Cell-cycle dysregulation in breast cancer: breast cancer therapies targeting the cell cycle

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

CDK inhibitors: positive and negative regulators of G1-phase progression

1999 • 6,003 citations

Cancer Cell Cycles

1996 • 5,379 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Cancer statistics, 2000

2000 • 3,907 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

Inhibitors of mammalian G1 cyclin-dependent kinases.

1995 • 3,258 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

Genetic Heterogeneity and Penetrance Analysis of the BRCA1 and BRCA2 Genes in Breast Cancer Families

1998 • 2,920 citations

Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

1991 • 2,774 citations

Multinational Study of the Efficacy and Safety of Humanized Anti-HER2 Monoclonal Antibody in Women Who Have HER2-Overexpressing Metastatic Breast Cancer That Has Progressed After Chemotherapy for Metastatic Disease

1999 • 2,747 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

The Risk of Cancer Associated with Specific Mutations ofBRCA1andBRCA2among Ashkenazi Jews

1997 • 2,255 citations

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

1994 • 2,154 citations

A signature motif in transcriptional co-activators mediates binding to nuclear receptors

1997 • 2,100 citations

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

1994 • 2,071 citations

Growth Factors and Cancer

1991 • 2,044 citations

The Sentinel Node in Breast Cancer — A Multicenter Validation Study

1998 • 2,025 citations

Transforming growth factor beta

2011 • 1,990 citations

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.

1994 • 1,970 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27

1995 • 1,848 citations

Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease.

1992 • 1,496 citations

Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells

1997 • 1,466 citations

New functional activities for the p21 family of CDK inhibitors.

1997 • 1,414 citations

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1998 • 1,248 citations

Cyclin D1 Expression Is Regulated Positively by the p42/p44 and Negatively by the p38/HOG Pathway

1996 • 1,203 citations

Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease.

1992 • 1,190 citations

Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

1988 • 1,160 citations

The p21Cip1 and p27Kip1 CDK `inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts

1999 • 1,152 citations

A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas

1990 • 1,140 citations

D-type cyclin-dependent kinase activity in mammalian cells.

1994 • 1,073 citations

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

1997 • 1,055 citations

Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185

1986 • 1,020 citations

Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks

1999 • 1,005 citations

Inhibition of cyclin-dependent kinases by p21.

1995 • 999 citations

Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice

1994 • 982 citations

Tissue Distribution and Quantitative Analysis of Estrogen Receptor-α (ERα) and Estrogen Receptor-β (ERβ) Messenger Ribonucleic Acid in the Wild-Type and ERα-Knockout Mouse

1997 • 968 citations

Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells.

1996 • 964 citations

Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta.

1995 • 959 citations

Human Smad3 and Smad4 Are Sequence-Specific Transcription Activators

1998 • 916 citations

Cyclin E-CDK2 is a regulator of p27Kip1.

1997 • 915 citations

Genetic analysis of breast cancer in the cancer and steroid hormone study.

1991 • 915 citations

Dynamic Changes of BRCA1 Subnuclear Location and Phosphorylation State Are Initiated by DNA Damage

1997 • 910 citations

Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes

1984 • 906 citations

A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases

1998 • 899 citations

Annual hazard rates of recurrence for breast cancer after primary therapy.

1996 • 833 citations

Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility.

1996 • 827 citations

The effects of estrogens and antiestrogens on hormone-responsive human breast cancer in long-term tissue culture.

1976 • 820 citations

Centrosome Amplification and a Defective G2–M Cell Cycle Checkpoint Induce Genetic Instability in BRCA1 Exon 11 Isoform–Deficient Cells

1999 • 814 citations

Transforming p21 Mutants and c-Ets-2 Activate the Cyclin D1 Promoter through Distinguishable Regions

1995 • 803 citations

The murine gene p27Kip1 is haplo-insufficient for tumour suppression

1998 • 796 citations

Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: Synergistic action of oncogenes in vivo

1987 • 796 citations

Treatment of Breast Cancer

1998 • 790 citations

Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions.

