Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

1994 • 5,994 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

Linkage of Early-Onset Familial Breast Cancer to Chromosome 17q21

1990 • 2,505 citations

Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells

1977 • 1,411 citations

Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium.

1993 • 1,269 citations

Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein

1992 • 1,231 citations

Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor.

1994 • 1,046 citations

Genetic analysis of breast cancer in the cancer and steroid hormone study.

1991 • 915 citations

Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties

1992 • 846 citations

Catalysis of ATP-Dependent Homologous DNA Pairing and Strand Exchange by Yeast RAD51 Protein

1994 • 843 citations

Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over

1996 • 800 citations

Targeted disruption of the Rad51 gene leads to lethality in embryonic mice.

1996 • 789 citations

Breast and Other Cancers in Families with Ataxia-Telangiectasia

1987 • 730 citations

FIDELITY MECHANISMS IN DNA REPLICATION

1991 • 709 citations

A Mutation in Mouse rad51 Results in an Early Embryonic Lethal That Is Suppressed by a Mutation in p53

1996 • 692 citations

Human Rad51 Protein Promotes ATP-Dependent Homologous Pairing and Strand Transfer Reactions In Vitro

1996 • 670 citations

The Tumor Suppressor Gene Brca1 Is Required for Embryonic Cellular Proliferation in the Mouse

1996 • 652 citations

Does this have a familiar RING?

1996 • 632 citations

Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families

1994 • 626 citations

Biochemistry and genetics of eukaryotic mismatch repair.

1996 • 598 citations

Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes.

1995 • 556 citations

Meiotic Pachytene Arrest in MLH1-Deficient Mice

1996 • 549 citations

Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis

1995 • 536 citations

Familial breast-ovarian cancer locus on chromosome 17q12-q23

1991 • 513 citations

Inheritance of human breast cancer: evidence for autosomal dominant transmission in high-risk families.

1988 • 510 citations

THE TUMOR SUPPRESSOR GENES

1993 • 509 citations

DNA strand exchange mediated by a RAD51-ssDNA nucleoprotein filament with polarity opposite to that of RecA

1995 • 484 citations

RecA homologs Dmc1 and Rad51 interact to form multiple nuclear complexes prior to meiotic chromosome synapsis

1994 • 479 citations

Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities

1996 • 468 citations

Hereditary breast cancer: Pathobiology, prognosis, and BRCA1 and BRCA2 gene linkage

1996 • 463 citations

Evidence for a transcriptional activation function of BRCA1 C-terminal region

1996 • 443 citations

DNA repair mutants defining G2 checkpoint pathways in Schizosaccharomyces pombe.

1992 • 417 citations

Meiosis: how could it work?

1996 • 417 citations

The RING Finger

1993 • 417 citations

Allele losses in the region 17q12–21 in familial breast and ovarian cancer involve the wild–type chromosome

1992 • 414 citations

Mutations in the BRCA1 gene in families with early-onset breast and ovarian cancer

1994 • 389 citations

Simultaneous visualization of seven different DNA probes by in situ hybridization using combinatorial fluorescence and digital imaging microscopy.

1992 • 385 citations

Somatic mutations in the BRCA1 gene in sporadic ovarian tumours

1995 • 377 citations

The Schizosaccharomyces pombe rad3 checkpoint gene.

1996 • 366 citations

The gene encoding a major component of the lateral elements of synaptonemal complexes of the rat is related to X-linked lymphocyte-regulated genes.

1994 • 363 citations

Growth retardation and tumour inhibition by BRCA1

1996 • 360 citations

p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction.

1996 • 346 citations

The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues

1995 • 345 citations

A human RNA polymerase II complex associated with SRB and DNA-repair proteins

1996 • 341 citations

Common origins of BRCA1 mutations in Canadian breast and ovarian cancer families

1994 • 334 citations

A collaborative survey of 80 mutations in the BRCA1 breast and ovarian cancer susceptibility gene. Implications for presymptomatic testing and screening

1995 • 329 citations

Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development.

1996 • 318 citations

Aberrant Subcellular Localization of BRCA1 in Breast Cancer

1995 • 310 citations

Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members.

1995 • 299 citations

The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes.

1996 • 282 citations

Binding to DNA and the Retinoblastoma Gene Product Promoted by Complex Formation of Different E2F Family Members

1993 • 271 citations

BRCA1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner.

1996 • 267 citations

cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein.

1996 • 261 citations

Biochemistry of Genetic Recombination: Energetics and Mechanism of DNA Strand Exchange

1991 • 259 citations

A Collaborative Survey of 80 Mutations in the BRCA1 Breast and Ovarian Cancer Susceptibility Gene

1995 • 243 citations

Checkpoint controls in Schizosaccharomyces pombe: rad1.

1992 • 224 citations

Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice.

1995 • 200 citations

Helical interactions in homologous pairing and strand exchange driven by RecA protein.

1991 • 196 citations

Differential subcellular localization, expression and biological toxicity of BRCA1 and the splice variant BRCA1-Δ11b

1997 • 195 citations

Hormone-dependent regulation of BRCA1 in human breast cancer cells.

1995 • 178 citations

Dynamic changes in Rad51 distribution on chromatin during meiosis in male and female vertebrates

1995 • 177 citations

S phase specific formation of the human Rad51 protein nuclear foci in lymphocytes.

1996 • 163 citations

Localization of RecA-like recombination proteins on chromosomes of the lily at various meiotic stages.

1995 • 155 citations

Chromomere analysis of the chromosome complement of rye

1953 • 150 citations

Cell cycle regulation of BRCA1 messenger RNA in human breast epithelial cells.

1996 • 146 citations

BRCA1 expression is induced before DNA synthesis in both normal and tumor-derived breast cells.

1996 • 143 citations

Induction of apoptosis by the tumor suppressor protein BRCA1.

1996 • 140 citations

Loss of heterozygosity in familial tumors from three BRCA1-linked kindreds.

1994 • 130 citations

Synaptonemal complex antigen location and conservation.

1987 • 119 citations

The rad3+ gene of Schizosaccharomyces pombe is involved in multiple checkpoint functions and in DNA repair.

1992 • 111 citations

Presynaptic association of Rad51 protein with selected sites in meiotic chromatin.

1996 • 109 citations

Antisense RNA to the putative tumor suppressor gene BRCA1 transforms mouse fibroblasts.

1996 • 75 citations

BRCA1 mRNA is expressed highly during meiosis and spermiogenesis but not during mitosis of male germ cells.

1996 • 38 citations

BRCA1, a gene involved in inherited predisposition to breast and ovarian cancer

1996 • 24 citations

Untitled

1997 • 3 citations