Targeting Prefrontal Cortical Dopamine D1 and N-Methyl-D-Aspartate Receptor Interactions in Schizophrenia Treatment

An Integrative Theory of Prefrontal Cortex Function

2001 • 11,688 citations

A synaptic model of memory: long-term potentiation in the hippocampus

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Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

1994 • 3,437 citations

Recent advances in the phencyclidine model of schizophrenia

1991 • 2,886 citations

Long-Term Potentiation--A Decade of Progress?

1999 • 2,701 citations

Heteromeric NMDA Receptors: Molecular and Functional Distinction of Subtypes

1992 • 2,527 citations

Dopamine in schizophrenia: a review and reconceptualization

1991 • 1,963 citations

Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex

1997 • 1,743 citations

Glutamate Receptor Dysfunction and Schizophrenia

1995 • 1,682 citations

NMDA receptor subunits: diversity, development and disease

2001 • 1,677 citations

Modulation of memory fields by dopamine Dl receptors in prefrontal cortex

1995 • 1,600 citations

The Role and Regulation of Adenosine in the Central Nervous System

2001 • 1,595 citations

The principal features and mechanisms of dopamine modulation in the prefrontal cortex

2004 • 1,560 citations

D1 Dopamine Receptors in Prefrontal Cortex: Involvement in Working Memory

1991 • 1,365 citations

The Neuropsychopharmacology of Phencyclidine From NMDA Receptor Hypofunction to the Dopamine Hypothesis of Schizophrenia

1999 • 1,300 citations

Effects of cAMP Simulate a Late Stage of LTP in Hippocampal CA1 Neurons

1993 • 1,212 citations

Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: Evidence from a novel positron emission tomography method

1997 • 1,147 citations

N-methyl-D-aspartic acid receptor structure and function

1994 • 989 citations

The Neurobiology of Slow Synaptic Transmission

2001 • 873 citations

Projections from the Rat Prefrontal Cortex to the Ventral Tegmental Area: Target Specificity in the Synaptic Associations with Mesoaccumbens and Mesocortical Neurons

2000 • 872 citations

Regional and cellular fractionation of working memory

1996 • 821 citations

Supranormal Stimulation of D₁Dopamine Receptors in the Rodent Prefrontal Cortex Impairs Spatial Working Memory Performance

1997 • 805 citations

Prefrontal Dopamine D₁Receptors and Working Memory in Schizophrenia

2002 • 724 citations

Increased dopamine transmission in schizophrenia: relationship to illness phases

1999 • 713 citations

Decreased prefrontal dopamine D1 receptors in schizophrenia revealed by PET

1997 • 707 citations

DARPP-32: An Integrator of Neurotransmission

2004 • 693 citations

Evidence of dysfunction of a prefrontal-limbic network in schizophrenia: a magnetic resonance imaging and regional cerebral blood flow study of discordant monozygotic twins

1992 • 665 citations

Oligomerization of G-protein-coupled transmitter receptors

2001 • 652 citations

Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia

2002 • 640 citations

Glycine and N-methyl-D-aspartate receptors: physiological significance and possible therapeutic applications.

1998 • 621 citations

Half a century of antipsychotics and still a central role for dopamine D2 receptors

2003 • 620 citations

Dynamic Visualization of Local Protein Synthesis in Hippocampal Neurons

2001 • 602 citations

Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons

1999 • 557 citations

Neuromodulatory actions of dopamine in the neostriatum are dependent upon the excitatory amino acid receptor subtypes activated.

