Integrins and T Cell–Mediated Immunity

Integrins

2002 • 8,127 citations

The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

1999 • 3,025 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

VLA Proteins in the Integrin Family: Structures, Functions, and Their Role on Leukocytes

1990 • 1,592 citations

T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

1989 • 1,587 citations

Crystal Structure of the Extracellular Segment of Integrin αVβ3 in Complex with an Arg-Gly-Asp Ligand

2002 • 1,571 citations

An αβ T Cell Receptor Structure at 2.5 Å and Its Orientation in the TCR-MHC Complex

1996 • 1,282 citations

Crystal Structure of the Extracellular Segment of Integrin αVβ3

2001 • 1,256 citations

Two-Photon Imaging of Lymphocyte Motility and Antigen Response in Intact Lymph Node

2002 • 1,177 citations

Global Conformational Rearrangements in Integrin Extracellular Domains in Outside-In and Inside-Out Signaling

2002 • 1,134 citations

α4 integrins mediate lymphocyte attachment and rolling under physiologic flow

1995 • 1,018 citations

Chemokines and the Arrest of Lymphocytes Rolling Under Flow Conditions

1998 • 1,013 citations

The Duration of Antigenic Stimulation Determines the Fate of Naive and Effector T Cells

1998 • 890 citations

Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation

2001 • 861 citations

The LFA-1 ligand ICAM-1 provides an important costimulatory signal for T cell receptor-mediated activation of resting T cells.

1990 • 799 citations

Leukocyte–endothelial-cell interactions in leukocyte transmigration and the inflammatory response

2003 • 798 citations

Dynamic Imaging of T Cell-Dendritic Cell Interactions in Lymph Nodes

2002 • 707 citations

Distinct Dendritic Cell Populations Sequentially Present Antigen to CD4 T Cells and Stimulate Different Aspects of Cell-Mediated Immunity

2003 • 702 citations

The Talin Head Domain Binds to Integrin β Subunit Cytoplasmic Tails and Regulates Integrin Activation

1999 • 697 citations

T Cell Receptor Signaling Precedes Immunological Synapse Formation

2002 • 695 citations

An endothelial ligand for L-Selectin is a novel mucin-like molecule

1992 • 660 citations

JAM-1 is a ligand of the β2 integrin LFA-1 involved in transendothelial migration of leukocytes

2002 • 636 citations

Rap1 signalling: adhering to new models

2001 • 601 citations

Dynamics of CD8+ T cell priming by dendritic cells in intact lymph nodes

2003 • 599 citations

Breaking the Integrin Hinge

1996 • 567 citations

Lymph-Borne Chemokines and Other Low Molecular Weight Molecules Reach High Endothelial Venules via Specialized Conduits While a Functional Barrier Limits Access to the Lymphocyte Microenvironments in Lymph Node Cortex

2000 • 562 citations

The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies.

1990 • 561 citations

Distinct roles of L-selectin and integrins α4β7 and LFA-1 in lymphocyte homing to Peyer's patch-HEV in situ: The multistep model confirmed and refined

1995 • 520 citations

Structures of the αL I Domain and Its Complex with ICAM-1 Reveal a Shape-Shifting Pathway for Integrin Regulation

2003 • 518 citations

Chemokines Trigger Immediate β2 Integrin Affinity and Mobility Changes

2000 • 517 citations

Regulatory and Signaling Properties of the Vav Family

2000 • 513 citations

A Structural Mechanism of Integrin αIIbβ3 “Inside-Out” Activation as Regulated by Its Cytoplasmic Face

2002 • 511 citations

Signal transduction by the TCR for antigen

2000 • 505 citations

DC-SIGN–ICAM-2 interaction mediates dendritic cell trafficking

2000 • 498 citations

CD99 plays a major role in the migration of monocytes through endothelial junctions

2002 • 497 citations

Rapid Acquisition of Tissue-specific Homing Phenotypes by CD4+ T Cells Activated in Cutaneous or Mucosal Lymphoid Tissues

2002 • 490 citations

Enhancement of LFA-1-mediated cell adhesion by triggering through CD2 or CD3 on T lymphocytes

1989 • 482 citations

Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy

2003 • 480 citations

Expression of the integrin α_Eβ₇identifies unique subsets of CD25⁺as well as CD25⁻regulatory T cells

2002 • 476 citations

RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1

2003 • 462 citations

The Dendritic Cell Populations of Mouse Lymph Nodes

2001 • 461 citations

Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)-deficient mice.

