Synaptic Plasticity and Translation Initiation

Synaptic tagging and long-term potentiation

1997 • 1,689 citations

Protein synthesis and memory: A review.

1984 • 1,450 citations

Translational control of gene expression

2000 • 1,371 citations

Altered synaptic plasticity in a mouse model of fragile X mental retardation

2002 • 1,288 citations

The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory

2001 • 1,140 citations

Microarray Identification of FMRP-Associated Brain mRNAs and Altered mRNA Translational Profiles in Fragile X Syndrome

2001 • 1,113 citations

Internal ribosome entry sites in eukaryotic mRNA molecules

2001 • 975 citations

A Requirement for Local Protein Synthesis in Neurotrophin-Induced Hippocampal Synaptic Plasticity

1996 • 948 citations

Circularization of mRNA by Eukaryotic Translation Initiation Factors

1998 • 940 citations

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

1997 • 927 citations

Role for Rapid Dendritic Protein Synthesis in Hippocampal mGluR-Dependent Long-Term Depression

2000 • 922 citations

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

1998 • 872 citations

Translational Control by MAPK Signaling in Long-Term Synaptic Plasticity and Memory

2004 • 828 citations

The cap and poly(A) tail function synergistically to regulate mRNA translational efficiency.

1991 • 795 citations

A Critical Period for Macromolecular Synthesis in Long-Term Heterosynaptic Facilitation in Aplysia

1986 • 767 citations

Identification and Characterization of Pancreatic Eukaryotic Initiation Factor 2 α-Subunit Kinase, PEK, Involved in Translational Control

1998 • 763 citations

FMR1 Protein: Conserved RNP Family Domains and Selective RNA Binding

1993 • 721 citations

Gene-Specific Regulation by General Translation Factors

2002 • 720 citations

A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus

2001 • 705 citations

Ribosomal S6 Kinase Signaling and the Control of Translation

1999 • 679 citations

PHAS-I as a Link Between Mitogen-Activated Protein Kinase and Translation Initiation

1994 • 672 citations

The Fragile X Syndrome Protein FMRP Associates with BC1 RNA and Regulates the Translation of Specific mRNAs at Synapses

2003 • 672 citations

Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation.

1996 • 671 citations

Preferential localization of polyribosomes under the base of dendritic spines in granule cells of the dentate gyrus

1982 • 665 citations

Drosophila Fragile X-Related Gene Regulates the MAP1B Homolog Futsch to Control Synaptic Structure and Function

2001 • 648 citations

Fragile X mental retardation protein is translated near synapses in response to neurotransmitter activation

1997 • 636 citations

Dynamic Visualization of Local Protein Synthesis in Hippocampal Neurons

2001 • 602 citations

Evidence that fragile X mental retardation protein is a negative regulator of translation

2001 • 573 citations

EUKARYOTIC PROTEIN SYNTHESIS

1985 • 538 citations

Fragile X Mental Retardation Protein: Nucleocytoplasmic Shuttling and Association with Somatodendritic Ribosomes

1997 • 534 citations

A Transient, Neuron-Wide Form of CREB-Mediated Long-Term Facilitation Can Be Stabilized at Specific Synapses by Local Protein Synthesis

1999 • 510 citations

Activation of the Phosphoinositide 3-Kinase-Akt-Mammalian Target of Rapamycin Signaling Pathway Is Required for Metabotropic Glutamate Receptor-Dependent Long-Term Depression

2004 • 504 citations

CPEB-Mediated Cytoplasmic Polyadenylation and the Regulation of Experience-Dependent Translation of α-CaMKII mRNA at Synapses

1998 • 485 citations

Phosphorylation of the Cap-Binding Protein Eukaryotic Translation Initiation Factor 4E by Protein Kinase Mnk1 In Vivo

1999 • 449 citations

The fragile X mental retardation protein inhibits translation via interacting with mRNA

2001 • 445 citations

A Neuronal Isoform of CPEB Regulates Local Protein Synthesis and Stabilizes Synapse-Specific Long-Term Facilitation in Aplysia

2003 • 426 citations

Chemical Induction of mGluR5- and Protein Synthesis–Dependent Long-Term Depression in Hippocampal Area CA1

