The glycine transporter-1 inhibitors NFPS and Org 24461: a pharmacological study

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A simplified method of evaluating dose-effect experiments.

1948 • 7,047 citations

Glycine potentiates the NMDA response in cultured mouse brain neurons

1987 • 3,116 citations

Psychopharmacology: The Fourth Generation of Progress

1995 • 2,920 citations

Recent advances in the phencyclidine model of schizophrenia

1991 • 2,886 citations

The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation.

1962 • 2,522 citations

The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N‐methyl‐aspartate

1983 • 1,400 citations

Neurotransmitter Transporters: Recent Progress

1993 • 1,089 citations

<scp>d</scp> -Serine is an endogenous ligand for the glycine site of the N -methyl- <scp>d</scp> -aspartate receptor

2000 • 1,075 citations

[3H]Ketanserin (R 41 468), a selective 3H-ligand for serotonin2 receptor binding sites. Binding properties, brain distribution, and functional role.

1982 • 1,049 citations

Reversal of Phencyclidine Effects by a Group II Metabotropic Glutamate Receptor Agonist in Rats

1998 • 1,002 citations

The current status of the dopamine hypothesis of schizophrenia

1988 • 962 citations

Do Novel Antipsychotics Have Similar Pharmacological Characteristics? A Review of the Evidence

1998 • 719 citations

D-Alanine Added to Antipsychotics for the Treatment of Schizophrenia

2005 • 670 citations

Effects of Ketamine in Normal and Schizophrenic Volunteers

2001 • 646 citations

Glycine and N-methyl-D-aspartate receptors: physiological significance and possible therapeutic applications.

1998 • 621 citations

The binding of serotonergic ligands to the porcine choroid plexus: Characterization of a new type of serotonin recognition site

1984 • 598 citations

Characterization of the binding of 3H-SCH 23390, a selective D-1 receptor antagonist ligand, in rat striatum

1984 • 566 citations

The Glutamatergic Dysfunction Hypothesis for Schizophrenia

1996 • 558 citations

Exploration of mice in a black and white test box: Validation as a model of anxiety

1989 • 535 citations

Serotonin model of schizophrenia: emerging role of glutamate mechanisms

2000 • 520 citations

Glycine transporters are differentially expressed among CNS cells

1995 • 515 citations

Creativity and Psychopathology a Study of 291 World-Famous Men

1994 • 489 citations

The novel anticonvulsant MK‐801 binds to the activated state of the N‐methyl‐<scp>d</scp>‐aspartate receptor in rat brain

1987 • 452 citations

Cloning and expression of a glycine transporter reveal colocalization with NMDA receptors

1992 • 428 citations

Glutamate in CNS disorders as a target for drug development: an update

1998 • 423 citations

Binding characteristics of 3H-prazosin to rat brain α-adrenergic receptors

1979 • 419 citations

Modulation of N -methyl- <scp>d</scp> -aspartate receptor function by glycine transport

1998 • 410 citations

Dissociative anesthesia: further pharmacologic studies and first clinical experience with the phencyclidine derivative CI-581.

1966 • 389 citations

Schizophrenia and Glutamatergic Transmission

1998 • 385 citations

Pharmacological Differentiation and Characterization of 5‐HT_1A, 5‐HT_1B, and 5‐HT_1C Binding Sites in Rat Frontal Cortex

1986 • 344 citations

Controlled, dose-response study of sertindole and haloperidol in the treatment of schizophrenia. Sertindole Study Group

1997 • 311 citations

The NMDA-receptor antagonist CPP abolishes neurogenic ‘wind-up pain’ after intrathecal administration in humans

1992 • 302 citations

Catalepsy as a rodent model for detecting antipsychotic drugs with extrapyramidal side effect liability

1995 • 222 citations

Glycine Uptake Governs Glycine Site Occupancy at NMDA Receptors of Excitatory Synapses

1998 • 219 citations

D-amino acids as putative neurotransmitters: focus on D-serine.

2000 • 212 citations

Multiple sites for the regulation of the N-methyl-D-aspartate receptor.

1988 • 208 citations

Safety and Tolerability of the Glutamate Antagonist CGS 19755 (Selfotel) in Patients With Acute Ischemic Stroke

1995 • 206 citations

New Insights into the Biology of Schizophrenia through the Mechanism of Action of Clozapine

1995 • 173 citations

Cloning of the human glycine transporter type 1: molecular and pharmacological characterization of novel isoform variants and chromosomal localization of the gene in the human and mouse genomes.

1994 • 160 citations

Gene structure and glial expression of the glycine transporter GlyT1 in embryonic and adult rodents

1995 • 144 citations

Recovery of neuropsychological functions during reduction in use of phencyclidine

1991 • 141 citations

Differential effects of classical and newer antipsychotics on the hypermotility induced by two dose levels of d-amphetamine

1995 • 139 citations

mCPP-induced anxiety in the light-dark box in rats - a new method for screening anxiolytic activity

1998 • 133 citations

Blockade of phencyclidine-induced hyperlocomotion by clozapine and MDL 100,907 in rats reflects antagonism of 5-HT2A receptors

1995 • 121 citations

Characterization and autoradiographical localization of non‐adrenoceptor idazoxan binding sites in the rat brain

1992 • 120 citations

Neuronal mechanisms of ketamine-induced anesthesia

1968 • 118 citations

Understanding the Mechanism of Action of Atypical Antipsychotic Drugs

1993 • 110 citations

Transporter explosion: update on uptake

1992 • 110 citations

Reversal of phencyclidine-induced effects by glycine and glycine transport inhibitors