1993 • 552 citations

Targeting the dopamine D1 receptor in schizophrenia: insights for cognitive dysfunction

2004 • 547 citations

Enhanced and Impaired Attentional Performance After Infusion of D1 Dopaminergic Receptor Agents into Rat Prefrontal Cortex

2000 • 542 citations

Dual Regulation of NMDA Receptor Functions by Direct Protein-Protein Interactions with the Dopamine D1 Receptor

2002 • 527 citations

Activity-dependent regulation of dendritic synthesis and trafficking of AMPA receptors

2004 • 518 citations

Regulation of NMDA Receptors by an Associated Phosphatase-Kinase Signaling Complex

1999 • 497 citations

D₁Receptor Modulation of Hippocampal–Prefrontal Cortical Circuits Integrating Spatial Memory with Executive Functions in the Rat

1998 • 482 citations

NMDA-dependent modulation of CA1 local circuit inhibition

1996 • 481 citations

Catecholamine regulation of the prefrontal cortex

1997 • 478 citations

Neuroleptics increase C-FOS expression in the forebrain: Contrasting effects of haloperidol and clozapine

1992 • 477 citations

Chronic Stress Induces Impairment of Spatial Working Memory Because of Prefrontal Dopaminergic Dysfunction

2000 • 471 citations

Dopamine as the wind of the psychotic fire: new evidence from brain imaging studies

1999 • 452 citations

Selective Targeting of Newly Synthesized Arc mRNA to Active Synapses Requires NMDA Receptor Activation

2001 • 451 citations

NMDA receptor antagonists impair prefrontal cortex function as assessed via spatial delayed alternation performance in rats: modulation by dopamine

1996 • 450 citations

Direct protein–protein coupling enables cross-talk between dopamine D5 and γ-aminobutyric acid A receptors

2000 • 437 citations

The physiological approach: functional architecture of working memory and disordered cognition in schizophrenia

1999 • 424 citations

Bringing Order to the Glutamate Chaos in Schizophrenia

2003 • 412 citations

Modulation of N -methyl- <scp>d</scp> -aspartate receptor function by glycine transport

1998 • 410 citations

Glycine binding primes NMDA receptor internalization

2003 • 408 citations

Reversal of Antipsychotic-Induced Working Memory Deficits by Short-Term Dopamine D1 Receptor Stimulation

2000 • 402 citations

Dopamine D1/D5 receptor modulation of excitatory synaptic inputs to layer V prefrontal cortex neurons

2000 • 394 citations

Electrophysiological Characterization of GABAergic Neurons in the Ventral Tegmental Area

1998 • 387 citations

Prefrontal cortex regulates burst firing and transmitter release in rat mesolimbic dopamine neurons studied in vivo

1993 • 386 citations

Lamina-Specific Alterations in the Dopamine Innervation of the Prefrontal Cortex in Schizophrenic Subjects

1999 • 385 citations

The pharmacology of mesolimbic dopamine neurons: a dual-probe microdialysis study in the ventral tegmental area and nucleus accumbens of the rat brain

1996 • 376 citations

Dopaminergic modulation of impaired cognitive activation in the anterior cingulate cortex in schizophrenia

1995 • 374 citations

Impaired Long-Term Memory and NR2A-Type NMDA Receptor-Dependent Synaptic Plasticity in Mice Lacking c-Fos in the CNS

2003 • 371 citations

Corticolimbic Dopamine Neurotransmission Is Temporally Dissociated from the Cognitive and Locomotor Effects of Phencyclidine

1998 • 368 citations

Dopamine D1 Receptor-Dependent Trafficking of Striatal NMDA Glutamate Receptors to the Postsynaptic Membrane

2001 • 368 citations

Development of the Prefrontal Cortex during Adolescence: Insights into Vulnerable Neural Circuits in Schizophrenia

1997 • 367 citations

GABA-containing neurons in the rat ventral tegmental area project to the prefrontal cortex

2000 • 359 citations

Comparison of set-shifting ability in patients with chronic schizophrenia and frontal lobe damage

1999 • 355 citations

Thresholds for synaptic activation of transcription factors in hippocampus: correlation with long-term enhancement

1993 • 345 citations

Roles of NMDA receptor activity and nitric oxide production in brain development

2000 • 337 citations

Glycine transporter I inhibitor, N-Methylglycine (sarcosine), added to antipsychotics for the treatment of schizophrenia

