Radiation-induced apoptosis in normal and pre-neoplastic mammary glandsin vivo: Significance of gland differentiation and p53 status

p53 Mutations in Human Cancers

1991 • 8,133 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

The p53-mdm-2 autoregulatory feedback loop.

1993 • 1,795 citations

Apoptosis: Mechanisms and Roles in Pathology

1991 • 1,368 citations

DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2

1994 • 671 citations

Apoptosis and the regulation of cell numbers in normal and neoplastic tissues: an overview

1992 • 600 citations

The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice.

1994 • 564 citations

p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis

1994 • 366 citations

Morphological evaluation of cell turnover in relation to the menstrual cycle in the “resting” human breast

1981 • 341 citations

Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability.

1995 • 280 citations

Bcl-2: a repressor of lymphocyte death

1992 • 217 citations

Heterogeneity in the Development of Apoptosis in Irradiated Murine Tumours of Different Histologies

1993 • 203 citations

Mutations in the p53 gene in primary human breast cancers.

1991 • 165 citations

Development of mammary preneoplasias in vivo from mouse mammary epithelial cell lines in vitro.

1992 • 111 citations

A Role for Calcium in Regulating Apoptosis in Rat Thymocytes Irradiatedin Vitro

1992 • 82 citations

Response of Parotid Gland Organ Culture to Radiation

1989 • 62 citations

Mutations in p53 are frequent in the preneoplastic stage of mouse mammary tumor development.

1993 • 49 citations

Morphological and functional properties of TM preneoplastic mammary outgrowths.

1993 • 47 citations

Proliferative and secretory activity in the pregnant and lactating human breast

1988 • 46 citations

p53 mutations selected in vivo when mouse mammary epithelial cells form hyperplastic outgrowths are not necessary for establishment of mammary cell lines in vitro.

1993 • 31 citations