1999 • 99 citations

Modulation of a Recombinant Glycine Transporter (GLYT1b) by Activation of Protein Kinase C

1995 • 96 citations

Discovery and SAR of Org 24598—A Selective Glycine Uptake Inhibitor

2001 • 94 citations

Antagonism of phencyclidine-induced hyperactivity by glycine in mice

1986 • 94 citations

Species variations in dopamine receptor binding

1979 • 94 citations

Pharmacological assessment of the role of the glycine transporter GlyT-1 in mediating high-affinity glycine uptake by rat cerebral cortex and cerebellum synaptosomes

2001 • 93 citations

N[3‐(4′‐fluorophenyl)‐3‐(4′‐phenylphenoxy)propyl]sarcosine (NFPS) is a selective persistent inhibitor of glycine transport

2001 • 92 citations

Rat pup isolation calls are reduced by functional antagonists of the NMDA receptor

1990 • 89 citations

Blockade of phencyclidine‐induced effects by a nitric oxide donor

2000 • 84 citations

Changes in EEG spectral power in the prefrontal cortex of conscious rats elicited by drugs interacting with dopaminergic and noradrenergic transmission

1999 • 83 citations

S 16924 ((R)-2-[1-[2-(2,3-dihydro-benzo[1,4] dioxin-5-yloxy)-ethyl]-pyrrolidin-3yl]-1-(4-fluoro-phenyl)-ethanone), a novel, potential antipsychotic with marked serotonin (5-HT)1A agonist properties: II. Functional profile in comparison to clozapine and haloperidol.

1998 • 82 citations

MK-801-induced hyperlocomotion: Differential effects of M100907, SDZ PSD 958 and raclopride

1997 • 74 citations

Anxiolytic activity of glycine-B antagonists and partial agonists—No relation to intrinsic activity in the patch clamp

1997 • 71 citations

Glycyldodecylamide, a phencyclidine behavioral antagonist, blocks cortical glycine uptake: implications for schizophrenia and substance abuse

1997 • 70 citations

Ziprasidone

2002 • 64 citations

Analysis of a Gene Encoding Two Glycine Transporter Variants Reveals Alternative Promoter Usage and a Novel Gene Structure

1998 • 64 citations

Effects of Risperidone on Phencyclidine-Induced Behaviors: Comparison with Haloperidol and Ritanserin

1994 • 63 citations

Effects of phencyclidine (PCP) and MK 801 on the EEGq in the prefrontal cortex of conscious rats; antagonism by clozapine, and antagonists of AMPA‐, α₁‐ and 5‐HT_2A‐receptors

2002 • 61 citations

Glycine maintains excitement

1989 • 61 citations

Characterization of the 5′ region of the rat brain glycine transporter GLYT2 gene: identification of a novel isoform

1998 • 60 citations

Continuous Phencyclidine Treatment Induces Schizophrenia-Like Hyperreactivity of Striatal Dopamine Release

2001 • 58 citations

Effects of antiparkinson drugs on a phenothiazine-induced catatonic reaction.

1962 • 56 citations

Towards More Effective Antipsychotic Treatment

1994 • 54 citations

Glycinergic augmentation of NMDA receptor-mediated neurotransmission in the treatment of schizophrenia.

1996 • 53 citations

Dopamine Efflux from Striatum After Chronic Nicotine: Evidence for Autoreceptor Desensitization

1992 • 51 citations

Pharmacological characterization of locomotor sensitization induced by chronic phencyclidine administration.

2001 • 47 citations

Effects of four antipsychotics on punished responding in rats

1993 • 42 citations

Preferential inhibition of dizocilpine-induced hyperlocomotion by olanzapine

1999 • 35 citations

[3H]Glycine uptake in rat hippocampus: kinetic analysis and autoradiographic localization

1992 • 34 citations

S-16924 [(R)-2-[1-[2-(2,3-dihydro-benzo[1,4]dioxin-5-yloxy)-ethyl]- pyrrolidin-3yl]-1-(4-fluorophenyl)-ethanone], a novel, potential antipsychotic with marked serotonin1A agonist properties: III. Anxiolytic actions in comparison with clozapine and haloperidol.

1999 • 30 citations

Alpha-1 and alpha-2 adrenoceptor binding in cerebral cortex: Competition studies with [3H]prazosin and [3H]idazoxan

1987 • 28 citations

Comparison of binding at strychnine-sensitive (inhibitory glycine receptor) and strychnine-insensitive ( receptor) glycine binding sites

1992 • 28 citations

Anticonflict effect of the glycine B receptor partial agonist, D -cycloserine, in rats. Pharmacological analysis

2000 • 27 citations

The role of glycineB binding site and glycine transporter (GlyT1) in the regulation of [3H]GABA and [3H]glycine release in the rat brain.

2001 • 17 citations

Effect of glycine on antidepressant- and anxiolytic-like action of 1-aminocyclopropanecarboxylic acid (ACPC) in rats.

1996 • 8 citations

Interaction of permanently charged chlorpromazine and dopamine analogs with the striatal D-1 dopaminergic receptor

1989 • 7 citations

Autoradiographical evaluation of [3H]glycine uptake in rat forebrain: Cellular localization in the hippocampus

1993 • 7 citations

Deleted Work

1955 • 0 citations