Corticolimbic Dopamine Neurotransmission Is Temporally Dissociated from the Cognitive and Locomotor Effects of Phencyclidine

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

AChE-stained horizontal sections of the rat brain in stereotaxic coordinates

1980 • 4,422 citations

Subanesthetic Effects of the Noncompetitive NMDA Antagonist, Ketamine, in Humans

1994 • 3,182 citations

Recent advances in the phencyclidine model of schizophrenia

1991 • 2,886 citations

Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex

1997 • 1,743 citations

Glutamate Receptor Dysfunction and Schizophrenia

1995 • 1,682 citations

Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects.

1996 • 1,275 citations

Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: Evidence from a novel positron emission tomography method

1997 • 1,147 citations

Study of a New Schizophrenomimetic Drug—Sernyl

1959 • 922 citations

Supranormal Stimulation of D₁Dopamine Receptors in the Rodent Prefrontal Cortex Impairs Spatial Working Memory Performance

1997 • 805 citations

Selective 60HDA-induced destruction of mesolimbic dopamine neurons: Abolition of psychostimulant-induced locomotor activity in rats

1976 • 706 citations

NMDA Receptor Function and Human Cognition: The Effects of Ketamine in Healthy Volunteers

1996 • 667 citations

Role of cortical N-methyl-D-aspartate receptors in auditory sensory memory and mismatch negativity generation: implications for schizophrenia.

1996 • 647 citations

Dopamine Axon Varicosities in the Prelimbic Division of the Rat Prefrontal Cortex Exhibit Sparse Immunoreactivity for the Dopamine Transporter

1998 • 578 citations

Amphetamine, cocaine, phencyclidine and nomifensine increase extracellular dopamine concentrations preferentially in the nucleus accumbens of freely moving rats

1989 • 562 citations

NMDA receptor antagonists impair prefrontal cortex function as assessed via spatial delayed alternation performance in rats: modulation by dopamine

1996 • 450 citations

The NMDA antagonist MK-801 causes marked locomotor stimulation in monoamine-depleted mice

1989 • 426 citations

Effects of 6-hydroxydopamine lesions of the nucleus accumbens septi and olfactory tubercle on feeding, locomotor activity, and amphetamine anorexia in the rat.

1978 • 421 citations

Concomitant characterization of behavioral and striatal neurotransmitter response to amphetamine using in vivo microdialysis

1989 • 402 citations

Enduring Cognitive Deficits and Cortical Dopamine Dysfunction in Monkeys After Long-Term Administration of Phencyclidine

1997 • 401 citations

Brain microdialysis of GABA and glutamate: What does it signify?

1997 • 393 citations

The pharmacology of mesolimbic dopamine neurons: a dual-probe microdialysis study in the ventral tegmental area and nucleus accumbens of the rat brain

1996 • 376 citations

Clozapine antagonizes phencyclidine-induced deficits in sensorimotor gating of the startle response.

1994 • 334 citations

Rewarding Actions of Phencyclidine and Related Drugs in Nucleus Accumbens Shell and Frontal Cortex

1996 • 331 citations

Subchronic Phencyclidine Administration Reduces Mesoprefrontal Dopamine Utilization and Impairs Prefrontal Cortical-Dependent Cognition in the Rat

1997 • 320 citations

Functional synergism between putative gamma-aminobutyrate-containing neurons and pyramidal neurons in prefrontal cortex.

1994 • 318 citations

Synaptic Regulation of Mesocorticolimbic Dopamine Neurons

1996 • 289 citations

Characterization of the Dopaminergic Innervation of the Primate Frontal Cortex Using a Dopamine-specific Antibody

1993 • 283 citations

Excitatory amino acid receptors in hippocampal neurons: Kainate fails to desensitize them

1986 • 271 citations

6-Hydroxydopamine lesion of the rat prefrontal cortex increases locomotor activity, impairs acquisition of delayed alternation tasks, but does not affect uninterrupted tasks in the radial maze

1990 • 253 citations

Phencyclidine-induced stereotyped behaviour and social isolation in rats

1996 • 248 citations

Behavioral rating scales for assessing phencyclidine-induced locomotor activity, stereotypes behavior and ataxia in rats

1979 • 236 citations

Cocaine: An in vivo microdialysis evaluation of its acute action on dopamine transmission in rat striatum

