The promoter of Alzheimer's disease amyloid A4 precursor gene.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

THE HEAT-SHOCK RESPONSE

1986 • 4,580 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

1985 • 4,276 citations

Supercoil Sequencing: A Fast and Simple Method for Sequencing Plasmid DNA

1985 • 2,505 citations

DNA Methylation and Gene Function

1980 • 2,069 citations

CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements

1987 • 1,792 citations

Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

1984 • 1,633 citations

Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus

1987 • 1,589 citations

Human Proto-Oncogene c- jun Encodes a DNA Binding Protein with Structural and Functional Properties of Transcription Factor AP-1

1987 • 1,353 citations

Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease

1987 • 1,316 citations

Morphology and growth, tumorigenicity, and cytogenetics of human neuroblastoma cells in continuous culture.

1973 • 1,284 citations

DNA METHYLATION AND GENE ACTIVITY

1983 • 1,115 citations

Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

1988 • 1,098 citations

Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

1988 • 1,093 citations

A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

1988 • 1,052 citations

Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels.

1985 • 1,025 citations

Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene

1984 • 955 citations

Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene

1986 • 829 citations

Isolation of transcription factors that discriminate between different promoters recognized by RNA polymerase II

1983 • 779 citations

Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40

1987 • 762 citations

A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes

1986 • 740 citations

Common DNA binding site for Fos protein complexesand transcription factor AP-1

1988 • 613 citations

Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides.

1987 • 589 citations

Alzheimer's disease amyloidogenic glycoprotein: expression pattern in rat brain suggests a role in cell contact.

1988 • 444 citations

Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease.

1988 • 392 citations

Purification and Properties of Drosophila Heat Shock Activator Protein

1987 • 388 citations

Specific interaction between enhancer-containing molecules and cellular components

1984 • 374 citations

Adenosine deaminase: characterization and expression of a gene with a remarkable promoter.

1985 • 329 citations

Localization of Amyloid β Protein Messenger RNA in Brains from Patients with Alzheimer's Disease

1987 • 297 citations

Failure of familial Alzheimer's disease to segregate with the A4-amyloid gene in several European families

1987 • 275 citations

Neuronal localization of amyloid beta protein precursor mRNA in normal human brain and in Alzheimer's disease.

1987 • 222 citations

In situ hybridization of nucleus basalis neurons shows increased beta-amyloid mRNA in Alzheimer disease.

1988 • 186 citations

Differential regulation of amyloid-beta-protein mRNA expression within hippocampal neuronal subpopulations in Alzheimer disease.

1988 • 176 citations

Chemical classes of amyloid substance.

1971 • 161 citations

Structure of the murine Thy-1 gene.

1985 • 118 citations

Distribution of precursor amyloid-beta-protein messenger RNA in human cerebral cortex: relationship to neurofibrillary tangles and neuritic plaques.

1988 • 101 citations

Proto-oncogene c-myc is expressed in cerebellar neurons at different developmental stages.

1986 • 96 citations

Neuroanatomical localization and quantification of amyloid precursor protein mRNA by in situ hybridization in the brains of normal, aneuploid, and lesioned mice.

1988 • 85 citations

Localization of the putative precursor of Alzheimer's disease-specific amyloid at nuclear envelopes of adult human muscle.

1988 • 76 citations

Localization of amyloid beta protein messenger RNA in brains from patients with Alzheimerʼs disease

1988 • 39 citations