Interaction between G Proteins and Tyrosine Kinases upon T Cell Receptor·CD3-mediated Signaling

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions

1995 • 1,367 citations

Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme

1989 • 1,244 citations

Activation of the β1 isozyme of phospholipase C by α subunits of the Gq class of G proteins

1991 • 774 citations

Increase of the Catalytic Activity of Phospholipase C-γ1 by Tyrosine Phosphorylation

1990 • 650 citations

Partial T cell signaling: Altered phospho-? and lack of zap70 recruitment in APL-induced T cell anergy

1994 • 608 citations

The Role of the T Cell Receptor in Positive and Negative Selection of Developing T Cells

1990 • 589 citations

Essential role for ZAP-70 in both positive and negative selection of thymocytes

1995 • 554 citations

Defective T cell receptor signaling and CD8+ thymic selection in humans lacking Zap-70 kinase

1994 • 552 citations

Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway

1995 • 541 citations

Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction.

1990 • 526 citations

Human Severe Combined Immunodeficiency Due to a Defect in ZAP-70, a T Cell Tyrosine Kinase

1994 • 516 citations

ZAP-70 Deficiency in an Autosomal Recessive form of Severe Combined Immunodeficiency

1994 • 495 citations

T Cell Antigen Receptor-Mediated Activation of Phospholipase C Requires Tyrosine Phosphorylation

1990 • 476 citations

The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein.

1991 • 415 citations

Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-gamma 1.

1991 • 351 citations

Molecular Events Mediating T Cell Activation

1990 • 303 citations

Vasopressin-, angiotensin II-, and alpha 1-adrenergic-induced inhibition of Ca2+ transport by rat liver plasma membrane vesicles.

1984 • 279 citations

A simple structure encodes G protein-activating function of the IGF-II/mannose 6-phosphate receptor

1990 • 278 citations

G alpha 16, a G protein alpha subunit specifically expressed in hematopoietic cells.

1991 • 263 citations

T Cell Activation Induces Rapid Tyrosine Phosphorylation of a Limited Number of Cellular Substrates

1989 • 258 citations

The Human T-Cell Receptor

1984 • 232 citations

Regulation of phospholipase C by G proteins

1992 • 205 citations

Cholera toxin inhibits the T-cell antigen receptor-mediated increases in inositol trisphosphate and cytoplasmic free calcium.

1986 • 202 citations

Purification and characterization of two G-proteins that activate the beta 1 isozyme of phosphoinositide-specific phospholipase C. Identification as members of the Gq class.

1991 • 191 citations

A mutation that prevents GTP-dependent activation of the α chain of Gs

1988 • 176 citations

Identification of the GTP-binding protein encoded by Gi3 complementary DNA.

1988 • 169 citations

Bombesin, vasopressin, and endothelin rapidly stimulate tyrosine phosphorylation in intact Swiss 3T3 cells.

1991 • 156 citations

Stimulation of Phospholipase C-γ1 Membrane Association by Epidermal Growth Factor

1990 • 153 citations

The G226A mutant of Gs alpha highlights the requirement for dissociation of G protein subunits.

1992 • 148 citations

Activation of resting T lymphocytes by anti-CD3 (T3) antibodies in the absence of monocytes.

1985 • 129 citations

Pertussis toxin-sensitive Gi protein involvement in epidermal growth factor-induced activation of phospholipase C-gamma in rat hepatocytes.

1991 • 121 citations

Bradykinin and bombesin rapidly stimulate tyrosine phosphorylation of a 120-kDa group of proteins in Swiss 3T3 cells.

1991 • 117 citations

Tyrosine phosphorylation of G protein alpha subunits by pp60c-src.

1992 • 110 citations

Activating and inactivating mutations of the alpha subunit of Gi2 protein have opposite effects on proliferation of NIH 3T3 cells.

1991 • 110 citations

Aluminum fluoride induces phosphatidylinositol turnover, elevation of cytoplasmic free calcium, and phosphorylation of the T cell antigen receptor in murine T cells.

1987 • 86 citations

Evidence for opioid receptor-mediated activation of the G-proteins, Go and Gi2, in membranes of neuroblastoma x glioma (NG108-15) hybrid cells

1991 • 68 citations

Function of a Heterologous Muscarinic Receptor in T Cell Antigen Receptor Signal Transduction Mutants

1989 • 58 citations

Analysis of stimulation-G protein subunit coupling by using active insulin-like growth factor II receptor peptide.

1991 • 49 citations

Cholera toxin inhibits resting human T cell activation via a cAMP-independent pathway.

1989 • 41 citations

The role of G-proteins versus protein tyrosine kinases in the regulation of lymphocyte activation

1992 • 39 citations

The G protein coupling T cell antigen receptor/CD3‐complex and phospholipase C in the human T cell lymphoma Jurkat is not a target for cholera toxin

1990 • 19 citations

An analysis of the role of guanine nucleotide binding proteins in antigen receptor/CD3 antigen coupling to phospholipase C.

1991 • 18 citations

Evidence that a G-protein transduces signals initiated by the protein-tyrosine kinase v-Fps

1991 • 16 citations

IL-1 stimulates a diverging signaling pathway in EL4 6.1 thymoma cells. IL-2 release, but not IL-2 receptor expression, is sensitive to pertussis toxin.

1995 • 15 citations

Genetic variation in multigene families

1977 • 14 citations

Evidence for GTP-binding protein involvement in the tyrosine phosphorylation of the T cell receptor zeta chain.

1992 • 14 citations

Expression of GTP-binding protein alpha subunits in human thymocytes

1995 • 12 citations