Single-channel evidence for glycine and NMDA requirement in NMDA receptor activation

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

A synaptic model of memory: long-term potentiation in the hippocampus

1993 • 11,303 citations

Magnesium gates glutamate-activated channels in mouse central neurones

1984 • 3,999 citations

Cloned Glutamate Receptors

1994 • 3,989 citations

Glycine potentiates the NMDA response in cultured mouse brain neurons

1987 • 3,116 citations

Enzyme structure and mechanism

1977 • 2,935 citations

Enzyme structure and mechanism

1978 • 2,897 citations

Single-Channel Recording

1995 • 2,565 citations

Molecular Diversity of Glutamate Receptors and Implications for Brain Function

1992 • 2,535 citations

Excitatory amino acid neurotoxicity and neurodegenerative disease

1990 • 1,781 citations

Molecular cloning and characterization of the rat NMDA receptor

1991 • 1,780 citations

Requirement for Glycine in Activation of NMDA-Receptors Expressed in Xenopus Oocytes

1988 • 1,415 citations

Molecular diversity of the NMDA receptor channel

1992 • 1,354 citations

2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a Neuroprotectant for Cerebral Ischemia

1990 • 1,125 citations

Rat hippocampal neurons in dispersed cell culture

1977 • 1,106 citations

Fitting and Statistical Analysis of Single-Channel Records

1983 • 1,098 citations

N-methyl-D-aspartic acid receptor structure and function

1994 • 989 citations

Single channel recording

1984 • 981 citations

Permeation and block of N‐methyl‐D‐aspartic acid receptor channels by divalent cations in mouse cultured central neurones.

1987 • 934 citations

Blockade of "NMDA" Receptors Disrupts Experience-Dependent Plasticity of Kitten Striate Cortex

1987 • 920 citations

Excitatory amino acid receptors and synaptic plasticity

1990 • 872 citations

Data transformations for improved display and fitting of single-channel dwell time histograms

1987 • 828 citations

The role of divalent cations in the N‐methyl‐D‐aspartate responses of mouse central neurones in culture.

1988 • 810 citations

Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs

1992 • 805 citations

A Glycine Site Associated with N‐Methyl‐<scp>d</scp>‐Aspartic Acid Receptors: Characterization and Identification of a New Class of Antagonists

1989 • 723 citations

Glutamate activates multiple single channel conductances in hippocampal neurons

1987 • 691 citations

On the stochastic properties of bursts of single ion channel openings and of clusters of bursts

1982 • 564 citations

Energetics of Ligand Binding to Proteins

1975 • 519 citations

7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex.

1988 • 517 citations

Two classes of N-methyl-D-aspartate recognition sites: differential distribution and differential regulation by glycine.

1988 • 495 citations

A receptor for protons in the nerve cell membrane

1980 • 494 citations

The glycine site of the NMDA receptor — five years on

1993 • 440 citations

Excitatory amino acid receptors in epilepsy

1990 • 428 citations

Multiple-conductance channels activated by excitatory amino acids in cerebellar neurons

1987 • 420 citations

Regulation of NMDA receptor desensitization in mouse hippocampal neurons by glycine

1989 • 408 citations

Activation of multiple-conductance state chloride channels in spinal neurones by glycine and GABA

1983 • 402 citations

Mechanisms of excitotoxicity in neurologic diseases

1992 • 382 citations

Involvement of the N -Methyl D-Aspartate (NMDA) Receptor in Synapse Elimination During Cerebellar Development

1992 • 308 citations

Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord

1982 • 302 citations

L-Glutamate has higher affinity than other amino acids for [3H]-D-AP5 binding sites in rat brain membranes

1984 • 293 citations

Actions of ketamine, phencyclidine and MK‐801 on NMDA receptor currents in cultured mouse hippocampal neurones.

1991 • 278 citations

Single-channel conductances of NMDA receptors expressed from cloned cDNAs: comparison with native receptors

1992 • 261 citations

Glycine enhances NMDA-receptor mediated synaptic potentials in neocortical slices

1989 • 234 citations

Glycine potentiates strychnine-induced convulsions: role of NMDA receptors

1988 • 227 citations

Sites for Antagonism on the N-Methyl-D-Aspartate Receptor Channel Complex

1991 • 216 citations

A kinetic analysis of the modulation of N‐methyl‐D‐aspartic acid receptors by glycine in mouse cultured hippocampal neurones.

1990 • 216 citations

Sampling, log binning, fitting, and plotting durations of open and shut intervals from single channels and the effects of noise

1987 • 207 citations

Modulation of N‐methyl‐D‐aspartic acid receptor desensitization by glycine in mouse cultured hippocampal neurones.

1990 • 199 citations

Selective blockade of N-methyl-D-aspartate (NMDA)-induced convulsions by NMDA antagonists and putative glycine antagonists: relationship with phencyclidine-like behavioral effects.

