Transcriptional regulation of Alzheimer's disease genes: implications for susceptibility

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

1993 • 8,888 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1991 • 4,533 citations

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

1993 • 4,145 citations

Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease

1997 • 4,137 citations

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1995 • 3,985 citations

Candidate Gene for the Chromosome 1 Familial Alzheimer's Disease Locus

1995 • 2,548 citations

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1996 • 2,543 citations

Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?

1993 • 2,146 citations

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1995 • 2,028 citations

Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia

1996 • 1,951 citations

Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium

1997 • 1,868 citations

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1998 • 1,786 citations

Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)

1994 • 1,700 citations

Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

1996 • 1,467 citations

Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1

1996 • 1,439 citations

Transcription factor AP-2 mediates induction by two different signal-transduction pathways: Protein kinase C and cAMP

1987 • 1,391 citations

Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor

1990 • 1,388 citations

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

1997 • 1,259 citations

Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

1988 • 1,098 citations

A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

1988 • 1,052 citations

Skeletal and CNS Defects in Presenilin-1-Deficient Mice

1997 • 953 citations

Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

1994 • 866 citations

A Familial Alzheimer's Disease Locus on Chromosome 1

1995 • 810 citations

Differential Effects of Apolipoproteins E3 and E4 on Neuronal Growth in Vitro

1994 • 797 citations

Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system.

1985 • 786 citations

Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage.

1991 • 762 citations

Presenilin 1 is required for Notch 1 and Dll1 expression in the paraxial mesoderm

1997 • 721 citations

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

1995 • 705 citations

GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase

1990 • 677 citations

Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins

1987 • 666 citations

Amyloid A4 Protein and Its Precursor in Down's Syndrome and Alzheimer's Disease

1989 • 651 citations

Amyloid β Protein (Aβ) in Alzheimeri's Disease Brain

1995 • 646 citations

Transcription from a TATA-less promoter requires a multisubunit TFIID complex.

1991 • 618 citations

Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells.

1989 • 586 citations

Expression of apolipoprotein E during nerve degeneration and regeneration.

1986 • 563 citations

Alzheimer–associated presenilins 1 and 2 : Neuronal expression in brain and localization to intracellular membranes in mammalian cells

1996 • 549 citations

Developmental Expression of Sp1 in the Mouse

1991 • 533 citations

A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve.

1989 • 532 citations

Jun-Fos and receptors for vitamins A and D recognize a common response element in the human osteocalcin gene

1990 • 522 citations

The E280A presenilin 1 Alzheimer mutation produces increased Aβ42 deposition and severe cerebellar pathology

1996 • 478 citations

The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families

1995 • 453 citations

Apolipoprotein E4 allele in a population–based study of early–onset Alzheimer's disease

1994 • 449 citations

Alzheimer's disease amyloidogenic glycoprotein: expression pattern in rat brain suggests a role in cell contact.

1988 • 444 citations

Estimation of the Genetic Contribution of Presenilin-1 and -2 Mutations in a Population-Based Study of Presenile Alzheimer Disease

1998 • 431 citations

Risk Estimates of Dementia by Apolipoprotein E Genotypes From a Population-Based Incidence Study: The Rotterdam Study

1998 • 394 citations

Astrocytic apolipoprotein E mRNA and GFAP mRNA in hippocampus after entorhinal cortex lesioning

1991 • 386 citations

Frequency and distribution of Alzheimer's disease in Europe: A collaborative study of 1980–1990 prevalence findings

1991 • 383 citations

Protein Topology of Presenilin 1

1996 • 374 citations

A full genome scan for late onset Alzheimer's disease

1999 • 358 citations

Expression of β-amyloid precursor protein in reactive astrocytes following neuronal damage

1989 • 345 citations

Epidemiology of Alzheimer's Disease

1992 • 340 citations

Apolipoprotein E Affects the Rate of Alzheimer Disease Expression: β-Amyloid Burden Is a Secondary Consequence Dependent on APOE Genotype and Duration of Disease

1994 • 332 citations

Mapping of a gene predisposing to early–onset Alzheimer's disease to chromosome 14q24.3

1992 • 332 citations

Apolipoprotein E polymorphism in a Danish population compared to findings in 45 other study populations around the world

1992 • 328 citations

The promoter of Alzheimer's disease amyloid A4 precursor gene.

