

1998 • 58 citations

Transforming growth factor-β in in vivo resistance

1996 • 46 citations

Swift Is a Novel BRCT Domain Coactivator of Smad2 in Transforming Growth Factor β Signaling

2001 • 44 citations

Transforming growth factor-beta 1 overexpression produces drug resistance in vivo: reversal by decorin.

1998 • 42 citations

Functional Analysis of SoxR Residues Affecting Transduction of Oxidative Stress Signals into Gene Expression

2004 • 37 citations

Radiation-induced apoptosis in normal and pre-neoplastic mammary glandsin vivo: Significance of gland differentiation and p53 status

1996 • 36 citations

Transforming growth factor-beta and response to anticancer therapies in human liver and gastric tumors in vitro and in vivo.

2000 • 36 citations

Mutation analysis of transforming growth factor beta type II receptor, Smad2, Smad3 and Smad4 in esophageal squamous cell carcinoma.

2000 • 33 citations

True

2000 • 33 citations

Radiation and other pathological changes in breast tissue after conservation treatment for carcinoma.

1990 • 30 citations

Modifications of p53 Protein and Accumulation of p21 and gadd45 mRNA in TGF-β1 Growth Inhibited Cells

1997 • 30 citations

Structural and functional consequences of methionine oxidation in thrombomodulin

2004 • 30 citations

Increased Sensitivity of Transforming Growth Factor (TGF) β1 Null Cells to Alkylating Agents Reveals a Novel Link between TGFβ Signaling and O 6-Methylguanine Methyltransferase Promoter Hypermethylation

2001 • 28 citations

TRANSFORMING GROWTH FACTOR-β1 (TGF-β1): A POTENTIAL RECOVERY SIGNAL IN THE POST-ISCHEMIC KIDNEY

2002 • 28 citations

Transforming growth factor-β is an endogenous radioresistance factor in the esophageal adenocarcinoma cell line OE-33

2003 • 26 citations

Reduced thoracic vertebrae metastases following post mastectomy parasternal irradiation

1985 • 25 citations

Cytogenetic evidence for gene amplification in mouse skin carcinogenesis.

1986 • 16 citations

Heterogeneity in the transforming growth factor β response of esophageal cancer cells

2002 • 15 citations

TGF-β1 Inhibits BRCA1 Expression through a Pathway That Requires pRb

2000 • 14 citations

Role of GADD34 in modulation of cisplatin cytotoxicity

2005 • 14 citations

Radiation Treatment of Prostate Bone Metastases and the Biological Considerations

1992 • 12 citations

High value of the radiobiological parameter Dq correlates to expression of the transforming growth factor β type II receptor in a panel of small cell lung cancer cell lines

1998 • 4 citations