Inducible expression of cyclin D1 in T-47D human breast cancer cells is sufficient for Cdk2 activation and pRB hyperphosphorylation

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

1994 • 2,154 citations

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

1994 • 2,071 citations

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.

1994 • 1,970 citations

pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

1994 • 1,932 citations

Cyclin D1 is a nuclear protein required for cell cycle progression in G1.

1993 • 1,605 citations

Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

1993 • 1,258 citations

Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle

1991 • 1,190 citations

Human Cyclin E, a Nuclear Protein Essential for the G₁-to-S Phase Transition

1995 • 1,132 citations

Distinct Roles for Cyclin-Dependent Kinases in Cell Cycle Control

1993 • 1,096 citations

D-type cyclin-dependent kinase activity in mammalian cells.

1994 • 1,073 citations

Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts.

1993 • 1,057 citations

Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

1993 • 1,047 citations

Formation and Activation of a Cyclin E-cdk2 Complex During the G ₁ Phase of the Human Cell Cycle

1992 • 1,046 citations

The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

1989 • 1,031 citations

D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA

1992 • 1,023 citations

Acceleration of the G₁/S Phase Transition by Expression of Cyclins Dl and E with an Inducible System

1994 • 986 citations

Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice

1994 • 982 citations

The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element

1989 • 931 citations

Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins

1992 • 906 citations

Association of human cyclin E with a periodic G1-S phase protein kinase

1992 • 900 citations

Isolation of three novel human cyclins by rescue of G1 cyclin (cln) function in yeast

1991 • 846 citations

Identification of G1 kinase activity for cdk6, a novel cyclin D partner.

1994 • 798 citations

Cyclin-Dependent Regulation of G ₁ in Mammalian Fibroblasts

1993 • 767 citations

Human D-type cyclin

1991 • 712 citations

Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining.

1994 • 673 citations

Expression and amplification of cyclin genes in human breast cancer.

1993 • 667 citations

Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system.

1994 • 659 citations

TGFβ inhibition of Cdk4 synthesis is linked to cell cycle arrest

1993 • 544 citations

Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product

1991 • 541 citations

Redundant cyclin overexpression and gene amplification in breast cancer cells.

1993 • 526 citations

Cyclin D1 protein expression and function in human breast cancer

1994 • 515 citations

Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation.

1993 • 514 citations

Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase

1991 • 475 citations

Function of a human cyclin gene as an oncogene.

1994 • 471 citations

Cell Cycle-Dependent Regulation of Phosphorylation of the Human Retinoblastoma Gene Product

1989 • 457 citations

Overexpression of cyclin D1 in rat fibroblasts causes abnormalities in growth control, cell cycle progression and gene expression.

1993 • 393 citations

Cyclin D1 induction in breast cancer cells shortens G1 and is sufficient for cells arrested in G1 to complete the cell cycle.

1994 • 377 citations

Cyclin D1 Is Dispensable for G₁ Control in Retinoblastoma Gene-Deficient Cells Independently of cdk4 Activity

1995 • 370 citations

Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product.

1995 • 355 citations

The retinoblastoma protein is phosphorylated on multiple sites by human cdc2.

1991 • 343 citations

Human cyclin-dependent kinase 2 is activated during the S and G2 phases of the cell cycle and associates with cyclin A.

1992 • 331 citations

The cell cycle and the retinoblastoma protein family

1994 • 309 citations

The cdk2 kinase is required for the G1-to-S transition in mammalian cells.

1993 • 307 citations

Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc2 kinase.

1991 • 304 citations

Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase.

1994 • 299 citations

Growth factor, steroid, and steroid antagonist regulation of cyclin gene expression associated with changes in T-47D human breast cancer cell cycle progression.

1993 • 295 citations

Differential expression and regulation of Cyclin D1 protein in normal and tumor human cells: association with Cdk4 is required for Cyclin D1 function in G1 progression.

1994 • 280 citations

DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1.

1994 • 279 citations

Growth-regulated expression of D-type cyclin genes in human diploid fibroblasts.

1992 • 277 citations

CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1.

1994 • 260 citations

CDK2 encodes a 33-kDa cyclin A-associated protein kinase and is expressed before CDC2 in the cell cycle.

1992 • 230 citations

Oncogenic activity of cyclin D1 revealed through cooperation with Ha-ras: link between cell cycle control and malignant transformation.

1994 • 219 citations

Progestins Both Stimulate and Inhibit Breast Cancer Cell Cycle Progression while Increasing Expression of Transforming Growth Factor α, Epidermal Growth Factor Receptor, c-fos, and c-myc Genes

1991 • 218 citations

Phosphorylation of the retinoblastoma protein by cdk2.

1992 • 217 citations

The Retinoblastoma Protein: More than a Tumor Suppressor

1994 • 205 citations

Homology probing: identification of cDNA clones encoding members of the protein-serine kinase family.

1987 • 191 citations

Regulation of G1/S transition by cyclins D2 and D3 in hematopoietic cells.

1993 • 179 citations

Progestins both stimulate and inhibit breast cancer cell cycle progression while increasing expression of transforming growth factor alpha, epidermal growth factor receptor, c-fos, and c-myc genes.

1991 • 172 citations

Cloning and characterization of human cyclin D3, a cDNA closely related in sequence to the PRAD1/cyclin D1 proto-oncogene.

1992 • 150 citations

Protein-DNA Interactions in Vivo Upstream of a Cell Cycle-Regulated Human H4 Histone Gene

1987 • 139 citations

Inducible acceleration of G1 progression through tetracycline-regulated expression of human cyclin E.

1994 • 129 citations

Autocrine production of insulin-like growth factor II using an inducible expression system results in reduced estrogen sensitivity of MCF-7 human breast cancer cells.

1991 • 57 citations

Acute effects of growth factors on T-47D breast cancer cell cycle progression

1993 • 30 citations