1988 • 309 citations

Localization of Amyloid β Protein Messenger RNA in Brains from Patients with Alzheimer's Disease

1987 • 297 citations

Neuropathological changes in scrapie and Alzheimer's disease are associated with increased expression of apolipoprotein E and cathepsin D in astrocytes

1991 • 297 citations

Evidence that the 42- and 40-amino acid forms of amyloid β protein are generated from the β-amyloid precursor protein by different protease activities

1996 • 291 citations

Phosphorylation, Subcellular Localization, and Membrane Orientation of the Alzheimer's Disease-associated Presenilins

1997 • 291 citations

Expression of Presenilin 1 and 2 (PS1 and PS2) in Human and Murine Tissues

1996 • 290 citations

Nucleotide sequence and structure of the human apolipoprotein E gene.

1985 • 289 citations

A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia

1998 • 287 citations

Enhanced Production and Oligomerization of the 42-residue Amyloid β-Protein by Chinese Hamster Ovary Cells Stably Expressing Mutant Presenilins

1997 • 283 citations

Regulation of transcription factor AP-2 by the morphogen retinoic acid and by second messengers.

1989 • 260 citations

Nerve growth factor increases mRNA levels for the prion protein and the beta-amyloid protein precursor in developing hamster brain.

1988 • 254 citations

Nerve injury stimulates the secretion of apolipoprotein E by nonneuronal cells.

1986 • 253 citations

Expression of amyloid precursor protein mRNAs in endothelial, neuronal and glial cells: modulation by interleukin-1

1992 • 250 citations

Genomic organization of the human amyloid beta-protein precursor gene

1990 • 248 citations

The Role of APP Processing and Trafficking Pathways in the Formation of Amyloid β‐Proteina

1996 • 244 citations

Allelic polymorphisms in the transcriptional regulatory region of apolipoprotein E gene

1998 • 232 citations

Neuronal localization of amyloid beta protein precursor mRNA in normal human brain and in Alzheimer's disease.

1987 • 222 citations

A far-downstream hepatocyte-specific control region directs expression of the linked human apolipoprotein E and C-I genes in transgenic mice.

1993 • 216 citations

Identification and differential expression of a novel alternative splice isoform of the beta A4 amyloid precursor protein (APP) mRNA in leukocytes and brain microglial cells.

1992 • 215 citations

Endoproteolytic Cleavage and Proteasomal Degradation of Presenilin 2 in Transfected Cells

1997 • 213 citations

Membrane Topology of the C. elegans SEL-12 Presenilin

1996 • 204 citations

Differential expression of ets-1 and ets-2 proto-oncogenes during murine embryogenesis.

1994 • 201 citations

Effects of apolipoprotein E, beta-very low density lipoproteins, and cholesterol on the extension of neurites by rabbit dorsal root ganglion neurons in vitro.

1992 • 199 citations

A new polymorphism in the APOE promoter associated with risk of developing Alzheimer's disease

1998 • 190 citations

The Zinc Finger Protein CTCF Binds to the APBβ Domain of the Amyloid β-Protein Precursor Promoter

1997 • 187 citations

In situ hybridization of nucleus basalis neurons shows increased beta-amyloid mRNA in Alzheimer disease.

1988 • 186 citations

Amyloid β protein (Aβ) deposition in chromosome 14–linked Alzheimer's disease: Predominance of Aβ₄₂₍₄₃₎

1996 • 183 citations

Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage.

1992 • 180 citations

Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence.

1995 • 179 citations

Differential regulation of amyloid-beta-protein mRNA expression within hippocampal neuronal subpopulations in Alzheimer disease.

