Genetic Heterogeneity and Penetrance Analysis of the BRCA1 and BRCA2 Genes in Breast Cancer Families

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

1994 • 5,994 citations

Identification of the breast cancer susceptibility gene BRCA2

1995 • 3,581 citations

Strategies for multilocus linkage analysis in humans.

1984 • 2,600 citations

Linkage of Early-Onset Familial Breast Cancer to Chromosome 17q21

1990 • 2,505 citations

The Risk of Cancer Associated with Specific Mutations ofBRCA1andBRCA2among Ashkenazi Jews

1997 • 2,255 citations

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

1997 • 2,063 citations

Localization of a Breast Cancer Susceptibility Gene, BRCA2 , to Chromosome 13q12-13

1994 • 1,884 citations

The 1993–94 Généthon human genetic linkage map

1994 • 1,870 citations

Risks of cancer in BRCA1-mutation carriers

1994 • 1,865 citations

Breast and ovarian cancer incidence in BRCA1-mutation carriers. Breast Cancer Linkage Consortium.

1995 • 1,602 citations

Faster sequential genetic linkage computations.

1993 • 1,378 citations

Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium.

1993 • 1,269 citations

Genetic analysis of breast cancer in the cancer and steroid hormone study.

1991 • 915 citations

The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds

1996 • 849 citations

Conformation-sensitive gel electrophoresis for rapid detection of single-base differences in double-stranded PCR products and DNA fragments: evidence for solvent-induced bends in DNA heteroduplexes.

1993 • 685 citations

Germline mutations of the BRCA1 gene in breast and ovarian cancer families provide evidence for a genotype–phenotype correlation

1995 • 497 citations

Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis

1997 • 487 citations

Variation of risks of breast and ovarian cancer associated with different germline mutations of the BRCA2 gene

1997 • 437 citations

Cancer Risks in Two Large Breast Cancer Families Linked to BRCA2 on Chromosome 13q12‐13

1997 • 389 citations

Growth retardation and tumour inhibition by BRCA1

1996 • 360 citations

Rapid detection of BRCA1 mutations by the protein truncation test

1995 • 317 citations

An evaluation of genetic heterogeneity in 145 breast-ovarian cancer families. Breast Cancer Linkage Consortium.

1995 • 268 citations

Mutation analysis of the BRCA2 gene in 49 site–specific breast cancer families

1996 • 261 citations

Closing in on a breast cancer gene on chromosome 17q.

1992 • 217 citations

Risk of prostate, ovarian, and endometrial cancer among relatives of women with breast cancer.

1992 • 188 citations

Moderate frequency of BRCA1 and BRCA2 germ-line mutations in Scandinavian familial breast cancer.

1997 • 181 citations

Mutations in BRCA1 and BRCA2 in breast cancer families: are there more breast cancer-susceptibility genes?

1997 • 177 citations

A high proportion of novel mutations in BRCA1 with strong founder effects among Dutch and Belgian hereditary breast and ovarian cancer families.

1997 • 171 citations

BRCA2 in American families with four or more cases of breast or ovarian cancer: recurrent and novel mutations, variable expression, penetrance, and the possibility of families whose cancer is not attributable to BRCA1 or BRCA2.

1997 • 168 citations

Familial male breast cancer is not linked to the BRCA1 locus on chromosome 17q

1994 • 158 citations

Dinucleotide repeat polymorphisms at the D17S250 and D17S261 loci

1990 • 152 citations

BRCA1 sequence variations in 160 individuals referred to a breast/ovarian family cancer clinic. Institut Curie Breast Cancer Group.

1997 • 146 citations

Loss of heterozygosity and linkage analysis in breast carcinoma: indication for a putative third susceptibility gene on the short arm of chromosome 8.

1995 • 132 citations

Strong indication for a breast cancer susceptibility gene on chromosome 8p12-p22: linkage analysis in German breast cancer families

1997 • 121 citations

THRA1 and D17S183 flank an interval of < 4 cM for the breast-ovarian cancer gene (BRCA1) on chromosome 17q21.

1993 • 88 citations

Rapid detection of regionally clustered germ-line BRCA1 mutations by multiplex heteroduplex analysis. UKCCCR Familial Ovarian Cancer Study Group.

1996 • 79 citations