1989 • 218 citations

Blockade of phencyclidine-induced hyperlocomotion by olanzapine, clozapine and serotonin receptor subtype selective antagonists in mice

1997 • 216 citations

Direct Measurement of AMPA Receptor Desensitization Induced by Glutamatergic Synaptic Transmission

1996 • 209 citations

Glutamate Modulation of Dopamine Measured in Vivo with Positron Emission Tomography (PET) and 11C-Raclopride in Normal Human Subjects

1998 • 199 citations

Effects of NMDA antagonism on striatal dopamine release in healthy subjects: Application of a novel PET approach

1998 • 197 citations

Failure of haloperidol to block the effects of phencyclidine and dizocilpine on prepulse inhibition of startle

1991 • 189 citations

Differential effects of single and repeated ketamine administration on dopamine, serotonin and GABA transmission in rat medial prefrontal cortex

1997 • 172 citations

The behavioral and neurochemical effects of phencyclidine in humans and animals: some implications for modeling psychosis

1996 • 169 citations

Neuropharmacology of Phencyclidine: Basic Mechanisms and Therapeutic Potential

1990 • 160 citations

Observations on the psychotomimetic effects of sernyl

1961 • 159 citations

Differential effect of cocaine on extracellular dopamine levels in rat medial prefrontal cortex and nucleus accumbens: Comparison to amphetamine

1989 • 156 citations

Glutamatergic Regulation of Basal and Stimulus‐Activated Dopamine Release in the Prefrontal Cortex

1998 • 145 citations

Activation and Desensitization of Hippocampal Kainate Receptors

1997 • 144 citations

Mesolimbic and mesocortical dopamine activation induced by phencyclidine: contrasting pattern to striatal response

1987 • 133 citations

Excitatory Amino Acid Receptors in the Ventral Tegmental Area Regulate Dopamine Release in the Ventral Striatum

1996 • 130 citations

Perspectives

1976 • 129 citations

The Effect of 1-Arylcyclohexylamine (Sernyl) on Twelve Normal Volunteers

1960 • 125 citations

Effects of d-amphetamine and phencyclidine on behavior and extracellular concentrations of neurotensin and dopamine in the ventral striatum and the medial prefrontal cortex of the rat

1995 • 123 citations

Effect of phenycyclidine on dopamine release in the rat prefrontal cortex; an in vivo microdialysis study

1994 • 120 citations

Phencyclidine- and Dizocilpine-Induced Hyperlocomotion Are Differentially Mediated

1994 • 113 citations

The role of nucleus accumbens dopamine in the neurochemical and behavioral effects of phencyclidine: a microdialysis and behavioral study

1993 • 106 citations

Anxiogenic drugs beta-CCE and FG 7142 increase extracellular dopamine levels in nucleus accumbens

1992 • 104 citations

Dopamine receptor antagonists block amphetamine and phencyclidine-induced motor stimulation in rats

1994 • 96 citations

The glycine/NMDA receptor antagonist, R‐(+)‐HA‐966, blocks activation of the mesolimbic dopaminergic system induced by phencyclidine and dizocilpine (MK‐801) in rodents

1993 • 94 citations

Regulation of glutamate efflux by excitatory amino acid receptors: evidence for tonic inhibitory and phasic excitatory regulation.

1995 • 91 citations

The role of dopamine and AMPA/kainate receptors in the nucleus accumbens in the hypermotility response to MK801

1993 • 90 citations

The effect of phencyclidine on dopamine synthesis and metabolism in rat striatum

1980 • 85 citations

Desensitization of Kainate Receptors by Kainate, Glutamate and Diastereomers of 4-Methylglutamate

1997 • 82 citations

The effects of haloperidol and clozapine on PCP- and amphetamine-induced suppression of social behavior in the rat

1994 • 80 citations

Characterization of Excitatory Amino Acid Modulation of Dopamine Release in the Prefrontal Cortex of Conscious Rats

1996 • 78 citations

Selective memory impairment by phencyclidine in rats

1987 • 77 citations

Differential effects of phencyclidine and methamphetamine on dopamine metabolism in rat frontal cortex and striatum as revealed by in vivo dialysis

1996 • 77 citations

[Dopaminergic A10 neurons and frontal system (author's transl)].

1981 • 70 citations

Differential effect of ketamine on the reference and working memory versions of the Morris water maze task.