1988 • 176 citations

Inhibition of presenilin 1 expression is promoted by p53 and p21WAF-1and results in apoptosis and tumor suppression

1998 • 175 citations

Mutant Human Presenilin 1 Protects presenilin 1 Null Mouse against Embryonic Lethality and Elevates Aβ1–42/43 Expression

1998 • 169 citations

The precursor of Alzheimer??s disease amyloid A4 protein resembles a cell-surface receptor

1987 • 162 citations

The Carboxyl Termini of β-Amyloid Peptides 1-40 and 1-42 Are Generated by Distinct γ-Secretase Activities

1996 • 162 citations

Beta A4-amyloid protein precursor mRNA isoforms without exon 15 are ubiquitously expressed in rat tissues including brain, but not in neurons.

1994 • 160 citations

Amyloidogenic processing of the human amyloid precursor protein in primary cultures of rat hippocampal neurons

1996 • 158 citations

Astrocyte cell lineage. V. Similarity of astrocytes that form in the presence of dBcAMP in cultures to reactive astrocytes in vivo

1984 • 157 citations

In VivoExpression and Regulation of Elk-1, a Target of the Extracellular-Regulated Kinase Signaling Pathway, in the Adult Rat Brain

1998 • 155 citations

Presenilins Are Processed by Caspase-type Proteases

1997 • 155 citations

Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins

1998 • 154 citations

Interleukin-1β and Glutamate Activate the NF-κB/Rel Binding Site from the Regulatory Region of the Amyloid Precursor Protein Gene in Primary Neuronal Cultures

1996 • 152 citations

Complementary DNA for the mouse homolog of the human amyloid beta protein precursor

1987 • 146 citations

Reciprocal expression of human ETS1 and ETS2 genes during T-cell activation: regulatory role for the protooncogene ETS1.

1990 • 146 citations

Competition for Overlapping Sites in the Regulatory Region of the Drosophila Gene Krüppel

1992 • 145 citations

Pronounced impact of Th1/E47cs mutation compared with -491 AT mutation on neural APOE gene expression and risk of developing Alzheimer's disease

1998 • 135 citations

An Alzheimer's Disease-Linked PS1 Variant Rescues the Developmental Abnormalities of PS1-Deficient Embryos

1998 • 131 citations

Genetic susceptibility to Alzheimer disease

1995 • 128 citations

Analysis of the 5′ Sequence, Genomic Structure, and Alternative Splicing of thepresenilin-1Gene (PSEN1) Associated with Early Onset Alzheimer Disease

1997 • 126 citations

Multiple tissue-specific elements control the apolipoprotein E/C-I gene locus in transgenic mice

1991 • 126 citations

SV40 stimulates expression of the transacting factor Sp1 at the mRNA level.

1990 • 124 citations

Enhancement of amyloid β 42 secretion by 28 different presenilin 1 mutations of familial Alzheimer's disease

1999 • 123 citations

Expression of the human apolipoprotein E gene is regulated by multiple positive and negative elements.

1988 • 120 citations

A new A4 amyloid mRNA contains a domain homologous to serine protease inhibitors

1988 • 119 citations

Increased plasma amyloid β protein 1–42 levels in Down syndrome

1998 • 108 citations

Retinoic acid induced differentiated neuroblastoma cells show increased expression of the βA4 amyloid gene of Alzheimer's disease and an altered splicing pattern

1990 • 107 citations

Promoter activity of the gene encoding the beta-amyloid precursor protein is up-regulated by growth factors, phorbol ester, retinoic acid and interleukin-1

1995 • 106 citations

Distribution of precursor amyloid-beta-protein messenger RNA in human cerebral cortex: relationship to neurofibrillary tangles and neuritic plaques.

1988 • 101 citations

Molecular Genetics of Alzheimer Disease: Identification of Genes and Gene Mutations

1995 • 98 citations

Identification and Characterization of a κB/Rel Binding Site in the Regulatory Region of the Amyloid Precursor Protein Gene

1995 • 98 citations

Genetic variability in the regulatory region of presenilin 1 associated with risk for Alzheimer's disease and variable expression

2000 • 95 citations

Mutant Presenilin 2 Transgenic Mouse: Effect on an Age-Dependent Increase of Amyloid β-Protein 42 in the Brain

1998 • 93 citations

The expression of the amyloid precursor protein (APP) is regulated by two GC-elements in the promoter

1992 • 93 citations

The promoter activity of the gene encoding Alzheimer β-amyloid precursor protein (APP) is regulated by two blocks of upstream sequences

1991 • 93 citations

Identification and neuron specific expression of the S182/presenilin I protein in human and rodent brains

1996 • 91 citations

Neuronal Localization of Presenilin-1 and Association with Amyloid Plaques and Neurofibrillary Tangles in Alzheimer’s Disease

1997 • 89 citations

Distortion of Allelic Expression of Apolipoprotein E in Alzheimer's Disease

1997 • 86 citations

Pattern of gradient of apolipoprotein E allele *4 frequencies in western Europe.

