Imaging immune cell interactions and functions: SMACs and the Immunological Synapse

The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

1999 • 3,025 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

Lymphocyte responses and cytokines

1994 • 1,860 citations

The Immunological Synapse

2001 • 987 citations

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

2000 • 890 citations

T Cell Receptor Signaling Precedes Immunological Synapse Formation

2002 • 695 citations

Selective modulation of protein kinase C-Θ during T-cell activation

1997 • 558 citations

Continuous T cell receptor signaling required for synapse maintenance and full effector potential

2003 • 405 citations

Staging and resetting T cell activation in SMACs

2002 • 343 citations

Cell Biology of Cytotoxic and Helper T Cell Functions: Immunofluorescence Microscopic Studies of Single Cells and Cell Couples

1989 • 296 citations

The specific direct interaction of helper T cells and antigen-presenting B cells.

1986 • 246 citations

Polarized expression of cytokines in cell conjugates of helper T cells and splenic B cells.

1991 • 241 citations

Reorientation of the microtubule-organizing center and the Golgi apparatus in cloned cytotoxic lymphocytes triggered by binding to lysable target cells.

1984 • 230 citations

Coclustering of CD4 (L3T4) molecule with the T-cell receptor is induced by specific direct interaction of helper T cells and antigen-presenting cells.

1987 • 194 citations

The specific direct interaction of helper T cells and antigen-presenting B cells. II. Reorientation of the microtubule organizing center and reorganization of the membrane-associated cytoskeleton inside the bound helper T cells.

1987 • 177 citations

Small splenic B cells that bind to antigen-specific T helper (Th) cells and face the site of cytokine production in the Th cells selectively proliferate: immunofluorescence microscopic studies of Th-B antigen-presenting cell interactions.

1994 • 168 citations

The specific interaction of helper T cells and antigen-presenting B cells. IV. Membrane and cytoskeletal reorganizations in the bound T cell as a function of antigen dose.

1989 • 166 citations

On the mechanism of unidirectional killing in mixtures of two cytotoxic T lymphocytes. Unidirectional polarization of cytoplasmic organelles and the membrane-associated cytoskeleton in the effector cell.

1986 • 122 citations

The reorientation of the Golgi apparatus and the microtubule-organizing center in the cytotoxic effector cell is a prerequisite in the lysis of bound target cells.

1985 • 106 citations