Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abrogated by c-Myc.

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

Principles of CDK regulation

1995 • 3,267 citations

Inhibitors of mammalian G1 cyclin-dependent kinases.

1995 • 3,258 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

G1 phase progression: Cycling on cue

1994 • 2,706 citations

Production of high-titer helper-free retroviruses by transient transfection.

1993 • 2,280 citations

G ₁ Events and Regulation of Cell Proliferation

1989 • 2,203 citations

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

1994 • 2,154 citations

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1990 • 2,129 citations

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

1994 • 2,071 citations

Mammalian G1 cyclins

1993 • 1,990 citations

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.

1994 • 1,970 citations

pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

1994 • 1,932 citations

Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27

1995 • 1,848 citations

Mice Lacking p27 Display Increased Body Size, Multiple Organ Hyperplasia, Retinal Dysplasia, and Pituitary Tumors

1996 • 1,583 citations

A Syndrome of Multiorgan Hyperplasia with Features of Gigantism, Tumorigenesis, and Female Sterility in p27 -Deficient Mice

1996 • 1,488 citations

Enhanced Growth of Mice Lacking the Cyclin-Dependent Kinase Inhibitor Function of p27

1996 • 1,283 citations

D-type cyclins

1995 • 978 citations

Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta.

1995 • 959 citations

Cellular Targets for Activation by the E2F1 Transcription Factor Include DNA Synthesis- and G₁/S-Regulatory Genes

1995 • 910 citations

lnterleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin

1994 • 903 citations

Translational Control of p27 ^Kip1 Accumulation During the Cell Cycle

1996 • 864 citations

myc FUNCTION AND REGULATION

1992 • 790 citations

Proteins of the Myc Network: Essential Regulators of Cell Growth and Differentiation

1996 • 787 citations

c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines.

1994 • 747 citations

Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation

1994 • 742 citations

Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.

1994 • 731 citations

Cdc25 cell-cycle phosphatase as a target of c-myc

1996 • 691 citations

Requirement of p27 ^Kip1 for Restriction Point Control of the Fibroblast Cell Cycle

1996 • 683 citations

Novel INK4 Proteins, p19 and p18, Are Specific Inhibitors of the Cyclin D-Dependent Kinases CDK4 and CDK6

1995 • 657 citations

The IL-2 Receptor Complex: Its Structure, Function, and Target Genes

1993 • 601 citations

The MYC protein activates transcription of the alpha-prothymosin gene.

1991 • 589 citations

Functional role for c-myc in mitogenic response to platelet-derived growth factor

1984 • 578 citations

Oncogenic activity of the c-Myc protein requires dimerization with Max

1993 • 543 citations

Induction of p21 (WAF-1/CIP1) during differentiation.

1994 • 493 citations

Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation.

1996 • 485 citations

The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth.

1994 • 484 citations

Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max

1992 • 458 citations

Definition of regions in human c-myc that are involved in transformation and nuclear localization.

1987 • 457 citations

An amino-terminal c-myc domain required for neoplastic transformation activates transcription.

1990 • 413 citations

Cdk inhibitors in development and cancer

1996 • 410 citations

The c-Myc protein induces cell cycle progression and apoptosis through dimerization with Max.

1993 • 392 citations

Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E.

1996 • 365 citations

Myc—Max—Mad: a transcription factor network controlling cell cycle progression, differentiation and death

1994 • 365 citations

Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site.

1995 • 363 citations

What is the restriction point?

1995 • 345 citations

The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E.

1993 • 341 citations

p27Kip1: chromosomal mapping to 12p12-12p13.1 and absence of mutations in human tumors.

1995 • 338 citations

A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cells.

1994 • 332 citations

Molecular analysis of the cyclin-dependent kinase inhibitor gene p27/Kip1 in human malignancies.

1995 • 327 citations

Differential modulation of cyclin gene expression by MYC.

