Structure of the Hepatic Control Region of the Human Apolipoprotein E/C-I Gene Locus

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

A Receptor-Mediated Pathway for Cholesterol Homeostasis

1986 • 5,638 citations

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

1993 • 4,145 citations

Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

1988 • 3,984 citations

Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

1993 • 3,693 citations

Tissue-specific in vitro transcription from the mouse albumin promoter

1986 • 1,322 citations

Molecular cloning (2nd Ed)

1989 • 1,191 citations

Plasma lipoproteins: apolipoprotein structure and function.

1984 • 1,130 citations

Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs.

1985 • 1,052 citations

Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily.

1990 • 1,044 citations

The HMG domain of lymphoid enhancer factor 1 bends DNA and facilitates assembly of functional nucleoprotein structures

1992 • 684 citations

[20] Isolation of RNA using guanidinium salts

1987 • 614 citations

The Alu Family of Dispersed Repetitive Sequences

1982 • 611 citations

Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and alpha 1-antitrypsin genes.

1989 • 545 citations

Apolipoprotein E ∈4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases

1993 • 504 citations

A glimpse at chromosomal order

1987 • 423 citations

The formation and function of DNase I hypersensitive sites in the process of gene activation.

1988 • 394 citations

A fundamental division in the Alu family of repeated sequences.

1988 • 383 citations

Isolation, characterization, and mapping to chromosome 19 of the human apolipoprotein E gene.

1985 • 352 citations

Increased γ-globin expression in a nondeletion HPFH mediated by an erythroid-specif ic DNA-binding factor

1989 • 298 citations

Nucleotide sequence and structure of the human apolipoprotein E gene.

1985 • 289 citations

Matrix-attachment regions can impart position-independent regulation of a tissue-specific gene in transgenic mice.

1992 • 288 citations

The chicken lysozyme 5' matrix attachment region increases transcription from a heterologous promoter in heterologous cells and dampens position effects on the expression of transfected genes.

1990 • 276 citations

Chromosomal ARS and CEN elements bind specifically to the yeast nuclear scaffold

1988 • 251 citations

Cell-type specific activity of two glucocorticoid responsive units of rat tyrosine aminotransferase gene is associated with multiple binding sites for C/EBP and a novel liver-specific nuclear factor

1991 • 234 citations

A far-downstream hepatocyte-specific control region directs expression of the linked human apolipoprotein E and C-I genes in transgenic mice.

1993 • 216 citations

A Nonerythroid GATA-Binding Protein Is Required for Function of the Human Preproendothelin-1 Promoter in Endothelial Cells

1990 • 163 citations

The locus for apolipoprotein E (apoE) is linked to the complement component C3 (C3) locus on chromosome 19 in man

1982 • 161 citations

Fine-structure mapping of the three mouse alpha-fetoprotein gene enhancers.

1988 • 137 citations

Two copies of the human apolipoprotein C-I gene are linked closely to the apolipoprotein E gene.

1988 • 134 citations

Multiple tissue-specific elements control the apolipoprotein E/C-I gene locus in transgenic mice

1991 • 126 citations

Promoter elements and factors involved in hepatic transcription of the human ApoA-I gene positive and negative regulators bind to overlapping sites.

1991 • 112 citations

[61] Northern and southern blots

1987 • 108 citations

Site-directed mutagenesis reveals a liver transcription factor essential for the albumin transcriptional enhancer.

1990 • 103 citations

The minimal requirements for activity in transgenic mice of hypersensitive site 3 of the beta globin locus control region.

1993 • 103 citations

Localization of DNA protein-binding sites in the proximal and distal promoter regions of the mouse alpha-fetoprotein gene.

1990 • 95 citations

HMG-D is an architecture-specific protein that preferentially binds to DNA containing the dinucleotide TG.

1995 • 90 citations

Identification and characterization of transcriptional regulatory regions associated with expression of the human apolipoprotein E gene.

1988 • 73 citations

Functional analysis of a liver-specific enhancer of the hepatitis B virus.

1991 • 69 citations

Cloning and sequencing of PYBP, a pyrimidine-rich specific single strand DNA-binding protein

1991 • 69 citations

In the absence of a downstream element, the apolipoprotein E gene is expressed at high levels in kidneys of transgenic mice.

1990 • 60 citations

Different liver nuclear proteins bind to similar DNA sequences in the 5' flanking regions of three hepatic genes

1989 • 59 citations

Localization of a liver-specific enhancer in the apolipoprotein E/C-I/C-II gene locus

1993 • 58 citations

Characterization of a human apolipoprotein E gene enhancer element and its associated protein factors.

1990 • 54 citations

Characterization of a novel liver-specific enhancer in the human prothrombin gene.

1991 • 53 citations

The Mechanism by Which the Human Apolipoprotein B Gene Reducer Operates Involves Blocking of Transcriptional Activation by Hepatocyte Nuclear Factor 3

1993 • 50 citations

A factor binding GATAAG confers tissue specificity on the promoter of the humanζ-globin gene

1990 • 47 citations

Increased erythrold-specific expression of a mutated HPFH γ-globin promoter requires the erythroid factor NFE-1

1989 • 42 citations

Nuclear factors AF-1 and C/EBP bind to the human ApoB gene promoter and modulate its transcriptional activity in hepatic cells.

1990 • 37 citations

The enhancer of the human transferrin gene is organized in two structural and functional domains

1991 • 28 citations

Identification and characterization of two enhancers of the human albumin gene.

1992 • 27 citations