Glycine Tranporter-1 Blockade Potentiates NMDA-Mediated Responses in Rat Prefrontal Cortical Neurons In Vitro and In Vivo

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

A synaptic model of memory: long-term potentiation in the hippocampus

1993 • 11,303 citations

Magnesium gates glutamate-activated channels in mouse central neurones

1984 • 3,999 citations

Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

1994 • 3,437 citations

Glycine potentiates the NMDA response in cultured mouse brain neurons

1987 • 3,116 citations

Recent advances in the phencyclidine model of schizophrenia

1991 • 2,886 citations

Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones

1984 • 2,822 citations

Long-Term Potentiation--A Decade of Progress?

1999 • 2,701 citations

Heteromeric NMDA Receptors: Molecular and Functional Distinction of Subtypes

1992 • 2,527 citations

NMDA receptor subunits: diversity, development and disease

2001 • 1,677 citations

Requirement for Glycine in Activation of NMDA-Receptors Expressed in Xenopus Oocytes

1988 • 1,415 citations

N-methyl-D-aspartic acid receptor structure and function

1994 • 989 citations

D-serine, an endogenous synaptic modulator: localization to astrocytes and glutamate-stimulated release.

1995 • 823 citations

Activity-Dependent Decrease in NMDA Receptor Responses During Development of the Visual Cortex

1992 • 731 citations

D-Alanine Added to Antipsychotics for the Treatment of Schizophrenia

2005 • 670 citations

Functional and Pharmacological Differences Between RecombinantN-Methyl-<scp>d</scp>-Aspartate Receptors

1998 • 662 citations

Glycine and N-methyl-D-aspartate receptors: physiological significance and possible therapeutic applications.

1998 • 621 citations

NR2A Subunit Expression Shortens NMDA Receptor Synaptic Currents in Developing Neocortex

1997 • 612 citations

Glutamatergic Mechanisms in Schizophrenia

2002 • 579 citations

Channel kinetics determine the time course of NMDA receptor-mediated synaptic currents

1990 • 570 citations

D-serine added to antipsychotics for the treatment of schizophrenia

1998 • 557 citations

Developmental regulation of NMDA receptor-mediated synaptic currents at a central synapse

1992 • 529 citations

The glycinergic inhibitory synapse

2001 • 519 citations

7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex.

1988 • 517 citations

Glycine transporters are differentially expressed among CNS cells

1995 • 515 citations

Efficacy of High-Dose Glycine in the Treatment of Enduring Negative Symptoms of Schizophrenia

1999 • 484 citations

Molecular Determinants of Agonist Discrimination by NMDA Receptor Subunits: Analysis of the Glutamate Binding Site on the NR2B Subunit

1997 • 470 citations

A Placebo-Controlled Trial of D-Cycloserine Added to Conventional Neuroleptics in Patients With Schizophrenia

1999 • 435 citations

Cloning and expression of a glycine transporter reveal colocalization with NMDA receptors

1992 • 428 citations

The physiological approach: functional architecture of working memory and disordered cognition in schizophrenia

1999 • 424 citations

Prefrontal function in schizophrenia: confounds and controversies

1996 • 420 citations

d-Serine as a Neuromodulator: Regional and Developmental Localizations in Rat Brain Glia Resemble NMDA Receptors

1997 • 410 citations

Modulation of N -methyl- <scp>d</scp> -aspartate receptor function by glycine transport

1998 • 410 citations

Regulation of NMDA receptor desensitization in mouse hippocampal neurons by glycine

1989 • 408 citations

Synaptic Desensitization of NMDA Receptors by Calcineurin

1995 • 404 citations

NMDA channel behavior depends on agonist affinity

1992 • 401 citations

Mechanisms generating the time course of dual component excitatory synaptic currents recorded in hippocampal slices

1990 • 396 citations

Inactivation of NMDA channels in cultured hippocampal neurons by intracellular calcium

1993 • 394 citations

Schizophrenia and Glutamatergic Transmission

1998 • 385 citations

Amelioration of negative symptoms in schizophrenia by glycine

1994 • 349 citations

Functional Comparison of <scp>d</scp>‐Serine and Glycine in Rodents: The Effect on Cloned NMDA Receptors and the Extracellular Concentration