1999 • 428 citations

Maintenance of Human T Cell Anergy: Blocking of IL-2 Gene Transcription by Activated Rap1

1997 • 420 citations

The Small Gtpase, Rap1, Mediates Cd31-Induced Integrin Adhesion

2000 • 419 citations

Costimulation of proliferative responses of resting CD4+ T cells by the interaction of VLA-4 and VLA-5 with fibronectin or VLA-6 with laminin.

1990 • 400 citations

The Phosphotyrosine Binding-like Domain of Talin Activates Integrins

2002 • 400 citations

Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes

2002 • 390 citations

Antigen receptor engagement delivers a stop signal to migrating T lymphocytes

1997 • 386 citations

Mucosal T Lymphocyte Numbers Are Selectively Reduced in Integrin αE (CD103)-Deficient Mice

1999 • 377 citations

Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow

2003 • 362 citations

Expression and function of the MAdCAM-1 receptor, integrin alpha 4 beta 7, on human leukocytes.

1994 • 350 citations

Integrin alpha E beta 7 mediates adhesion of T lymphocytes to epithelial cells.

1993 • 344 citations

Adhesion-activating phorbol ester increases the mobility of leukocyte integrin LFA-1 in cultured lymphocytes.

1996 • 343 citations

Staging and resetting T cell activation in SMACs

2002 • 343 citations

Avidity regulation of integrins: the driving force in leukocyte adhesion

2000 • 342 citations

Rap1 Is a Potent Activation Signal for Leukocyte Function-Associated Antigen 1 Distinct from Protein Kinase C and Phosphatidylinositol-3-OH Kinase

2000 • 340 citations

Subsecond Induction of α4 Integrin Clustering by Immobilized Chemokines Stimulates Leukocyte Tethering and Rolling on Endothelial Vascular Cell Adhesion Molecule 1 under Flow Conditions

2000 • 327 citations

LFA-1–mediated Adhesion Is Regulated by Cytoskeletal Restraint and by a Ca2+-dependent Protease, Calpain

1998 • 324 citations

Coupling of the TCR to Integrin Activation by SLAP-130/Fyb

2001 • 314 citations

Intestinal dendritic cells increase T cell expression of α4β7 integrin

2002 • 309 citations

The involvement of lipid rafts in the regulation of integrin function

2002 • 302 citations

Fyn-Binding Protein (Fyb)/Slp-76–Associated Protein (Slap), Ena/Vasodilator-Stimulated Phosphoprotein (Vasp) Proteins and the Arp2/3 Complex Link T Cell Receptor (Tcr) Signaling to the Actin Cytoskeleton

2000 • 294 citations

Functional antigen-independent synapses formed between T cells and dendritic cells

2001 • 287 citations

Activation of Integrin αIIbß3 by Modulation of Transmembrane Helix Associations

2003 • 285 citations

Positive Regulation of T Cell Activation and Integrin Adhesion by the Adapter Fyb/Slap

2001 • 282 citations

Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling

2002 • 276 citations

The dimensions of the T lymphocyte glycoprotein leukosialin and identification of linear protein epitopes that can be modified by glycosylation.

1991 • 266 citations

Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production

1997 • 265 citations

Selective expression of integrin alpha 4 beta 7 on a subset of human CD4+ memory T cells with Hallmarks of gut-trophism.