2004 • 335 citations

Release of Adenosine by Activation of NMDA Receptors in the Hippocampus

1994 • 329 citations

GABA-containing neurons in the ventral tegmental area project to the nucleus accumbens in rat brain

1995 • 326 citations

Free d-aspartate and d-serine in the mammalian brain and periphery

1997 • 322 citations

A Dopamine/D1 Receptor/Protein Kinase A/Dopamine- and cAMP-Regulated Phosphoprotein (M_r32 kDa)/Protein Phosphatase-1 Pathway Regulates Dephosphorylation of the NMDA Receptor

1998 • 322 citations

Electrical stimulation of the prefrontal cortex increases dopamine release in the nucleus accumbens of the rat: modulation by metabotropic glutamate receptors

1995 • 316 citations

Subunit- and site-specific pharmacology of the NMDA receptor channel

1999 • 311 citations

Dopaminergic Modulation of NMDA-Induced Whole Cell Currents in Neostriatal Neurons in Slices: Contribution of Calcium Conductances

1998 • 290 citations

Inactivation of the Glycine Transporter 1 Gene Discloses Vital Role of Glial Glycine Uptake in Glycinergic Inhibition

2003 • 289 citations

Amphetamine and Dopamine-Induced Immediate Early Gene Expression in Striatal Neurons Depends on Postsynaptic NMDA Receptors and Calcium

1996 • 287 citations

Prefrontal DA Transmission at D1 Receptors and the Pathology of Schizophrenia

2003 • 276 citations

Dopamine Enhancement of NMDA Currents in Dissociated Medium-Sized Striatal Neurons: Role of D1 Receptors and DARPP-32

2002 • 267 citations

Cortical Regulation of Subcortical Dopamine Release: Mediation via the Ventral Tegmental Area

1995 • 260 citations

Regional Distribution and Developmental Variation of the Glycine Transporters GLYT1 and GLYT2 in the Rat CNS

1995 • 253 citations

Dopaminergic Stimulation of Local Protein Synthesis Enhances Surface Expression of GluR1 and Synaptic Transmission in Hippocampal Neurons

2005 • 248 citations

Selective alterations in prefrontal cortical GABA neurotransmission in schizophrenia: a novel target for the treatment of working memory dysfunction

2003 • 247 citations

Selective prefrontal cortex inputs to dopamine cells: implications for schizophrenia

2002 • 245 citations

Presynaptic regulation of recurrent excitation by D1 receptors in prefrontal circuits

2000 • 243 citations

Amplification of dopaminergic signaling by a positive feedback loop

2000 • 237 citations

Potentiation of NMDA receptor currents by dopamine D ₁ receptors in prefrontal cortex

2004 • 236 citations

Glycine Tranporter-1 Blockade Potentiates NMDA-Mediated Responses in Rat Prefrontal Cortical Neurons In Vitro and In Vivo

2003 • 230 citations

Developmental Changes in NMDA Receptor Glycine Affinity and Ifenprodil Sensitivity Reveal Three Distinct Populations of NMDA Receptors in Individual Rat Cortical Neurons

1998 • 229 citations

Mesocortical Dopamine Neurons Operate in Distinct Temporal Domains Using Multimodal Signaling

2005 • 227 citations

Delay-dependent modulation of memory retrieval by infusion of a dopamine D₁ agonist into the rat medial prefrontal cortex.

2001 • 226 citations

Regulation of Dopamine D1 Receptor Trafficking and Desensitization by Oligomerization with Glutamate N-Methyl-D-aspartate Receptors

2003 • 225 citations

Dopamine Neurons Mediate a Fast Excitatory Signal via Their Glutamatergic Synapses

2004 • 219 citations

The regulation of subcortical dopamine systems by the prefrontal cortex: interactions of central dopamine systems and the pathogenesis of schizophrenia

1992 • 218 citations

Effects of (S)-ketamine on striatal dopamine: a [11C]raclopride PET study of a model psychosis in humans

2000 • 217 citations

A kinetic analysis of the modulation of N‐methyl‐D‐aspartic acid receptors by glycine in mouse cultured hippocampal neurones.

