A conditional form of Bruton's tyrosine kinase is sufficient to activate multiple downstream signaling pathways via PLC Gamma 2 in B cells

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Differential activation of transcription factors induced by Ca2+ response amplitude and duration

1997 • 1,533 citations

Tyrosine kinases Lyn and Syk regulate B cell receptor-coupled Ca2+ mobilization through distinct pathways.

1994 • 664 citations

BLNK

1998 • 501 citations

A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2.

1996 • 494 citations

GENETIC ANALYSIS OF B CELL ANTIGEN RECEPTOR SIGNALING

1999 • 432 citations

Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation

1998 • 410 citations

Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase.

1993 • 348 citations

Construction and Characterization of a Conditionally Active Version of the Serine/Threonine Kinase Akt

1998 • 318 citations

BLNK Required for Coupling Syk to PLCγ2 and Rac1-JNK in B Cells

1999 • 313 citations

Bruton's Tyrosine Kinase Is Required for Activation of Iκb Kinase and Nuclear Factor κb in Response to B Cell Receptor Engagement

2000 • 299 citations

BCAP

2000 • 271 citations

BLNK

2000 • 221 citations

PtdIns-3,4,5-P3

1998 • 220 citations

Bruton's Tyrosine Kinase Links the B Cell Receptor to Nuclear Factor κb Activation

2000 • 215 citations

The role of Bruton's tyrosine kinase in B-cell development and function: a genetic perspective

2000 • 204 citations

Requirement of phospholipase C-gamma 2 activation in surface immunoglobulin M-induced B cell apoptosis.

1995 • 199 citations

Identification of the SH2 Domain Binding Protein of Bruton’s Tyrosine Kinase as BLNK—Functional Significance of Btk-SH2 Domain in B-Cell Antigen Receptor-Coupled Calcium Signaling

1999 • 199 citations

Involvement of Guanosine Triphosphatases and Phospholipase C-γ2 in Extracellular Signal–regulated Kinase, c-Jun NH2-terminal Kinase, and p38 Mitogen-activated Protein Kinase Activation by the B Cell Antigen Receptor

1998 • 195 citations

Xid-like Phenotypes

2000 • 195 citations

The role of Bruton's tyrosine kinase in B-cell development and function: a genetic perspective

2000 • 192 citations

BAP-135, a target for Bruton’s tyrosine kinase in response to B cell receptor engagement

1997 • 182 citations

Btk function in B cell development and response

1998 • 181 citations

Different Protein Tyrosine Kinases Are Required for B Cell Antigen Receptor–mediated Activation of Extracellular Signal–Regulated kinase, c-Jun NH2-terminal Kinase 1, and p38 Mitogen-activated Protein Kinase

1998 • 169 citations

BTK as a Mediator of Radiation-Induced Apoptosis in DT-40 Lymphoma B Cells

1996 • 166 citations

Src Family Protein Tyrosine Kinases Induce Autoactivation of Bruton's Tyrosine Kinase

1995 • 151 citations

Tec Kinases

2000 • 151 citations

Transphosphorylation of Bruton's Tyrosine Kinase on Tyrosine 551 Is Critical for B Cell Antigen Receptor Function

1997 • 129 citations

Phosphorylation of two regulatory tyrosine residues in the activation of Bruton’s tyrosine kinase via alternative receptors

1997 • 129 citations

Phospholipase C-γ2 Couples Bruton's Tyrosine Kinase to the NF-κB Signaling Pathway in B Lymphocytes

2001 • 129 citations

An essential role for Bruton's [corrected] tyrosine kinase in the regulation of B-cell apoptosis.

1996 • 117 citations

Regulation of Nuclear Localization and Transcriptional Activity of TFII-I by Bruton’s Tyrosine Kinase

1999 • 110 citations

Involvement of Wiskott-Aldrich Syndrome Protein in B-Cell Cytoplasmic Tyrosine Kinase Pathway

1999 • 108 citations

Bruton's Tyrosine Kinase Controls a Sustained Calcium Signal Essential for B Lineage Development and Function

1999 • 105 citations

Tec family kinases in lymphocyte signaling and function

2000 • 103 citations

Nucleocytoplasmic Shuttling of Bruton's Tyrosine Kinase

2000 • 91 citations

Conditional Transformation of Cells and Rapid Activation of the Mitogen-Activated Protein Kinase Cascade by An Estradiol-Dependent Human Raf-1 Protein Kinase

1993 • 86 citations

Functions of Bruton's tyrosine kinase in mast and B cells

1999 • 79 citations

Transgene Expression of bcl-xL Permits Anti-immunoglobulin (Ig)–induced Proliferation in xid B Cells

1998 • 74 citations

Kinase Activation of the Non-receptor Tyrosine Kinase Etk/BMX Alone Is Sufficient to Transactivate STAT-mediated Gene Expression in Salivary and Lung Epithelial Cells

1999 • 72 citations

Reconstitution of Btk Signaling by the Atypical Tec Family Tyrosine Kinases Bmx and Txk

1999 • 69 citations

The Transcription FactorBrightAssociates with Bruton’s Tyrosine Kinase, the Defective Protein in Immunodeficiency Disease

2000 • 65 citations

Signalling of Bruton's Tyrosine Kinase, Btk

1999 • 61 citations

Complementation of Defective Colony-Stimulating Factor 1 Receptor Signaling and Mitogenesis by Raf and v-Src

1999 • 56 citations

Hormone-conditional transformation by fusion proteins of c-Abl and its transforming variants.

1993 • 51 citations

The Proto-oncogene p120CblIs a Downstream Substrate of the Hck Protein-Tyrosine Kinase

1999 • 27 citations

Immune‐Complex Assays for Tyrosine Protein Kinases

1993 • 14 citations