Histone deacetylase inhibitors: novel anticancer agents

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases

1996 • 2,873 citations

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

1999 • 1,865 citations

Histone acetylation and transcriptional regulatory mechanisms

1998 • 1,793 citations

The CBP co-activator is a histone acetyltransferase

1996 • 1,773 citations

A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p

1996 • 1,769 citations

A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

1996 • 1,457 citations

Nuclear Receptor Repression Mediated by a Complex Containing SMRT, mSin3A, and Histone Deacetylase

1997 • 1,251 citations

Retinoblastoma protein recruits histone deacetylase to repress transcription

1998 • 1,231 citations

A complex containing N-CoR, mSln3 and histone deacetylase mediates transcriptional repression

1997 • 1,218 citations

Role of the histone deacetylase complex in acute promyelocytic leukaemia

1998 • 1,091 citations

Fusion proteins of the retinoic acid receptor-α recruit histone deacetylase in promyelocytic leukaemia

1998 • 1,021 citations

Rb Interacts with Histone Deacetylase to Repress Transcription

1998 • 965 citations

Histone Deacetylases Associated with the mSin3 Corepressor Mediate Mad Transcriptional Repression

1997 • 945 citations

Retinoblastoma protein represses transcription by recruiting a histone deacetylase

1998 • 919 citations

A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases

1998 • 899 citations

What's Up and Down with Histone Deacetylation and Transcription?

1997 • 831 citations

Three proteins define a class of human histone deacetylases related to yeast Hda1p

1999 • 744 citations

Histone Deacetylase Activity Is Required for Full Transcriptional Repression by mSin3A

1997 • 739 citations

Trichostatin A and trapoxin: Novel chemical probes for the role of histone acetylation in chromatin structure and function

1995 • 719 citations

The TAFII250 Subunit of TFIID Has Histone Acetyltransferase Activity

1996 • 705 citations

A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors

1999 • 686 citations

Distinct interactions of PML-RARα and PLZF-RARα with co-repressors determine differential responses to RA in APL

1998 • 571 citations

Apicidin: A novel antiprotozoal agent that inhibits parasite histone deacetylase

1996 • 543 citations

p21 ^WAF1 is required for butyrate-mediated growth inhibition of human colon cancer cells

1998 • 530 citations

Therapeutic Targeting of Transcription in Acute Promyelocytic Leukemia by Use of an Inhibitor of Histone Deacetylase

1998 • 517 citations

FR901228, a Potent Antitumor Antibiotic, Is a Novel Histone Deacetylase Inhibitor

1998 • 481 citations

Isolation and Characterization of cDNAs Corresponding to an Additional Member of the Human Histone Deacetylase Gene Family

1997 • 431 citations

Conjunction dysfunction: CBP/p300 in human disease

1998 • 406 citations

Histone Deacetylase 1 Can Repress Transcription by Binding to Sp1

1999 • 397 citations

MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3)

1997 • 323 citations

The E7 oncoprotein associates with Mi2 and histone deacetylase activity to promote cell growth

1999 • 313 citations

p300 gene alterations in colorectal and gastric carcinomas.

1996 • 293 citations

Characterization of a human RPD3 ortholog, HDAC3

1998 • 292 citations

Histone Deacetylase Inhibitor Activates the WAF1/Cip1 Gene Promoter through the Sp1 Sites

1997 • 291 citations

Transcriptional Regulation of the MDR1 Gene by Histone Acetyltransferase and Deacetylase Is Mediated by NF-Y

1998 • 289 citations

Identification of a Cellular Protein That Specifically Interacts with the Essential Cysteine Region of the HIV-1 Tat Transactivator

1996 • 284 citations

Histone acetylation and cancer

1999 • 261 citations

Oral sodium phenylbutyrate therapy in homozygous beta thalassemia: a clinical trial

1995 • 257 citations

Reactivation of silenced, virally transduced genes by inhibitors of histone deacetylase

1997 • 250 citations

Oxamflatin is a novel antitumor compound that inhibits mammalian histone deacetylase

1999 • 235 citations

Inhibitors of histone deacetylase relieve ETO-mediated repression and induce differentiation of AML1-ETO leukemia cells.

1999 • 195 citations

Depudecin induces morphological reversion of transformed fibroblasts via the inhibition of histone deacetylase

1998 • 192 citations

Short-chain fatty acid-initiated cell cycle arrest and apoptosis of colonic epithelial cells is linked to mitochondrial function.

1997 • 181 citations

Unrestricted cell cycling and cancer

1995 • 164 citations

Apoptotic death in adenocarcinoma cell lines induced by butyrate and other histone deacetylase inhibitors

1997 • 160 citations

Histone deacetylase inhibitors as potential anti-skin cancer agents.

1999 • 140 citations

Both Sp1 and Sp3 are responsible for p21waf1 promoter activity induced by histone deacetylase inhibitor in NIH3T3 cells

1999 • 132 citations

Butyrate as a differentiating agent: pharmacokinetics, analogues and current status

1994 • 130 citations

Anti-tumour activity in vitro and in vivo of selective differentiating agents containing hydroxamate

1999 • 114 citations

Carboxypeptidase A3 (CPA3): a novel gene highly induced by histone deacetylase inhibitors during differentiation of prostate epithelial cancer cells.

1999 • 107 citations

Differential Expression of Human Histone Deacetylase mRNAs in Response to Immune Cell Apoptosis Induction by Trichostatin A and Butyrate

1998 • 99 citations

Fiber-derived butyrate and the prevention of colon cancer

1997 • 90 citations

The BRCA2 is a histone acetyltransferase

1998 • 64 citations

Butyrate modulates DNA-damage-induced p53 response by induction of p53-independent differentiation and apoptosis

1997 • 62 citations

E2F as a Regulator of Keratinocyte Proliferation: Implications for Skin Tumor Development

1997 • 54 citations

Modulation of galectin-1 content in human head and neck squamous carcinoma cells by sodium butyrate

1998 • 43 citations

Tumor selectivity and transcriptional activation by azelaic bishydroxamic acid in human melanocytic cells

1997 • 39 citations

Epidermal cell‐shape regulation and subpopulation kinetics during butyrate‐induced terminal maturation of normal and SV40‐transformed human keratinocytes: Epithelial models of differentiation therapy

1990 • 19 citations