1996 • 772 citations

Inhibition of NIH 3T3 Cell Proliferation by a Mutant ras Protein with Preferential Affinity for GDP

1988 • 757 citations

Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast

1990 • 753 citations

Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice

1988 • 745 citations

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation

1999 • 744 citations

Steroid Hormone Receptors: Interaction with Deoxyribonucleic Acid and Transcription Factors*

1993 • 724 citations

TGFα overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas

1990 • 714 citations

CDK-Independent Activation of Estrogen Receptor by Cyclin D1

1997 • 698 citations

Cdc25 cell-cycle phosphatase as a target of c-myc

1996 • 691 citations

The activities of two Ets-related transcription factors required for drosophila eye development are modulated by the Ras/MAPK pathway

1994 • 690 citations

A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors

1999 • 686 citations

Requirement of p27 ^Kip1 for Restriction Point Control of the Fibroblast Cell Cycle

1996 • 683 citations

Nucleophosmin/B23 Is a Target of CDK2/Cyclin E in Centrosome Duplication

2000 • 671 citations

Taxol induces bcl-2 phosphorylation and death of prostate cancer cells.

1996 • 662 citations

Nonclinical studies addressing the mechanism of action of trastuzumab (Herceptin).

1999 • 650 citations

p21-containing cyclin kinases exist in both active and inactive states.

1994 • 646 citations

The microtubule-affecting drug paclitaxel has antiangiogenic activity.

1996 • 643 citations

Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation

1995 • 603 citations

Estrogenic Regulation of Growth and Polypeptide Growth Factor Secretion in Human Breast Carcinoma

1987 • 576 citations

Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA

1995 • 561 citations

Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1

1995 • 552 citations

Role of co-activators and co-repressors in the mechanism of steroid/thyroid receptor action.

1997 • 534 citations

A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors.

1996 • 532 citations

Avian sarcoma virus-transforming protein, pp60src shows protein kinase activity specific for tyrosine

1980 • 510 citations

BRCA1 Required for Transcription-Coupled Repair of Oxidative DNA Damage

1998 • 502 citations

CDC25 Phosphatases as Potential Human Oncogenes

1995 • 498 citations

BRCA1 Inhibition of Estrogen Receptor Signaling in Transfected Cells

1999 • 494 citations

Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP.

1988 • 470 citations

Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F

1997 • 468 citations

Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities

1996 • 468 citations

Development of mammary hyperplasia and neoplasia in MMTV-TGFα transgenic mice

1990 • 447 citations

Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer

1999 • 445 citations

Cdc25A is a novel phosphatase functioning early in the cell cycle.

1994 • 442 citations

Estrogen-induced Activation of Cdk4 and Cdk2 during G1-S Phase Progression Is Accompanied by Increased Cyclin D1 Expression and Decreased Cyclin-dependent Kinase Inhibitor Association with Cyclin E-Cdk2

1997 • 438 citations

Rac Regulation of Transformation, Gene Expression, and Actin Organization by Multiple, PAK-Independent Pathways

1997 • 433 citations

The human F box protein β-Trcp associates with the Cul1/Skp1 complex and regulates the stability of β-catenin

1999 • 432 citations

Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas

1999 • 421 citations

Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme.

1994 • 415 citations

Genetic alteration of the c-myc protooncogene (MYC) in human primary breast carcinomas.

1986 • 413 citations

Tumor suppressor activity of the TGF-β pathway in human cancers

1996 • 412 citations

Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms.

1998 • 408 citations

Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21 ^CIP1/WAF1 and cyclin D proteins

1998 • 401 citations

In vivo gene expression profile analysis of human breast cancer progression.

1999 • 396 citations

The c-Myc protein induces cell cycle progression and apoptosis through dimerization with Max.

1993 • 392 citations

Cyclin D1 Stimulation of Estrogen Receptor Transcriptional Activity Independent of cdk4†

1997 • 386 citations

Growth Factors in Breast Cancer

1995 • 378 citations

Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-β in cells lacking the CDK inhibitor p15

1997 • 378 citations

HER-2/neu Blocks Tumor Necrosis Factor-induced Apoptosis via the Akt/NF-κB Pathway

2000 • 375 citations

Estrogen receptor gene disruption: molecular characterization and experimental and clinical phenotypes.

1996 • 371 citations

The addition of Herceptin (humanized anti-HER2 antibody) to first-line chemotherapy for HER2-overexpressing metastatic breast cancer (HER2+ MBC) markedly increases anti-cancer activity: A randomized, multinational controlled phase II trial.

