The relevance of transforming growth factor β1 in pulmonary injury after radiation therapy

Cancer: Principles and Practice of Oncology.

1991 • 8,402 citations

Tolerance of normal tissue to therapeutic irradiation

1991 • 4,329 citations

Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

1986 • 2,878 citations

Transforming growth factor beta

2011 • 1,990 citations

Cancer statistics, 1994

1994 • 1,345 citations

Effects of Concomitant Cisplatin and Radiotherapy on Inoperable Non-Small-Cell Lung Cancer

1992 • 1,287 citations

A Randomized Trial of Induction Chemotherapy plus High-Dose Radiation versus Radiation Alone in Stage III Non-Small-Cell Lung Cancer

1990 • 1,163 citations

Accelerated Healing of Incisional Wounds in Rats Induced by Transforming Growth Factor-β

1987 • 938 citations

Calculation of complication probability factors for non-uniform normal tissue irradiation: The effective volume method gerald

1989 • 880 citations

Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis.

1991 • 794 citations

Stimulation of the chemotactic migration of human fibroblasts by transforming growth factor beta.

1987 • 791 citations

Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin.

1990 • 740 citations

Hepatic toxicity resulting from cancer treatment

1995 • 686 citations

Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions.

1995 • 668 citations

Transforming Growth Factors β1 and α in Chronic Liver Disease

1991 • 655 citations

A perpetual cascade of cytokines postirradiation leads to pulmonary fibrosis

1995 • 641 citations

Histogram reduction method for calculating complication probabilities for three-dimensional treatment planning evaluations

1991 • 542 citations

Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor.

1991 • 521 citations

Maternal Rescue of Transforming Growth Factor-β 1 Null Mice

1994 • 494 citations

A randomized phase I/II trial of hyperfractionated radiation therapy with total doses of 60.0 Gy to 79.2 Gy: possible survival benefit with greater than or equal to 69.6 Gy in favorable patients with Radiation Therapy Oncology Group stage III non-small-cell lung carcinoma: report of Radiation Therapy Oncology Group 83-11.

1990 • 474 citations

Mannose 6-Phosphate Receptors and Lysosomal Enzyme Targeting

1989 • 473 citations

Polypeptide Transforming Growth Factors Isolated from Bovine Sources and Used for Wound Healing in Vivo

1983 • 451 citations

A prospective randomized study of various irradiation doses and fractionation schedules in the treatment of inoperable non-oat-cell carcinoma of the lung. Preliminary report by the radiation therapy oncology group

1980 • 447 citations

Latent transforming growth factor-beta in serum. A specific complex with alpha 2-macroglobulin.

1987 • 434 citations

Transforming growth factor-beta activation in irradiated murine mammary gland.

1994 • 414 citations

Effect of antibody to transforming growth factor beta on bleomycin induced accumulation of lung collagen in mice.

1993 • 402 citations

The effect of transforming growth factor-beta on cell proliferation and collagen formation by lung fibroblasts.

1987 • 399 citations

Optimization of radiation therapy, III: A method of assessing complication probabilities from dose-volume histograms

1987 • 377 citations

M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity

1995 • 352 citations

Impact of tumor control on survival in carcinoma of the lung treated with irradiation

1986 • 331 citations

Absence of TGF-β Receptors and Growth Inhibitory Responses in Retinoblastoma Cells

1988 • 331 citations

Transforming Growth Factor β as a Predictor of Liver and Lung Fibrosis after Autologous Bone Marrow Transplantation for Advanced Breast Cancer

1993 • 318 citations

Astro plenary: Effect of chemotherapy on locally advanced non-small cell lung carcinoma: A randomized study of 353 patients

1991 • 269 citations

Transforming growth factor-beta is a strong and fast acting positive regulator of the level of type-1 plasminogen activator inhibitor mRNA in WI-38 human lung fibroblasts.

1987 • 247 citations

Resistance to inhibition of cell growth by transforming growth factor-beta and its role in oncogenesis.

1993 • 239 citations

Interruptions of high-dose radiation therapy decrease longterm survival of favorable patients with unresectable nonsmall cell carcinoma of the lung: analysis of 1244 cases from 3 radiation therapy oncology group (RTOG) trials

1993 • 230 citations

Molecular biology mechanisms in the radiation induction of pulmonary injury syndromes: Interrelationship between the alveolar macrophage and the septal fibroblast

1992 • 216 citations

Plasma transforming growth factor-β1 in patients with hepatocellular carcinoma. Comparison with chronic liver diseases

1994 • 215 citations

Elevated Plasma Transforming Growth Factor-β1 Levels in Breast Cancer Patients Decrease After Surgical Removal of the Tumor

1995 • 207 citations

Early alterations in extracellular matrix and transforming growth factor β gene expression in mouse lung indicative of late radiation fibrosis

1994 • 207 citations

Inoperable non-small cell lung cancer: Radiation with or without chemotherapy

1988 • 205 citations

Results of radical radiation therapy in clinical stage I, technically operable non-small cell lung cancer

1988 • 204 citations

Alterations in pulmonary mRNA encoding procollagens, fibronectin and transforming growth factor-beta precede bleomycin-induced pulmonary fibrosis in mice.

