Effects of (S)-ketamine on striatal dopamine: a [11C]raclopride PET study of a model psychosis in humans

Subanesthetic Effects of the Noncompetitive NMDA Antagonist, Ketamine, in Humans

1994 • 3,182 citations

Simplified Reference Tissue Model for PET Receptor Studies

1996 • 1,980 citations

The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N‐methyl‐aspartate

1983 • 1,400 citations

Distribution of N-methyl-D-aspartate-sensitive L-[3H]glutamate-binding sites in rat brain

1985 • 1,294 citations

Study of a New Schizophrenomimetic Drug—Sernyl

1959 • 922 citations

Pharmacologic effects of CI‐581, a new dissociative anesthetic, in man

1965 • 717 citations

Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia

1980 • 703 citations

Ketamine-Induced Exacerbation of Psychotic Symptoms and Cognitive Impairment in Neuroleptic-Free Schizophrenics

1997 • 670 citations

NMDA Receptor Function and Human Cognition: The Effects of Ketamine in Healthy Volunteers

1996 • 667 citations

ARCHIVES OF NEUROLOGY AND PSYCHIATRY

1923 • 584 citations

The Standardized Psychometric Assessment of Altered States of Consciousness (ASCs) in Humans

1998 • 510 citations

Comparison of Methods for Analysis of Clinical [¹¹C]Raclopride Studies

1996 • 461 citations

NMDA receptor antagonists impair prefrontal cortex function as assessed via spatial delayed alternation performance in rats: modulation by dopamine

1996 • 450 citations

Effects of ketamine on sensory perception: evidence for a role of N-methyl-D-aspartate receptors.

1992 • 412 citations

Association of ketamine-induced psychosis with focal activation of the prefrontal cortex in healthy volunteers

1997 • 393 citations

Frontal Cortical and Left Temporal Glutamatergic Dysfunction in Schizophrenia

1989 • 392 citations

Differential psychopathology and patterns of cerebral glucose utilisation produced by (S)- and (R)-ketamine in healthy volunteers using positron emission tomography (PET)

1997 • 388 citations

Prefrontal cortex regulates burst firing and transmitter release in rat mesolimbic dopamine neurons studied in vivo

1993 • 386 citations

Metabolic hyperfrontality and psychopathology in the ketamine model of psychosis using positron emission tomography (PET) and [18F]fluorodeoxyglucose (FDG)

1997 • 349 citations

SPECT imaging of striatal dopamine release after amphetamine challenge.

1995 • 330 citations

Striatal binding of the PET ligand ¹¹C‐raclopride is altered by drugs that modify synaptic dopamine levels

1993 • 285 citations

5-HT Modulation of Dopamine Release in Basal Ganglia in Psilocybin-Induced Psychosis in Man—A PET Study with [11C]raclopride

1999 • 277 citations

(3H]MK-801 binding sites in postmortem brain regions of schizophrenic patients

1989 • 250 citations

Increased frontal and reduced parietal glucose metabolism in acute untreated schizophrenia

1989 • 201 citations

Glutamate Modulation of Dopamine Measured in Vivo with Positron Emission Tomography (PET) and 11C-Raclopride in Normal Human Subjects

1998 • 199 citations

Effects of NMDA antagonism on striatal dopamine release in healthy subjects: Application of a novel PET approach

1998 • 197 citations

Reproducibility of repeated measures of carbon-11-raclopride binding in the human brain.

1993 • 183 citations

Differential Control by N‐Methyl‐D‐Aspartate and Kainate of Striatal Dopamine Release In Vivo: A Trans‐Striatal Dialysis Study

1988 • 175 citations

Correlation of positive symptoms exclusively to hyperperfusion or hypoperfusion of cerebral cortex in never-treated schizophrenics

1997 • 171 citations

Topographical distribution of possible glutamatergic pathways from the frontal cortex to the striatum and substantia nigra in rats

1982 • 171 citations

Mode of Action of Atypical Neuroleptics in Relation to the Phencyclidine Model of Schizophrenia: Role of 5-HT2 Receptor and α1-Adrenoreceptor Antagonism

1995 • 154 citations

Prazosin inhibits MK-801-induced hyperlocomotion and dopamine release in the nucleus accumbens

1996 • 125 citations

Effects of d-amphetamine and phencyclidine on behavior and extracellular concentrations of neurotensin and dopamine in the ventral striatum and the medial prefrontal cortex of the rat

1995 • 123 citations

MK-801, phencyclidine (PCP), and PCP-like drugs increase burst firing in rat A10 dopamine neurons: Comparison to competitive NMDA antagonists

1993 • 122 citations

Regional effects of MK-801 on dopamine release: effects of competitive NMDA or 5-HT2A receptor blockade.

1996 • 117 citations

Increases in strychnine-insensiive glycine binding sites in cerebral cortex of chronic schizophrenics: Evidence for glutamate hypothesis

1994 • 114 citations

Effects of dizocilpine (MK-801) on rat midbrain dopamine cell activity: differential actions on firing pattern related to anatomical localization

1993 • 111 citations

MK-801 elevates the etracellular concentration of dopamine in the rat prefrontal cortex and increases the density of striatal dopamine D1 receptors

1993 • 92 citations

Alterations in phencyclidine and sigma binding sites in schizophrenic brains

1991 • 90 citations

Prefrontal dysfunction in young acute neuroleptic-naive schizophrenic patients: A resting and activation SPECT study

1994 • 89 citations

NMDA receptor related agents : biochemistry, pharmacology and behavior

1991 • 86 citations

Differential effects of phencyclidine and methamphetamine on dopamine metabolism in rat frontal cortex and striatum as revealed by in vivo dialysis

1996 • 77 citations

Deficient NMDA-mediated glutamate release from synaptosomes of schizophrenics

1991 • 71 citations

The role ofN-methyl-d-aspartate receptors in the regulation of physiologically released dopamine

1995 • 61 citations

Hypofrontality revisited: a high resolution single photon emission computed tomography study in schizophrenia.

1995 • 58 citations

Hallucinogenic drug induced states resemble acute endogenous psychoses: results of an empirical study

1998 • 58 citations

Inhibitory Effect of MK-801 on Amantadine-Induced Dopamine Release in the Rat Striatum

1996 • 50 citations

Effects of phencyclidine, MK-801 and 1,3-di(2-tolyl) guanidine on non-dopaminergic midbrain neurons

1993 • 47 citations

The chiral forms of ketamine as probes for NMDA receptor functions in humans

1991 • 44 citations

Prazosin modulates the changes in firing pattern and transmitter release induced by raclopride in the mesolimbic, but not in the nigrostriatal dopaminergic system

1994 • 43 citations

The Study of Neurotransmitter Interactions Using Positron Emission Tomography and Functional Coupling

1996 • 19 citations

Alterations in striatal dopamine overflow during rotational behavior induced by amphetamine, phencyclidine, and MK-801

1997 • 17 citations

The N-methyl-D-aspartate receptor and schizophrenia.

1996 • 6 citations