1990 • 216 citations

High-dose glycine added to olanzapine and risperidone for the treatment of schizophrenia

2004 • 214 citations

Role of the dorsomedial striatum in behavioral flexibility for response and visual cue discrimination learning.

2002 • 214 citations

Differential effects of chronic antipsychotic drug treatment on extracellular glutamate and dopamine concentrations

1994 • 203 citations

Modulation of N‐methyl‐D‐aspartic acid receptor desensitization by glycine in mouse cultured hippocampal neurones.

1990 • 199 citations

Regulation of Dopamine D1 Receptor Function by Physical Interaction with the NMDA Receptors

2004 • 196 citations

A Postsynaptic Interaction between Dopamine D₁and NMDA Receptors Promotes Presynaptic Inhibition in the Rat Nucleus Accumbens via Adenosine Release

1997 • 196 citations

Internalization of D1 Dopamine Receptor in Striatal NeuronsIn Vivoas Evidence of Activation by Dopamine Agonists

1998 • 196 citations

Excitotoxicity: Perspectives Based onN-Methyl-d-Aspartate Receptor Subtypes

2002 • 195 citations

Two glycine transporter variants with distinct localization in the CNS and peripheral tissues are encoded by a common gene

1993 • 194 citations

Extracellular concentration of endogenous free d-serine in the rat brain as revealed by in vivo microdialysis

1995 • 191 citations

Gene knockout of glycine transporter 1: Characterization of the behavioral phenotype

2004 • 188 citations

Developing a Neuronal Model for the Pathophysiology of Schizophrenia Based on the Nature of Electrophysiological Actions of Dopamine in the Prefrontal Cortex

1999 • 187 citations

Cortical regulation of subcortical dopamine systems and its possible relevance to schizophrenia

1993 • 186 citations

Postsynaptic integration of glutamatergic and dopaminergic signals in the striatum

1994 • 185 citations

Addiction: Making the Connection Between Behavioral Changes and Neuronal Plasticity in Specific Pathways

2002 • 184 citations

Molecular mechanisms associated with long-term consolidation of the NMDA signals

2000 • 179 citations

Dopamine D1-Dependent Trafficking of StriatalN-Methyl-d-aspartate Glutamate Receptors Requires Fyn Protein Tyrosine Kinase but Not DARPP-32

2004 • 174 citations

Glycine is a coagonist at the NMDA receptor/channel complex

1990 • 172 citations

L-Type Ca²⁺Channels Are Essential for Glutamate-Mediated CREB Phosphorylation andc-fosGene Expression in Striatal Neurons

1999 • 168 citations

The Glycine Transporter Type 1 InhibitorN-[3-(4′-Fluorophenyl)-3-(4′-Phenylphenoxy)Propyl]Sarcosine Potentiates NMDA Receptor-Mediated ResponsesIn Vivoand Produces an Antipsychotic Profile in Rodent Behavior

2003 • 167 citations

Selective up-regulation of dopamine D1 receptors in dendritic spines by NMDA receptor activation

2002 • 166 citations

ALX 5407: A Potent, Selective Inhibitor of the hGlyT1 Glycine Transporter

2001 • 165 citations

Glycine transporter type 1 blockade changes NMDA receptor‐mediated responses and LTP in hippocampal CA1 pyramidal cells by altering extracellular glycine levels

2004 • 164 citations

Subchronic Phencyclidine Administration Increases Mesolimbic Dopaminergic System Responsivity and Augments Stress- and Psychostimulant-Induced Hyperlocomotion

1998 • 162 citations

Glutamate receptors in the rat medial prefrontal cortex regulate set-shifting ability.

