Interaction between Btk TH and SH3 domain

Calculation of protein extinction coefficients from amino acid sequence data

1989 • 5,198 citations

Oncogenes and signal transduction

1991 • 2,816 citations

Estimation of globular protein secondary structure from circular dichroism

1981 • 2,139 citations

The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases

1993 • 1,438 citations

Three-dimensional structure of the tyrosine kinase c-Src

1997 • 1,402 citations

Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia

1993 • 1,338 citations

Crystal structure of the Src family tyrosine kinase Hck

1997 • 1,165 citations

A Self-Consistent Method for the Analysis of Protein Secondary Structure from Circular Dichroism

1993 • 1,032 citations

Structural basis for the binding of proline-rich peptides to SH3 domains

1994 • 1,016 citations

Evaluation of secondary structure of proteins from UV circular dichroism spectra using an unsupervised learning neural network

1993 • 998 citations

Two Binding Orientations for Peptides to the Src SH3 Domain: Development of a General Model for SH3-Ligand Interactions

1994 • 800 citations

Methods to Estimate the Conformation of Proteins and Polypeptides from Circular Dichroism Data

1996 • 607 citations

Activation of the Sire-family tyrosine kinase Hck by SH3 domain displacement

1997 • 601 citations

Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains

1994 • 519 citations

Left-handed Polyproline II Helices Commonly Occur in Globular Proteins

1993 • 461 citations

Activation of BTK by a Phosphorylation Mechanism Initiated by SRC Family Kinases

1996 • 445 citations

A target for Src in mitosis

1994 • 361 citations

Regulation of Btk Function by a Major Autophosphorylation Site Within the SH3 Domain

1996 • 321 citations

Regulatory intramolecular association in a tyrosine kinase of the Tec family

1997 • 274 citations

itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2.

1992 • 254 citations

The 2.35 å crystal structure of the inactivated form of chicken src: a dynamic molecule with multiple regulatory interactions

1997 • 251 citations

Structure of the PH domain and Btk motif from Bruton's tyrosine kinase: molecular explanations for X-linked agammaglobulinaemia

1997 • 240 citations

Specific interactions outside the proline-rich core of two classes of Src homology 3 ligands.

1995 • 240 citations

Poly(Pro)II Helixes in Globular Proteins: Identification and Circular Dichroic Analysis

1994 • 239 citations

Mechanism for Phosphorylation-induced Activation of the Phagocyte NADPH Oxidase Protein p47

1999 • 221 citations

An intramolecular SH3-domain interaction regulates c-Abl activity

1998 • 215 citations

Association of p62, a Multifunctional SH2- and SH3-Domain-Binding Protein, with src Family Tyrosine Kinases, Grb2, and Phospholipase Cγ-1

1995 • 198 citations

Identification of Itk/Tsk Src Homology 3 Domain Ligands

1996 • 193 citations

Protein Secondary Structure from Circular Dichroism Spectroscopy

1994 • 191 citations

The v-Src SH3 domain binds phosphatidylinositol 3'-kinase.

1993 • 180 citations

Selective binding of activated pp60c-src by an immobilized synthetic phosphopeptide modeled on the carboxyl terminus of pp60c-src.

1991 • 175 citations

Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction.

1994 • 172 citations

BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2.

1994 • 169 citations

Developmental regulation of a murine T-cell-specific tyrosine kinase gene, Tsk.

1993 • 144 citations

Expression of a novel form of Tec kinase in hematopoietic cells and mapping of the gene to chromosome 5 near Kit.

1993 • 142 citations

Structure and Expression of Novel Protein-Tyrosine Kinases, EMB and EMT, in Hematopoietic Cells

1993 • 131 citations

The protein product of the c-cbl protooncogene is phosphorylated after B cell receptor stimulation and binds the SH3 domain of Bruton's tyrosine kinase.

1995 • 131 citations

Binding of the Grb2 SH2 domain to phosphotyrosine motifs does not change the affinity of its SH3 domains for Sos proline-rich motifs.

1994 • 126 citations

Mutations of the humanBTK gene coding for bruton tyrosine kinase in X-linked agammaglobulinemia

1999 • 115 citations

X‐Linked Agammaglobulinemia and Other Immunoglobulin Deficiencies

1994 • 113 citations

Tec homology (TH) adjacent to the PH domain

1994 • 110 citations

Regulation of Btk by Src Family Tyrosine Kinases

1996 • 106 citations

4 Primary immunodeficiency mutation databases

2001 • 97 citations

Identification of Rlk, a Novel Protein Tyrosine Kinase with Predominant Expression in the T Cell Lineage

1995 • 92 citations

BTKbase: a database of XLA-causing mutations

1995 • 90 citations

Deletion within the Src homology domain 3 of Bruton's tyrosine kinase resulting in X-linked agammaglobulinemia (XLA).

1994 • 87 citations

TXK, a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12

1994 • 86 citations

β-II conformation of all-β proteins can be distinguished from unordered form by circular dichroism

1992 • 86 citations

DNA-based mutation analysis of Bruton's tyrosine kinase gene in patients with X-linked agammaglobulinaemia

1995 • 85 citations

Interaction between the retinal cyclic GMP phosphodiesterase inhibitor and transducin. Kinetics and affinity studies

1993 • 81 citations

The SH3 Domain of Bruton's Tyrosine Kinase Interacts with Vav, Sam68 and EWS

1997 • 76 citations

Solution Structure of the SH3 Domain from Bruton's Tyrosine Kinase^,

1998 • 74 citations

Thermal unfolding of small proteins with SH3 domain folding pattern

1998 • 58 citations

The SH3 domain of Bruton's tyrosine kinase displays altered ligand binding properties when auto‐phosphorylatedin vitro

1999 • 56 citations

An SH3-binding Site Conserved in Bruton's Tyrosine Kinase and Related Tyrosine Kinases Mediates Specific Protein Interactions in Vitro and in Vivo

1995 • 55 citations

Molecular and cellular analysis of Grb2 SH3 domain mutants: interaction with Sos and dynamin 1 1Edited by A. R. Fersht

1999 • 51 citations

The SH3 domain of Bruton's tyrosine kinase displays altered ligand binding properties when auto-phosphorylatedin vitro

1999 • 44 citations

Intermolecular interactions between the SH3 domain and the proline‐rich TH region of Bruton's tyrosine kinase

2001 • 44 citations

Missense mutations affecting a conserved cysteine pair in the TH domain of Btk

1997 • 41 citations

Mutation pattern in the Bruton's tyrosine kinase gene in 26 unrelated patients with X‐linked agammaglobulinemia

1997 • 40 citations

Mutation analysis in Bruton's tyrosine kinase, the X-linked agammaglobulinaemia gene, including identification of an insertional hotspot

1995 • 27 citations

Mutation pattern in the Bruton's tyrosine kinase gene in 26 unrelated patients with X-linked agammaglobulinemia

1997 • 25 citations

SH3 domain of Bruton's tyrosine kinase can bind to proline-rich peptides of TH domain of the kinase and p120cbl

1997 • 24 citations

Interactions between SH2 and SH3 Domains

1998 • 6 citations

P56lck: a transducing protein that binds to SH2 containing proteins and to phosphotyrosine containing proteins.

1994 • 5 citations