Pleckstrin Homology Domains Interact with Filamentous Actin

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

Dynamic Light Scattering

1985 • 4,912 citations

The Regulation of Rabbit Skeletal Muscle Contraction

1971 • 4,491 citations

Protein modules and signalling networks

1995 • 2,447 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate

1997 • 1,448 citations

Dynamic light scattering

2020 • 965 citations

Modular binding domains in signal transduction proteins

1995 • 962 citations

Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate

1994 • 749 citations

MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium–calmodulin

1992 • 728 citations

Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain

1995 • 597 citations

Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain.

1995 • 569 citations

Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase.

1996 • 560 citations

The PH domain: a common piece in the structural pathcwork of signalling proteins

1993 • 536 citations

A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2.

1996 • 494 citations

Binding of G protein beta gamma-subunits to pleckstrin homology domains.

1994 • 479 citations

The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase.

1993 • 467 citations

PH Domains: Diverse Sequences with a Common Fold Recruit Signaling Molecules to the Cell Surface

1996 • 464 citations

Activation of BTK by a Phosphorylation Mechanism Initiated by SRC Family Kinases

1996 • 445 citations

Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals

1998 • 436 citations

Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation

1998 • 410 citations

The Polyelectrolyte Nature of F-actin and the Mechanism of Actin Bundle Formation

1996 • 398 citations

Guidebook to the cytoskeletal and motor proteins

1994 • 374 citations

The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C.

1994 • 322 citations

Regulation of Btk Function by a Major Autophosphorylation Site Within the SH3 Domain

1996 • 321 citations

PH domain: the first anniversary

1994 • 318 citations

Actin-binding proteins

1991 • 289 citations

Structure of the binding site for inositol phosphates in a PH domain.

1995 • 281 citations

Rho: a connection between membrane receptor signalling and the cytoskeleton

1996 • 271 citations

Crystal structure at 2.2 Å resolution of the pleckstrin homology domain from human dynamin

1994 • 268 citations

Structure of the PH domain and Btk motif from Bruton's tyrosine kinase: molecular explanations for X-linked agammaglobulinaemia

1997 • 240 citations

Structure of the pleckstrin homology domain from β-spectrin

1994 • 233 citations

Membrane and cytoskeletal changes associated with IgE-mediated serotonin release from rat basophilic leukemia cells.

1985 • 224 citations

Tyrosine phosphorylation and activation of Bruton tyrosine kinase upon Fc epsilon RI cross-linking.

1994 • 221 citations

Solution structure of a pleckstrin-homology domain

1994 • 211 citations

Mutation of the Pleckstrin Homology Domain of Bruton's Tyrosine Kinase in Immunodeficiency Impaired Inositol 1,3,4,5-Tetrakisphosphate Binding Capacity

1996 • 203 citations

Phosphatidylinositol 3-kinase-γ activates Bruton’s tyrosine kinase in concert with Src family kinases

1997 • 192 citations

BAP-135, a target for Bruton’s tyrosine kinase in response to B cell receptor engagement

1997 • 182 citations

Btk function in B cell development and response

1998 • 181 citations

Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction.

1994 • 172 citations

AH/PH Domain-Mediated Interaction between Akt Molecules and Its Potential Role in Akt Regulation

1995 • 161 citations

Counterion induced bundle formation of rodlike polyelectrolytes

1996 • 145 citations

Bruton’s tyrosine kinase regulates apoptosis and JNK/SAPK kinase activity

1997 • 137 citations

Structure and Expression of Novel Protein-Tyrosine Kinases, EMB and EMT, in Hematopoietic Cells

1993 • 131 citations

Transphosphorylation of Bruton's Tyrosine Kinase on Tyrosine 551 Is Critical for B Cell Antigen Receptor Function

1997 • 129 citations

Crystal structure of the pleckstrin homology domain from dynamin

1994 • 120 citations

Tyrosine phosphorylation is required for mast cell activation by Fc epsilon RI cross-linking.

1992 • 101 citations

Activation and interaction with protein kinase C of a cytoplasmic tyrosine kinase, Itk/Tsk/Emt, on Fc epsilon RI cross-linking on mast cells.

1995 • 100 citations

Interactions between Protein Kinase C and Pleckstrin Homology Domains

1997 • 97 citations

Solution structure of pleckstrin homology domain of dynamin by heteronuclear NMR spectroscopy.

1995 • 88 citations

Phallotoxin and actin binding assay by fluorescence enhancement

1992 • 83 citations

Functions of Bruton's tyrosine kinase in mast and B cells

1999 • 79 citations

Production of recombinant rat interleukin-6 in Escherichia coli using a novel highly efficient expression vector pGEX-3T.

1992 • 33 citations

Guidebook to the cytoskeletal and motor proteins

1994 • 25 citations