1997 • 81 citations

The amyloid beta-protein precursor promoter. A region essential for transcriptional activity contains a nuclear factor binding domain.

1992 • 78 citations

Induction of amyloid precursor protein mRNA after heat shock in cultured human lymphoblastoid cells

1991 • 78 citations

Structure and expression of the alternatively-spliced forms of mRNA for the mouse homolog of Alzheimer's disease amyloid beta protein precursor

1989 • 77 citations

A polymorphism (G–>A transition) in the -78 position of the apolipoprotein A-I promoter increases transcription efficiency

1994 • 76 citations

Localization of the putative precursor of Alzheimer's disease-specific amyloid at nuclear envelopes of adult human muscle.

1988 • 76 citations

Screening for mutations in the open reading frame and promoter of the β-amyloid precursor protein gene in familial Alzheimer's disease: identification of a further family with APP717 Val→lle

1992 • 75 citations

Synthesis and secretion of Alzheimer amyloid βA4 precursor protein by stimulated human peripheral blood leucocytes

1990 • 73 citations

Identification and characterization of transcriptional regulatory regions associated with expression of the human apolipoprotein E gene.

1988 • 73 citations

A novel presenilin‐1 mutation: Increased β‐amyloid and neurofibrillary changes

1997 • 73 citations

The —491AA polymorphism in the APOE gene is associated with increased plasma apoE levels in Alzheimerʼs disease

1999 • 72 citations

A newly identified polymorphism in the apolipoprotein E enhancer gene region is associated with Alzheimer's disease and strongly with the epsilon 4 allele

1996 • 71 citations

Alzheimer amyloid-beta peptide forms denaturant-resistant complex with type epsilon 3 but not type epsilon 4 isoform of native apolipoprotein E.

1996 • 71 citations

Regulatory region of human amyloid precursor protein (APP) gene promotes neuron-specific gene expression in the CNS of transgenic mice.

1991 • 69 citations

Increased levels of the Kunitz protease inhibitor-containing βAPP mRNAs in rat brain following neurotoxic damage

1993 • 69 citations

Genomic Structure and Expression of STM2, the Chromosome 1 Familial Alzheimer Disease Gene

1996 • 69 citations

Identification and neuron specific expression of the S182/presenilin I protein in human and rodent brains

1996 • 69 citations

Increased gene expression of Alzheimer disease beta-amyloid precursor protein in senescent cultured fibroblasts.

1991 • 69 citations

Characterization of the 5′-end region and the first two exons of the β-protein precursor gene

1989 • 69 citations

Alzheimer's Disease Associated Presenilin-1 Holoprotein and Its 18−20 kDa C-Terminal Fragment Are Death Substrates for Proteases of the Caspase Family

1998 • 67 citations

Structure of the Hepatic Control Region of the Human Apolipoprotein E/C-I Gene Locus

1995 • 65 citations

Positive and negative regulatory elements for the expression of the Alzheimer's disease amyloid precursor-encoding gene in mouse

1992 • 64 citations

Transcription Factor AP-2 Regulates Human Apolipoprotein E Gene Expression in Astrocytoma Cells

1996 • 63 citations

Contrasting Role of Presenilin-1 and Presenilin-2 in Neuronal DifferentiationIn Vitro

1999 • 63 citations

In the absence of a downstream element, the apolipoprotein E gene is expressed at high levels in kidneys of transgenic mice.

1990 • 60 citations

Expression of presenilin-1 and -2 mRNAs in rat and Alzheimer's disease brains

1997 • 59 citations

Fibroblast growth factor induces β-amyloid precursor mRNA in glial but not neuronal cultured cells

1990 • 58 citations

Widespread neuronal expression of the presenilin-1 early-onset Alzheimer's disease gene in the murine brain.

