Estimation of the Genetic Contribution of Presenilin-1 and -2 Mutations in a Population-Based Study of Presenile Alzheimer Disease

Clinical diagnosis of Alzheimer's disease

1984 • 27,279 citations

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

1993 • 8,888 citations

The American Journal of Human Genetics

1950 • 5,048 citations

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1991 • 4,533 citations

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1995 • 3,985 citations

Candidate Gene for the Chromosome 1 Familial Alzheimer's Disease Locus

1995 • 2,548 citations

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1995 • 2,028 citations

Amyloid, the presenilins and Alzheimer's disease

1997 • 1,370 citations

Genetic Linkage Evidence for a Familial Alzheimer's Disease Locus on Chromosome 14

1992 • 941 citations

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

1995 • 705 citations

How sensitive is PCR-SSCP?

1993 • 468 citations

The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families

1995 • 453 citations

Apolipoprotein E4 allele in a population–based study of early–onset Alzheimer's disease

1994 • 449 citations

Protein Topology of Presenilin 1

1996 • 374 citations

Alzheimer's disease associated with mutations in presenilin 2 is rare and variably penetrant

1996 • 301 citations

Mutations of the presenilin I gene in families with early-onset Alzheimer's disease

1995 • 270 citations

Genetic association between intronic polymorphism in presenilin-1 gene and late-onset Alzheimer's disease

1996 • 244 citations

Presenilins and Alzheimer disease

1995 • 193 citations

Presenilin mutations in Alzheimer's disease

1998 • 191 citations

Molecular genetic analysis of familial early-onset Alzheimer's disease linked to chromosome 14q24.3

1995 • 179 citations

The presenilin genes: a new gene family involved in Alzheimer disease pathology

1996 • 165 citations

Evidence for a Six-transmembrane Domain Structure of Presenilin 1

1997 • 154 citations

Complete analysis of the presenilin 1 gene in early onset Alzheimerʼs disease

1996 • 151 citations

APOE genotype does not modulate age of onset in families with chromosome 14 encoded Alzheimer's disease

1994 • 131 citations

Analysis of the 5′ Sequence, Genomic Structure, and Alternative Splicing of thepresenilin-1Gene (PSEN1) Associated with Early Onset Alzheimer Disease

1997 • 126 citations

History of dementia and Parkinson's disease in 1st‐degree relatives of patients with Alzheimer's disease

1989 • 118 citations

Molecular Genetics of Alzheimer Disease: Identification of Genes and Gene Mutations

1995 • 98 citations

Genomic Structure and Expression of STM2, the Chromosome 1 Familial Alzheimer Disease Gene

1996 • 69 citations

Structure and alternative splicing of the Presenilin-2 gene

1996 • 49 citations

Sequence analysis of presenilin-1 gene mutation in Japanese Alzheimer's disease patients

1996 • 46 citations

A population-based study of familial Alzheimer disease: linkage to chromosomes 14, 19, and 21.

1994 • 43 citations