1993 • 321 citations

Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src

1995 • 309 citations

Altered Cell Cycle Kinetics, Gene Expression, and G₁ Restriction Point Regulation in Rb-Deficient Fibroblasts

1996 • 301 citations

Inactivation of a Cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes.

1994 • 289 citations

A cell cycle-regulated inhibitor of cyclin-dependent kinases.

1994 • 285 citations

Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes.

1995 • 254 citations

Formation of p27-CDK complexes during the human mitotic cell cycle.

1996 • 247 citations

Identification of a Myc-dependent step during the formation of active G1 cyclin-cdk complexes.

1995 • 243 citations

Redistribution of the CDK inhibitor p27 between different cyclin.CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation.

1995 • 237 citations

E2F and Cell Proliferation: A World Turned Upside Down

1996 • 234 citations

Gadd45 is a nuclear cell cycle regulated protein which interacts with p21Cip1.

1995 • 229 citations

Fibroblast lines expressing activated c-myc oncogenes are tumorigenic in nude mice and syngeneic animals

1984 • 212 citations

Assignment of the human p27Kip1 gene to 12p13 and its analysis in leukemias.

1995 • 207 citations

Cloning and characterization of murine p16INK4a and p15INK4b genes.

1995 • 197 citations

Abrogation of IL-3 and IL-2 dependence by recombinant murine retroviruses expressing v-myc oncogenes

1985 • 176 citations

The differentiation primary response gene MyD118, related to GADD45, encodes for a nuclear protein which interacts with PCNA and p21WAF1/CIP1.

1996 • 176 citations

Myc rescue of a mutant CSF-1 receptor impaired in mitogenic signalling

1991 • 175 citations

An Amino-Terminal c-Myc Domain Required for Neoplastic Transformation Activates Transcription

1990 • 153 citations

Transcriptional regulation during the mammalian cell cycle

1995 • 152 citations

Effects of c-myc Expression on Cell Cycle Progression

1994 • 141 citations

Inactivation of p27Kip1 by the viral E1A oncoprotein in TGFβ-treated cells

1996 • 135 citations

Alterations of the p27KIP1 gene in non-Hodgkin's lymphomas and adult T- cell leukemia/lymphoma

1995 • 134 citations

Overexpression of the c-Myc oncoprotein blocks the growth-inhibitory response but is required for the mitogenic effects of transforming growth factor beta 1.

1995 • 131 citations

Cell cycle-dependent phosphorylation of the retinoblastoma-related protein p130.

1995 • 129 citations

Activation of cyclin-dependent kinases by Myc mediates induction of cyclin A, but not apoptosis.

1996 • 127 citations

Proliferation is a prerequisite for bacterial superantigen-induced T cell apoptosis in vivo.

1995 • 123 citations

The gadd and MyD Genes Define a Novel Set of Mammalian Genes Encoding Acidic Proteins That Synergistically Suppress Cell Growth

1994 • 119 citations

Discrimination between different E-box-binding proteins at an endogenous target gene of c-myc.

1996 • 113 citations

Rescue of defective mitogenic signaling by D-type cyclins.

1995 • 111 citations

Regulation of the retinoblastoma protein-related protein p107 by G1 cyclin-associated kinases.

1996 • 110 citations

Definition of Regions in Human c-myc that are Involved in Transformation and Nuclear Localization

1987 • 106 citations

Inactivation of a Cdk2 Inhibitor during Interleukin 2-Induced Proliferation of Human T Lymphocytes

1994 • 94 citations

Effects of c-myc expression on cell cycle progression.

1994 • 93 citations

Abrogation of p53-induced cell cycle arrest by c-Myc: evidence for an inhibitor of p21WAF1/CIP1/SDI1.

1995 • 79 citations

Myc Function and Regulation

1992 • 60 citations

A Novel Inhibitor of Cyclin-Cdk Activity Detected in Transforming Growth Factor β-Arrested Epithelial Cells

1994 • 60 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 52 citations

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1990 • 33 citations

The IL-2 Receptor Complex: Its Structure, Function, and Target Genes

1993 • 33 citations