The −491 A/T polymorphism in the regulatory region of the Apolipoprotein E gene and early-onset Alzheimer's disease

Clinical diagnosis of Alzheimer's disease

1984 • 27,279 citations

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

1993 • 4,145 citations

Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

1993 • 3,693 citations

Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.

1990 • 2,936 citations

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

1994 • 1,813 citations

Determinants of disease and disability in the elderly: The Rotterdam elderly study

1991 • 1,166 citations

Handbook of Human Genetic Linkage.

1996 • 878 citations

Apolipoprotein E4 allele in a population–based study of early–onset Alzheimer's disease

1994 • 449 citations

Apolipoprotein E, ɛ4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region

1994 • 420 citations

A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia

1998 • 287 citations

A new polymorphism in the APOE promoter associated with risk of developing Alzheimer's disease

1998 • 190 citations

The apolipoprotein E ε2 allele is associated with an increased risk of early‐onset alzheimer's disease and a reduced survival

1995 • 130 citations

The −491A/T apolipoprotein E promoter polymorphism association with Alzheimer's disease: independent risk and linkage disequilibrium with the known APOE polymorphism

1998 • 55 citations

Genetic Epidemiology of Alzheimer Disease

1997 • 45 citations