Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

1984 • 2,762 citations

Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

1982 • 2,753 citations

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences

1984 • 2,564 citations

HUMAN PLASMA PROTEINASE INHIBITORS

1983 • 2,129 citations

Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene

1985 • 1,804 citations

Fused transcript of abl and bcr genes in chronic myelogenous leukaemia

1985 • 1,650 citations

The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF 1

1985 • 1,590 citations

Sequence and Structure of a Human Glucose Transporter

1985 • 1,557 citations

Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin

1985 • 1,523 citations

Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence

1984 • 1,339 citations

Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor

1986 • 1,226 citations

The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen

1984 • 1,153 citations

The neu oncogene encodes an epidermal growth factor receptor-related protein

1986 • 1,131 citations

Molecular cloning of a new transforming gene from a chemically transformed human cell line

1984 • 966 citations

Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats

1985 • 829 citations

Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts

1981 • 795 citations

THE MOLECULAR GENETICS OF CELLULAR ONCOGENES

1984 • 765 citations

Clonal cell lines from the rat central nervous system

1974 • 727 citations

Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations

1983 • 719 citations

Viral oncogenes

1985 • 605 citations

Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations

1983 • 553 citations

The neu Gene: an erb B-Homologous Gene Distinct from and Unlinked to the Gene Encoding the EGF Receptor

1985 • 513 citations

Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene

1983 • 429 citations

Down-modulation of an oncogene protein product and reversion of the transformed phenotype by monoclonal antibodies

1985 • 408 citations

POLYPEPTIDE GROWTH FACTORS

1984 • 381 citations

Amino-acid substitutions at codon 13 of the N-ras oncogene in human acute myeloid leukaemia

1985 • 372 citations

Expression of functional acetylcholine receptor from cloned cDNAs

1984 • 366 citations

Chemical Mutagenesis

1982 • 366 citations

Synthesis of rabbit β-globin in cultured monkey kidney cells following infection with a SV40 β-globin recombinant genome

1979 • 355 citations

p185, a product of the neu proto-oncogene, is a receptorlike protein associated with tyrosine kinase activity.

1986 • 341 citations

Identification of a phosphoprotein specifically induced by the transforming DNA of rat neuroblastomas

1982 • 251 citations

A molecular approach to leukemogenesis: mouse lymphomas contain an activated c-ras oncogene.

1984 • 192 citations

Activation of a c-K- ras Oncogene by Somatic Mutation in Mouse Lymphomas Induced by Gamma Radiation

1984 • 180 citations

Structural requirements of a membrane-spanning domain for protein anchoring and cell surface transport

1985 • 173 citations

Molecular cloning of the neu gene: absence of gross structural alteration in oncogenic alleles.

1986 • 158 citations

Monoclonal antibodies identify a cell-surface antigen associated with an activated cellular oncogene

1984 • 158 citations

Loss of the normal N-ras allele in a mouse thymic lymphoma induced by a chemical carcinogen.

1985 • 103 citations

ANALYSIS OF A MOUSE α-GLOBIN GENE MUTATION INDUCED BY ETHYLNITROSOUREA

1983 • 96 citations

c-erbB activation in avian leukosis virus-induced erythroblastosis: clustered integration sites and the arrangement of provirus in the c-erbB alleles.

1985 • 91 citations

A mutation in the beta-globin gene detected in the progeny of a female mouse treated with ethylnitrosourea.

1985 • 57 citations

Nervous-system-specific carcinogenesis by ethylnitrosourea in the rat: molecular and cellular aspects

1977 • 30 citations

Studies on the Light-transducing Pigment Bacteriorhodopsin

1983 • 13 citations