2003 • 162 citations

Modulatory Actions of Dopamine on NMDA Receptor-Mediated Responses Are Reduced in D_1A-Deficient Mutant Mice

1996 • 162 citations

Clozapine and haloperidol modulate N-methyl-D-aspartate- and non-N-methyl-D-aspartate receptor-mediated neurotransmission in rat prefrontal cortical neurons in vitro.

1997 • 158 citations

Local Synthesis of Proteins at Synaptic Sites on Dendrites: Role in Synaptic Plasticity and Memory Consolidation?

2002 • 155 citations

GABA_A Receptor Blockade in the Anterior Ventral Tegmental Area Increases Extracellular Levels of Dopamine in the Nucleus Accumbens of Rats

1997 • 154 citations

Regulation of DARPP‐32 dephosphorylation at PKA‐ and Cdk5‐sites by NMDA and AMPA receptors: distinct roles of calcineurin and protein phosphatase‐2A

2002 • 152 citations

Local cooling of pre‐frontal cortex induces pacemaker‐like firing of dopamine neurons in rat ventral tegmental area in vivo

1989 • 151 citations

Direct Evidence for Biphasic cAMP Responsive Element-Binding Protein Phosphorylation during Long-Term Potentiation in the Rat Dentate GyrusIn Vivo

1999 • 151 citations

Intracellular Modulation of NMDA Receptor Function by Antipsychotic Drugs

2000 • 150 citations

The effects of antipsychotic drugs on fos protein expression in the prefrontal cortex: Cellular localization and pharmacological characterization

1996 • 147 citations

Electrical stimulation of the prefrontal cortex increases cholecystokinin, glutamate, and dopamine release in the nucleus accumbens: an in vivo microdialysis study in freely moving rats.

1998 • 147 citations

Enhancement of Working Memory in Aged Monkeys by a Sensitizing Regimen of Dopamine D₁Receptor Stimulation

2004 • 147 citations

Brain activation during cognitive stimulation with the Wisconsin Card Sorting Test — a functional MRI study on healthy volunteers and schizophrenics

1997 • 145 citations

The contribution of the rat prelimbic-infralimbic areas to different forms of task switching.

2003 • 142 citations

Interactions between the glycine and glutamate binding sites of the NMDA receptor

1993 • 141 citations

Nucleus accumbens dopamine release modulation by mesolimbic GABAA receptors—an in vivo electrochemical study

1998 • 140 citations

The phosphoprotein DARPP-32 mediates cAMP-dependent potentiation of striatal N -methyl- <scp>d</scp> -aspartate responses

1997 • 138 citations

Stimulation of prefrontal cortex at physiologically relevant frequencies inhibits dopamine release in the nucleus accumbens

2001 • 138 citations

Cognitive function in schizophrenia

1997 • 138 citations

GABA_A receptors in the ventral tegmental area control bidirectional reward signalling between dopaminergic and non‐dopaminergic neural motivational systems

2001 • 137 citations

Glutamatergic and dopaminergic afferents to the prefrontal cortex regulate spatial working memory in rats

1999 • 136 citations

Impairment in perceptual attentional set-shifting following PCP administration: a rodent model of set-shifting deficits in schizophrenia

2005 • 131 citations

Involvement of γ-aminobutyric acid neurotransmission in phencyclidine-induced dopamine release in the medial prefrontal cortex

1998 • 131 citations

Structure, function and regulation of glycine neurotransporters

2003 • 130 citations

Glutamate regulation of DARPP-32 phosphorylation in neostriatal neurons involves activation of multiple signaling cascades

2005 • 127 citations

Systemic administration of amperozide, a new atypical antipsychotic drug, preferentially increases dopamine release in the rat medial prefrontal cortex

1994 • 126 citations

Effect of clozapine, haloperidol, or M100907 on phencyclidine-activated glutamate efflux in the prefrontal cortex