1993 • 254 citations

The mucosal vascular addressin is a tissue-specific endothelial cell adhesion molecule for circulating lymphocytes

1989 • 246 citations

Molecular Cloning of SLAP-130, an SLP-76-associated Substrate of the T Cell Antigen Receptor-stimulated Protein Tyrosine Kinases

1997 • 238 citations

Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity

2000 • 220 citations

Direct and Regulated Interaction of Integrin αEβ7 with E-Cadherin

1998 • 217 citations

Regulation of inflammation by collagen-binding integrins α1β1 and α2β1 in models of hypersensitivity and arthritis

2000 • 215 citations

Anatomical Origin of Dendritic Cells Determines Their Life Span in Peripheral Lymph Nodes

2000 • 208 citations

Presentation of Antigen by Endothelial Cells and Chemoattraction Are Required for Homing of Insulin-specific CD8+ T Cells

2003 • 203 citations

A fundamental subdivision of circulating lymphocytes defined by adhesion to mucosal addressin cell adhesion molecule-1. Comparison with vascular cell adhesion molecule-1 and correlation with beta 7 integrins and memory differentiation.

1996 • 191 citations

Vav1 Controls Integrin Clustering and MHC/Peptide-Specific Cell Adhesion to Antigen-Presenting Cells

2002 • 190 citations

GlyCAM-1, a physiologic ligand for L-selectin, activates beta 2 integrins on naive peripheral lymphocytes.

1996 • 184 citations

Spatial and molecular organization of lymph node T cell cortex: a labyrinthine cavity bounded by an epithelium-like monolayer of fibroblastic reticular cells anchored to basement membrane-like extracellular matrix

2001 • 182 citations

Rap1 GTPase-activating Protein SPA-1 Negatively Regulates Cell Adhesion

1999 • 175 citations

Rap1 Functions as a Key Regulator of T-Cell and Antigen-Presenting Cell Interactions and Modulates T-Cell Responses

2002 • 172 citations

α6 Integrins Are Required for Langerhans Cell Migration from the Epidermis

1997 • 170 citations

Association of the Membrane Proximal Regions of the α and β Subunit Cytoplasmic Domains Constrains an Integrin in the Inactive State

2001 • 163 citations

Chemoattractants Induce a Rapid and Transient Upregulation of Monocyte α4 Integrin Affinity for Vascular Cell Adhesion Molecule 1 Which Mediates Arrest

2001 • 162 citations

Rac Regulates Integrin-Mediated Spreading and Increased Adhesion of T Lymphocytes

1998 • 158 citations

The roles of membrane microdomains (rafts) in T cell activation

2003 • 154 citations

CD28 plays a critical role in the segregation of PKCθ within the immunologic synapse

2002 • 142 citations

Role of CD11/CD18 in adhesion and transendothelial migration of T cells. Analysis utilizing CD18-deficient T cell clones.

1991 • 136 citations

Three populations of mouse lymph node dendritic cells with different origins and dynamics

1997 • 133 citations

Collagen-binding integrin α1β1 regulates intestinal inflammation in experimental colitis

2002 • 131 citations

The LFA-1 Integrin Supports Rolling Adhesions on ICAM-1 Under Physiological Shear Flow in a Permissive Cellular Environment

2000 • 131 citations

Optimal selectin-mediated rolling of leukocytes during inflammationin vivorequires intercellular adhesion molecule-1 expression

1998 • 127 citations

Integrins in the Immune System

1999 • 122 citations

SKAP-55 regulates integrin adhesion and formation of T cell–APC conjugates

2003 • 120 citations

The Small GTPase Rap1 Is Required for Mn2+- and Antibody-induced LFA-1- and VLA-4-mediated Cell Adhesion

2002 • 116 citations

Importance of Innate Immunity and Collagen Binding Integrin α1β1 in TNBS-Induced Colitis

2002 • 116 citations

Distribution of α₄β₇ and α_Eβ₇ integrins on thymocytes, intestinal epithelial lymphocytes and peripheral lymphocytes

1996 • 106 citations

Vav1 transduces TCR signals required for LFA‐1 function and cell polarization at the immunological synapse

2003 • 105 citations

Superantigen-Induced T Cell:B Cell Conjugation Is Mediated by LFA-1 and Requires Signaling Through Lck, But Not ZAP-70