1998 • 366 citations

A role for histone deacetylase activity in HDAC1-mediated transcriptional repression

1998 • 363 citations

Alterations to either c-erbB-2(neu) or c-myc proto-oncogenes in breast carcinomas correlate with poor short-term prognosis.

1987 • 360 citations

The Cyclins and Cyclin-Dependent Kinase Inhibitors in Hormonal Regulation of Proliferation and Differentiation*

1999 • 358 citations

Cell cycle–regulated phosphorylation of p220^NPATby cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription

2000 • 356 citations

Methylation of the BRCA1 promoter region in sporadic breast and ovarian cancer: correlation with disease characteristics

1999 • 353 citations

GROWTH FACTORS AND CANCER

1985 • 352 citations

A novel candidate metastasis-associated gene, mta1, differentially expressed in highly metastatic mammary adenocarcinoma cell lines. cDNA cloning, expression, and protein analyses.

1994 • 350 citations

Cyclin D1 Is Required for Transformation by Activated Neu and Is Induced through an E2F-Dependent Signaling Pathway

2000 • 346 citations

17beta-Estradiol induces cyclin D1 gene transcription, p36D1-p34cdk4 complex activation and p105Rb phosphorylation during mitogenic stimulation of G(1)-arrested human breast cancer cells.

1996 • 344 citations

The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2.

1997 • 344 citations

Rescue of Cyclin D1 Deficiency by Knockin Cyclin E

1999 • 340 citations

Oestrogen-responsive human breast cancer in long term tissue culture

1975 • 339 citations

Cyclins D1 and D2 mediate Myc-induced proliferation via sequestration of p27Kip1 and p21Cip1

1999 • 333 citations

Convergence of Mitogenic Signalling Cascades from Diverse Classes of Receptors at the Cyclin D–Cyclin-Dependent Kinase–pRb-Controlled G₁ Checkpoint

1996 • 331 citations

Amino-terminal domains of c-myc and N-myc proteins mediate binding to the retinoblastoma gene product

1991 • 326 citations

The Prognostic Significance of Altered Cyclin-Dependent Kinase Inhibitors in Human Cancer

1999 • 323 citations

D-Type Cyclin-Dependent Kinase Activity in Mammalian Cells

1994 • 322 citations

Docetaxel (Taxotere®) a review of preclinical and clinical experience. Part I

1995 • 319 citations

Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abrogated by c-Myc.

1996 • 319 citations

Cyclin-Binding Motifs Are Essential for the Function of p21^CIP1

1996 • 313 citations

Cyclin/Cdk-Dependent Initiation of DNA Replication in a Human Cell-Free System

1997 • 311 citations

Characterization of protein tyrosine kinases from human breast cancer: involvement of the c-src oncogene product.

1992 • 309 citations

Breast Cancer

1992 • 303 citations

Isolation and characterization of a gene specifically expressed in different metastatic cells and whose deduced gene product has a high degree of homology to a Ca2+-binding protein family.

1989 • 302 citations

Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1

1998 • 301 citations

Cell Transformation by RNA Tumor Viruses

1977 • 298 citations

Growth factor, steroid, and steroid antagonist regulation of cyclin gene expression associated with changes in T-47D human breast cancer cell cycle progression.

1993 • 295 citations

THE GENETICS OF BREAST CANCER SUSCEPTIBILITY

1998 • 290 citations

Inactivation of a Cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes.

1994 • 289 citations

Neu and its ligands: From an oncogene to neural factors

1993 • 286 citations

Estrogen-Dependent Cyclin E-cdk2 Activation through p21 Redistribution

1997 • 277 citations

Ras Transformation Results in an Elevated Level of Cyclin D1 and Acceleration of G₁ Progression in NIH 3T3 cells

1995 • 276 citations

A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen

1995 • 276 citations

Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility

1996 • 275 citations

Steroid hormone receptors: interaction with deoxyribonucleic acid and transcription factors

1993 • 264 citations

The int-2 gene product acts as an epithelial growth factor in transgenic mice.

