Identification and Characterization of a κB/Rel Binding Site in the Regulatory Region of the Amyloid Precursor Protein Gene

A rapid micrqpreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

1991 • 2,362 citations

CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements

1987 • 1,792 citations

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.

1989 • 1,752 citations

IMF-κB and Rel: Participants in a Multiform Transcriptional Regulatory System

1993 • 967 citations

Normal and Abnormal Biology of the beta-Amyloid Precursor Protein

1994 • 813 citations

Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells.

1989 • 586 citations

Regulation of the NF-ηB/rel transcription factor and IηB inhibitor system

1993 • 541 citations

βA4 amyloid protein deposition in brain after head trauma

1991 • 465 citations

Constitutive NF-kB Activity in Neurons

1994 • 400 citations

Expression of the Alzheimer amyloid precursor gene transcripts in the human brain

1988 • 386 citations

Expression of β-amyloid precursor protein in reactive astrocytes following neuronal damage

1989 • 345 citations

NF-κB Subunit Regulation in Nontransformed CD4 ⁺ T Lymphocytes

1992 • 322 citations

The promoter of Alzheimer's disease amyloid A4 precursor gene.

1988 • 309 citations

Sequence-specific interactions of nuclear factors with the insulin gene enhancer

1986 • 309 citations

Is amyloidogenesis during Alzheimer's disease due to an IL-1-/IL-6-mediated ‘acute phase response’ in the brain?

1991 • 267 citations

Expression of amyloid precursor protein mRNAs in endothelial, neuronal and glial cells: modulation by interleukin-1

1992 • 250 citations

Relation of Neuronal APP-751/APP-695 mRNA Ratio and Neuritic Plaque Density in Alzheimer's Disease

1990 • 248 citations

Genomic organization of the human amyloid beta-protein precursor gene

1990 • 248 citations

Brain synapses contain inducible forms of the transcription factor NF-κB

1993 • 225 citations

In situ hybridization of nucleus basalis neurons shows increased beta-amyloid mRNA in Alzheimer disease.

1988 • 186 citations

Differential regulation of amyloid-beta-protein mRNA expression within hippocampal neuronal subpopulations in Alzheimer disease.

1988 • 176 citations

Degeneration in vitro of post-mitotic neurons overexpressing the Alzheimer amyloid protein precursor

1992 • 175 citations

Expression of APP in the early stage of brain damage

1991 • 152 citations

c-rel activates but v-rel suppresses transcription from kappa B sites.

1991 • 146 citations

A direct role for protein kinase C and the transcription factor Jun/AP-1 in the regulation of the Alzheimer's beta-amyloid precursor protein gene.

1994 • 105 citations

The promoter activity of the gene encoding Alzheimer β-amyloid precursor protein (APP) is regulated by two blocks of upstream sequences

1991 • 93 citations

The expression of the amyloid precursor protein (APP) is regulated by two GC-elements in the promoter

1992 • 93 citations

NF-kappa B activates the HIV promoter in neurons.

1993 • 85 citations

Alzheimer beta A4-amyloid protein precursor in immunocompetent cells.

1992 • 85 citations

The amyloid beta-protein precursor promoter. A region essential for transcriptional activity contains a nuclear factor binding domain.

1992 • 78 citations

Induction of amyloid precursor protein mRNA after heat shock in cultured human lymphoblastoid cells

1991 • 78 citations

Increased levels of the Kunitz protease inhibitor-containing βAPP mRNAs in rat brain following neurotoxic damage

1993 • 69 citations

Characterization of the 5′-end region and the first two exons of the β-protein precursor gene

1989 • 69 citations

The transcriptionally active factors mediating the effect of the HTLV-I Tax transactivator on the IL-2R alpha kappa B enhancer include the product of the c-rel proto-oncogene.

1993 • 45 citations

Two nuclear factor binding domains activate expression from the human amyloid beta-protein precursor promoter.

1994 • 37 citations