Regulation of transforming growth factor beta1 by nitric oxide.

The Transforming Growth Factor-beta Family

1990 • 3,028 citations

Transforming growth factor beta

2011 • 1,990 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

Regulation of biosynthesis of nitric oxide.

1994 • 1,698 citations

S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control

1996 • 1,604 citations

Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin.

1992 • 1,237 citations

The origin and function of tumor-associated macrophages

1992 • 1,081 citations

Expression and secretion of type beta transforming growth factor by activated human macrophages.

1987 • 981 citations

Synthesis of messenger RNAs for transforming growth factors alpha and beta and the epidermal growth factor receptor by human tumors.

1987 • 895 citations

Deactivation of macrophages by transforming growth factor-β

1988 • 876 citations

An Assay for Transforming Growth Factor-β Using Cells Transfected with a Plasminogen Activator Inhibitor-1 Promoter-Luciferase Construct

1994 • 749 citations

Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor beta.

1993 • 658 citations

Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex.

1990 • 647 citations

Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells.

1988 • 592 citations

Redox-mediated activation of latent transforming growth factor-beta 1.

1996 • 532 citations

Macrophage deactivating factor and transforming growth factors-beta 1 -beta 2 and -beta 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma.

1990 • 507 citations

Transforming growth factor beta: the good, the bad, and the ugly.

1994 • 491 citations

Immunodetection and quantitation of the two forms of transforming growth factor‐beta (TGF‐β1 and TGF‐β2) secreted by cells in culture

1989 • 453 citations

Inflammatory and immunomodulatory roles of TGF-β

1989 • 450 citations

Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide.

1991 • 436 citations

Transforming growth factor-beta activation in irradiated murine mammary gland.

1994 • 414 citations

Biosynthesis of nitric oxide activates iron regulatory factor in macrophages.

1993 • 409 citations

Feedback inhibition of nitric oxide synthase activity by nitric oxide

1993 • 396 citations

Transforming growth factor-beta 1: histochemical localization with antibodies to different epitopes.

1989 • 378 citations

Activated murine macrophages induce apoptosis in tumor cells through nitric oxide-dependent or -independent mechanisms.

1994 • 372 citations

Macrophages and metastasis--a biological approach to cancer therapy.

1985 • 354 citations

Activation of human peripheral blood mononuclear cells by nitric oxide-generating compounds.

1993 • 353 citations

Physicochemical Activation of Recombinant Latent Transforming Growth Factor-beta's 1, 2, and 3

1990 • 343 citations

Inactivation of ribonucleotide reductase by nitric oxide

1991 • 331 citations

Chemical biology of nitric oxide: Regulation and protective and toxic mechanisms

1996 • 288 citations

Tumor-induced regulation of suppressor macrophage nitric oxide and TNF-alpha production. Role of tumor-derived IL-10, TGF-beta, and prostaglandin E2.

1994 • 244 citations

Production of transforming growth factors by human colon cancer lines.

1986 • 227 citations

Latent transforming growth factor β1 activation in situ: quantitative and functional evidence after low‐dose γ‐irradiation ¹

1997 • 227 citations

Transforming growth factor alpha and beta expression in human colon cancer lines: implications for an autocrine model.

1987 • 222 citations

On the expression of nitric oxide synthase by human macrophages. Why no NO?

1995 • 218 citations

S-nitrosylation of tissue-type plasminogen activator confers vasodilatory and antiplatelet properties on the enzyme.

1992 • 182 citations

Nitric oxide signaling: a possible role for G proteins.

1993 • 175 citations

Characterization of latent TGF-beta activation by murine peritoneal macrophages.

1995 • 174 citations

The production of transforming growth factor-beta in acute megakaryoblastic leukemia and its possible implications in myelofibrosis

1990 • 172 citations

Nitric oxide modulation of human leukemia cell differentiation and gene expression

1992 • 172 citations

Convenient Colorimetric and Fluorometric Assays for S-Nitrosothiols

1996 • 163 citations

Inhibition of angiogenesis, tumour growth and metastasis by the NO‐releasing vasodilators, isosorbide mononitrate and dinitrate

1995 • 156 citations

Nitric oxide up‐regulates the release of inflammatory mediators by mouse macrophages

1995 • 145 citations

Tumor necrosis factor-alpha-dependent production of reactive nitrogen intermediates mediates IFN-gamma plus IL-2-induced murine macrophage tumoricidal activity.

1992 • 144 citations

Nitric oxide/nucleophile complexes inhibit the in vitro proliferation of A375 melanoma cells via nitric oxide release.