1990 • 263 citations

c-Myc or Cyclin D1 Mimics Estrogen Effects on Cyclin E-Cdk2 Activation and Cell Cycle Reentry

1998 • 257 citations

Gene Regulation by Steroid Hormones

1990 • 255 citations

Partial rescue of Brca15–6 early embryonic lethality by p53 or p21 null mutation

1997 • 253 citations

Formation of p27-CDK complexes during the human mitotic cell cycle.

1996 • 247 citations

Inhibition of pp60c-Src reduces Bcl-XL expression and reverses the transformed phenotype of cells overexpressing EGF and HER-2 receptors

1999 • 247 citations

Determination of Neuronal Cell Fate: Lessons from the R7 Neuron of Drosophila

1994 • 245 citations

Cyclin D and oncogenesis

1993 • 233 citations

Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activity.

1994 • 233 citations

Estrogen regulates activity of cyclin-dependent kinases and retinoblastoma protein phosphorylation in breast cancer cells.

1996 • 233 citations

pp60v- Induction of Cyclin D1 Requires Collaborative Interactions between the Extracellular Signal-regulated Kinase, p38, and Jun Kinase Pathways

1999 • 227 citations

Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry

1998 • 227 citations

Peptide growth factor cross-talk with the estrogen receptor requires the A/B domain and occurs independently of protein kinase C or estradiol.

1996 • 225 citations

Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo

1998 • 220 citations

Progestins Both Stimulate and Inhibit Breast Cancer Cell Cycle Progression while Increasing Expression of Transforming Growth Factor α, Epidermal Growth Factor Receptor, c-fos, and c-myc Genes

1991 • 218 citations

Reciprocal Regulation of Neu Tyrosine Kinase Activity and Caveolin-1 Protein Expression in Vitro and in Vivo

1998 • 215 citations

Non-Ras targets of farnesyltransferase inhibitors: focus on Rho

1998 • 214 citations

Association of multiple copies of the c-erbB-2 oncogene with spread of breast cancer.

1987 • 214 citations

The Molecular Biology of RU486. Is There a Role for Antiprogestins in the Treatment of Breast Cancer?*

1992 • 212 citations

Combined analysis of studies of the effects of the matrix metalloproteinase inhibitor marimastat on serum tumor markers in advanced cancer: selection of a biologically active and tolerable dose for longer-term studies.

1998 • 211 citations

Overexpression of cyclin D1 messenger RNA predicts for poor prognosis in estrogen receptor-positive breast cancer.

1999 • 210 citations

Heteromeric and Homomeric Interactions Correlate with Signaling Activity and Functional Cooperativity of Smad3 and Smad4/DPC4

1997 • 207 citations

Activation of the Ras signalling pathway in human breast cancer cells overexpressing erbB-2.

1994 • 204 citations

Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45SKP2: evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway

1998 • 204 citations

Abrogation of p27 by cDNA Antisense Suppresses Quiescence (G0 State) in Fibroblasts

1996 • 203 citations

neu and ras initiate murine mammary tumors that share genetic markers generally absent in c-myc and int-2-initiated tumors.

1994 • 198 citations

Activation of Cyclin-Dependent Kinase 4 (cdk4) by Mouse MO15-Associated Kinase

1994 • 197 citations

New paradigms for the treatment of cancer: The role of anti-angiogenesis agents

2000 • 194 citations

Mammary cancer in transgenic mice expressing insulin-like growth factor II (IGF-II)

1995 • 190 citations

Novel Activating Mutations in the neu Proto-oncogene Involved in Induction of Mammary Tumors

1994 • 188 citations

Identification of the active region of the DNA synthesis inhibitory gene p21Sdi1/CIP1/WAF1.

1995 • 186 citations

The Many Roads That Lead to Ras

1993 • 185 citations

Ectopic TGFβ1 Expression in the Secretory Mammary Epithelium Induces Early Senescence of the Epithelial Stem Cell Population

1995 • 182 citations

Biology of TGF-β in knockout and transgenic mouse models

1997 • 178 citations

Inhibition of c-myc expression by phosphorothioate antisense oligonucleotide identifies a critical role for c-myc in the growth of human breast cancer.

1991 • 177 citations

Differences in breast cancer prognosis among African-American and Caucasian women

2000 • 176 citations

Expression of a truncated Int3 gene in developing secretory mammary epithelium specifically retards lobular differentiation resulting in tumorigenesis.