2001 • 384 citations

Maskin Is a CPEB-Associated Factor that Transiently Interacts with eIF-4E

1999 • 379 citations

Phosphorylation of CPE binding factor by Eg2 regulates translation of c-mos mRNA

2000 • 373 citations

NMDA receptor-mediated control of protein synthesis at developing synapses

2000 • 365 citations

Chemical Stimulation of Synaptosomes Modulates α-Ca²⁺/Calmodulin-Dependent Protein Kinase II mRNA Association to Polysomes

2000 • 359 citations

Eukaryotic translation initiation factors and regulators

2003 • 331 citations

Does phosphorylation of the cap‐binding protein eIF4E play a role in translation initiation?

2002 • 296 citations

Time-restricted role for dendritic activation of the mTOR-p70 ^S6K pathway in the induction of late-phase long-term potentiation in the CA1

2003 • 295 citations

Chromatographic resolution of in vivo phosphorylated and nonphosphorylated eukaryotic translation initiation factor eIF-4E: increased cap affinity of the phosphorylated form.

1994 • 285 citations

A Mammalian Homologue of GCN2 Protein Kinase Important for Translational Control by Phosphorylation of Eukaryotic Initiation Factor-2α

2000 • 276 citations

Functional properties of phosphorylated elongation factor 2

1990 • 274 citations

The brain-derived neurotrophic factor enhances synthesis of Arc in synaptoneurosomes

2002 • 266 citations

Phosphatidylinositol 3-Kinase Is Required for the Expression But Not for the Induction or the Maintenance of Long-Term Potentiation in the Hippocampal CA1 Region

2002 • 254 citations

Phosphorylation of Eukaryotic Initiation Factor 4E Markedly Reduces Its Affinity for Capped mRNA

2002 • 252 citations

Extracellular Signal-Regulated Protein Kinase Activation Is Required for Metabotropic Glutamate Receptor-Dependent Long-Term Depression in Hippocampal Area CA1

2004 • 247 citations

Phosphorylation of CPEB by Eg2 Mediates the Recruitment of CPSF into an Active Cytoplasmic Polyadenylation Complex

2000 • 238 citations

Visualization of the Distribution of Autophosphorylated Calcium/Calmodulin-Dependent Protein Kinase II after Tetanic Stimulation in the CA1 Area of the Hippocampus

1997 • 234 citations

Transduction of Growth or Mitogenic Signals into Translational Activation of TOP mRNAs Is Fully Reliant on the Phosphatidylinositol 3-Kinase-Mediated Pathway but Requires neither S6K1 nor rpS6 Phosphorylation

2002 • 230 citations

Dual MAP kinase pathways mediate opposing forms of long-term plasticity at CA3–CA1 synapses

2000 • 223 citations

Phosphatidylinositol 3-Kinase Regulates the Induction of Long-Term Potentiation through Extracellular Signal-Related Kinase-Independent Mechanisms

2003 • 219 citations

Dissolution of the maskin-eIF4E complex by cytoplasmic polyadenylation and poly(A)-binding protein controls cyclin B1 mRNA translation and oocyte maturation

2002 • 217 citations

Brief theta-burst stimulation induces a transcription-dependent late phase of LTP requiring cAMP in area CA1 of the mouse hippocampus.

1997 • 209 citations

Signaling and Transcriptional Mechanisms in Pituitary Development

2001 • 208 citations

New insights into fragile X syndrome: from molecules to neurobehaviors

2003 • 201 citations

Brain-derived Neurotrophic Factor Enhances Neuronal Translation by Activating Multiple Initiation Processes

2001 • 199 citations

Purified Recombinant Fmrp Exhibits Selective RNA Binding as an Intrinsic Property of the Fragile X Mental Retardation Protein

1998 • 193 citations

Regulation of elongation factor‐2 by multisite phosphorylation

1993 • 181 citations

Translation initiation: adept at adapting

1999 • 165 citations

Glutamate-dependent phosphorylation of elongation factor-2 and inhibition of protein synthesis in neurons.