2001 • 126 citations

Electrical Stimulation of the Prefrontal Cortex Increases Cholecystokinin, Glutamate, and Dopamine Release in the Nucleus Accumbens: anIn VivoMicrodialysis Study in Freely Moving Rats

1998 • 126 citations

NMDA Receptor Antagonists Disinhibit Rat Posterior Cingulate and Retrosplenial Cortices: A Potential Mechanism of Neurotoxicity

2002 • 125 citations

NMDA Receptor Pharmacology: Perspectives from Molecular Biology

2001 • 122 citations

Why glycine transporters have different stoichiometries

2002 • 121 citations

Presynaptic D₁Dopamine Receptors in Primate Prefrontal Cortex: Target-Specific Expression in the Glutamatergic Synapse

2005 • 119 citations

Actions of clozapine and haloperidol on the extracellular levels of excitatory amino acids in the prefrontal cortex and striatum of conscious rats

1993 • 118 citations

Attenuation of specific PCP-evoked behaviors by the potent mGlu2/3 receptor agonist, LY379268 and comparison with the atypical antipsychotic, clozapine

2000 • 116 citations

Role of Glycine in the N‐Methyl‐d‐Aspartate‐Mediated Neuronal Cytotoxicity

1990 • 113 citations

Neural substrates of memory: From synapse to system

2002 • 112 citations

Regulation and function of local protein synthesis in neuronal dendrites

2002 • 111 citations

Synaptic Plasticity and Translation Initiation

2004 • 110 citations

Interaction of Dopamine D1 and NMDA Receptors Mediates Acute Clozapine Potentiation of Glutamate EPSPs in Rat Prefrontal Cortex

2002 • 109 citations

Synaptic Basis of Persistent Activity in Prefrontal Cortex In Vivo and in Organotypic Cultures

2003 • 108 citations

Protein phosphorylation in neuronal plasticity and gene expression

1995 • 107 citations

Reversal of Phencyclidine-Induced Dopaminergic Dysregulation by N-Methyl-D-Aspartate Receptor/Glycine-site Agonists

2003 • 104 citations

Subfield‐specific immediate early gene expression associated with hippocampal long‐term potentiation in vivo

2001 • 101 citations

Allosteric modulation of G-protein coupled receptors

2004 • 98 citations

Prefrontal cortical involvement in phencyclidine-induced activation of the mesolimbic dopamine system: behavioral and neurochemical evidence

1998 • 96 citations

Dopamine Agonist Treatment of Schizophrenia With N-Propylnorapomorphine

1986 • 95 citations

Hypofrontality in neuroleptic-naive schizophrenic patients during the Wisconsin Card Sorting Test - a fMRI study

2001 • 95 citations

The glycine transporter-1 inhibitors NFPS and Org 24461: a pharmacological study

2003 • 94 citations

NMDA antagonist effects on striatal dopamine release: Positron emission tomography studies in humans

2001 • 93 citations

Pharmacological assessment of the role of the glycine transporter GlyT-1 in mediating high-affinity glycine uptake by rat cerebral cortex and cerebellum synaptosomes

2001 • 93 citations

Differential effects of the D1-DA receptor antagonist SCH39166 on positive and negative symptoms of schizophrenia

1995 • 93 citations

Effects of cannabinoids on prefrontal neuronal responses to ventral tegmental area stimulation

2001 • 92 citations

N[3‐(4′‐fluorophenyl)‐3‐(4′‐phenylphenoxy)propyl]sarcosine (NFPS) is a selective persistent inhibitor of glycine transport

2001 • 92 citations

Sustained enhancement of AMPA receptor- and NMDA receptor-mediated currents induced by dopamine d1/d5 receptor activation in the hippocampus: An essential role of postsynaptic Ca2+

2000 • 91 citations

Molecular mechanisms that underlie structural and functional changes atthe postsynaptic membrane duringsynaptic plasticity

