Inhibition of Transforming Growth Factor-β1 Signaling Attenuates Ataxia Telangiectasia Mutated Activity in Response to Genotoxic Stress

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

2003 • 3,385 citations

Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints

2004 • 3,161 citations

Cell-cycle checkpoints and cancer

2004 • 2,699 citations

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

2005 • 2,633 citations

ATM and related protein kinases: safeguarding genome integrity

2003 • 2,516 citations

TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders

2000 • 2,354 citations

TGF-β signaling in tumor suppression and cancer progression

2001 • 2,235 citations

ATM Phosphorylates Histone H2AX in Response to DNA Double-strand Breaks

2001 • 1,861 citations

Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer

2003 • 1,572 citations

Post‐translational modifications and activation of p53 by genotoxic stresses

2001 • 1,076 citations

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

2005 • 1,034 citations

Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

2004 • 859 citations

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

2000 • 807 citations

The two faces of transforming growth factor β in carcinogenesis

2003 • 740 citations

Functional differentiation and alveolar morphogenesis of primary mammary cultures on reconstituted basement membrane

1989 • 700 citations

ATM and ATR: networking cellular responses to DNA damage

2001 • 595 citations

Initiating Cellular Stress Responses

2004 • 543 citations

Redox-mediated activation of latent transforming growth factor-beta 1.

1996 • 532 citations

DNA damage-induced activation of ATM and ATM-dependent signaling pathways

2004 • 472 citations

Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage

2003 • 463 citations

Dual roles of ATM in the cellular response to radiation and in cell growth control.

1996 • 415 citations

Transforming growth factor-beta activation in irradiated murine mammary gland.

1994 • 414 citations

Mammalian cell cycle checkpoints: signalling pathways and their organization in space and time

2004 • 374 citations

The p53 response to DNA damage

2004 • 329 citations

The cellular response to general and programmed DNA double strand breaks

2004 • 300 citations

ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses

2001 • 276 citations

Nuclear Retention of ATM at Sites of DNA Double Strand Breaks

2001 • 275 citations

Involvement of novel autophosphorylation sites in ATM activation

2006 • 272 citations

Synthesis and Activity of New Aryl- and Heteroaryl-Substituted Pyrazole Inhibitors of the Transforming Growth Factor-β Type I Receptor Kinase Domain

2003 • 231 citations

Latent transforming growth factor β1 activation in situ: quantitative and functional evidence after low‐dose γ‐irradiation ¹

1997 • 227 citations

Radiation-induced transforming growth factor beta and subsequent extracellular matrix reorganization in murine mammary gland.

1993 • 208 citations

Loss of expression of transforming growth factor beta in skin and skin tumors is associated with hyperproliferation and a high risk for malignant conversion.

1993 • 207 citations

Temporal modulation of TGF-beta 1 and beta-actin gene expression in pig skin and muscular fibrosis after ionizing radiation.

1993 • 165 citations

Targeted deletion of the TGF-beta 1 gene causes rapid progression to squamous cell carcinoma.

1994 • 155 citations

Imaging Features that Discriminate between Foci Induced by High- and Low-LET Radiation in Human Fibroblasts

2006 • 154 citations

Latent Transforming Growth Factor-β Activation in Mammary Gland

2002 • 146 citations

Transforming growth factor-beta1 mediates cellular response to DNA damage in situ.

2002 • 141 citations

Temporal Modulation of TGF-β1 and β-Actin Gene Expression in Pig Skin and Muscular Fibrosis after Ionizing Radiation

1993 • 128 citations

Transforming growth factor beta 1 suppresses genomic instability independent of a G1 arrest, p53, and Rb.

1996 • 115 citations

Coactivation of AP-1 activity and TGF-β1 gene expression in the stress response of normal skin cells to ionizing radiation

1997 • 115 citations

ATP Activates Ataxia-Telangiectasia Mutated (ATM) in Vitro

2003 • 91 citations

Integrative radiation carcinogenesis: interactions between cell and tissue responses to DNA damage

2004 • 88 citations

Defects in transforming growth factor-β signaling cooperate with a Ras oncogene to cause rapid aneuploidy and malignant transformation of mouse keratinocytes

1999 • 62 citations

Multiple Signaling Pathways Involving ATM

2000 • 54 citations

Checkpoint signaling: Epigenetic events sound the DNA strand‐breaks alarm to the ATM protein kinase

2003 • 48 citations

Ataxia Telangiectasia-mutated Protein Can Regulate p53 and Neuronal Death Independent of Chk2 in Response to DNA Damage

2003 • 44 citations

How tissues respond to damage at the cellular level: orchestration by transforming growth factor-β (TGF-β)

2005 • 30 citations

Increased Sensitivity of Transforming Growth Factor (TGF) β1 Null Cells to Alkylating Agents Reveals a Novel Link between TGFβ Signaling and O 6-Methylguanine Methyltransferase Promoter Hypermethylation

2001 • 28 citations

ATM: Sounding the Double-strand Break Alarm

2000 • 19 citations

Latent TGF-Beta activation in mammary gland: Regulation by ovarian hormones affects ductal and alveolar proliferation

2002 • 12 citations