Increased levels of the Kunitz protease inhibitor-containing βAPP mRNAs in rat brain following neurotoxic damage

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

The rat brain in stereotaxic coordinates

1983 • 28,962 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

1990 • 1,975 citations

Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus

1987 • 1,589 citations

Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease

1987 • 1,316 citations

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein

1989 • 1,237 citations

Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

1988 • 1,098 citations

Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

1988 • 1,093 citations

A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

1988 • 1,052 citations

Neurotoxicity of a Fragment of the Amyloid Precursor Associated with Alzheimer's Disease

1989 • 904 citations

Intraventricular kainic acid preferentially destroys hippocampal pyramidal cells

1978 • 745 citations

Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides.

1987 • 589 citations

Dementia of the Alzheimer Type

1980 • 518 citations

Secreted form of amyloid β protein precursor is involved in the growth regulation of fibroblasts

1989 • 477 citations

Amyloid β Protein Enhances the Survival of Hippocampal Neurons in Vitro

1989 • 470 citations

Alzheimer's disease amyloidogenic glycoprotein: expression pattern in rat brain suggests a role in cell contact.

1988 • 444 citations

Expression of β amyloid protein precursor mRNAs: Recognition of a novel alternatively spliced form and quantitation in alzheimer's disease using PCR

1990 • 426 citations

Formation of β-amyloid protein deposits in brains of transgenic mice

1991 • 385 citations

Selective reinnervation of hippocampal area CA1 and the fascia dentata after destruction of CA3-CA4 afferents with kainic acid

1980 • 380 citations

The regulation of amyloid β protein precursor secretion and its modulatory role in cell adhesion

1989 • 355 citations

New Perspectives on Alzheimer's Disease

1986 • 349 citations

Expression of β-amyloid precursor protein in reactive astrocytes following neuronal damage

1989 • 345 citations

Localization of Amyloid β Protein Messenger RNA in Brains from Patients with Alzheimer's Disease

1987 • 297 citations

Cortical and subcortical patterns of synaptophysinlike immunoreactivity in Alzheimer's disease.

1991 • 292 citations

Degeneration of hippocampal CA3 pyramidal cells induced by intraventricular kainic acid

1980 • 257 citations

Amyloid Protein Precursor Messenger RNAs: Differential Expression in Alzheimer's Disease

1988 • 254 citations

The kinetics and morphological characteristics of the macrophage-microglial response to kainic acid-induced neuronal degeneration

1991 • 252 citations

A4 Protein in Alzheimer's Disease: Primary and Secondary Cellular Events in Extracellular Amyloid Deposition

1989 • 236 citations

Diffuse plaques do not accentuate synapse loss in Alzheimer's disease.

1990 • 209 citations

Selective induction of Kunitz-type protease inhibitor domain-containing amyloid precursor protein mRNA after persistent focal ischemia in rat cerebral cortex

1991 • 206 citations

β-Amyloid protein promotes neuritic branching in hippocampal cultures

1990 • 188 citations

In situ hybridization of nucleus basalis neurons shows increased beta-amyloid mRNA in Alzheimer disease.

1988 • 186 citations

Differential regulation of amyloid-beta-protein mRNA expression within hippocampal neuronal subpopulations in Alzheimer disease.

1988 • 176 citations

Senile plaques as aberrant sprout-stimulating structures

1986 • 161 citations

Immunocytochemical localization of the precursor protein for β-amyloid in the rat central nervous system

1988 • 153 citations

Tissue-specific expression of three types of β-protein precursor mRNA: Enhancement of protease inhibitor-harboring types in Alzheimer's disease brain

1989 • 152 citations

Three types of amyloid protein precursor mRNA in human brain: Their differential expression in Alzheimer's disease

1988 • 150 citations

Kainic acid: Neurophysiological and neurotoxic actions

1979 • 150 citations

Complementary DNA for the mouse homolog of the human amyloid beta protein precursor

1987 • 146 citations

Amyloid β-protein precursor is associated with extracellular matrix

1990 • 106 citations

Deposition of ?/A4 protein along neuronal plasma membranes in diffuse senile plaques

1991 • 105 citations

CELLULAR LOCALIZATION OF MESSENGER RNA ENCODING AMYLOID-BETA-PROTEIN IN NORMAL TISSUE AND IN ALZHEIMER DISEASE

1988 • 104 citations

β-Amyloid from Alzheimer disease brains inhibits sprouting and survival of sympathetic neurons

1991 • 103 citations

Distribution of precursor amyloid-beta-protein messenger RNA in human cerebral cortex: relationship to neurofibrillary tangles and neuritic plaques.

1988 • 101 citations

Selective reduction of mRNA for the β-amyloid precursor protein that lacks a Kunitz-type protease inhibitor motif in cortex from Alzheimer brains☆

1988 • 97 citations

Molecular cloning and characterization of a cDNA encoding the cerebrovascular and neuritic plaque amyloid peptides

1988 • 87 citations

Structure and expression of the alternatively-spliced forms of mRNA for the mouse homolog of Alzheimer's disease amyloid beta protein precursor

1989 • 77 citations

The Alzheimer amyloid precursor-related transcript lacking the β/A4 sequence is specifically increased in Alzheimer's disease brain

1990 • 76 citations

Characterization of human cDNA and genomic clones for glial fibrillary acidic protein

1990 • 76 citations

Monoclonal antibodies to a synthetic peptide homologous with the first 28 amino acids of Alzheimer's disease beta-protein recognize amyloid and diverse glial and neuronal cell types in the central nervous system.

1989 • 68 citations

β-Amyloid precursor protein gene is differentially expressed in axotomized sensory and motor systems

1991 • 67 citations

Altered levels of amyloid protein precursor transcripts in the basal forebrain of behaviorally impaired aged rats.

1990 • 66 citations

Morphological studies on neuroglia

1981 • 62 citations

Changes to synaptic ultrastructure in field CA1 of the rat hippocampus following intracerebroventricular injection of kainic acid

1991 • 49 citations

Specificity of Synaptic Growth in Brain: Remodeling Induced by Kainic Acid Lesions

1979 • 44 citations

The sequence of the two extra exora In rat preA4

1989 • 38 citations

Molecular Neuroanatomy of Neurotransmitter Receptors: The Use of in situ Hybridization Histochemistry for the Study of Their Anatomical and Cellular Localization

1991 • 19 citations

In situ hybridization of nucleus basalis neurons shows increased β-amyloid mRNA in Alzheimerʼs disease

1988 • 16 citations

The use of in situ Hybridization Histochemistry for the Analysis of Neurotransmitter Receptor Expression at the Microscopic Level

1991 • 16 citations

Differential regulation of amyloid β-protein mRNA expression within hippocampal neuronal sub-populations in Alzheimerʼs disease

1988 • 15 citations