2001 • 104 citations

A novel function for the Tec family tyrosine kinase Itk in activation of β1 integrins by the T-cell receptor

2001 • 104 citations

Transition From Rolling to Firm Adhesion Is Regulated by the Conformation of the I Domain of the Integrin Lymphocyte Function-associated Antigen-1

2002 • 101 citations

High Affinity Very Late Antigen-4 Subsets Expressed on T Cells Are Mandatory for Spontaneous Adhesion Strengthening But Not for Rolling on VCAM-1 in Shear Flow

1999 • 99 citations

Reprograming T cells: the role of extracellular matrix in coordination of T cell activation and migration

2001 • 99 citations

Solution structures of the cytoplasmic tail complex from platelet integrin αIIb- and β3-subunits

2002 • 99 citations

Three Populations of Mouse Lymph Node Dendritic Cells with Different Origins and Dynamics

1998 • 99 citations

FYN-T-FYB-SLP-76 Interactions Define a T-cell Receptor ζ/CD3-mediated Tyrosine Phosphorylation Pathway That Up-regulates Interleukin 2 Transcription in T-cells

1999 • 98 citations

The role of ICAM-1 molecule in the migration of Langerhans cells in the skin and regional lymph node

2001 • 96 citations

In Vivo Treatment with Anti-ICAM-1 and Anti-LFA-1 Antibodies Inhibits Contact Sensitization-Induced Migration of Epidermal Langerhans Cells to Regional Lymph Nodes

1994 • 95 citations

Enhancement of CD3‐induced activation of human intestinal intraepithelial lymphocytes by stimulation of the β₇‐containing integrin defined by HML‐1 monoclonal antibody

1992 • 89 citations

Paxillin Binding to the α4 Integrin Subunit Stimulates LFA-1 (Integrin αLβ2)-Dependent T Cell Migration by Augmenting the Activation of Focal Adhesion Kinase/Proline-Rich Tyrosine Kinase-2

2003 • 89 citations

Maturation-Dependent Expression and Function of the CD49d Integrin on Monocyte-Derived Human Dendritic Cells

2000 • 86 citations

Administration of mAb against alpha E beta 7 prevents and ameliorates immunization-induced colitis in IL-2-/- mice.

1999 • 84 citations

Focal adhesion kinase regulates β1 integrin-dependent T cell migration through an HEF1 effector pathway

2001 • 82 citations

A novel adhesion pathway that regulates dendritic cell trafficking and T cell interactions

2002 • 80 citations

Cutting Edge: A Novel Function for the SLAP-130/FYB Adapter Protein in β1 Integrin Signaling and T Lymphocyte Migration

2000 • 79 citations

Negative Regulation of T Cell Antigen Receptor-mediated Crk-L-C3G Signaling and Cell Adhesion by Cbl-b

2003 • 79 citations

Cutaneous Inflammatory Disorder in Integrin αE (CD103)-Deficient Mice

2000 • 76 citations

Analysis of Thymocyte Development Reveals That the Gtpase Rhoa Is a Positive Regulator of T Cell Receptor Responses in Vivo

2001 • 75 citations

Administration of mAb Against αEβ7 Prevents and Ameliorates Immunization-Induced Colitis in IL-2−/− Mice

1999 • 66 citations

Translocation of CrkL to Focal Adhesions Mediates Integrin-Induced Migration Downstream of Src Family Kinases

2003 • 64 citations

Stimulation of naïve T‐cell adhesion and immunological synapse formation by chemokine‐dependent and ‐independent mechanisms

2002 • 63 citations

Expression of the mucosal T cell integrin αM290β7 by a major subpopulation of dendritic cells in mice

1993 • 63 citations

Rho and Rho-associated Kinase Modulate the Tyrosine Kinase PYK2 in T-cells through Regulation of the Activity of the Integrin LFA-1