1996 • 56 citations

Identification of caspases that cleave presenilin‐1 and presenilin‐2

1999 • 56 citations

Transcriptional activation of Alzheimer's β-amyloid precursor protein gene by stress

1995 • 56 citations

The −491A/T apolipoprotein E promoter polymorphism association with Alzheimer's disease: independent risk and linkage disequilibrium with the known APOE polymorphism

1998 • 55 citations

Characterization of a human apolipoprotein E gene enhancer element and its associated protein factors.

1990 • 54 citations

Single base pair substitutions within the HLA-DRA gene promoter separate the functions of the X1 and X2 boxes.

1992 • 52 citations

Sp1 Can Displace GHF-1 from Its Distal Binding Site and Stimulate Transcription from the Growth Hormone Gene Promoter

1990 • 52 citations

Genetic association of the presenilin-1 regulatory region with early-onset Alzheimer's disease in a population-based sample

1999 • 51 citations

Diffuse Plaques in the Cerebellum and Corpus Striatum in Down's Syndrome Contain Amyloid β Protein (Aβ) only in the Form of Aβ42(43)

1996 • 50 citations

Structure and alternative splicing of the Presenilin-2 gene

1996 • 49 citations

Apolipoprotein E promoter and α2-Macroglobulin polymorphisms are not genetically associated with Chinese late onset Alzheimer's disease

1999 • 49 citations

Antisense‐Induced Reduction of Presenilin 1 Expression Selectively Increases the Production of Amyloid β42 in Transfected Cells

1999 • 45 citations

Apolipoprotein E promoter polymorphism and sporadic Alzheimer's disease in a Japanese population

1999 • 45 citations

Presenilin‐1 protein expression in familial and sporadic Alzheimer's disease

1997 • 45 citations

Functional identification of the promoter of the gene encoding the Rhesus monkey β-amyloid precursor protein

1998 • 44 citations

Apolipoprotein E and α-1-antichymotrypsin allele polymorphism in sporadic and familial Alzheimer's disease

1999 • 43 citations

An Upstream Element Containing an ETS Binding Site Is Crucial for Transcription of the Human Presenilin-1 Gene

1999 • 42 citations

Structure and Expression of Mouse Apolipoprotein E Grene1

1989 • 40 citations

Widespread immunoreactivity of presenilin in neurons of normal and Alzheimer's disease brains: double-labeling immunohistochemical study

1996 • 40 citations

Genetic variability at the amyloid-β precursor protein locus may contribute to the risk of late-onset Alzheimer's disease

1999 • 40 citations

Heat shock factor-1 mediates the transcriptional activation of Alzheimer's β-amyloid precursor protein gene in response to stress

1996 • 39 citations

The −491 A/T polymorphism in the regulatory region of the Apolipoprotein E gene and early-onset Alzheimer's disease

1998 • 39 citations

Transient increase in intracellular concentration of adenosine 3′:5′‐cyclic monophosphate results in morphological and biochemical differentiation of C₆ glioma cells in culture

1987 • 38 citations

Two nuclear factor binding domains activate expression from the human amyloid beta-protein precursor promoter.

1994 • 37 citations

The upstream stimulatory factor functionally interacts with the Alzheimer amyloid β-protein precursor gene

1995 • 36 citations

Polymorphisms of the human apolipoprotein E promoter and bleomycin hydrolase gene: risk factors for Alzheimer's dementia?