1998 • 91 citations

Dopamine Depletion and In Vivo Binding of PET D1 Receptor Radioligands: Implications for Imaging Studies in Schizophrenia

2003 • 90 citations

Enhancement of the NMDA receptor function by reduction of glycine transporter-1 expression

2004 • 89 citations

(−)-Stepholidine: a potential novel antipsychotic drug with dual D1 receptor agonist and D2 receptor antagonist actions

2002 • 86 citations

Allosteric Modulation of G Protein-Coupled Receptors

2004 • 84 citations

Clozapine Preferentially Increases Dopamine Release in the Rhesus Monkey Prefrontal Cortex Compared with the Caudate Nucleus

1999 • 84 citations

N-Methyl-D-Aspartate Receptor-Coupled GlycineB Receptors in the Pathogenesis and Treatment of Schizophrenia: A Critical Review

2002 • 84 citations

Allosteric modulation of G protein-coupled receptors: perspectives and recent developments

2004 • 83 citations

NMDA receptors are movin’ in

2004 • 82 citations

Differential Effects of Locally Administered Clozapine and Haloperidol on Dopamine Efflux in the Rat Prefrontal Cortex and Caudate‐Putamen

1994 • 80 citations

Brain region effects of clozapine on amino acid and monoamine transmission.

1994 • 80 citations

Decreased Phosphorylation of NMDA Receptor Type 1 at Serine 897 in Brains of Patients with Schizophrenia

2004 • 75 citations

Equilibrium and kinetic study of glycine action on the N‐methyl‐D‐aspartate receptor in cultured mouse brain neurons.

1992 • 75 citations

Effect of picrotoxin and nipecotic acid on inhibitory response of dopaminergic neurons in the ventral tegmental area to stimulation of the nucleus accumbens

1980 • 71 citations

Reduced prefrontal cortical dopamine, but not acetylcholine, release in vivo after repeated, intermittent phencyclidine administration to rats

1998 • 64 citations

Analysis of a Gene Encoding Two Glycine Transporter Variants Reveals Alternative Promoter Usage and a Novel Gene Structure

1998 • 64 citations

G-protein-coupled receptor allosterism: the promise and the problem(s)

2004 • 58 citations

In vivo stimulated dopamine release in the nucleus accumbens: modulation by the prefrontal cortex

1995 • 58 citations

The Group II Metabotropic Glutamate Receptor Agonist (−)-2-Oxa-4-aminobicyclo[3.1.0.]hexane-4,6-dicarboxylate (LY379268) and Clozapine Reverse Phencyclidine-Induced Behaviors in Monoamine-Depleted Rats

2002 • 57 citations

Blockade of NMDA receptors located at the dorsomedial prefrontal cortex impairs spatial working memory in rats

1999 • 56 citations

Translational Control at the Synapse

2004 • 52 citations

Dopaminergic modulation of early signs of excitotoxicity in visualized rat neostriatal neurons

1998 • 52 citations

Glycine transporter isoforms in the mammalian central nervous system: structures, functions and therapeutic promises.

2003 • 52 citations

The therapeutic potential of glycine transporter-1 inhibitors

2004 • 51 citations

Effects of clozapine, haloperidol and iloperidone on neurotransmission and synaptic plasticity in prefrontal cortex and their accumulation in brain tissue: an in vitro study

2003 • 51 citations

Inhibition by various antipsychotic drugs of the G‐protein‐activated inwardly rectifying K⁺ (GIRK) channels expressed in Xenopus oocytes

2000 • 51 citations

Dopamine D1/D5 receptor activation fails to initiate an activity-independent late-phase LTP in rat hippocampus

2004 • 46 citations

Clozapine Potentiation ofN-Methyl-d-aspartate Receptor Currents in the Nucleus Accumbens: Role of NR2B and Protein Kinase A/Src Kinases

