Promoter polymorphism (-491A/T) in the APOE gene of Finnish Alzheimer's disease patients and control individuals

Clinical diagnosis of Alzheimer's disease

1984 • 27,279 citations

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

1993 • 8,888 citations

Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

1988 • 3,984 citations

Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

1993 • 3,693 citations

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.

1993 • 1,480 citations

Genetic associations with human longevity at the APOE and ACE loci

1994 • 1,079 citations

Handbook of Human Genetic Linkage.

1996 • 878 citations

Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease.

1995 • 596 citations

Apolipoprotein E4 allele in a population–based study of early–onset Alzheimer's disease

1994 • 449 citations

Genotyping and sequence analysis of apolipoprotein E isoforms*1

1988 • 304 citations

A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia

1998 • 287 citations

Allelic polymorphisms in the transcriptional regulatory region of apolipoprotein E gene

1998 • 232 citations

Association of apolipoprotein E phenotypes with late onset Alzheimer's disease: population based study

1994 • 201 citations

A new polymorphism in the APOE promoter associated with risk of developing Alzheimer's disease

1998 • 190 citations

Pronounced impact of Th1/E47cs mutation compared with -491 AT mutation on neural APOE gene expression and risk of developing Alzheimer's disease

1998 • 135 citations

A newly identified polymorphism in the apolipoprotein E enhancer gene region is associated with Alzheimer's disease and strongly with the epsilon 4 allele

1996 • 71 citations

The −491A/T apolipoprotein E promoter polymorphism association with Alzheimer's disease: independent risk and linkage disequilibrium with the known APOE polymorphism

1998 • 55 citations

Apolipoprotein E polymorphism and Alzheimer's disease in Eastern Finland

1995 • 40 citations