1990 • 68 citations

MK-801 increases locomotor activity without elevating extracellular dopamine levels in the nucleus accumbens

1996 • 67 citations

Phencyclidine-induced stereotyped behavior in monkeys: Antagonism by pimozide

1978 • 66 citations

Acute and chronic behavioral interactions between phencyclidine (PCP) and amphetamine: Evidence for a dopaminergic role in some PCP-induced behaviors

1985 • 66 citations

Locomotor activation induced by MK-801 in the rat: postsynaptic interactions with dopamine receptors in the ventral striatum

1994 • 65 citations

Effects of Risperidone on Phencyclidine-Induced Behaviors: Comparison with Haloperidol and Ritanserin

1994 • 63 citations

Phencyclidine and the midbrain dopamine system: Electrophysiology and behavior

1994 • 61 citations

Resistance of the Dopamine D2LReceptor to Desensitization Accompanies the Up-Regulation of Receptors on to the Surface of Sf9 Cells1

1997 • 60 citations

Effects of dopaminergic drugs on phencyclidine-induced behavior in the rat

1981 • 59 citations

Effects of drugs of abuse and cholinergic agents on delayed matching-to-sample responding in the squirrel monkey.

1993 • 58 citations

Neuropharmacological studies of phencyclidine (PCP)-induced behavioral stimulation in mice

1980 • 57 citations

Differential effect of ketamine on the reference and working memory versions of the Morris water maze task.

1990 • 56 citations

Interactions between excitatory amino acids and dopamine systems in the forebrain

1995 • 55 citations

Extracellular dopamine and amphetamine after systemic amphetamine administration: comparison to the behavioral response.

1997 • 53 citations

The non-NMDA glutamate receptor antagonist GYKI 52466 counteracts locomotor stimulation and anticataleptic activity induced by the NMDA antagonist dizocilpine

1993 • 53 citations

Medial prefrontal cortex lesions and spatial delayed alternation in the developing rat: Recovery of sparing?

1992 • 52 citations

Differential effects of CGP 37849 and MK-801, competitive and noncompetitive NMDA antagonists, with respect to the modulation of sensorimotor gating and dopamine outflow in the prefrontal cortex of rats

1994 • 49 citations

DNQX inhibits phencyclidine (PCP) and ketamine induction of the hsp70 heat shock gene in the rat cingulate and retrosplenial cortex

1995 • 44 citations

Behavioural and neurochemical interactions of the AMPA antagonist GYKI 52466 and the non-competitive NMDA antagonist dizocilpine in rats

1995 • 43 citations

Paradoxical regulation of dopamine receptors in transfected 293 cells.

1993 • 42 citations

Phlorrhizin diabetes in fasting or fed hypophysectomized dogs

1932 • 42 citations

Memory: Recording experience in cells and circuits: Diversity in memory research

1996 • 41 citations

Excitatory amino acid receptors mediate the orofacial stereotypy elicited by dopaminergic stimulation of the ventrolateral striatum

1994 • 40 citations

Medial prefrontal cortex lesions and spatial delayed alternation in the developing rat: Recovery of sparing?

1992 • 33 citations

Effect of NE-100, a novel σ receptor ligand, on phencyclidine-induced cognitive dysfunction

1994 • 33 citations

Behavioral effects of phencyclidine and ketamine alone and in combination with other drugs

1987 • 30 citations

Resistance of the Dopamine D2L Receptor to Desensitization Accompanies the Up-Regulation of Receptors on to the Surface of Sf9 Cells

1997 • 28 citations

Effects of N-allylnormetazocine (skf 10,047), phencyclidine, and other psychomotor stimulants in the rat following 6-hydroxydopamine lesion of the ventral tegmental area

1986 • 25 citations

Concurrent locomotor stimulation and decrease in dopamine release in rats and mice after treatment with the competitive NMDA receptor antagonists D-CPPene and CGS 19755

1996 • 25 citations

Characterization of two central AMPA-preferring receptors having distinct location, function and pharmacology

1994 • 22 citations

Effects of and interactions between antagonists for different sites on the NMDA receptor complex on hippocampal and striatal acetylcholine efflux in vivo

1996 • 20 citations

Modulating ketamine-induced thought disorder with lorazepam and haloperidol in humans

1995 • 10 citations

The Dopaminergic and Glutamatergic Systems in Schizophrenia

1990 • 5 citations