Alterations of Smad signaling in human breast carcinoma are associated with poor outcome: a tissue microarray study.

Nonparametric Estimation from Incomplete Observations

1992 • 45,923 citations

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

Tissue microarrays for high-throughput molecular profiling of tumor specimens

1998 • 4,104 citations

A Human Cell Line From a Pleural Effusion Derived From a Breast Carcinoma 2

1973 • 2,431 citations

In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain

1977 • 1,743 citations

Type beta transforming growth factor: a bifunctional regulator of cellular growth.

1985 • 1,107 citations

Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways

1996 • 899 citations

Molecular Predictors of Survival after Adjuvant Chemotherapy for Colon Cancer

2001 • 878 citations

MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal Carcinoma

1996 • 855 citations

Validation of Tissue Microarray Technology in Breast Carcinoma

2000 • 800 citations

Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer.

1995 • 743 citations

DPC4 gene in various tumor types.

1996 • 680 citations

Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining.

1994 • 673 citations

Establishment and characterization of a cell line of human breast carcinoma origin

1979 • 653 citations

Long-term human breast carcinoma cell lines of metastatic origin: Preliminary characterization

1978 • 634 citations

Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: evidence that DPC4 inactivation occurs late in neoplastic progression.

2000 • 574 citations

Apoptotic cell death and tissue remodelling during mouse mammary gland involution

1992 • 536 citations

Cyclin D1 protein expression and function in human breast cancer

1994 • 515 citations

A transforming growth factor beta receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability.

1995 • 445 citations

Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers.

1999 • 395 citations

Establishment and characterization of three new continuous cell lines derived from human breast carcinomas.

1978 • 373 citations

Immunohistochemical staining for transforming growth factor beta 1 associates with disease progression in human breast cancer.

1992 • 346 citations

Epithelial mouse mammary cell line exhibiting normal morphogenesis in vivo and functional differentiation in vitro.

1984 • 336 citations

Expression of transforming growth factor beta type II receptor leads to reduced malignancy in human breast cancer MCF-7 cells

1994 • 325 citations

Defective repression of c- myc in breast cancer cells: A loss at the core of the transforming growth factor β growth arrest program

2001 • 320 citations

Transforming growth factor-β1 is a new form of tumor suppressor with true haploid insufficiency

1998 • 319 citations

Two Syngeneic Cell Lines from Human Breast Tissue: The Aneuploid Mammary Epithelial (Hs578T) and the Diploid Myoepithelial (Hs578Bst) Cell Lines 2

1977 • 299 citations

Immunohistochemical Labeling for Dpc4 Mirrors Genetic Status in Pancreatic Adenocarcinomas

2000 • 296 citations

Mammary tumor suppression by transforming growth factor beta 1 transgene expression.

1995 • 292 citations

Cultivation of Human Breast Carcinomas<xref ref-type="fn" rid="FN1">2</xref>

1958 • 277 citations

Latency, activation, and binding proteins of TGF-?

2001 • 262 citations

Inhibition of mammary duct development but not alveolar outgrowth during pregnancy in transgenic mice expressing active TGF-beta 1.

1993 • 260 citations

BALB and kirsten murine sarcoma viruses alter growth and differentiation of EGF-dependent BALB/c mouse epidermal keratinocyte lines

1983 • 224 citations

Targeting expression of a transforming growth factor beta 1 transgene to the pregnant mammary gland inhibits alveolar development and lactation.

1993 • 224 citations

Immunocytochemical localization of secreted transforming growth factor-beta 1 to the advancing edges of primary tumors and to lymph node metastases of human mammary carcinoma.

1993 • 208 citations

Transgenic mice overexpressing a dominant-negative mutant type II transforming growth factor beta receptor show enhanced tumorigenesis in the mammary gland and lung in response to the carcinogen 7,12-dimethylbenz-[a]-anthracene.

1997 • 195 citations

Expression of growth factors, growth inhibiting factors, and their receptors in invasive breast cancer. I: An inventory in search of autocrine and paracrine loops

1998 • 175 citations

Resistance to transforming growth factor beta and activin due to reduced receptor expression in human breast tumor cell lines.

1995 • 155 citations

Transforming growth factor beta1 in ductal carcinoma in situ and invasive carcinomas of the breast

1992 • 154 citations

Transforming growth factor beta type I receptor kinase mutant associated with metastatic breast cancer.

1998 • 154 citations

Transforming growth factor-β in breast cancer: A working hypothesis

1997 • 154 citations

Characterization of Functional Domains within Smad4/DPC4

1997 • 151 citations

DPC4 (SMAD4) mediates transforming growth factor-β1 (TGF-β1) induced growth inhibition and transcriptional response in breast tumour cells

1997 • 134 citations

Transforming Growth Factor-β and Breast Cancer Risk in Women With Mammary Epithelial Hyperplasia

1999 • 134 citations

Comparison of Methods for Extracting DNA from Formalin-Fixed Paraffin Sections for Nonisotopic PCR

1996 • 132 citations

Latency and activation in the control of TGF-β

1996 • 121 citations

Loss of expression of transforming growth factor beta type II receptor correlates with high tumour grade in human breast in‐situ and invasive carcinomas

2000 • 118 citations

A cell line (HBL-100) established from human breast milk

1982 • 108 citations

Localization of transforming growth factor-β isotypes in lesions of the human breast

1992 • 107 citations

Structural alterations of transforming growth factor-? receptor genes in human cervical carcinoma

1999 • 100 citations

Epithelial HBL-100 cell line derived from milk of an apparently healthy woman harbours SV40 genetic information

1985 • 96 citations

Dpc4 transcriptional activation and dysfunction in cancer cells.

1998 • 90 citations

Transforming growth factor-? responsiveness inDPC4/SMAD4-null cancer cells

1999 • 89 citations

Inhibitory effects of activin on the growth and morpholgenesis of primary and transformed mammary epithelial cells.

1996 • 86 citations

Transforming growth factor-β and breast cancer: Mammary gland development

2000 • 77 citations

Inhibiting mutations in the transforming growth factor beta type 2 receptor in recurrent human breast cancer.

2001 • 76 citations

Effects of transforming growth factor β on growth of human mammary epithelial cells in culture

1989 • 76 citations

Overexpression of human cyclin D1 reduces the transforming growth factor beta (TGF-beta) type II receptor and growth inhibition by TGF-beta 1 in an immortalized human esophageal epithelial cell line.

1994 • 71 citations

TGFβ Signal Transduction

2010 • 65 citations

Transforming Growth Factor-β Inhibits Lactogenic Hormone Induction of β-Casein Expression in HC11 Mouse Mammary Epithelial Cells

1990 • 46 citations

Expression profile of agonistic Smads in human breast cancer cells: Absence of regulation by estrogens

1999 • 39 citations

Human mammary gland and breast carcinoma contain immunoreactive inhibin/activin subunits: evidence for a secretion into cystic fluid

1999 • 37 citations

Expression and secretion of TGF-beta isoforms and expression of TGF-beta-receptors I, II and III in normal and neoplastic human breast.

1999 • 33 citations

Expression of transforming growth factor-β receptor type II and tumorigenicity in human breast adenocarcinoma MCF-7 cells

1998 • 30 citations

Smad Protein Expression and Activation in Transforming Growth Factor-β Refractory Human Squamous Cell Carcinoma Cells

2001 • 24 citations

Functional characterization of transforming growth factor beta type II receptor mutants in human cancer.

1998 • 18 citations

Transforming Growth Factor- ? Type II Receptor Is Infrequently Expressed in Human Breast Cancer

1996 • 5 citations

Deleted Work

1955 • 0 citations