Differential regulation of NFAT and SRF by the B cell receptor via a PLC -Ca2+-dependent pathway

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

Differential activation of transcription factors induced by Ca2+ response amplitude and duration

1997 • 1,533 citations

Sensitivity of CaM Kinase II to the Frequency of Ca ²⁺ Oscillations

1998 • 1,263 citations

B Cell Development Pathways

2001 • 1,185 citations

Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element

1988 • 983 citations

Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors

1986 • 883 citations

Tyrosine kinases Lyn and Syk regulate B cell receptor-coupled Ca2+ mobilization through distinct pathways.

1994 • 664 citations

Signal-Regulated Activation of Serum Response Factor Is Mediated by Changes in Actin Dynamics

1999 • 656 citations

Regulation of B-cell fate by antigen-receptor signals

2002 • 619 citations

Mechanisms of capacitative calcium entry

2001 • 536 citations

Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C

1993 • 523 citations

The ability of a ternary complex to form over the serum response element correlates with serum inducibility of the human c-fos promoter

1989 • 495 citations

A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2.

1996 • 494 citations

Activation of BTK by a Phosphorylation Mechanism Initiated by SRC Family Kinases

1996 • 445 citations

GENETIC ANALYSIS OF B CELL ANTIGEN RECEPTOR SIGNALING

1999 • 432 citations

Genetic evidence for involvement of type 1,type 2and type 3inositol 1,4,5-trisphosphate receptors in signal transduction through the B-cell antigen receptor

1997 • 415 citations

Functional analysis of a growth factor-responsive transcription factor complex

1993 • 386 citations

Capacitative calcium entry channels

1999 • 380 citations

RasGRP links T-cell receptor signaling to Ras

2000 • 315 citations

Inducible binding of a factor to the c-fos enhancer

1986 • 310 citations

Mutation of the c-fos gene dyad symmetry element inhibits serum inducibility of transcription in vivo and the nuclear regulatory factor binding in vitro.

1987 • 238 citations

Calcium Activates Serum Response Factor-Dependent Transcription By A Ras- and Elk-1-Independent Mechanism That Involves a Ca²⁺/Calmodulin-Dependent Kinase

1995 • 215 citations

Involvement of Guanosine Triphosphatases and Phospholipase C-γ2 in Extracellular Signal–regulated Kinase, c-Jun NH2-terminal Kinase, and p38 Mitogen-activated Protein Kinase Activation by the B Cell Antigen Receptor

1998 • 195 citations

Avian Serum Response Factor Expression Restricted Primarily to Muscle Cell Lineages Is Required for α-Actin Gene Transcription

1996 • 186 citations

Serum response factor: discovery, biochemistry, biological roles and implications for tissue injury healing.

2002 • 172 citations

Serum-regulated transcription by serum response factor (SRF): a novel role for the DNA binding domain.

1994 • 162 citations

Synergism in ternary complex formation between the dimeric glycoprotein p67SRF, polypeptide p62TCF and the c-fos serum response element.

1990 • 157 citations

The chicken B cell line DT40: a novel tool for gene disruption experiments

2001 • 134 citations

BLNK mediates Syk-dependent Btk activation

2001 • 132 citations

Regulation of MCL1 through a Serum Response Factor/Elk-1-mediated Mechanism Links Expression of a Viability-promoting Member of the BCL2 Family to the Induction of Hematopoietic Cell Differentiation

1999 • 122 citations

Molecular analysis of the interaction of calcineurin with drug-immunophilin complexes

1994 • 116 citations

Serum response factor: transcriptional regulation of genes induced by growth factors and differentiation

1995 • 110 citations

Regulation of Btk by Src Family Tyrosine Kinases

1996 • 106 citations

Expression of the Bcl-2 homologue Mcl-1 correlates with survival of peripheral blood B lymphocytes.

1996 • 103 citations

Ternary complex formation over the c-fos serum response element: p62TCF exhibits dual component specificity with contacts to DNA and an extended structure in the DNA-binding domain of p67SRF.

1992 • 94 citations

Tyrosine Residues in Phospholipase Cγ2 Essential for the Enzyme Function in B-cell Signaling

2001 • 91 citations

Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling

2002 • 77 citations

Block of current through single calcium channels by Fe, Co, and Ni. Location of the transition metal binding site in the pore.

1991 • 75 citations

Mutation of the c-fos Gene Dyad Symmetry Element Inhibits Serum Inducibility of Transcription In Vivo and the Nuclear Regulatory Factor Binding In Vitro

1987 • 72 citations

The role of calcineurin in lymphocyte activation

2000 • 61 citations

Differential activation of transcription factors induced by Ca2+ response amplitude and duration

1997 • 59 citations

Cleavage of the Serum Response Factor during Death Receptor-induced Apoptosis Results in an Inhibition of the c-FOS Promoter Transcriptional Activity

2000 • 53 citations

In vivo regulation of interleukin-2 receptor alpha gene transcription by the coordinated binding of constitutive and inducible factors in human primary T cells.

1995 • 51 citations

Interaction between NF-kappa B- and serum response factor-binding elements activates an interleukin-2 receptor alpha-chain enhancer specifically in T lymphocytes.

1993 • 43 citations

The proline rich region of the Tec homology domain of ITK regulates its activity

2002 • 41 citations

Vav1 Couples T Cell Receptor to Serum Response Factor-dependent Transcription via a MEK-dependent Pathway

2002 • 35 citations

RasGRP links T-cell receptor signaling to Ras

2000 • 34 citations

Serum Response Factor Cleavage by Caspases 3 and 7 Linked to Apoptosis in Human BJAB Cells

2001 • 27 citations

MEKK1 Is Essential for DT40 Cell Apoptosis in Response to Microtubule Disruption

2001 • 27 citations

Activation of IL-2 receptor alpha-chain gene by individual members of the rel oncogene family in association with serum response factor.

1995 • 25 citations

Activation and Function of the Rap1 Gtpase in B Lymphocytes

2001 • 25 citations

Capacitative calcium entry channels

1999 • 22 citations

Mechanisms of protein A superantigen-induced signal transduction for proliferation of mouse B cell

1999 • 19 citations

Interaction Between Nf-κB- and Serum Response Factor-Binding Elements Activates an Interleukin-2 Receptor α-Chain Enhancer Specifically in T Lymphocytes

1993 • 11 citations

Synergy between Signal Transduction Pathways is Obligatory for Expression of c-FOS in B and T Cell Lines: Implication for c-FOS Control via Surface Immunoglobulin and T Cell Antigen Receptors

1995 • 9 citations

In-Vivo Regulation of Interleukin-2 Receptor-Alpha Gene-Transcription by the Coordinated Binding of Constitutive and Inducible Factors in Human Primary T-Cells

1995 • 1 citations