1996 • 174 citations

Progestins both stimulate and inhibit breast cancer cell cycle progression while increasing expression of transforming growth factor alpha, epidermal growth factor receptor, c-fos, and c-myc genes.

1991 • 172 citations

Growth factor expression in normal, benign, and malignant breast tissue

1988 • 161 citations

Overexpression of erbB-2 or EGF receptor proteins present in early stage mammary carcinoma is detected simultaneously in matched primary tumors and regional metastases.

1989 • 160 citations

Overexpression of Bcl-2 inhibits alveolar cell apoptosis during involution and accelerates c-myc-induced tumorigenesis of the mammary gland in transgenic mice

1997 • 159 citations

c-Src Kinase Activity Is Required for Hepatocyte Growth Factor-induced Motility and Anchorage-independent Growth of Mammary Carcinoma Cells

1998 • 156 citations

SNF2β-BRG1 is Essential for the Viability of F9 Murine Embryonal Carcinoma Cells

1997 • 156 citations

The Cyclins and Cyclin-Dependent Kinase Inhibitors in Hormonal Regulation of Proliferation and Differentiation

1999 • 154 citations

Genetic Prodrug Activation Therapy for Breast Cancer: A Phase I Clinical Trial oferbB-2–Directed Suicide Gene Expression

1999 • 147 citations

BRCA1-associated growth arrest is RB-dependent

1999 • 147 citations

Antitumor effect of a farnesyl protein transferase inhibitor in mammary and lymphoid tumors overexpressing N-ras in transgenic mice.

1998 • 146 citations

Wnt-10b directs hypermorphic development and transformation in mammary glands of male and female mice

1997 • 145 citations

The Cyclin D1 Gene Is Transcriptionally Repressed by Caveolin-1

2000 • 145 citations

Novel activating mutations in the neu proto-oncogene involved in induction of mammary tumors.

1994 • 144 citations

Proto-oncogene abnormalities in human breast cancer: correlations with anatomic features and clinical course of disease.

1987 • 143 citations

THE RISK OF CANCER ASSOCIATED WITH SPECIFIC MUTATIONS OF BRCA1 AND BRCA2 AMONG ASHKENAZI JEWS

1997 • 142 citations

Human TAF(II)135 potentiates transcriptional activation by the AF-2s of the retinoic acid, vitamin D3, and thyroid hormone receptors in mammalian cells.

1997 • 141 citations

Induction of apoptosis by the tumor suppressor protein BRCA1.

1996 • 140 citations

Steroid Hormone Regulation of Nuclear Proto-oncogenes*

1993 • 135 citations

Fumagillin analog in the treatment of Kaposi's sarcoma: a phase I AIDS Clinical Trial Group study. AIDS Clinical Trial Group No. 215 Team.

1998 • 134 citations

Activation of cyclin-dependent kinase 4 (cdk4) by mouse MO15-associated kinase.

1994 • 129 citations

Transgenes expressing the Wnt-1 and int-2 proto-oncogenes cooperate during mammary carcinogenesis in doubly transgenic mice.

1992 • 128 citations

Activation of cyclin-dependent kinases by Myc mediates induction of cyclin A, but not apoptosis.

1996 • 127 citations

Regulatory Mechanisms in Breast Cancer

1991 • 124 citations

Disruption of estrogen receptor gene prevents 17 beta estradiol-induced angiogenesis in transgenic mice.

1996 • 124 citations

Oncogenic Signals of HER-2/neu in Regulating the Stability of the Cyclin-dependent Kinase Inhibitor p27

2000 • 123 citations

Identification of binding domains on the p21Cip1 cyclin-dependent kinase inhibitor.

1995 • 123 citations

NDF/heregulin induces persistence of terminal end buds and adenocarcinomas in the mammary glands of transgenic mice.

1996 • 123 citations

Overexpression of a Kinase-deficient Transforming Growth Factor-β Type II Receptor in Mouse Mammary Stroma Results in Increased Epithelial Branching

1999 • 122 citations

Phase II Evaluation of Thalidomide in Patients With Metastatic Breast Cancer

2000 • 117 citations

Activity of thalidomide in AIDS-related Kaposi's sarcoma and correlation with HHV8 titre

1998 • 116 citations

Transgenic expression of tpr-met oncogene leads to development of mammary hyperplasia and tumors.