1995 • 327 citations

Free d-aspartate and d-serine in the mammalian brain and periphery

1997 • 322 citations

Atypical neural messengers

2001 • 296 citations

Patch clamp studies on the kinetics and selectivity of N-methyl-d-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan)

1993 • 278 citations

Novel Neurotransmitters and Their Neuropsychiatric Relevance

2000 • 264 citations

Electrophysiological and morphological properties of layers V-VI principal pyramidal cells in rat prefrontal cortex in vitro

1996 • 260 citations

The Astroglial ASCT2 Amino Acid Transporter as a Mediator of Glutamine Efflux

1999 • 231 citations

Developmental Changes in NMDA Receptor Glycine Affinity and Ifenprodil Sensitivity Reveal Three Distinct Populations of NMDA Receptors in Individual Rat Cortical Neurons

1998 • 229 citations

The glycine binding site of the N-methyl-D-aspartate receptor subunit NR1: identification of novel determinants of co-agonist potentiation in the extracellular M3-M4 loop region.

1996 • 225 citations

<scp>d-</scp>Serine Added to Clozapine for the Treatment of Schizophrenia

1999 • 224 citations

Glycine Uptake Governs Glycine Site Occupancy at NMDA Receptors of Excitatory Synapses

1998 • 219 citations

A kinetic analysis of the modulation of N‐methyl‐D‐aspartic acid receptors by glycine in mouse cultured hippocampal neurones.

1990 • 216 citations

D-amino acids as putative neurotransmitters: focus on D-serine.

2000 • 212 citations

Identification of Amino Acid Residues of the NR2A Subunit That Control Glutamate Potency in Recombinant NR1/NR2A NMDA Receptors

1998 • 199 citations

Modulation of N‐methyl‐D‐aspartic acid receptor desensitization by glycine in mouse cultured hippocampal neurones.

1990 • 199 citations

Two glycine transporter variants with distinct localization in the CNS and peripheral tissues are encoded by a common gene

1993 • 194 citations

Extracellular concentration of endogenous free d-serine in the rat brain as revealed by in vivo microdialysis

1995 • 191 citations

Developing a Neuronal Model for the Pathophysiology of Schizophrenia Based on the Nature of Electrophysiological Actions of Dopamine in the Prefrontal Cortex

1999 • 187 citations

Glycine is a coagonist at the NMDA receptor/channel complex

1990 • 172 citations

Control of NMDA Receptor Activation by a Glycine Transporter Co-Expressed inXenopusOocytes

1997 • 170 citations

The behavioral and neurochemical effects of phencyclidine in humans and animals: some implications for modeling psychosis

1996 • 169 citations

ALX 5407: A Potent, Selective Inhibitor of the hGlyT1 Glycine Transporter

2001 • 165 citations

Glycine reverses antagonism of N-methyl-D-aspartate (NMDA) by 1-hydroxy-3-aminopyrrolidone-2 (HA-966) but not by D-2-amino-5-phophonovalerate (D-AP5) on rat cortical slices

1988 • 162 citations

Calcium-dependent inactivation of synaptic NMDA receptors in hippocampal neurons

1995 • 162 citations

Cloning of the human glycine transporter type 1: molecular and pharmacological characterization of novel isoform variants and chromosomal localization of the gene in the human and mouse genomes.

1994 • 160 citations

Stereospecificity of blood-brain barrier permeability to amino acids

1973 • 159 citations

Gene structure and glial expression of the glycine transporter GlyT1 in embryonic and adult rodents

1995 • 144 citations

Interactions between the glycine and glutamate binding sites of the NMDA receptor

1993 • 141 citations

7‐クロルキヌレン酸はN‐メチル‐D‐アスパラギン酸受容体複合体のグリシン調節部位での選択的きっ抗物質である

1988 • 130 citations

HA-966 antagonizes N-methyl-D-aspartate receptors through a selective interaction with the glycine modulatory site

1989 • 128 citations

Glial transport of the neuromodulator d-serine

2002 • 128 citations

The role of N-Methyl-D-Aspartate (NMDA) receptor-mediated neurotransmission in the pathophysiology and therapeutics of psychiatric syndromes

1998 • 122 citations

Glycine decreases desensitization of N-methyl-D-aspartate (NMDA) receptors expressed in Xenopus oocytes and is required for NMDA responses.

