Activation of latent TGF-β by thrombospondin-1: mechanisms and physiology

The Transforming Growth Factor-beta Family

1990 • 3,028 citations

A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1

1999 • 1,965 citations

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

1993 • 1,941 citations

Control of Angiogenesis in Fibroblasts by p53 Regulation of Thrombospondin-1

1994 • 1,460 citations

TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes

1997 • 1,404 citations

Thrombospondin-1 Is a Major Activator of TGF-β1 In Vivo

1998 • 1,151 citations

Transforming growth factor-beta in disease: the dark side of tissue repair.

1992 • 1,126 citations

A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin.

1990 • 1,062 citations

Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture.

1989 • 914 citations

Transforming growth factor–β3 is required for secondary palate fusion

1995 • 895 citations

Expression of transforming growth factor beta is elevated in human and experimental diabetic nephropathy.

1993 • 819 citations

An activated form of transforming growth factor beta is produced by cocultures of endothelial cells and pericytes.

1989 • 767 citations

Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin.

1990 • 740 citations

Hyperglycemia and Diabetic Kidney Disease: The Case for Transforming Growth Factor–β as a Key Mediator

1995 • 560 citations

Redox-mediated activation of latent transforming growth factor-beta 1.

1996 • 532 citations

Glomerulosclerosis induced by in vivo transfection of transforming growth factor-beta or platelet-derived growth factor gene into the rat kidney.

1993 • 525 citations

Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor.

1991 • 521 citations

Latent transforming growth factor-β: Structural features and mechanisms of activation

1997 • 511 citations

Macrophage production of transforming growth factor beta and fibroblast collagen synthesis in chronic pulmonary inflammation.

1989 • 502 citations

Neutralising antibody to TGF-β1,2 reduces cutaneous scarring in adult rodents

1994 • 499 citations

Thrombospondin causes activation of latent transforming growth factor- beta secreted by endothelial cells by a novel mechanism [published erratum appears in J Cell Biol 1993 Sep;122(5):following 1143]

1993 • 467 citations

Loss of Fibrinogen Rescues Mice from the Pleiotropic Effects of Plasminogen Deficiency

1996 • 428 citations

Transforming growth factor-beta activation in irradiated murine mammary gland.

1994 • 414 citations

Regulation of Transforming Growth Factor-β Activation by Discrete Sequences of Thrombospondin 1

1995 • 413 citations

Transforming growth factor-beta: a general review.

1996 • 400 citations

Human Mast Cell Chymase and Leukocyte Elastase Release Latent Transforming Growth Factor-β1 from the Extracellular Matrix of Cultured Human Epithelial and Endothelial Cells

1995 • 398 citations

Processing of Transforming Growth Factor β1 Precursor by Human Furin Convertase

1995 • 395 citations

Thrombospondins: structure and regulation of expression

1992 • 345 citations

The Activation Sequence of Thrombospondin-1 Interacts with the Latency-associated Peptide to Regulate Activation of Latent Transforming Growth Factor-β

1999 • 336 citations

Transforming growth factor β: a matter of life and death

1994 • 306 citations

Requirement for transglutaminase in the activation of latent transforming growth factor-beta in bovine endothelial cells.

1993 • 290 citations

Increased Renal Production of Transforming Growth Factor-β1 in Patients with Type II Diabetes

1997 • 275 citations

Thrombospondin binds and activates the small and large forms of latent transforming growth factor-beta in a chemically defined system.

1994 • 274 citations

Thrombospondin modulates focal adhesions in endothelial cells.

1989 • 271 citations

Role for carbohydrate structures inTGF-β1 latency

1989 • 270 citations

Transforming growth factor-beta complexes with thrombospondin.

1992 • 256 citations

The type 1 repeats of thrombospondin 1 activate latent transforming growth factor-beta.

1994 • 250 citations

Redox-mediated activation of latent transforming growth factor-beta 1

1996 • 245 citations

Role of the latent TGF-beta binding protein in the activation of latent TGF-beta by co-cultures of endothelial and smooth muscle cells.

1993 • 241 citations

Site-directed Mutagenesis of Cysteine Residues in the Pro Region of the Transforming Growth Factor β1 Precursor

1989 • 220 citations

The pro domain of pre-pro-transforming growth factor .beta.1 when independently expressed is a functional binding protein for the mature growth factor

1990 • 185 citations

Activation of Rat Alveolar Macrophage-Derived Latent Transforming Growth Factor β-1 by Plasmin Requires Interaction with Thrombospondin-1 and its Cell Surface Receptor, CD36

1999 • 173 citations

Thrombospondins

1991 • 169 citations

Transforming growth factor‐β: activity and efficacy in animal models of wound healing

1995 • 159 citations

Hyperglycemia and diabetic kidney disease. The case for transforming growth factor-beta as a key mediator

1995 • 136 citations

Thrombospondin in Early Human Wound Tissue

1987 • 135 citations

Heparin-binding peptides from the type I repeats of thrombospondin. Structural requirements for heparin binding and promotion of melanoma cell adhesion and chemotaxis.

1992 • 120 citations

Onset and progression of pathological lesions in transforming growth factor-beta 1-deficient mice.

1995 • 95 citations

The Thrombospondin Gene Family

1995 • 92 citations

Diverse mechanisms for cell attachment to platelet thrombospondin

1993 • 90 citations

Expression of thrombospondins by endothelial cells. Injury is correlated with TSP-1.

1995 • 80 citations

Thrombospondin 1 is expressed by proliferating mesangial cells and is up-regulated by PDGF and bFGF in vivo

1995 • 77 citations

Structural characterization of the latent complex between transforming growth factor β1 and β1-latency-associated peptide

1996 • 76 citations

Genetic origins of protein shape and interaction rules

1995 • 73 citations

Role of the extracellular matrix protein thrombospondin in the early development of the mouse embryo.

1990 • 71 citations

Identification and analysis of discrete functional domains in the pro region of pre-pro-transforming growth factor beta 1.

1991 • 69 citations

Induction of Transforming Growth Factor β by the Antiestrogens Droloxifene, Tamoxifen, and Toremifene in MCF-7 Cells

1991 • 66 citations

Inhibition of fibronectin binding and fibronectin-mediated cell adhesion to collagen by a peptide from the second type I repeat of thrombospondin.

1993 • 62 citations

Thrombospondin secretion by cultured human glomerular mesangial cells.

1987 • 60 citations

Increased renal production of transforming growth factor-beta1 in patients with type II diabetes

1997 • 55 citations

Thrombospondin in human glomerulopathies. A marker of inflammation and early fibrosis.

1994 • 45 citations

Identification of Glucose-Regulated Genes in Human Mesangial Cells by mRNA Differential Display

1997 • 37 citations

Analysis of Small Latent Transforming Growth Factor-β Complex Formation and Dissociation by Surface Plasmon Resonance

1997 • 36 citations

Photodynamic therapy inhibits transforming growth factor β activity associated with vascular smooth muscle cell injury

1997 • 32 citations

Role of Carbohydrate Structures in the Binding of β1-Latency-Associated Peptide to Ligands

1997 • 26 citations

Thrombospondin peptides are potent inhibitors of mesangial and glomerular endothelial cell proliferation in vitro and in vivo

1999 • 25 citations

Deleted Work

1955 • 0 citations