1996 • 112 citations

Adenovirus-mediated p53 gene therapy has greater efficacy when combined with chemotherapy against human head and neck, ovarian, prostate, and breast cancer

1999 • 110 citations

Distinct Angiogenic patterns are associated with high-gradein situ ductal carcinomas of the breast

1997 • 110 citations

neu/ERBB2 Cooperates with p53-172H during Mammary Tumorigenesis in Transgenic Mice

1997 • 107 citations

Localization of transforming growth factor-β isotypes in lesions of the human breast

1992 • 107 citations

Direct and specific interaction of c-Src with Neu is involved in signaling by the epidermal growth factor receptor.

1995 • 104 citations

Frequency of p53 Mutations in Breast Carcinomas From Ashkenazi Jewish Carriers of BRCA1 Mutations

1999 • 102 citations

Constitutive expression of a truncated INT3 gene in mouse mammary epithelium impairs differentiation and functional development.

1995 • 98 citations

Regulation of estrogen receptor transcriptional enhancement by the cyclin A/Cdk2 complex

1997 • 95 citations

Cardiac toxicity of trastuzumab (Herceptin): Implications for the design of adjuvant trials

2001 • 94 citations

Inactivation of a Cdk2 Inhibitor during Interleukin 2-Induced Proliferation of Human T Lymphocytes

1994 • 94 citations

Differential expression of a novel gene, WDNM1, in nonmetastatic rat mammary adenocarcinoma cells.

1988 • 93 citations

Keratinocyte growth factor induces mammary and prostatic hyperplasia and mammary adenocarcinoma in transgenic mice.

1996 • 91 citations

<i>neu</i>(c-erbB-2/HER2) and the Epidermal Growth Factor Receptor (EGFR) in Breast Cancer

1993 • 88 citations

Transforming Potential of Dbl Family Proteins Correlates with Transcription from the Cyclin D1 Promoter but Not with Activation of Jun NH2-terminal Kinase, p38/Mpk2, Serum Response Factor, or c-Jun

1998 • 88 citations

Estrogen regulates activity of cyclin-dependent kinases and retinoblastoma protein phosphorylation in breast cancer cells

1996 • 88 citations

In Vivo Amplification and Rearrangement of c-myc Oncogene in Human Breast Tumors

1988 • 84 citations

Peptide growth factor cross-talk with the estrogen receptor requires the A/B domain and occurs independently of protein kinase C or estradiol

1996 • 81 citations

C-MYC: evidence for multiple regulatory functions.

1990 • 79 citations

Induction of mammary epithelial hyperplasias and mammary tumors in transgenic mice expressing a murine mammary tumor virus/activated c-src fusion gene.

1995 • 78 citations

Suppression of Gene Amplification in Human Cell Hybrids

1992 • 76 citations

Angiogenic growth factors in preinvasive breast disease.

1999 • 75 citations

Growth Factor, Steroid, and Steroid Antagonist Regulation of Cyclin Gene Expression Associated With Changes in T-47D Human Breast Cancer Cell Cycle Progression

1993 • 74 citations

Inherited genetic predisposition in breast cancer

1999 • 74 citations

Differential Modulation of G1 Cyclins and the Cdk Inhibitor p27 by Platelet-derived Growth Factor and Plasma Factors in Density-arrested Fibroblasts

1996 • 71 citations

Therapeutic Antitumor Response After Immunization with an Admixture of Recombinant Vaccinia Viruses Expressing a Modified MUC1 Gene and the Murine T-Cell Costimulatory Molecule B7

1997 • 69 citations

Metastasizing mammary carcinomas in H19 enhancers-Igf2 transgenic mice.

1998 • 68 citations

Is TP53 dysfunction required for BRCA1-associated carcinogenesis?

1999 • 64 citations

Amplification and protein over-expression of the neu/HER-2/c-erbB-2 protooncogene in human breast carcinomas: relationship to loss of gene sequences on chromosome 17, family history and prognosis

1990 • 63 citations

Growth factors in breast cancer

1995 • 56 citations

Loss of anti-mitotic effects of Bcl-2 with retention of anti-apoptotic activity during tumor progression in a mouse model

1999 • 54 citations

The molecular biology of RU486. Is there a role for antiprogestins in the treatment of breast cancer?