1993 • 137 citations

Increased secretion of type beta transforming growth factor accompanies viral transformation of cells.

1985 • 132 citations

Activation of nitric oxide synthase gene for inhibition of cancer metastasis

1996 • 127 citations

Expression of TGF-beta gene in adult T cell leukemia

1988 • 122 citations

Activation of Latent Transforming Growth Factor ß

1993 • 118 citations

Human monocytes are stimulated for nitric oxide release in vitro by some tumor cells but not by cytokines and lipopolysaccharide

1994 • 118 citations

Spontaneously increased production of nitric oxide and aberrant expression of the inducible nitric oxide synthase in vivo in the transforming growth factor beta 1 null mouse.

1996 • 115 citations

Monitoring Reactions of Nitric Oxide with Peptides and Proteins by Electrospray Ionization-Mass Spectrometry

1995 • 113 citations

Control of Nitric Oxide Production by Transforming Growth Factor-β1: Mechanistic Insights and Potential Relevance to Human Disease

1997 • 103 citations

Nitric Oxide Regulates IL-8 Expression in Melanoma Cells at the Transcriptional Level

1995 • 90 citations

Nitric Oxide Regulation of IL-8 Expression in Human Endothelial Cells

1995 • 81 citations

Exogenous nitric oxide regulates IFN-gamma plus lipopolysaccharide-induced nitric oxide synthase expression in mouse macrophages.

1995 • 81 citations

Secretion of Toxic Oxygen Products by Macrophages: Regulatory Cytokines and their Effects on the Oxidase

1986 • 79 citations

γ‐Interferon‐Induced Activation of Latent Transforming Growth Factor‐β by Human Monocytes

1990 • 73 citations

Mechanisms and modulation of macrophage activation.

1991 • 63 citations

Characterization of IL-2 receptor expression and function on murine macrophages.

1990 • 59 citations

Aberrant TGF-β Production and Regulation in Metastatic Malignancy

1990 • 59 citations

Nitric Oxide Regulates Interleukin 1 Bioactivity Released from Murine Macrophages

1996 • 58 citations

Interleukin-12 Gene-Expression of Macrophages Is Regulated by Nitric Oxide

1996 • 58 citations

Immunocytochemical localization of latent transforming growth factor-?1 activation by stimulated macrophages

1999 • 54 citations

Expression of Inducible Nitric Oxide Synthase in Cerebral Endothelial Cells Is Regulated by Cytokine‐Activated Astrocytes

1995 • 51 citations

Tumor Necrosis Factor‐α (TNF‐α), Interferon‐γ, and Interleukin‐6 but Not TNF‐β Induce Differentiation of Neuroblastoma Cells: The Role of Nitric Oxide

1994 • 48 citations

Increased mortality, blunted production of nitric oxide, and increased production of TNF-α in endotoxemic TGF-β1 transgenic mice

1998 • 41 citations

Cytokine Regulation of Nitric Oxide Synthase in Mouse Retinal Pigment Epithelial Cells in Culture

1994 • 37 citations

Particular types of tumor cells have the capacity to convert transforming growth factor beta from a latent to an active form.

1992 • 36 citations

IL-1 alpha induces expression of active transforming growth factor-beta in nonproliferating T cells via a post-transcriptional mechanism.

1990 • 34 citations

Identification of a transforming growth factor beta-1 activator derived from a human gastric cancer cell line

1995 • 33 citations

Involvement of a transforming‐growth‐factor‐β‐like molecule in tumor‐cell‐derived inhibition of nitric‐oxide synthesis in cerebral endothelial cells

1995 • 21 citations

Modulation of nitric oxide production in RAW 264.7 cells by transforming growth factor-beta and interleukin-10: differential effects on free and encapsulated immunomodulator

1997 • 21 citations

L-Arginine/Nitric Oxide Pathway: A Possible Signal Transduction Mechanism for the Regulation of the Chemokine IL-8 in Human Mesangial Cells

1993 • 17 citations

Improvement of Macrophage Dysfunction by Administration of Anti‐transforming Growth Factor‐β Antibody in EL4‐bearing Hosts

1994 • 17 citations

Potentiation of retinoic acid-induced U-937 differentiation into respiratory burst-competent cells by nitric oxide donors

1995 • 15 citations

A redox-based mechanism for induction of interleukin-1 production by nitric oxide in a human colonic epithelial cell line (HT29-Cl.16E)

1996 • 12 citations