Defects in transforming growth factor-β signaling cooperate with a Ras oncogene to cause rapid aneuploidy and malignant transformation of mouse keratinocytes

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Requirement for p53 and p21 to Sustain G ₂ Arrest After DNA Damage

1998 • 2,784 citations

Cell Cycle Control and Cancer

1994 • 2,575 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

1993 • 1,941 citations

pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

1994 • 1,932 citations

Mutations of mitotic checkpoint genes in human cancers

1998 • 1,482 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism.

1995 • 938 citations

Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis

1986 • 865 citations

Abnormal Centrosome Amplification in the Absence of p53

1996 • 802 citations

The Transforming Growth Factor-βs

1990 • 741 citations

A p53-Dependent Mouse Spindle Checkpoint

1995 • 668 citations

Characterization of the p53-Dependent Postmitotic Checkpoint following Spindle Disruption

1998 • 498 citations

CDC25 Phosphatases as Potential Human Oncogenes

1995 • 498 citations

Genetic changes in the transforming growth factor beta (TGF-beta) type II receptor gene in human gastric cancer cells: correlation with sensitivity to growth inhibition by TGF-beta.

1994 • 431 citations

Transient excess of MYC activity can elicit genomic instability and tumorigenesis

1999 • 409 citations

Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-β in cells lacking the CDK inhibitor p15

1997 • 378 citations

A Role for Endothelial NO Synthase in LTP Revealed by Adenovirus-Mediated Inhibition and Rescue

1996 • 304 citations

Behavior of myc and ras oncogenes in transformation of rat embryo fibroblasts.

1986 • 272 citations

Genetic changes in skin tumor progression: Correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7

1990 • 270 citations

Expression of a dominant-negative mutant TGF-beta type II receptor in transgenic mice reveals essential roles for TGF-beta in regulation of growth and differentiation in the exocrine pancreas

1997 • 257 citations

Mouse skin cells resistant to terminal differentiation associated with initiation of carcinogenesis

1981 • 228 citations

Loss of receptors for transforming growth factor beta in human T-cell malignancies.

1994 • 219 citations

An activated Harvey ras oncogene produces benign tumours on mouse epidermal tissue

1986 • 218 citations

Loss of expression of transforming growth factor beta in skin and skin tumors is associated with hyperproliferation and a high risk for malignant conversion.

1993 • 207 citations

Transgenic mice overexpressing a dominant-negative mutant type II transforming growth factor beta receptor show enhanced tumorigenesis in the mammary gland and lung in response to the carcinogen 7,12-dimethylbenz-[a]-anthracene.

1997 • 195 citations

Development of murine epidermal cell lines which contain an activated rasHa oncogene and form papillomas in skin grafts on athymic nude mouse hosts.

1988 • 183 citations

[1] Isolation and utilization of epidermal keratinocytes for oncogene research

1995 • 158 citations

Targeted deletion of the TGF-beta 1 gene causes rapid progression to squamous cell carcinoma.

1994 • 155 citations

Loss of heterozygosity and mutational alterations of the p53 gene in skin tumours of interspecific hybrid mice.

1991 • 139 citations

Expression of a dominant negative type II TGF-β receptor in mouse skin results in an increase in carcinoma incidence and an acceleration of carcinoma development

1998 • 123 citations

Progressive dysplasia and aneuploidy are hallmarks of mouse skin papillomas: relevance to malignancy.

1987 • 123 citations

Progression of squamous carcinoma cells to spindle carcinomas of mouse skin is associated with an imbalance of H-ras alleles on chromosome 7.

1991 • 116 citations

Transforming growth factor beta 1 suppresses genomic instability independent of a G1 arrest, p53, and Rb.

1996 • 115 citations

Improved sandwich enzyme-linked immunosorbent assays for transforming growth factor β1

1993 • 112 citations

Nonrandom duplication of the chromosome bearing a mutated Ha-ras-1 allele in mouse skin tumors.

1990 • 98 citations

Sequential trisomization of chromosomes 6 and 7 in mouse skin premalignant lesions

1989 • 96 citations

Aneuploidy, an early event in mouse skin tumor development

1986 • 85 citations

Transforming growth factor beta 1 regulation of c-myc expression, pRB phosphorylation, and cell cycle progression in keratinocytes.

1992 • 81 citations

Induction and Autocrine Receptor Binding of Transforming Growth Factor-β2 during Terminal Differentiation of Primary Mouse Keratinocytes

1990 • 81 citations

Adenovirus-mediated Transfer of a Truncated Transforming Growth Factor-β (TGF-β) Type II Receptor Completely and Specifically Abolishes Diverse Signaling by TGF-β in Vascular Wall Cells in Primary Culture

1996 • 80 citations

Behavior of myc and ras Oncogenes in Transformation of Rat Embryo Fibroblasts

1986 • 67 citations

Mechanism of enhancement of DNA expression consequent to cointernalization of a replication-deficient adenovirus and unmodified plasmid DNA

1994 • 63 citations

Lack of transforming growth factor-beta 1 expression in benign skin tumors of p53null mice is prognostic for a high risk of malignant conversion.

1994 • 61 citations

Cytogenetic profile of mouse skin tumors induced by the viral Harvey-ras gene

1988 • 16 citations

Development of an in vitro model to study carcinogen-induced neoplastic progression of initiated mouse epidermal cells.

1992 • 15 citations

Thiourea analogues of resiniferatoxin as ligands for the vanilloid receptor

1995 • 10 citations