Isoform-Specific Activation of Latent Transforming Growth Factor β (LTGF-β) by Reactive Oxygen Species

Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus

2003 • 5,611 citations

TGF-β signaling in tumor suppression and cancer progression

2001 • 2,235 citations

A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1

1999 • 1,965 citations

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis.

2000 • 1,945 citations

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

1993 • 1,941 citations

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis

2000 • 1,604 citations

Making sense of latent TGFβ activation

2002 • 1,579 citations

TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes

1997 • 1,404 citations

Free Radicals in Biology: Oxidative Stress and the Effects of Ionizing Radiation

1994 • 1,396 citations

A colorimetric method for determining low concentrations of mercaptans

1958 • 1,058 citations

Abnormal lung development and cleft palate in mice lacking TGF–β3 indicates defects of epithelial–mesenchymal interaction

1995 • 1,027 citations

An Assay for Transforming Growth Factor-β Using Cells Transfected with a Plasminogen Activator Inhibitor-1 Promoter-Luciferase Construct

1994 • 749 citations

The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP–dependent activation of TGF-β1

2002 • 701 citations

Activation of latent TGF-β by thrombospondin-1: mechanisms and physiology

2000 • 563 citations

Redox-mediated activation of latent transforming growth factor-beta 1.

1996 • 532 citations

Transforming growth factor beta: the good, the bad, and the ugly.

1994 • 491 citations

Integrin αVβ6-mediated activation of latent TGF-β requires the latent TGF-β binding protein-1

2004 • 459 citations

Characterization of the activation of latent TGF-beta by co-cultures of endothelial cells and pericytes or smooth muscle cells: a self-regulating system.

1990 • 449 citations

Transforming growth factor-beta activation in irradiated murine mammary gland.

1994 • 414 citations

Latent Transforming Growth Factor-β (TGF-β) Binding Proteins: Orchestrators of TGF-β Availability

2004 • 414 citations

Physicochemical Activation of Recombinant Latent Transforming Growth Factor-beta's 1, 2, and 3

1990 • 343 citations

SOD, oxidative stress and human pathologies: a brief history and a future vision

2005 • 307 citations

Coordinated regulation of apoptosis and cell proliferation by transforming growth factor beta 1 in cultured uterine epithelial cells.

1991 • 279 citations

Role for carbohydrate structures inTGF-β1 latency

1989 • 270 citations

Apoptosis Induced by Transforming Growth Factor-β in Fetal Hepatocyte Primary Cultures

1996 • 262 citations

Redox-mediated activation of latent transforming growth factor-beta 1

1996 • 245 citations

Interactions between Growth Factors and Integrins: Latent Forms of Transforming Growth Factor-β Are Ligands for the Integrin αvβ1

1998 • 229 citations

Latent transforming growth factor β1 activation in situ: quantitative and functional evidence after low‐dose γ‐irradiation ¹

1997 • 227 citations

Site-directed Mutagenesis of Cysteine Residues in the Pro Region of the Transforming Growth Factor β1 Precursor

1989 • 220 citations

Radiation-induced transforming growth factor beta and subsequent extracellular matrix reorganization in murine mammary gland.

1993 • 208 citations

Redox modulation of cellular signaling and metabolism through reversible oxidation of methionine sensors in calcium regulatory proteins

2004 • 159 citations

Chronic liver injury, TGF-β, and cancer

2001 • 156 citations

The recombinant proregion of transforming growth factor beta1 (latency-associated peptide) inhibits active transforming growth factor beta1 in transgenic mice.

1996 • 147 citations

Regulation of transforming growth factor beta1 by nitric oxide.

1999 • 142 citations

Transforming growth factor-beta1 mediates cellular response to DNA damage in situ.

2002 • 141 citations

Asbestos-derived reactive oxygen species activate TGF-β1

2004 • 137 citations

Overexpression of extracellular superoxide dismutase reduces acute radiation induced lung toxicity

2005 • 97 citations

Real-time Monitoring of the Interactions of Transforming Growth Factor-β (TGF-β) Isoforms with Latency-associated Protein and the Ectodomains of the TGF-β Type II and III Receptors Reveals Different Kinetic Models and Stoichiometries of Binding

2001 • 86 citations

Hypothesis: pathogenesis of systemic sclerosis.

2003 • 86 citations

Enhanced rate of H2O2 release from bovine pulmonary artery endothelial cells induced by TGF-beta 1

1993 • 75 citations

Manipulation of TGF-β to control autoimmune and chronic inflammatory diseases

1999 • 72 citations

Latent forms of TGF‐β: Molecular Structure and Mechanisms of Activation

2007 • 67 citations

Normal tissue injury after cancer therapy is a local response exacerbated by an endocrine effect of TGFβ

1995 • 67 citations

A Method for Detection of Hydroxyl Radicals in the Vicinity of Biomolecules Using Radiation-induced Fluorescence of Coumarin

1993 • 67 citations

Oxidative Protein Cross-linking Reactions Involvingl-Tyrosine in Transforming Growth Factor-β1-stimulated Fibroblasts

2001 • 66 citations

Transforming growth factor-β1 induces extracellular matrix formation in glomerulonephritis

1990 • 65 citations

Reactive Oxygen Species Act at both TGF-β-Dependent and -Independent Steps during Induction of Apoptosis of Transformed Cells by Normal Cells

1996 • 63 citations

Latent TGF‐β binding protein‐3 (LTBP‐3) requires binding to TGF‐β for secretion

2002 • 49 citations

Structural and functional consequences of methionine oxidation in thrombomodulin

2004 • 30 citations

TRANSFORMING GROWTH FACTOR-β1 (TGF-β1): A POTENTIAL RECOVERY SIGNAL IN THE POST-ISCHEMIC KIDNEY

2002 • 28 citations

Enhanced Expression of Neuropeptides in Human Breast Cancer Cell Lines Following Irradiation

1998 • 15 citations