2001 • 63 citations

The Affinity of Integrin α4β1 Governs Lymphocyte Migration

2001 • 63 citations

The GTPase Rac-1 Controls Cell Fate in the Thymus by Diverting Thymocytes from Positive to Negative Selection

2001 • 59 citations

Chemokine Stimulation of Lymphocyte α4Integrin Avidity but Not of Leukocyte Function-associated Antigen-1 Avidity to Endothelial Ligands under Shear Flow Requires Cholesterol Membrane Rafts

2002 • 55 citations

Reduced Gut Intraepithelial Lymphocytes in VLA1 Null Mice

2000 • 55 citations

Differential activation-dependent regulation of integrin function in cultured human T-leukemic cell lines

1994 • 54 citations

Leukocyte Rolling Velocities and Migration Are Optimized by Cooperative L-Selectin and Intercellular Adhesion Molecule-1 Functions

2002 • 54 citations

Direct contact between reticular fibers and migratory cells in the paracortex of mouse lymph nodes. A morphological and quantitative study.

1988 • 49 citations

Chemokines stimulate human T lymphocyte transendothelial migration to utilize VLA-4 in addition to LFA-1

2001 • 49 citations

Human blood dendritic cells: binding to vascular endothelium and expression of adhesion molecules

1997 • 46 citations

Molecular Mechanisms of IL-2 Gene Regulation Following Costimulation Through LFA-1

2001 • 45 citations

Regulation of β1 Integrin-Mediated Adhesion by T Cell Receptor Signaling Involves ZAP-70 but Differs from Signaling Events That Regulate Transcriptional Activity

2000 • 43 citations

The GTPase Rap1 Regulates Phorbol 12-Myristate 13-Acetate-stimulated but Not Ligand-induced β1Integrin-dependent Leukocyte Adhesion

2002 • 41 citations

Alpha 4 beta 1 integrin-mediated tyrosine phosphorylation in human T cells: characterization of Crk- and Fyn-associated substrates (pp105, pp115, and human enhancer of filamentation-1) and integrin-dependent activation of p59fyn1.

1997 • 40 citations

Cas-L is required for beta 1 integrin-mediated costimulation in human Tcells.

1999 • 36 citations

Expression of tenascin in developing and adult mouse lymphoid organs.

1993 • 35 citations

Involvement of the adapter protein CRKL in integrin-mediated adhesion

1999 • 35 citations

Regulation of T Cell Activation and Tolerance by Phospholipase Cγ-1-Dependent Integrin Avidity Modulation

2003 • 35 citations

Lck tyrosine kinase is important for activation of the CD11a/CD18-integrins in human T lymphocytes

2002 • 34 citations

LFA-1-Mediated Costimulation of CD8+ T Cell Proliferation Requires Phosphatidylinositol 3-Kinase Activity

2001 • 32 citations

Cas-L Is Required for β1 Integrin-Mediated Costimulation in Human T Cells

1999 • 30 citations

Extracellular Matrix Conditions T Cells for Adhesion to Tissue Interstitium

2003 • 30 citations

Recognition of E-cadherin by Integrin αEβ7

2001 • 29 citations

β2-Integrin, LFA-1, and TCR/CD3 Synergistically Induce Tyrosine Phosphorylation of Focal Adhesion Kinase (pp125FAK) in PHA-Activated T Cells

1999 • 27 citations

Elastic fibers associated with collagenous fibrils surrounded by reticular cells in lymph nodes of the rat as revealed by electron microscopy after orcein staining

1981 • 23 citations

Lymphocytes Expressing α1β1 Integrin (Very Late Antigen-1) in Peripheral Blood of Patients with Arthritis Are a Subset of CD45RO+ T-Cells Primed for Rapid Adhesion to Collagen IV

2002 • 19 citations

Distribution of basement membrane laminin and type IV collagen in human reactive lymph nodes

1986 • 17 citations

Activation-dependent changes in soluble fibronectin binding and expression of β1 integrin activation epitopes in T cells: relationship to T cell adhesion and migration

2000 • 3 citations

Disabling multiple integrins from the inside out

2003 • 1 citations