1990 • 117 citations

Role of Glycine in the N‐Methyl‐d‐Aspartate‐Mediated Neuronal Cytotoxicity

1990 • 113 citations

Calcium‐mediated modulation of N‐methyl‐D‐aspartate (NMDA) responses in cultured rat hippocampal neurones.

1993 • 111 citations

Free and conjugated amino acids in human CSF: Influence of age and sex

1985 • 108 citations

Modulation of NMDA receptor-mediated responses by glycine and d-serine in the rat thalamus in vivo

1989 • 105 citations

Glutamate activation of a single NMDA receptorchannel produces a cluster of channel openings

1991 • 99 citations

Reversal of phencyclidine-induced effects by glycine and glycine transport inhibitors

1999 • 99 citations

The effect of agonist concentration, membrane voltage and calcium on n-methyl-d-aspartate receptor desensitization

1990 • 98 citations

Pharmacological assessment of the role of the glycine transporter GlyT-1 in mediating high-affinity glycine uptake by rat cerebral cortex and cerebellum synaptosomes

2001 • 93 citations

N[3‐(4′‐fluorophenyl)‐3‐(4′‐phenylphenoxy)propyl]sarcosine (NFPS) is a selective persistent inhibitor of glycine transport

2001 • 92 citations

Dual-component NMDA receptor currents at a single central synapse

1990 • 91 citations

Contributions of Voltage-Gated Ca²⁺Channels in the Proximal versus Distal Dendrites to Synaptic Integration in Prefrontal Cortical Neurons

1997 • 84 citations

Molecular biology of glycinergic neurotransmission

1997 • 83 citations

Activation of the glycine site in the NMDA receptor is necessary for the induction of LTP

1990 • 81 citations

Glutamatergic hippocampal formation projections to prefrontal cortex in the rat are regulated by GABAergic inhibition and show convergence with glutamatergic projections from the limbic thalamus

1994 • 77 citations

Characterization of the binding of [3H]L-689,560, an antagonist for the glycine site on the N-methyl-D-aspartate receptor, to rat brain membranes.

1992 • 73 citations

The co-agonist concept: is the NMDA-associated glycine receptor saturated in vivo?

1995 • 71 citations

Cognitive deficit in schizophrenia and its neurochemical basis

1999 • 70 citations

Analysis of a Gene Encoding Two Glycine Transporter Variants Reveals Alternative Promoter Usage and a Novel Gene Structure

1998 • 64 citations

Modulation of NMDA receptors by glycine ? introduction to some basic aspects and recent developments

1998 • 61 citations

[3H]MDL 105,519, a high-affinity radioligand for the N-methyl-D-aspartate receptor-associated glycine recognition site.

1996 • 56 citations

Voltage‐dependent Kinetics of N‐Methyl‐d‐aspartate Synaptic Currents in Rat Cerebellar Granule Cells

1994 • 46 citations

Glycine is required for NMDA receptor activation: electrophysiological evidence from intact rat hippocampus

1992 • 36 citations

[3H]Glycine uptake in rat hippocampus: kinetic analysis and autoradiographic localization

1992 • 34 citations

Characterization of glycine release mediated by glycine transporter 1 stably expressed in HEK-293 cells

1997 • 33 citations

Desensitization of N-methyl-D-aspartate receptors in neurons dissociated from adult rat hippocampus.

1991 • 32 citations

ModuEation of the NMDA receptor by D-serine in the cortex and the spinal cord, in vitro

1990 • 31 citations

Single-channel evidence for glycine and NMDA requirement in NMDA receptor activation

1996 • 29 citations

Evidence for involvement of endogenous glycine in the induction of long-term potentiation in the dentate gyrus of anesthetized rats

1991 • 29 citations

Glycine at the NMDA receptor in cat visual cortex: saturation and changes with age

1996 • 19 citations

High dose glycine nutrition affects glial cell morphology in rat hippocampus and cerebellum

1999 • 17 citations