2005 • 45 citations

Dopamine D₁ Receptor‐Induced Gene Transcription Is Modulated by DARPP‐32

2000 • 44 citations

NMDA but Not AMPA Receptor Antagonists Impair the Delay-Interposed Radial Maze Performance of Rats

1997 • 43 citations

Presynaptic inhibition at excitatory hippocampal synapses: development and role of presynaptic Ca2+ channels

1996 • 42 citations

Blockade of Glycine Transporter-1 (GLYT-1) Potentiates NMDA Receptor-Mediated Synaptic Transmission in Hypoglossal Motorneurons

2004 • 42 citations

Active release of glycine or d-serine saturates the glycine site of NMDA receptors at the cerebellar mossy fibre to granule cell synapse

2003 • 41 citations

Persistent activation of the dopamine D1 receptor contributes to prolonged receptor desensitization: studies with A-77636.

1996 • 41 citations

GPCR Drug Discovery Through the Exploitation of Allosteric Drug Binding Sites

2002 • 40 citations

Whole cell and single channel analysis of the kinetics of glycine‐sensitive N‐methyl‐D‐aspartate receptor desensitization

1993 • 39 citations

The Glycine Coagonist Site of the NMDA Receptor

1990 • 39 citations

Chronic high-dose glycine nutrition: effects on rat brain cell morphology

2001 • 35 citations

D1 and NMDA receptors hook up: expanding on an emerging theme

2003 • 35 citations

Allosteric modulators of metabotropic glutamate receptors: lessons learnt from mGlu1, mGlu2 and mGlu5 potentiators and antagonists

2004 • 34 citations

Effects of selective dopamine depletion in medial prefrontal cortex on basal and evoked extracellular dopamine in neostriatum

1995 • 33 citations

Modulation of the ability of clozapine to facilitate NMDA‐ and electrically evoked responses in pyramidal cells of the rat medial prefrontal cortex by dopamine: pharmacological evidence

2003 • 32 citations

Formation of oligomers by G protein-coupled receptors.

2002 • 31 citations

Activation of presynaptic D1 dopamine receptors by dopamine increases the frequency of spontaneous excitatory postsynaptic currents through protein kinase A and protein kinase C in pyramidal cells of rat prelimbic cortex

2002 • 30 citations

Single-channel evidence for glycine and NMDA requirement in NMDA receptor activation

1996 • 29 citations

Effects of partial dopamine loss in the medial prefrontal cortex on local baseline and stress-evoked extracellular dopamine concentrations

1999 • 29 citations

Agonist-induced morphologic decrease in cellular d1A dopamine receptor staining

1997 • 29 citations

The Molecular Basis of Dopamine and Glutamate Interactions in the Striatum

1997 • 27 citations

Involvement of receptor reserve in D1 agonistic action of (−)-stepholidine in lesioned rats

1997 • 26 citations

Synaptic plasticity:

1999 • 22 citations

The effect of phencyclidine on the basal and high potassium evoked extracellular GABA levels in the striatum of freely-moving rats: an in vivo microdialysis study

1995 • 21 citations

Mechanisms of translational control in dendrites

2003 • 21 citations

Is cyclic AMP involved in excitatory amino acid-evoked adenosine release from rat cortical slices?

1994 • 20 citations

Differential Effects of Dopamine Antagonists on Evoked Dopamine Release from Slices of Striatum and Nucleus Accumbens in Rats

1995 • 19 citations

Glycine transporter isoforms show differential subcellular localization in PC12 cells

2002 • 19 citations

Phencyclidine impairs temporal order memory for spatial locations in rats

1995 • 17 citations

GTP regulation of (−)-stepholidine binding to RH of D1 dopamine receptors in calf striatum

1997 • 17 citations

Intrahippocampal Injections of Phencyclidine but not Naloxone Disrupt Acquisition of a Spatial Continuous Recognition Memory Task

1997 • 13 citations

In Vivo Characterization of Changes in Glycine Levels Induced by GlyT1 Inhibitors

2003 • 12 citations