1999 • 35 citations

Induction of β-amyloid precursor protein isoform mRNAs by bFGF in astrocytes

1993 • 35 citations

Enhancer function and novel DNA binding protein activity in the near upstream βAPP gene promoter

1999 • 35 citations

Overlapping Binding Sites of Two Different Transcription Factors in the Promoter of the Human Gene for the Alzheimer Amyloid Precursor Protein

1993 • 35 citations

Injury induces presenilin-1 gene expression in mouse brain

1996 • 34 citations

Neuronal Expression and Intracellular Localization of Presenilins in Normal and Alzheimer Disease Brains

1997 • 34 citations

Transcriptional Regulation of the Mouse Presenilin-1 Gene

1997 • 33 citations

Proteolytic processing of presenilin‐1 (PS‐1) is not associated with Alzheimer's disease with or without PS‐1 mutations

1997 • 33 citations

Promoter polymorphism (-491A/T) in the APOE gene of Finnish Alzheimer's disease patients and control individuals

1999 • 32 citations

Structural features of the 5′ upstream regulatory region of the gene encoding rat amyloid precursor protein

1993 • 31 citations

USF binds to the APBα sequence in the promoter of the amyloid β-protein precursor gene

1995 • 28 citations

DGGE method for the mutational analysis of the coding and proximal promoter regions of the Alzheimer's disease presenilin-1 gene: Two novel mutations

1999 • 27 citations

Immunoreactivity of presenilin-1 in human, rat and mouse brain

1997 • 27 citations

An region upstream of the gene promoter for the β-amyloid precursor protein interacts with proteins from nuclear extracts of the human brain and PC12 cells

1998 • 26 citations

The Initiator Element and Proximal Upstream Sequences Affect Transcriptional Activity and Start Site Selection in the Amyloid β-Protein Precursor Promoter

1996 • 26 citations

Immunoreactivity of Presenilin-1 and Tau in Alzheimer's Disease Brain

1998 • 26 citations

Structure and expression of the rat apolipoprotein E gene.

1986 • 26 citations

The −491A/T polymorphism of the Apolipoprotein E gene is associated with the ApoEϵ4 allele and Alzheimer's Disease

1999 • 25 citations

Expression of apolipoprotein E during nerve degeneration and regeneration

1986 • 24 citations

Cloning and characterization of the presenilin-2 gene promoter

1998 • 24 citations

No evidence that common allelic variation in the Amyloid Precursor Protein (APP) gene confers susceptibility to Alzheimer's disease

1995 • 23 citations

Analysis of the c‐FOS gene on chromosome 14 and the promoter of the amyloid precursor protein gene in familial Alzheimer's disease

1993 • 22 citations

Promoter activity of the beta-amyloid precursor protein gene is negatively modulated by an upstream regulatory element

1999 • 20 citations

Sp1 can displace GHF-1 from its distal binding site and stimulate transcription from the growth hormone gene promoter.

1990 • 17 citations

Epidemiology of Alzheimer's Disease

1991 • 16 citations

Neuronal expression of STM2 mRNA in human brain is reduced in Alzheimer's disease.

1996 • 15 citations

Complete nucleotide sequence of the gene encoding the rat apolipoprotein E

1986 • 14 citations

Conserved elements in the 5′ regulatory region of the amyloid precursor protein gene in primates

1997 • 13 citations

Characterization of an Upstream Regulatory Element of the Human Apolipoprotein E Gene, and Purification of Its Binding Protein from the Human Placenta1

1995 • 13 citations

Regional and Cellular Localization of Presenilin-2 RNA in Rat and Human Brain

1997 • 13 citations

PROMOTER OF ALZHEIMER??S DISEASE AMYLOID A4 PRECURSOR GENE

1988 • 11 citations

Expression of Neuronal mRNAs in Alzheimer Type Degeneration of the Nervous System

1989 • 11 citations

Determination of the genomic organization of human presenilin 1 by fiber-FISH analysis and restriction mapping of cloned DNA

1999 • 8 citations

The apolipoprotein gene family: organization of upstream elements and regulation of gene expression.

1990 • 6 citations

Increasing amyloid peptide precursor production and its impact on Alzheimer's disease

1989 • 6 citations

Characterization of an upstream regulatory sequence and its binding protein in the mouse apolipoprotein E gene

1995 • 4 citations

Downstream regulatory elements stimulate expression of the human apolipoprotein E gene in the liver and suppress expression in the kidney of transgenic mice.

1990 • 4 citations

Variable neuron-specific presenilin 1 transcription increases risk for Alzheimer's disease

2000 • 4 citations

Molecular analysis of the promoter region of the gene encoding the beta-amyloid precursor protein.

1995 • 3 citations

Deleted Work

1955 • 0 citations