1990 • 198 citations

Activation of N‐methyl‐D‐aspartate receptors by L‐glutamate in cells dissociated from adult rat hippocampus.

1992 • 182 citations

Glycine is a coagonist at the NMDA receptor/channel complex

1990 • 172 citations

Glycine reverses antagonism of N-methyl-D-aspartate (NMDA) by 1-hydroxy-3-aminopyrrolidone-2 (HA-966) but not by D-2-amino-5-phophonovalerate (D-AP5) on rat cortical slices

1988 • 162 citations

Spontaneous openings of the acetylcholine receptor channel.

1984 • 162 citations

Interactions between the glycine and glutamate binding sites of the NMDA receptor

1993 • 141 citations

Biochemical evidence that glycine allosterically regulates an NMDA receptor-coupled ion channel

1987 • 140 citations

Competitive antagonists and partial agonists at the glycine modulatory site of the mouse N‐methyl‐D‐aspartate receptor.

1990 • 139 citations

Indole-2-Carboxylic Acid: A Competitive Antagonist of Potentiation by Glycine at the NMDA Receptor

1989 • 138 citations

Excitatory amino acids in epilepsy and potential novel therapies

1992 • 131 citations

Currents through single glutamate receptor channels in outside‐out patches from rat cerebellar granule cells.

1991 • 129 citations

Excitatory Amino Acids and Neuronal Plasticity

1990 • 121 citations

Glycine decreases desensitization of N-methyl-D-aspartate (NMDA) receptors expressed in Xenopus oocytes and is required for NMDA responses.

1990 • 117 citations

[3H]CPP, a new competitive ligand for NMDA receptors

1986 • 108 citations

Characterization df a [³H]Glycine Recognition Site as a Modulatory Site of the N‐Methyl‐D‐Aspartate Receptor Complex

1989 • 106 citations

Modulation of NMDA receptor-mediated responses by glycine and d-serine in the rat thalamus in vivo

1989 • 105 citations

Activity of 5,7-dichlorokynurenic acid, a potent antagonist at the N-methyl-D-aspartate receptor-associated glycine binding site.

1990 • 102 citations

Glutamate activation of a single NMDA receptorchannel produces a cluster of channel openings

1991 • 99 citations

Statistical discrimination of fractal and Markov models of single-channel gating

1988 • 95 citations

N-methyl-D-aspartate/glycine and quisqualate/kainate receptors expressed in Xenopus oocytes: antagonist pharmacology.

1989 • 90 citations

Selectivity of quinoxalines and kynurenines as antagonists of the glycine site on N-methyl-D-aspartate receptors.

1989 • 89 citations

Polyamines regulate glycine interaction with the N‐methyl‐<scp>D</scp>‐aspartate receptor

1990 • 80 citations

Selectivity of amino acid transmitters acting at N-methyl-D-aspartate and amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors.

1992 • 70 citations

[3H]5,7-Dichlorokynurenic acid, a novel radioligand labels NMDA receptor-associated glycine binding sites

1991 • 66 citations

The effect of NMDA receptor glycine site antagonists on hypoxia-induced neurodegeneration of rat cortical cell cultures

1990 • 66 citations

Kynurenic acid analogues with improved affinity and selectivity for the glycine site on the N-methyl-D-aspartate receptor from rat brain.

1992 • 63 citations

Dual effect of glycine on NMDA-induced neurotoxicity in rat cortical cultures

1990 • 61 citations

Calcium‐activated potassium channels in rat muscle inactivate from a short‐duration open state.

1985 • 57 citations

Concentration-jump experiments with NMDA antagonists in mouse cultured hippocampal neurons

1990 • 57 citations

Evidence for glycine modulation of excitatory synaptic inputs to retinal ganglion cells

1995 • 50 citations

N‐Methyl‐D‐Aspartate Recognition Site Ligands Modulate Activity at the Coupled Glycine Recognition Site

1990 • 47 citations

Glycine-insensitive NMDA-sensitive receptor expressed in Xenopus oocytes by guinea pig cerebellar mRNA

1990 • 44 citations

Allosteric Modulation of N-Methyl-D-Aspartate Receptors

1990 • 43 citations

5,7-Dichlorokynurenic acid, a potent and selective competitive antagonist of the glycine site on NMDA receptors

1990 • 42 citations

Potent indole- and quinoline-containing N-methyl-D-aspartate antagonists acting at the strychnine-insensitive glycine binding site.

1992 • 39 citations

The Glycine Coagonist Site of the NMDA Receptor

1990 • 39 citations

Glycine is required for NMDA receptor activation: electrophysiological evidence from intact rat hippocampus

1992 • 36 citations

Desensitization of N-methyl-D-aspartate receptors in neurons dissociated from adult rat hippocampus.

1991 • 32 citations

[53] Preventing artifacts and reducing errors in single-channel analysis

1992 • 28 citations

Burst kinetics of single NMDA receptor currents in cell‐attached patches from rat brain cortical neurons in culture.

1995 • 26 citations