1988 • 199 citations

Thoracic Radiation Therapy Alone Compared with Combined Chemoradiotherapy for Locally Unresectable Non-Small Cell Lung Cancer

1991 • 190 citations

Frequent loss of heterozygosity on 6q at the mannose 6-phosphate/insulin-like growth factor II receptor locus in human hepatocellular tumors.

1995 • 189 citations

Hepatic veno-occlusive disease after bone marrow transplantation. Immunohistochemical identification of the material within occluded central venules.

1987 • 184 citations

Transforming growth factor-beta 1 expression in irradiated liver.

1990 • 178 citations

The Reversal of an Adriamycin® Induced Healing Impairment with Chemoattractants and Growth Factors

1986 • 175 citations

Experience with CHART

1991 • 163 citations

Local control in medically inoperable lung cancer: An analysis of its importance in outcome and factors determining the probability of tumor eradication

1993 • 162 citations

Transforming growth factor β levels in rat wound chambers

1987 • 161 citations

Elevated levels of transforming growth factor beta messenger RNA and its polypeptide in human hepatocellular carcinoma.

1991 • 150 citations

Changes in plasma TGFβ levels during pulmonary radiotherapy as a predictor of the risk of developing radiation pneumonitis

1994 • 147 citations

Changes in plasma transforming growth factor beta during radiotherapy and the risk of symptomatic radiation-induced pneumonitis

1997 • 146 citations

Transforming Growth Factor-β1 Expression in Irradiated Liver

1990 • 145 citations

The utility of SPECT lung perfusion scans in minimizing and assessing the physiologic consequences of thoracic irradiation

1993 • 143 citations

Hyperfractionated radiotherapy of human tumors: Overview of the randomized clinical trials

1997 • 130 citations

Pulmonary Considerations of Organ Transplantation Part 3

1991 • 125 citations

How much could the radiotherapy dose be altered for individual patients based on a predictive assay of normal-tissue radiosensitivity?

1996 • 124 citations

Transforming growth factor beta 1 induces cachexia and systemic fibrosis without an antitumor effect in nude mice.

1991 • 121 citations

Optimization of radiation therapy

1994 • 121 citations

Liver Disease after Human Marrow Transplantation

1987 • 114 citations

PULMONARY VENOOCCLUSIVE DISEASE FOLLOWING BONE MARROW TRANSPLANTATION1

1989 • 113 citations

Differences in Correlation of mRNA Gene Expression in Mice Sensitive and Resistant to Radiation-Induced Pulmonary Fibrosis

1995 • 103 citations

Transforming growth factor beta and fibroblast growth factor as promoters of tumor progression to malignancy.

1993 • 82 citations

Plasma transforming growth factor-β1 reflects disease status in patients with lung cancer after radiotherapy: a possible tumor marker

1996 • 81 citations

Transforming Growth Factor-Beta Receptors and Mannose 6-Phosphate/Insulin-Like Growth Factor-II Receptor Expression in Human Hepatocellular Carcinoma

1995 • 74 citations

Pulmonary Considerations of Organ Transplantation: Part 2

1991 • 69 citations

Normal tissue injury after cancer therapy is a local response exacerbated by an endocrine effect of TGFβ

1995 • 67 citations

Radiation Sensitivity of the Liver

1990 • 60 citations

Radical Radiotherapy and Chemotherapy in Localized Inoperable Non-Small-Cell Lung Cancer: A Randomized Trial

1993 • 56 citations

Growth suppression by transforming growth factor β1 of human small-cell lung cancer cell lines is associated with expression of the type II receptor

1994 • 47 citations

Transforming growth factor beta and the cell surface in tumor progression

1993 • 41 citations

Early increases in pulmonary mRNA encoding procollagens and transforming growth factor-beta in mice sensitive to cyclophosphamide-induced pulmonary fibrosis.

1989 • 41 citations

Dose-dependent radiation effect on microvasculature and repair.

1987 • 35 citations

Frequency of Veno-occlusive Disease of the Liver in Bone Marrow Transplantation with a Modified Busulfan/Cyclophosphamide Preparative Regimen

1990 • 34 citations

Growth factor balance and tumor progression

1994 • 32 citations

The relationship between tumor response and survival following radiotherapy for carcinoma of the bronchus

1984 • 31 citations

Changes in plasma transforming growth factor beta in response to high-dose chemotherapy for stage II breast cancer: possible implications for the prevention of hepatic veno-occlusive disease and pulmonary drug toxicity.

1995 • 27 citations

Expression of c-erbB2, TGF-β1 and pS2 genes in primary human breast cancers

1992 • 22 citations

The pulmonary complications of bone marrow transplantation in adults.

1989 • 21 citations

Transforming Growth Factor Beta: A Plasma Tumor Marker

2003 • 10 citations

Role of transforming growth factor‐β and hepatocyte growth factor in late normal tissue effects of radiation

1993 • 8 citations

315 Plasma TGF-B levels during radiotherapy with or without carboplatin predicts pneumonitis in stage III non-small cell lung cancer (NSCLC)

1997 • 6 citations

99 Randomised multicentre trial of chart versus conventional radiotherapy in non-small lung cancer — Interim results and implications

1996 • 4 citations