1992 • 51 citations

Mode of estrogen action on cell proliferation in CAMA‐1 cells: II. Sensitivity of G1 phase population

1987 • 51 citations

C-Src Activation by ErbB2 Leads to Attachment-Independent Growth of Human Breast Epithelial Cells

1998 • 46 citations

Aberrant reproductive phenotypes evident in transgenic mice expressing the wild-type mouse estrogen receptor.

1994 • 46 citations

Oncogenicity of the ret transforming gene in MMTV/ret transgenic mice.

1990 • 45 citations

Isolation of Gene Associated With High Metastatic Potential in Rat Mammary Adenocarcinomas

1990 • 43 citations

Nuclear redistribution of BRCA1 during viral infection.

1998 • 43 citations

Acceleration of mammary neoplasia in transforming growth factor alpha transgenic mice by 7,12-dimethylbenzanthracene.

1994 • 39 citations

Steroid hormone regulation of nuclear proto-oncogenes

1993 • 39 citations

Inducible expression of cyclin D1 in T-47D human breast cancer cells is sufficient for Cdk2 activation and pRB hyperphosphorylation

1996 • 38 citations

Differential regulation of AP1 activity by retinoic acid in hormone-dependent and -independent breast cancer cells

1995 • 37 citations

Intermolecular association and trans-phosphorylation of different neu-kinase forms permit SH2-dependent signaling and oncogenic transformation.

1995 • 33 citations

Disruption of estrogen receptor gene prevents 17 beta estradiol-induced angiogenesis in transgenic mice

1996 • 33 citations

Transforming growth factor-beta1 recruits histone deacetylase 1 to a p130 repressor complex in transgenic mice in vivo.

2000 • 31 citations

Steroids, growth factors, and cell cycle controls in breast cancer

1991 • 31 citations

Regulation of cyclin E and p27kip during mitosis in BALB/c 3T3 cells.

1995 • 30 citations

Metastasis-Associated genes and metastatic tumor progression.

1999 • 30 citations

Motility and invasive potency of murine T‐lymphoma cells: effect of microtubule inhibitors.

1994 • 30 citations

Effects of the Progestin Antagonist RU 486 on T-47D Breast Cancer Cell Cycle Kinetics and Cell Cycle Regulatory Genes

1993 • 29 citations

Search for metastasis suppressor genes.

1989 • 28 citations

Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways.

1997 • 27 citations

Gene replacement with the human BRCA1 locus: tissue specific expression and rescue of embryonic lethality in mice

2000 • 24 citations

Histone deacetylase inhibitors: novel anticancer agents

1999 • 23 citations

BRCA1-associated growth arrest is RB-dependent

1999 • 20 citations

Amino-terminal domains of c-myc and N-myc proteins mediate binding to the retinoblastoma gene product

1991 • 19 citations

Transforming growth factor activity in pleural and peritoneal effusions from cancer and non-cancer patients.

1987 • 15 citations

Determination of Neuronal Cell Fate: Lessons From the R7 Neuron of Drosophila

1994 • 14 citations

Aberrant reproductive phenotypes evident in transgenic mice expressing the wild-type mouse estrogen receptor

1994 • 12 citations

Distinct Angiogenic patterns are associated with high‐grade in situ ductal carcinomas of the breast

1997 • 9 citations

Immortalization and malignant transformation of differentiated cells by oncogenes in vitro and in transgenic mice.

1989 • 9 citations

Transgenic mice in cancer research.

1989 • 8 citations

The Application of High Density Microarray for Analysis of Mitogenic Signaling and Cell-Cycle in the Adrenal

2000 • 5 citations

Metastasizing mammary carcinomas in H19 enhancers‐Igf2 transgenic mice

1998 • 5 citations

Inherited genetic predisposition in breast cancer

1999 • 4 citations

Phase II Evaluation Of Thalidomide In Patients With Metastatic Breast Cancer

2001 • 4 citations

Inducible expression of cyclin D1 in T‐47D human breast cancer cells is sufficient for Cdk2 activation and pRB hyperphosphorylation

1996 • 2 citations

Transgenic Mice in Cancer Research

2002 • 2 citations