1997 • 163 citations

A Role for the Cytoplasmic Polyadenylation Element in NMDA Receptor-Regulated mRNA Translation in Neurons

2001 • 161 citations

Internal initiation of translation of five dendritically localized neuronal mRNAs

2001 • 160 citations

Glutamate-Dependent Phosphorylation of Elongation Factor-2 and Inhibition of Protein Synthesis in Neurons

1997 • 159 citations

Selective Modulation of Some Forms of Schaffer Collateral-CA1 Synaptic Plasticity in Mice With a Disruption of the CPEB-1 Gene

2004 • 158 citations

Mechanism of elongation factor 2 (EF‐2) inactivation upon phosphorylation Phosphorylated EF‐2 is unable to catalyze translocation

1989 • 157 citations

Poly(A)-binding Protein is Associated with Neuronal BC1 and BC200 Ribonucleoprotein Particles

2002 • 148 citations

Long-term potentiation in dentate gyrus of the rat is inhibited by the phosphoinositide 3–kinase inhibitor, wortmannin

2000 • 147 citations

Sunrise at the Synapse

2003 • 120 citations

Mitogen-Activated Protein Kinase Regulates Early Phosphorylation and Delayed Expression of Ca²⁺/Calmodulin-Dependent Protein Kinase II in Long-Term Potentiation

2001 • 109 citations

NMDA receptor activation results in PKA‐ and ERK‐dependent Mnk1 activation and increased eIF4E phosphorylation in hippocampal area CA1

2004 • 105 citations

22 Translational Control of TOP mRNAs

2000 • 103 citations

Extracellular Signal-Regulated Kinase, Synaptic Plasticity, and Memory

2001 • 100 citations

Phosphorylation and Local Presynaptic Protein Synthesis in Calcium- and Calcineurin-Dependent Induction of Crayfish Long-Term Facilitation

2001 • 98 citations

Structural Features of Human Initiation Factor 4E, Studied by X-ray Crystal Analyses and Molecular Dynamics Simulations

2003 • 94 citations

Adenylyl cyclase-dependent form of chemical long-term potentiation triggers translational regulation at the elongation step

2003 • 79 citations

The Group I Metabotropic Glutamate Receptor Agonist (S)-3,5-Dihydroxyphenylglycine Induces a Novel Form of Depotentiation in the CA1 Region of the Hippocampus

2002 • 78 citations

Localization of translational components at the ultramicroscopic level at postsynaptic sites of the rat brain

2003 • 75 citations

Cloning and characterization of cDNA encoding rat hemin-sensitive initiation factor-2 alpha (eIF-2 alpha) kinase. Evidence for multitissue expression.

1994 • 72 citations

N -methyl- <scp>d</scp> -aspartate receptor activation and visual activity induce elongation factor-2 phosphorylation in amphibian tecta: A role for N -methyl- <scp>d</scp> -aspartate receptors in controlling protein synthesis

1997 • 70 citations

Serotonin activates S6 kinase in a rapamycin-sensitive manner in Aplysia synaptosomes.

2001 • 65 citations

Serotonin Activates S6 Kinase in a Rapamycin-Sensitive Manner inAplysiaSynaptosomes

2001 • 63 citations

27 Influence of Polyadenylation-induced Translation on Metazoan Development and Neuronal Synaptic Function

2000 • 63 citations

An activity-dependent switch to cap-independent translation triggered by eIF4E dephosphorylation

2003 • 60 citations

Eukaryotic Initiation Factor 2α Kinase and Phosphatase Activity during Postischemic Brain Reperfusion

1999 • 52 citations

The cytoplasmic polyadenylation element binding protein and polyadenylation of messenger RNA in Aplysia neurons

2002 • 43 citations

A novel actin cDNA is expressed in the neurons of Aplysia californica

1994 • 33 citations

Regulation of Eukaryotic Initiation Factor 4E Phosphorylation in the Nervous System of Aplysia californica

2000 • 24 citations

Cellular and subcellular distributions of translation initiation, elongation and release factors in rat hippocampus

2003 • 15 citations

Influence of the Length of the Phosphate Chain in mRNA 5′ Cap Analogues on Their Interaction with Eukaryotic Initiation Factor 4E

2003 • 5 citations

Protein Processing and Plasticity

2003 • 1 citations