Partial rescue of Brca15–6 early embryonic lethality by p53 or p21 null mutation

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

Cell Cycle Checkpoints: Preventing an Identity Crisis

1996 • 2,056 citations

Tumor spectrum analysis in p53-mutant mice

1994 • 2,034 citations

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

1994 • 2,025 citations

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

1994 • 1,475 citations

Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells

1997 • 1,466 citations

Radiation-induced cell cycle arrest compromised by p21 deficiency

1995 • 1,249 citations

Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein

1992 • 1,231 citations

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

1997 • 1,055 citations

Targeted disruption of the Rad51 gene leads to lethality in embryonic mice.

1996 • 789 citations

Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit

1993 • 778 citations

A Mutation in Mouse rad51 Results in an Early Embryonic Lethal That Is Suppressed by a Mutation in p53

1996 • 692 citations

The Tumor Suppressor Gene Brca1 Is Required for Embryonic Cellular Proliferation in the Mouse

1996 • 652 citations

Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities

1996 • 468 citations

Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest.

1996 • 385 citations

Semidominant Suppressors of Srs2 Helicase Mutations of Saccharomyces cerevisiae Map in the RAD51 Gene, Whose Sequence Predicts a Protein with Similarities to Procaryotic RecA Proteins

1992 • 328 citations

Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development.

1996 • 318 citations

V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors.

1996 • 280 citations

Semidominant suppressors of Srs2 helicase mutations of Saccharomyces cerevisiae map in the RAD51 gene, whose sequence predicts a protein with similarities to procaryotic RecA proteins.

1992 • 201 citations

Helical interactions in homologous pairing and strand exchange driven by RecA protein.

1991 • 196 citations

p53: A Cell Cycle Regulator Activated by DNA Damage

1995 • 121 citations

Morphological stages of postimplantation Embryonic development

1990 • 22 citations